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2.4.2.64: tRNA-guanosine34 queuine transglycosylase

This is an abbreviated version!
For detailed information about tRNA-guanosine34 queuine transglycosylase, go to the full flat file.

Word Map on EC 2.4.2.64

Reaction

guanine34 in tRNA
+
queuine
=
queuine34 in tRNA
 +
guanine

Synonyms

guanine,queuine-tRNA transglycosylase, QTRT1, QTRT2, QTRTD1, queuine tRNA-ribosyltransferase 1, queuine tRNA-ribosyltransferase domain-containing 1, TGT, tRNA-guanine transglycosidase, tRNA-guanine transglycosylase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.64 tRNA-guanosine34 queuine transglycosylase

Inhibitors

Inhibitors on EC 2.4.2.64 - tRNA-guanosine34 queuine transglycosylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,4-Diamino-6-hydroxypyrimidine
-
1.2 mM, 52% inhibition of exchange between free guanine with guanine
2,6-diamino-8-[[(1H-imidazol-2-yl)sulfanyl]methyl]quinazolin-4(3H)-one
-
2-butyl-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione
-
3-Deazaguanine
-
0.25 mM, 50% inhibition of exchange between free guanine with guanine
4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
-
4-aminophthalhydrazide
-
5,7-diamino-2,3-dihydro-phthalazine-1,4-dione
-
6-amino-3-(2-phenylethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
-
6-amino-3-benzyl-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
-
6-amino-4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
-
6-amino-4-phenyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
-
6-amino-4-[2-(4-methylphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
-
6-amino-4-[2-(methoxyphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
-
6-aminoimidazol[4,5-g]quinazolin-8(7H)-one
-
-
6-methylmercaptoguanine
-
0.05 mM, 65% inhibition of exchange between free guanine with guanine
6-thioguanine
-
0.05 mM, 74% inhibition of exchange between free guanine with guanine
7-(aminomethyl)-7-deazaguanine
-
0.01 mM, 28% inhibition
7-Deazaguanine
-
0.06 mM, 27% inhibition of exchange between free guanine with guanine
7-methylguanine
8-Azaguanine
-
0.05 mM, complete inhibition of exchange between free guanine with guanine
8-Bromoguanine
-
0.05 mM, 86% inhibition of exchange between free guanine with guanine
8-dimethylaminomethyl-7-deazaguanine
-
0.05 mM, 32% inhibition of exchange between free guanine with guanine
adenine
-
0.05 mM, 14% inhibition of exchange between free guanine with guanine
biopterin
Cd2+
-
10 mM
Co2+
-
10 mM
Cu2+
-
10 mM
folic acid
-
1.2 mM, complete inhibition of exchange between free guanine with guanine
isocytosine
-
1.2 mM, 52% inhibition of exchange between free guanine with guanine
lumazine
-
1.2 mM, 18% inhibition of exchange between free guanine with guanine
Mn2+
-
10 mM
neplanocin A
-
0.1 mM, 45% inhibition of exchange between free guanine with guanine
Ni2+
-
10 mM
Pb2+
-
10 mM
pterin
pterin-6-carboxylic acid
-
1.2 mM, 57% inhibition of exchange between free guanine with guanine
queuine
sepiapterin
-
0.13 mM, 33% inhibition of exchange between free guanine with guanine
tetrahydrobiopterin
-
0.02 mM, 82% inhibition of exchange between free guanine with guanine
xanthine
-
for the mutant enzyms D143S and D143T, xanthine is competitive, with respect to guanine
Zn2+
-
10 mM
additional information
-
design, synthesis, and in vitro evaluation of novel tricyclic TGT inhibitors based on the lin-benzoguanine scaffold
-