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EC 4.3.1.26 Details

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EC number

4.3.1.26

Accepted name

chromopyrrolate synthase

Reaction

2 2-imino-3-(7-chloroindol-3-yl)propanoate = dichlorochromopyrrolate + NH₃

Other name(s)

RebD, chromopyrrolic acid synthase

Systematic name

2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming)

Comment

This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. The enzyme also possesses catalase activity.

History

created 2010, deleted 2013

EC Tree

4.1 Carbon-carbon lyases

4.2 Carbon-oxygen lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

4.3.1.1 aspartate ammonia-lyase

4.3.1.2 methylaspartate ammonia-lyase

4.3.1.3 histidine ammonia-lyase

4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase

4.3.1.5 phenylalanine ammonia-lyase

4.3.1.6 β-alanyl-CoA ammonia-lyase

4.3.1.7 ethanolamine ammonia-lyase

4.3.1.8 created 1972, modified 1982, modified 1989, deleted 2003

4.3.1.9 glucosaminate ammonia-lyase

4.3.1.10 serine-sulfate ammonia-lyase

4.3.1.11 dihydroxyphenylalanine ammonia-lyase

4.3.1.12 ornithine cyclodeaminase

4.3.1.13 carbamoyl-serine ammonia-lyase

4.3.1.14 3-aminobutyryl-CoA ammonia-lyase

4.3.1.15 diaminopropionate ammonia-lyase

4.3.1.16 threo-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.17 L-serine ammonia-lyase

4.3.1.18 D-serine ammonia-lyase

4.3.1.19 threonine ammonia-lyase

4.3.1.20 erythro-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.21 created 1965 as EC 4.2.1.26, transferred 2002 to EC 4.3.1.21, deleted 2004

4.3.1.22 3,4-dihydroxyphenylalanine reductive deaminase

4.3.1.23 tyrosine ammonia-lyase

4.3.1.24 phenylalanine ammonia-lyase

4.3.1.25 phenylalanine/tyrosine ammonia-lyase

4.3.1.26 chromopyrrolate synthase

4.3.1.27 threo-3-hydroxy-D-aspartate ammonia-lyase

4.3.1.28 L-lysine cyclodeaminase

4.3.1.29 D-glucosaminate-6-phosphate ammonia-lyase

4.3.1.30 dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase

4.3.1.31 L-tryptophan ammonia lyase

4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

4.3.2 Amidine-lyases

4.3.3 Amine-lyases

4.3.99 Other carbon-nitrogen lyases

4.4 Carbon-sulfur lyases

4.5 Carbon-halide lyases

4.6 Phosphorus-oxygen lyases

4.7 carbon-phosphorus lyases

4.8 Nitrogen-oxygen lyases

4.98 ATP-independent chelatases

7.1 Catalysing the translocation of hydrons

7.2 Catalysing the translocation of inorganic cations

7.3 Catalysing the translocation of inorganic anions and their chelates

7.4 Catalysing the translocation of amino acids and peptides

7.5 Catalysing the translocation of carbohydrates and their derivatives

7.6 Catalysing the translocation of other compounds