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EC 4.3.1.9 Details

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EC number

4.3.1.9

Accepted name

glucosaminate ammonia-lyase

Reaction

2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH₃ (overall reaction);;(1a) 2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H₂O;;(1b) (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate (spontaneous);;(1c) (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H₂O = 2-dehydro-3-deoxy-D-gluconate + NH₃ (spontaneous)

Other name(s)

glucosaminic dehydrase, D-glucosaminate dehydratase, D-glucosaminic acid dehydrase, aminodeoxygluconate dehydratase, 2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating), aminodeoxygluconate ammonia-lyase, 2-amino-2-deoxy-D-gluconate ammonia-lyase, D-glucosaminate ammonia-lyase, D-glucosaminate ammonia-lyase (isomerizing, 2-dehydro-3-deoxy-D-gluconate-forming)

Systematic name

2-amino-2-deoxy-D-gluconate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)

CAS registry number

37290-91-8

Comment

Contains pyridoxal phosphate. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination to form the final product.

History

created 1972, (EC 4.3.1.21 created 1965 as EC 4.2.1.26, transferred 2002 to EC 4.3.1.21, incorporated 2004) modified 2004

EC Tree

4.1 Carbon-carbon lyases

4.2 Carbon-oxygen lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

4.3.1.1 aspartate ammonia-lyase

4.3.1.2 methylaspartate ammonia-lyase

4.3.1.3 histidine ammonia-lyase

4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase

4.3.1.5 phenylalanine ammonia-lyase

4.3.1.6 β-alanyl-CoA ammonia-lyase

4.3.1.7 ethanolamine ammonia-lyase

4.3.1.8 created 1972, modified 1982, modified 1989, deleted 2003

4.3.1.9 glucosaminate ammonia-lyase

4.3.1.10 serine-sulfate ammonia-lyase

4.3.1.11 dihydroxyphenylalanine ammonia-lyase

4.3.1.12 ornithine cyclodeaminase

4.3.1.13 carbamoyl-serine ammonia-lyase

4.3.1.14 3-aminobutyryl-CoA ammonia-lyase

4.3.1.15 diaminopropionate ammonia-lyase

4.3.1.16 threo-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.17 L-serine ammonia-lyase

4.3.1.18 D-serine ammonia-lyase

4.3.1.19 threonine ammonia-lyase

4.3.1.20 erythro-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.21 created 1965 as EC 4.2.1.26, transferred 2002 to EC 4.3.1.21, deleted 2004

4.3.1.22 3,4-dihydroxyphenylalanine reductive deaminase

4.3.1.23 tyrosine ammonia-lyase

4.3.1.24 phenylalanine ammonia-lyase

4.3.1.25 phenylalanine/tyrosine ammonia-lyase

4.3.1.26 chromopyrrolate synthase

4.3.1.27 threo-3-hydroxy-D-aspartate ammonia-lyase

4.3.1.28 L-lysine cyclodeaminase

4.3.1.29 D-glucosaminate-6-phosphate ammonia-lyase

4.3.1.30 dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase

4.3.1.31 L-tryptophan ammonia lyase

4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

4.3.2 Amidine-lyases

4.3.3 Amine-lyases

4.3.99 Other carbon-nitrogen lyases

4.4 Carbon-sulfur lyases

4.5 Carbon-halide lyases

4.6 Phosphorus-oxygen lyases

4.7 carbon-phosphorus lyases

4.7.1 carbon-phosphorus lyases (only sub-subclass identified to date)

4.8 Nitrogen-oxygen lyases

4.98 ATP-independent chelatases