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Information on EC 1.1.1.371 - scyllo-inositol 2-dehydrogenase (NADP+) for references in articles please use BRENDA:EC1.1.1.371
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EC Tree
IUBMB Comments The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)].
The expected taxonomic range for this enzyme is: Bacillus subtilis
Synonyms
iolU, IolW, NADP+-dependent SI dehydrogenase, yulF, yvaA,
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NADP+-dependent SI dehydrogenase
iolU
gene name
IolW
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NADP+-dependent SI dehydrogenase
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NADP+-dependent SI dehydrogenase
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yulF
gene name
yvaA
formerly, gene name
yvaA
formerly, gene name
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scyllo-inositol + NADP+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
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scyllo-inositol:NADP+ 2-oxidoreductase
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)].
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scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
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-
-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
no activity with NAD+
2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose
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r
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
recombinant His6-tagged YulF converts scyllo-inosose into SI in an NADPH-dependent manner
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-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
-
-
-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
recombinant His6-tagged YulF converts scyllo-inosose into SI in an NADPH-dependent manner
-
-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
no activity with NAD+
2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose
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r
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scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
O05265
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-
-
?
scyllo-inositol + NADP+
2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
O05265
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-
?
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NADP+
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no activity with NAD+
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1.68
2,4,6/3,5-pentahydroxycyclohexanone
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pH 7.5, 37°C
0.096
NADP+
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pH 7.5, 37°C
0.027
NADPH
-
pH 7.5, 37°C
34.3
scyllo-Inositol
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pH 7.5, 37°C
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SwissProt
brenda
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UniProt
brenda
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SwissProt
brenda
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UniProt
brenda
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brenda
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brenda
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evolution
IolW shares a significant similarity with YulF, another NADP+-dependent SI dehydrogenase; YulF shares a significant similarity with IolW, another NADP+-dependent SI dehydrogenase
evolution
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IolW shares a significant similarity with YulF, another NADP+-dependent SI dehydrogenase; YulF shares a significant similarity with IolW, another NADP+-dependent SI dehydrogenase
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additional information
when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW; when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW
additional information
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when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW; when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW
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IOLU_BACSU
Bacillus subtilis (strain 168)
328
0
36515
Swiss-Prot
IOLW_BACSU
Bacillus subtilis (strain 168)
358
0
40112
Swiss-Prot
A0A0E9Z9P9_KLEPN
346
0
38061
TrEMBL
A0A0K8M812_PSESF
339
0
36961
TrEMBL
A0A399E308_9DEIN
346
0
38848
TrEMBL
A0A4P6LTW9_9FIRM
392
0
43968
TrEMBL
A0A221UVC2_9FLAO
347
0
39122
TrEMBL
A0A0J1FIL3_9FIRM
358
0
39856
TrEMBL
A0A2P8ATA1_9ACTN
355
0
38099
TrEMBL
A0A378FHG4_KLEPN
346
0
38148
TrEMBL
A0A3B0N008_9RHOB
365
0
39477
TrEMBL
A0A2S6S6R5_9PROT
305
0
35388
TrEMBL
A0A2S6X2W3_9ACTN
360
0
37986
TrEMBL
A0A3P7S0X5_9FIRM
328
0
37607
TrEMBL
A0A163RB02_9CELL
347
0
36892
TrEMBL
A0A1S8RAY3_CLOBE
349
0
39540
TrEMBL
A0A2S6TNB7_9PROT
366
0
38544
TrEMBL
D2TZF7_9GAMM
348
0
38911
TrEMBL
A0A1S8PHF6_CLOBE
349
0
39634
TrEMBL
A0A1D2KBP8_BROTH
331
0
36743
TrEMBL
A0A399E5U4_9DEIN
346
0
38295
TrEMBL
A0A2Z2NVR0_9GAMM
349
0
38674
TrEMBL
A0A4Q7DAH6_9MICO
393
0
41077
TrEMBL
A0A2H5XDR6_9BACT
364
0
41084
TrEMBL
A0A0J1FCB3_9FIRM
108
0
11938
TrEMBL
A0A177HUD5_9ACTN
297
0
30633
TrEMBL
A0A1S8TT59_9CLOT
330
0
37185
TrEMBL
A0A1V2MY32_9ACTN
398
0
42257
TrEMBL
A0A448YBI2_9FIRM
313
0
35608
TrEMBL
A0A2Z2NV71_9GAMM
343
0
38009
TrEMBL
A0A2P7ZLZ1_9ACTN
360
0
38104
TrEMBL
A0A4Q8MW32_PASMD
350
0
39625
TrEMBL
A0A2H5ZZI4_9BACT
336
0
36708
TrEMBL
A0A1S8S8U2_CLOBE
349
0
39703
TrEMBL
A0A1S8Q0E3_CLOBE
349
0
39651
TrEMBL
W8TEE9_ECOLX
346
0
38242
TrEMBL
A0A1A7BZ79_9BURK
348
0
37790
TrEMBL
A0A1V4IV01_9CLOT
348
0
39666
TrEMBL
A0A399ELJ0_9DEIN
345
0
39097
TrEMBL
A0A385XZL2_9GAMM
349
0
38966
TrEMBL
A0A344UW58_9ACTN
343
0
36765
TrEMBL
A0A1D9PNL3_9BACI
346
0
38325
TrEMBL
A0A2H5X4H1_9BACT
342
0
39253
TrEMBL
A0A2H5X234_9BACT
356
0
40125
TrEMBL
A0A448Y9J1_9FIRM
315
0
35843
TrEMBL
A0A448Y6X8_9FIRM
116
0
13279
TrEMBL
A0A4P6ZCQ8_9FLAO
336
0
38003
TrEMBL
A0A3Q9J0U3_9MICO
333
0
35534
TrEMBL
A0A140L2D6_9CLOT
353
0
39872
TrEMBL
A0A1J7D1V4_KLEPN
372
0
40850
TrEMBL
A0A2X0QXZ0_9LACT
326
0
36244
TrEMBL
A0A231GZJ4_9NOCA
344
0
36650
TrEMBL
A0A1G4G489_9PORP
355
0
39880
TrEMBL
A0A4P6M5V1_9FIRM
354
0
40057
TrEMBL
A0A2Z4ACU4_9BACT
346
0
39310
TrEMBL
A0A066SVM5_ECOLX
346
0
38242
TrEMBL
A0A1Y0XCL2_BACAM
346
0
38452
TrEMBL
A0A0J1FQN8_9FIRM
353
0
39566
TrEMBL
A0A2Z2NWM0_9GAMM
334
0
36683
TrEMBL
A0A2H5WR08_9BACT
425
1
46995
TrEMBL
A0A385ZRK8_9ACTN
357
0
37987
TrEMBL
A0A2R8CGM5_9GAMM
343
0
37955
TrEMBL
A0A2S2DU46_9BACT
348
0
39296
TrEMBL
A0A2H5XG58_9BACT
350
0
37512
TrEMBL
A0A483BDA4_OENOE
319
0
35877
TrEMBL
A0A348A7E1_BACAN
343
0
38759
TrEMBL
A0A199XPM8_9FLAO
346
0
38777
TrEMBL
A0A4Q7DBE0_9MICO
360
0
38441
TrEMBL
A0A2H5WXQ6_9BACT
463
0
50980
TrEMBL
A0A2S2E1U0_9ALTE
357
0
40116
TrEMBL
A0A509DS84_9GAMM
346
0
38621
TrEMBL
A0A2Z4LR50_9FLAO
452
0
50623
TrEMBL
A0A1U9SJU2_ECOLX
346
0
38300
TrEMBL
A0A3P5GRW6_ECOLX
315
0
35349
TrEMBL
A0A3P4ILP3_KLEPN
372
0
40915
TrEMBL
A0A369QKC6_9BACT
353
1
39538
TrEMBL
A0A3P5Y517_STRCB
319
0
35383
TrEMBL
A0A2J7VYJ2_9BURK
353
0
38147
TrEMBL
A0A3P5DC39_ECOLX
346
0
38245
TrEMBL
A0A345DAR9_9BURK
352
0
38092
TrEMBL
A0A1K2FRJ8_9ACTN
356
0
37265
TrEMBL
A0A2S2DRY5_9BACT
465
0
52062
TrEMBL
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Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
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expression in Escherichia coli as a C-terminally His6-tagged fusion protein
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gene iolW, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family; gene yulF, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family, recombinant expression of His6-tagged YulF
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induced during growth on scyllo-inositol
induced during growth on scyllo-inositol
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induced during growth on scyllo-inositol
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Morinaga, T.; Ashida, H.; Yoshida, K.
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis
Microbiology
156
1538-1546
2010
Bacillus subtilis 168 (O32223), Bacillus subtilis (O32223)
brenda
Kang, D.M.; Tanaka, K.; Takenaka, S.; Ishikawa, S.; Yoshida, K.I.
Bacillus subtilis iolU encodes an additional NADP(+)-dependent scyllo-inositol dehydrogenase
Biosci. Biotechnol. Biochem.
81
1026-1032
2017
Bacillus subtilis 168 (O05265), Bacillus subtilis 168 (O32223), Bacillus subtilis (O05265), Bacillus subtilis (O32223)
brenda
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1.1.1.371 scyllo-inositol 2-dehydrogenase (NADP+)
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