1.14.14.74: albendazole monooxygenase (hydroxylating)

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For detailed information about albendazole monooxygenase (hydroxylating), go to the full flat file.

Reaction

Synonyms

CYP2J2

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.74 albendazole monooxygenase (hydroxylating)

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Results	in table
14	AA Sequence
1	Cloned(Commentary)
1	General Information
13	IC50 Value
4	Inhibitors
1	Localization
1	Natural Substrates/ Products (Substrates)
2	Organism
3	Protein Variants
1	Reaction
2	Reference
2	Source Tissue
5	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name

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Reference on EC 1.14.14.74 - albendazole monooxygenase (hydroxylating)

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744049

Wu, Z.; Lee, D.; Joo, J.; Shin, J.; Kang, W.; Oh, S.; Lee, D.; Lee, S.; Yea, S.; Lee, H.; Lee, T.; Liu, K.

CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems

Antimicrob. Agents Chemother.

5448-5456

2013

Homo sapiens (P51589)

23959307

744774

Lee, E.; Kim, J.H.; Shon, J.C.; Wu, Z.; Kim, H.J.; Gim, M.; Lee, T.; Liu, K.H.

Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes

Drug Metab. Pharmacokinet.

159-163

2018

Homo sapiens (P51589)

29759885