Information on EC 4.3.1.9 - glucosaminate ammonia-lyase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.9 glucosaminate ammonia-lyase
IUBMB Comments
Contains pyridoxal phosphate. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination to form the final product.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
ammonia-lyase, glucosaminate, D-glucosaminate dehydrogenase, D-glucosaminic acid dehydrase, EC 4.3.1.21, ec4.2.1.26, ec4.3.1.21, GADH, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH3
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2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O
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(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate
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(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH3
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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