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EC Tree
IUBMB Comments The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)].
The enzyme appears in viruses and cellular organisms
Synonyms
iolU ,
IolW , NADP+-dependent SI dehydrogenase,
yulF ,
yvaA ,
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NADP+-dependent SI dehydrogenase
iolU
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IolW
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NADP+-dependent SI dehydrogenase
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NADP+-dependent SI dehydrogenase
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yulF
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yvaA
formerly, gene name
yvaA
formerly, gene name
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scyllo-inositol + NADP+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
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scyllo-inositol:NADP+ 2-oxidoreductase
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)].
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scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
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?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
no activity with NAD+
2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose
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r
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
recombinant His6-tagged YulF converts scyllo-inosose into SI in an NADPH-dependent manner
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?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
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-
-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
recombinant His6-tagged YulF converts scyllo-inosose into SI in an NADPH-dependent manner
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-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
no activity with NAD+
2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose
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r
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scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
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-
-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
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?
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NADP+
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no activity with NAD+
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1.68
2,4,6/3,5-pentahydroxycyclohexanone
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pH 7.5, 37°C
0.096
NADP+
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pH 7.5, 37°C
0.027
NADPH
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pH 7.5, 37°C
34.3
scyllo-Inositol
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pH 7.5, 37°C
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SwissProt
brenda
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UniProt
brenda
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SwissProt
brenda
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UniProt
brenda
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brenda
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brenda
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evolution
IolW shares a significant similarity with YulF, another NADP+-dependent SI dehydrogenase; YulF shares a significant similarity with IolW, another NADP+-dependent SI dehydrogenase
evolution
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IolW shares a significant similarity with YulF, another NADP+-dependent SI dehydrogenase; YulF shares a significant similarity with IolW, another NADP+-dependent SI dehydrogenase
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additional information
when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW; when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW
additional information
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when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW; when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW
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Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
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expression in Escherichia coli as a C-terminally His6-tagged fusion protein
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gene iolW, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family; gene yulF, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family, recombinant expression of His6-tagged YulF
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induced during growth on scyllo-inositol
induced during growth on scyllo-inositol
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induced during growth on scyllo-inositol
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Morinaga, T.; Ashida, H.; Yoshida, K.
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis
Microbiology
156
1538-1546
2010
Bacillus subtilis 168 (O32223), Bacillus subtilis (O32223)
brenda
Kang, D.M.; Tanaka, K.; Takenaka, S.; Ishikawa, S.; Yoshida, K.I.
Bacillus subtilis iolU encodes an additional NADP(+)-dependent scyllo-inositol dehydrogenase
Biosci. Biotechnol. Biochem.
81
1026-1032
2017
Bacillus subtilis 168 (O05265), Bacillus subtilis 168 (O32223), Bacillus subtilis (O05265), Bacillus subtilis (O32223)
brenda
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Enzyme Nomenclature
1.1.1.371 scyllo-inositol 2-dehydrogenase (NADP+)
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