Information on EC 1.3.99.8 - 2-furoyl-CoA dehydrogenase

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EC Tree 1 Oxidoreductases 1.3 Acting on the CH-CH group of donors 1.3.99 With unknown physiological acceptors 1.3.99.8 2-furoyl-CoA dehydrogenase

IUBMB Comments

A copper protein. The oxygen atom of the -OH produced is derived from water, not O₂; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH₂- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH₂-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.

The expected taxonomic range for this enzyme is: Pseudomonas putida

Reaction Schemes

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S-(5-hydroxy-2-furoyl)-CoA

reduced acceptor

Synonyms
2-furoyl-coa dehydrogenase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

2-furoyl coenzyme A dehydrogenase

2-furoyl coenzyme A hydroxylase

dehydrogenase, 2-furoyl coenzyme A

furoyl-CoA hydroxylase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor

3 entries

2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor

mechanism