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EC 4.3.1.22 Details

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EC number

4.3.1.22

Accepted name

3,4-dihydroxyphenylalanine reductive deaminase

Reaction

L-dopa + NADH = 3,4-dihydroxyphenylpropanoate + NAD⁺ + NH₃

Other name(s)

reductive deaminase, DOPA-reductive deaminase, DOPARDA

Systematic name

3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming)

Comment

Forms part of the L-phenylalanine-catabolism pathway in the anoxygenic phototrophic bacterium Rhodobacter sphaeroides OU5. NADPH is oxidized more slowly than NADH.

History

created 2007

EC Tree

4.1 Carbon-carbon lyases

4.2 Carbon-oxygen lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

4.3.1.1 aspartate ammonia-lyase

4.3.1.2 methylaspartate ammonia-lyase

4.3.1.3 histidine ammonia-lyase

4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase

4.3.1.5 phenylalanine ammonia-lyase

4.3.1.6 β-alanyl-CoA ammonia-lyase

4.3.1.7 ethanolamine ammonia-lyase

4.3.1.8 created 1972, modified 1982, modified 1989, deleted 2003

4.3.1.9 glucosaminate ammonia-lyase

4.3.1.10 serine-sulfate ammonia-lyase

4.3.1.11 dihydroxyphenylalanine ammonia-lyase

4.3.1.12 ornithine cyclodeaminase

4.3.1.13 carbamoyl-serine ammonia-lyase

4.3.1.14 3-aminobutyryl-CoA ammonia-lyase

4.3.1.15 diaminopropionate ammonia-lyase

4.3.1.16 threo-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.17 L-serine ammonia-lyase

4.3.1.18 D-serine ammonia-lyase

4.3.1.19 threonine ammonia-lyase

4.3.1.20 erythro-3-hydroxy-L-aspartate ammonia-lyase

4.3.1.21 created 1965 as EC 4.2.1.26, transferred 2002 to EC 4.3.1.21, deleted 2004

4.3.1.22 3,4-dihydroxyphenylalanine reductive deaminase

4.3.1.23 tyrosine ammonia-lyase

4.3.1.24 phenylalanine ammonia-lyase

4.3.1.25 phenylalanine/tyrosine ammonia-lyase

4.3.1.26 chromopyrrolate synthase

4.3.1.27 threo-3-hydroxy-D-aspartate ammonia-lyase

4.3.1.28 L-lysine cyclodeaminase

4.3.1.29 D-glucosaminate-6-phosphate ammonia-lyase

4.3.1.30 dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase

4.3.1.31 L-tryptophan ammonia lyase

4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

4.3.2 Amidine-lyases

4.3.3 Amine-lyases

4.3.99 Other carbon-nitrogen lyases

4.4 Carbon-sulfur lyases

4.5 Carbon-halide lyases

4.6 Phosphorus-oxygen lyases

4.7 carbon-phosphorus lyases

4.8 Nitrogen-oxygen lyases

4.98 ATP-independent chelatases

7.1 Catalysing the translocation of hydrons

7.2 Catalysing the translocation of inorganic cations

7.3 Catalysing the translocation of inorganic anions and their chelates

7.4 Catalysing the translocation of amino acids and peptides

7.5 Catalysing the translocation of carbohydrates and their derivatives

7.6 Catalysing the translocation of other compounds