1.14.14.74: albendazole monooxygenase (hydroxylating)

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For detailed information about albendazole monooxygenase (hydroxylating), go to the full flat file.

Reaction

Synonyms

CYP2J2

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.74 albendazole monooxygenase (hydroxylating)

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Systematic Name on EC 1.14.14.74 - albendazole monooxygenase (hydroxylating)

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albendazole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

CYP2J2 is a microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. cf. EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming).