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Literature summary for 2.4.2.64 extracted from
- tRNA-guanine transglycosylase from E. coli: a ping-pong kinetic mechanism is consistent with nucleophilic catalysis (2003), Bioorg. Chem., 31, 331-344.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is required for pathogenicity in Shigella flexneri and therefor is a potentially novel antibacterial target | Shigella flexneri |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-methylguanine | - |
Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | - |
? | - |
? | |
| additional information | Shigella flexneri | the enzyme is required for virulence | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Shigella flexneri | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| guanine34 in tRNA + queuine = queuine34 in tRNA + guanine | ping-pong kinetic mechanism | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
Escherichia coli | ? | - |
? | |
| additional information | the enzyme is required for virulence | Shigella flexneri | ? | - |
? | |
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Release 2023.1 (January 2023)
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