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Acquired Immunodeficiency Syndrome
Connecting Replication and Repair: YoaA, a Helicase-Related Protein, Promotes Azidothymidine Tolerance through Association with Chi, an Accessory Clamp Loader Protein.
Acquired Immunodeficiency Syndrome
Escherichia coli DbpA is a 3' --> 5' RNA helicase.
Acquired Immunodeficiency Syndrome
Helicase and polymerase move together close to the fork junction and copy DNA in one-nucleotide steps.
Acquired Immunodeficiency Syndrome
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Acquired Immunodeficiency Syndrome
On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing.
Acquired Immunodeficiency Syndrome
Structural Insights into a Unique Dimeric DEAD-Box Helicase CshA that Promotes RNA Decay.
Acquired Immunodeficiency Syndrome
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
Acquired Immunodeficiency Syndrome
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Acro-Osteolysis
A novel pathogenic variant p.Asp797Val in IFIH1 in a Japanese boy with overlapping Singleton-Merten syndrome and Aicardi-Goutières syndrome.
Acute Lung Injury
?-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling.
Addison Disease
Polymorphisms in the Interferon-Induced Helicase (IFIH1) locus and susceptibility to Addison's disease.
Adenocarcinoma
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Adenocarcinoma
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Adenocarcinoma
miR-545 inhibited pancreatic ductal adenocarcinoma growth by targeting RIG-I.
Adenocarcinoma
Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs.
Adenocarcinoma
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
Adenoviridae Infections
Adenovirus Virus-Associated RNAs Induce Type I Interferon Expression through a RIG-I-Mediated Pathway.
African Horse Sickness
Characterization of the nucleic acid binding activity of inner core protein VP6 of African horse sickness virus.
African Horse Sickness
Targeted mutational analysis to unravel the complexity of African horse sickness virus NS3 function in mammalian cells.
African Swine Fever
The identification of an African swine fever gene with conserved helicase motifs and a striking homology to herpes virus origin binding protein, UL9.
African Swine Fever
Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes.
African Swine Fever
Three African swine fever virus genes encoding proteins with homology to putative helicases of vaccinia virus.
alpha-Thalassemia
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
alpha-Thalassemia
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Alveolitis, Extrinsic Allergic
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Alzheimer Disease
Borrowing nuclear DNA helicases to protect mitochondrial DNA.
Alzheimer Disease
Decreased base excision repair and increased helicase activity in Alzheimer's disease brain.
Alzheimer Disease
eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.
Alzheimer Disease
Genetic variations in chromodomain helicase DNA-binding protein 5, gene-environment interactions and risk of sporadic Alzheimer's disease in Chinese population.
Alzheimer Disease
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Alzheimer Disease
Werner helicase polymorphism is not associated with Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.
Amyotrophic Lateral Sclerosis
DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4).
Amyotrophic Lateral Sclerosis
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Amyotrophic Lateral Sclerosis
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Amyotrophic Lateral Sclerosis
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Androgen-Insensitivity Syndrome
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Anemia
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Anemia
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Anemia, Diamond-Blackfan
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Anemia, Hypochromic
Chlorosis caused by two recessively interacting genes reveals a role of RNA helicase in hybrid breakdown in Arabidopsis thaliana.
Anemia, Hypochromic
Identification and regulation of host genes related to Rice stripe virus symptom production.
Anemia, Hypochromic
Leaf chlorosis in Arabidopsis thaliana hybrids is associated with transgenerational decline and imbalanced ribosome number.
Aortic Aneurysm, Abdominal
Endovascular abdominal aortic aneurysm sizing and case planning using the TeraRecon Aquarius workstation.
Apraxias
Ataxia with oculomotor apraxia type 2 fibroblasts exhibit increased susceptibility to oxidative DNA damage.
Apraxias
Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2.
Apraxias
Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.
Apraxias
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Apraxias
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Apraxias
Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.
Apraxias
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Arenaviridae Infections
Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production.
Arenaviridae Infections
Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells.
Arteriosclerosis
Chromatin changes in SMARCAL1 deficiency: A hypothesis for the gene expression alterations of Schimke immuno-osseous dysplasia.
Arteritis
Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases.
Arteritis
Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure.
Arteritis
ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex.
Arteritis
Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains.
Arthritis
[Damage-associated molecular patterns and chronic diseases]
Arthritis, Rheumatoid
Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses.
Arthritis, Rheumatoid
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.
Arthritis, Rheumatoid
Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes.
Arthritis, Rheumatoid
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.
Asthma
Genetic associations with viral respiratory illnesses and asthma control in children.
Asthma
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Astrocytoma
Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA.
Astrocytoma
RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population.
Ataxia
Ataxia with oculomotor apraxia type 2 fibroblasts exhibit increased susceptibility to oxidative DNA damage.
Ataxia
Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2.
Ataxia
Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.
Ataxia
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Ataxia
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Ataxia
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Ataxia Telangiectasia
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Ataxia Telangiectasia
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Ataxia Telangiectasia
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
Ataxia Telangiectasia
Genetic testing for hereditary prostate cancer: Current status and limitations.
Ataxia Telangiectasia
Germline genetic variants in men with prostate cancer and one or more additional cancers.
Ataxia Telangiectasia
Klotho suppresses RIG-I-mediated senescence-associated inflammation.
Ataxia Telangiectasia
Senataxin controls meiotic silencing through ATR activation and chromatin remodeling.
Atherosclerosis
Endothelial RIG-I activation impairs endothelial function.
Atherosclerosis
Expression of retinoic acid-inducible gene-I (RIG-I) in macrophages: possible involvement of RIG-I in atherosclerosis.
Atherosclerosis
Identification of candidate targets for the diagnosis and treatment of atherosclerosis by bioinformatics analysis.
Atherosclerosis
[Damage-associated molecular patterns and chronic diseases]
Autoimmune Diseases
A female autoimmunity gene exists: DDX3X.
Autoimmune Diseases
A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients.
Autoimmune Diseases
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-?B and sensitize to alkylating chemotherapy.
Autoimmune Diseases
Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.
Autoimmune Diseases
Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes.
Autoimmune Diseases
Global expression and CpG methylation analysis of primary endothelial cells before and after TNFa stimulation reveals gene modules enriched in inflammatory and infectious diseases and associated DMRs.
Autoimmune Diseases
HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.
Autoimmune Diseases
IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.
Autoimmune Diseases
Interferon induced with helicase C domain 1 (IFIH1) and virus-induced autoimmunity: a review.
Autoimmune Diseases
Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant.
Autoimmune Diseases
Retinoic acid-inducible gene-I is induced by double-stranded RNA and regulates the expression of CC chemokine ligand (CCL) 5 in human mesangial cells.
Autoimmune Diseases
RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
Autoimmune Diseases
RNA binding activates RIG-I by releasing an autorepressed signaling domain.
Autoimmune Diseases
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Autoimmune Diseases
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Autoimmune Diseases
Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
Autoimmune Diseases
UV radiation regulates Mi-2 through protein translation and stability.
Azoospermia
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Azoospermia
Complex transcriptional control of the AZFa gene DDX3Y in human testis.
Azoospermia
Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation.
Azoospermia
Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia.
Azoospermia
Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation.
Azoospermia
Progress in understanding the molecular functions of DDX3Y (DBY) in male germ cell development and maintenance.
Azoospermia
Translational control of the AZFa gene DDX3Y by 5'UTR exon-T extension.
Bacterial Infections
Inhibition of Viral Pathogenesis and Promotion of the Septic Shock Response to Bacterial Infection by IRF-3 Are Regulated by the Acetylation and Phosphorylation of Its Coactivators.
Bacterial Infections
Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis.
Bacterial Infections
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells.
Bacterial Infections
RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.
Blepharophimosis
De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome.
Bloom Syndrome
A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.
Bloom Syndrome
A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.
Bloom Syndrome
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.
Bloom Syndrome
A role for the amino terminus of human topoisomerase I.
Bloom Syndrome
Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases.
Bloom Syndrome
Absence of p53 enhances growth defects and etoposide sensitivity of human cells lacking the Bloom syndrome helicase BLM.
Bloom Syndrome
Accumulation of FFA-1, the Xenopus homolog of Werner helicase, and DNA polymerase delta on chromatin in response to replication fork arrest.
Bloom Syndrome
Atm is a negative regulator of intestinal neoplasia.
Bloom Syndrome
Augmented cell death with Bloom syndrome helicase deficiency.
Bloom Syndrome
Binding and melting of D-loops by the Bloom syndrome helicase.
Bloom Syndrome
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
Bloom Syndrome
BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells.
Bloom Syndrome
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.
Bloom Syndrome
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.
Bloom Syndrome
Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks.
Bloom Syndrome
Bloom syndrome helicase in meiosis: Pro-crossover functions of an anti-crossover protein.
Bloom Syndrome
Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction.
Bloom Syndrome
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Bloom Syndrome
Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans.
Bloom Syndrome
Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells.
Bloom Syndrome
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Bloom Syndrome
Bloom syndrome.
Bloom Syndrome
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Bloom Syndrome
Cellular defects caused by hypomorphic variants of the Bloom syndrome helicase gene BLM.
Bloom Syndrome
Centromere-Proximal Meiotic Crossovers in Drosophila melanogaster Are Suppressed by Both Highly Repetitive Heterochromatin and Proximity to the Centromere.
Bloom Syndrome
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Bloom Syndrome
Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome.
Bloom Syndrome
Chk1 protects against chromatin bridges by constitutively phosphorylating BLM serine 502 to inhibit BLM degradation.
Bloom Syndrome
Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.
Bloom Syndrome
Contribution of domain structure to the RNA 3' end processing and degradation functions of the nuclear exosome subunit Rrp6p.
Bloom Syndrome
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
Bloom Syndrome
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Bloom Syndrome
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex.
Bloom Syndrome
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.
Bloom Syndrome
Deficiency of bloom syndrome helicase activity is radiomimetic.
Bloom Syndrome
Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.
Bloom Syndrome
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors.
Bloom Syndrome
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair.
Bloom Syndrome
Disease-causing missense mutations in human DNA helicase disorders.
Bloom Syndrome
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.
Bloom Syndrome
DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase.
Bloom Syndrome
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Bloom Syndrome
Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.
Bloom Syndrome
Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.
Bloom Syndrome
Enhanced tumor formation in mice heterozygous for Blm mutation.
Bloom Syndrome
Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase.
Bloom Syndrome
Evolution of an MCM complex in flies that promotes meiotic crossovers by blocking BLM helicase.
Bloom Syndrome
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Bloom Syndrome
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.
Bloom Syndrome
Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?
Bloom Syndrome
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
Bloom Syndrome
Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage.
Bloom Syndrome
High BLM Expression Predicts Poor Clinical Outcome and Contributes to Malignant Progression in Human Cholangiocarcinoma.
Bloom Syndrome
Holliday Junction Processing Activity of the BLM-Topo III{alpha}-BLAP75 Complex.
Bloom Syndrome
Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure.
Bloom Syndrome
Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.
Bloom Syndrome
Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening.
Bloom Syndrome
Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.
Bloom Syndrome
Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks.
Bloom Syndrome
Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis.
Bloom Syndrome
Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.
Bloom Syndrome
Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system.
Bloom Syndrome
Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase.
Bloom Syndrome
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Bloom Syndrome
Mechanism of RecQ helicase mechanoenzymatic coupling reveals that the DNA interactions of the ADP-bound enzyme control translocation run terminations.
Bloom Syndrome
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.
Bloom Syndrome
Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability.
Bloom Syndrome
Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.
Bloom Syndrome
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.
Bloom Syndrome
Oligomeric ring structure of the Bloom's syndrome helicase.
Bloom Syndrome
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.
Bloom Syndrome
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination.
Bloom Syndrome
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
Bloom Syndrome
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.
Bloom Syndrome
PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA.
Bloom Syndrome
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Bloom Syndrome
Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA.
Bloom Syndrome
Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.
Bloom Syndrome
Recognition and Unfolding of c-MYC and Telomeric G-Quadruplex DNAs by the RecQ C-Terminal Domain of Human Bloom Syndrome Helicase.
Bloom Syndrome
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
Bloom Syndrome
Regulation of BLM Nucleolar Localization.
Bloom Syndrome
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
Bloom Syndrome
Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase.
Bloom Syndrome
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication.
Bloom Syndrome
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
Bloom Syndrome
RMI1 deficiency in mice protects from diet and genetic-induced obesity.
Bloom Syndrome
Role for RIF1-interacting partner DDX1 in BLM recruitment to DNA double-strand breaks.
Bloom Syndrome
Role of the Bloom's syndrome helicase in maintenance of genome stability.
Bloom Syndrome
Roles of the Bloom's syndrome helicase in the maintenance of genome stability.
Bloom Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Bloom Syndrome
RPA Phosphorylation Inhibits DNA Resection.
Bloom Syndrome
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.
Bloom Syndrome
Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila.
Bloom Syndrome
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
Bloom Syndrome
Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase.
Bloom Syndrome
Structural basis of Bloom syndrome (BS) causing mutations in the BLM helicase domain.
Bloom Syndrome
Structural Insight into BLM Recognition by TopBP1.
Bloom Syndrome
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Bloom Syndrome
Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination.
Bloom Syndrome
Super-sized deletions: Improved transposon excision screens using a mus309 mutant background.
Bloom Syndrome
Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.
Bloom Syndrome
The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling.
Bloom Syndrome
The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
Bloom Syndrome
The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis.
Bloom Syndrome
The Bloom syndrome helicase is a substrate of the mitotic Cdc2 kinase.
Bloom Syndrome
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Bloom Syndrome
The Bloom's syndrome helicase can promote the regression of a model replication fork.
Bloom Syndrome
The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.
Bloom Syndrome
The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.
Bloom Syndrome
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.
Bloom Syndrome
The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.
Bloom Syndrome
The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
Bloom Syndrome
The Bloom's syndrome helicase unwinds G4 DNA.
Bloom Syndrome
The Bloom's syndrome helicase: keeping cancer at bay.
Bloom Syndrome
The catalytic core of Leishmania donovani RECQ helicase unwinds a wide spectrum of DNA substrates and is stimulated by replication protein A.
Bloom Syndrome
The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling.
Bloom Syndrome
The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.
Bloom Syndrome
The Sgs1 helicase regulates chromosome synapsis and meiotic crossing over.
Bloom Syndrome
The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.
Bloom Syndrome
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase ? Elongation.
Bloom Syndrome
The Werner syndrome protein is a DNA helicase.
Bloom Syndrome
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
Bloom Syndrome
Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.
Bloom Syndrome
Time to bloom.
Bloom Syndrome
TopBP1 controls BLM protein level to maintain genome stability.
Bloom Syndrome
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.
Bloom Syndrome
Transcriptomic and protein expression analysis reveals clinicopathological significance of Bloom's syndrome helicase (BLM) in breast cancer.
Bloom Syndrome
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice.
Bloom Syndrome
Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination.
Bloom Syndrome
Unwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase.
Bloom Syndrome
Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates.
Bloom Syndrome
Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.
Bloom Syndrome
Werner syndrome: entering the helicase era.
Bluetongue
A coiled-coil motif in non-structural protein 3 (NS3) of bluetongue virus forms an oligomer.
Bluetongue
A DIVA system based on the detection of antibodies to non-structural protein 3 (NS3) of bluetongue virus.
Bluetongue
Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type ? interferon signaling by targeting STAT1.
Bluetongue
Bluetongue virus VP6 acts early in the replication cycle and can form the basis of chimeric virus formation.
Bluetongue
Bluetongue virus VP6 protein binds ATP and exhibits an RNA-dependent ATPase function and a helicase activity that catalyze the unwinding of double-stranded RNA substrates.
Bluetongue
Defining the structure-function relationships of bluetongue virus helicase protein VP6.
Bluetongue
Identification of four novel group-specific bluetongue virus NS3 protein B-cell epitopes.
Bluetongue
Sensing and control of Bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases.
Bluetongue
Structure based modification of Bluetongue virus helicase protein VP6 to produce a viable VP6-truncated BTV.
Bone Cysts, Aneurysmal
Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions.
Bone Marrow Failure Disorders
ATP-dependent helicase activity is dispensable for the physiological functions of Recql4.
Bone Marrow Failure Disorders
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
Bone Marrow Failure Disorders
RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility.
Borna Disease
Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.
Borna Disease
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Brain Diseases
A novel pathogenic variant p.Asp797Val in IFIH1 in a Japanese boy with overlapping Singleton-Merten syndrome and Aicardi-Goutières syndrome.
Brain Diseases
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
Brain Diseases
CHD2 myoclonic encephalopathy is frequently associated with self-induced seizures.
Brain Diseases
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Brain Ischemia
RIG-I contributes to the innate immune response after cerebral ischemia.
Brain Ischemia
The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke.
Brain Neoplasms
Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.
Brain Neoplasms
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Brain Neoplasms
Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation.
Brain Neoplasms
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
Breast Neoplasms
A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Breast Neoplasms
A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1.
Breast Neoplasms
A requirement of FancL and FancD2 monoubiquitination in DNA repair.
Breast Neoplasms
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Breast Neoplasms
Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases.
Breast Neoplasms
BACH1 Ser919Pro variant and breast cancer risk.
Breast Neoplasms
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Breast Neoplasms
BRIP1 rs10744996C>A variant increases the risk of chronic obstructive pulmonary disease in the Mongolian population of northern China.
Breast Neoplasms
CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors.
Breast Neoplasms
Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer.
Breast Neoplasms
Combined Use of Immunoreactivities of RIG-I with Efp/TRIM25 for Predicting Prognosis of Patients With Estrogen Receptor-positive Breast Cancer.
Breast Neoplasms
Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature-based meta-analysis and meta-regression analysis.
Breast Neoplasms
DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer.
Breast Neoplasms
DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.
Breast Neoplasms
DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer.
Breast Neoplasms
DEAD-box RNA Helicase 39 Promotes Invasiveness and Chemoresistance of ER-positive Breast Cancer.
Breast Neoplasms
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells.
Breast Neoplasms
Disease-causing missense mutations in human DNA helicase disorders.
Breast Neoplasms
eIF4F suppression in breast cancer affects maintenance and progression.
Breast Neoplasms
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Breast Neoplasms
Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy.
Breast Neoplasms
Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer.
Breast Neoplasms
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
Breast Neoplasms
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Breast Neoplasms
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Breast Neoplasms
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress.
Breast Neoplasms
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
Breast Neoplasms
FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.
Breast Neoplasms
Functional interplay between BRCA2/FancD1 and FancC in DNA repair.
Breast Neoplasms
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility.
Breast Neoplasms
G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells.
Breast Neoplasms
Genetic testing for hereditary prostate cancer: Current status and limitations.
Breast Neoplasms
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.
Breast Neoplasms
HAGE, the helicase antigen as a biomarker for breast cancer prognosis (WO2013144616).
Breast Neoplasms
Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer.
Breast Neoplasms
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
Breast Neoplasms
In vitro anti-cancer activity of doxorubicin against human RNA helicase, DDX3.
Breast Neoplasms
Induction of Apoptosis in Metastatic Breast Cancer Cells: XV. Downregulation of DNA Polymerase-? - Helicase Complex (Replisomes) and Glyco-Genes.
Breast Neoplasms
Induction of hemeoxygenase-1 expression after inhibition of hemeoxygenase activity promotes inflammation and worsens ischemic brain damage in mice.
Breast Neoplasms
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand.
Breast Neoplasms
Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.
Breast Neoplasms
Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.
Breast Neoplasms
Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion.
Breast Neoplasms
NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3.
Breast Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Breast Neoplasms
Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.
Breast Neoplasms
Prevalence of RECQL germline variants in Pakistani early-onset and familial breast cancer patients.
Breast Neoplasms
Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells.
Breast Neoplasms
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer.
Breast Neoplasms
Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97).
Breast Neoplasms
Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells.
Breast Neoplasms
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
Breast Neoplasms
RNA helicase DDX5 regulates microRNA expression and contributes to cytoskeletal reorganization in basal breast cancer cells.
Breast Neoplasms
RNAi screens identify CHD4 as an essential gene in breast cancer growth.
Breast Neoplasms
SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.
Breast Neoplasms
SMARCAD1 in Breast Cancer Progression.
Breast Neoplasms
SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.
Breast Neoplasms
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Breast Neoplasms
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Breast Neoplasms
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.
Breast Neoplasms
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.
Breast Neoplasms
The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells.
Breast Neoplasms
The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells.
Breast Neoplasms
The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.
Breast Neoplasms
The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy.
Breast Neoplasms
The functions of the multi-tasking Pfh1(Pif1) helicase.
Breast Neoplasms
The RNA helicase p68 modulates expression and function of the Delta133 isoform(s) of p53, and is inversely associated with Delta133p53 expression in breast cancer.
Breast Neoplasms
The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer.
Breast Neoplasms
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
Breast Neoplasms
Transcriptomic and protein expression analysis reveals clinicopathological significance of Bloom's syndrome helicase (BLM) in breast cancer.
Breast Neoplasms
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles.
Breast Neoplasms
Up-regulation of TLK1B by eIF4E overexpression predicts cancer recurrence in irradiated patients with breast cancer.
Bronchitis
An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cells.
Bronchitis
Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus.
Bronchitis
The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
Bunyaviridae Infections
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Burkitt Lymphoma
EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN.
Burkitt Lymphoma
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Burkitt Lymphoma
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Caliciviridae Infections
cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.
Candidiasis
The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.
Carcinogenesis
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
Carcinogenesis
ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.
Carcinogenesis
Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p.
Carcinogenesis
Biochemical quantification of ATPase activities during liver carcinogenesis.
Carcinogenesis
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.
Carcinogenesis
Cell biology of cancer: BRCA1 and sister chromatid pairing reactions?
Carcinogenesis
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Carcinogenesis
Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines.
Carcinogenesis
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Carcinogenesis
DDX21 promotes gastric cancer proliferation by regulating cell cycle.
Carcinogenesis
DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
Carcinogenesis
DDX3X: structure, physiologic functions and cancer.
Carcinogenesis
DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells.
Carcinogenesis
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Carcinogenesis
DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication.
Carcinogenesis
Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma.
Carcinogenesis
Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer.
Carcinogenesis
DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
Carcinogenesis
DNA helicases associated with genetic instability, cancer, and aging.
Carcinogenesis
Downregulation of MCM8 expression restrains the malignant progression of cholangiocarcinoma.
Carcinogenesis
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Carcinogenesis
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Carcinogenesis
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Carcinogenesis
Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection.
Carcinogenesis
From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis.
Carcinogenesis
Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.
Carcinogenesis
Harnessing the Activation of RIG-I Like Receptors to Inhibit Glioblastoma Tumorigenesis.
Carcinogenesis
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
Carcinogenesis
High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancer.
Carcinogenesis
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
Carcinogenesis
LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription.
Carcinogenesis
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Carcinogenesis
Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives.
Carcinogenesis
Mitochondria Autoimmunity and MNRR1 in Breast Carcinogenesis: A Review.
Carcinogenesis
Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.
Carcinogenesis
MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma.
Carcinogenesis
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Carcinogenesis
Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.
Carcinogenesis
Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
Carcinogenesis
Prognostic role of chromodomain helicase DNA binding protein 1-like protein in human solid cancers: A meta-analysis.
Carcinogenesis
RecQL4 helicase amplification is involved in human breast tumorigenesis.
Carcinogenesis
RIG-I Is a Tumor Suppressor and Biomarker of IFN-? Efficacy in HCC.
Carcinogenesis
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
Carcinogenesis
RNA helicase p68 deploys ?-catenin in regulating RelA/p65 gene expression: implications in colon cancer.
Carcinogenesis
RNAi screens identify CHD4 as an essential gene in breast cancer growth.
Carcinogenesis
Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis.
Carcinogenesis
Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.
Carcinogenesis
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Carcinogenesis
Severe gastrointestinal symptoms caused by a novel DDX3X variant.
Carcinogenesis
Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1.
Carcinogenesis
Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.
Carcinogenesis
Structural characterization of ?-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation.
Carcinogenesis
Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis.
Carcinogenesis
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Carcinogenesis
Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo.
Carcinogenesis
Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.
Carcinogenesis
The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set.
Carcinogenesis
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation In Vivo.
Carcinogenesis
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.
Carcinogenesis
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.
Carcinogenesis
The RNA helicase DDX3 is required for ovarian development and oocyte maturation in Locusta migratoria.
Carcinogenesis
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I.
Carcinogenesis
The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
Carcinogenesis
The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness.
Carcinogenesis
Tumor suppressor activity of RIG-I.
Carcinogenesis
Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.
Carcinogenesis
[Mechanisms of Epstein-Barr Virus-Mediated Oncogenesis].
Carcinoma
Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.
Carcinoma
Analysis of the RNA helicase A gene in human lung cancer.
Carcinoma
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Carcinoma
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Carcinoma
Corrigendum to "Decreased expression of DEAD-Box Helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy".
Carcinoma
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
Carcinoma
Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma.
Carcinoma
Decreased expression of DEAD-Box helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy.
Carcinoma
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Carcinoma
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Carcinoma
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
Carcinoma
Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
Carcinoma
Key contribution of eIF4H-mediated translational control in tumor promotion.
Carcinoma
Overexpression of RNA helicase p68 protein in cutaneous squamous cell carcinoma.
Carcinoma
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer.
Carcinoma
Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells.
Carcinoma
Small-molecule inhibitors targeting eIF4A in leukemia.
Carcinoma
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma.
Carcinoma
The DEAD-box RNA helicase DDX41 is a novel repressor of p21
Carcinoma
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
Carcinoma
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Carcinoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Carcinoma
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-?1 Silencing with RIG-I Activation in Pancreatic Cancer.
Carcinoma
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma.
Carcinoma
[RNA-dependent ATPase from the cells of a Krebs 2 ascitic carcinoma]
Carcinoma in Situ
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Carcinoma, Embryonal
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells.
Carcinoma, Hepatocellular
Characterization of HCV interactions with Toll-like receptors and RIG-I in liver cells.
Carcinoma, Hepatocellular
CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2.
Carcinoma, Hepatocellular
CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
Carcinoma, Hepatocellular
CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival.
Carcinoma, Hepatocellular
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling.
Carcinoma, Hepatocellular
DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity.
Carcinoma, Hepatocellular
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.
Carcinoma, Hepatocellular
Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20.
Carcinoma, Hepatocellular
DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
Carcinoma, Hepatocellular
Enhancement of interferon induction by ORF3 product of hepatitis E virus.
Carcinoma, Hepatocellular
Ftx non coding RNA-derived miR-545 promotes cell proliferation by targeting RIG-I in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Carcinoma, Hepatocellular
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a.
Carcinoma, Hepatocellular
Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Non-Homologous End Joining.
Carcinoma, Hepatocellular
Hepatitis E virus inhibits type I interferon induction by ORF1 products.
Carcinoma, Hepatocellular
Increased susceptibility of Huh7 cells to HCV replication does not require mutations in RIG-I.
Carcinoma, Hepatocellular
Knockdown of terminal differentiation induced ncRNA (TINCR) suppresses proliferation and invasion in hepatocellular carcinoma by targeting the miR-218-5p/DEAD-box helicase 5 (DDX5) axis.
Carcinoma, Hepatocellular
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.
Carcinoma, Hepatocellular
Overexpression and clinical relevance of the RNA helicase DHX15 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors.
Carcinoma, Hepatocellular
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III Characterization of DDX3X as a target of S-adenosylmethionine.
Carcinoma, Hepatocellular
RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma.
Carcinoma, Hepatocellular
Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus.
Carcinoma, Hepatocellular
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-?B Pathway.
Carcinoma, Hepatocellular
RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
Carcinoma, Hepatocellular
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
Carcinoma, Hepatocellular
RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes.
Carcinoma, Hepatocellular
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
Carcinoma, Hepatocellular
Tumor suppressor activity of RIG-I.
Carcinoma, Non-Small-Cell Lung
DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of ?-catenin.
Carcinoma, Non-Small-Cell Lung
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The DEAD-box RNA helicase 51 controls non-small cell lung cancer proliferation by regulating cell cycle progression via multiple pathways.
Carcinoma, Non-Small-Cell Lung
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Carcinoma, Renal Cell
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Carcinoma, Renal Cell
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
Carcinoma, Renal Cell
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Carcinoma, Renal Cell
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
Carcinoma, Squamous Cell
Corrigendum to "Decreased expression of DEAD-Box Helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy".
Carcinoma, Squamous Cell
Decreased expression of DEAD-Box helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy.
Carcinoma, Squamous Cell
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
Carcinoma, Squamous Cell
Overexpression of RNA helicase p68 protein in cutaneous squamous cell carcinoma.
Cardiotoxicity
Amidinoanthracyclines - a new group of potential anti-hepatitis C virus compounds.
Castleman Disease
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Cataract
Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.
Cataract
[Atypical Werner syndrome: Atypical progeroid syndrome: A case report]
Central Nervous System Viral Diseases
RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes.
Cerebellar Ataxia
Ataxia with oculomotor apraxia type 2 fibroblasts exhibit increased susceptibility to oxidative DNA damage.
Cerebellar Neoplasms
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.
Cerebral Cortical Thinning
Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome.
Cerebral Palsy
A child with a novel DDX3X variant mimicking cerebral palsy: a case report.
Charcot-Marie-Tooth Disease
Clinical diversity caused by novel IGHMBP2 variants.
CHARGE Syndrome
8q12.1q12.3 de novo microdeletion involving the CHD7 gene in a patient without the major features of CHARGE syndrome: case report and critical review of the literature.
CHARGE Syndrome
A case of CHARGE syndrome associated with hyperinsulinemic hypoglycemia in infancy.
CHARGE Syndrome
A novel CHD7 mutation in an adolescent presenting with growth and pubertal delay.
CHARGE Syndrome
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
CHARGE Syndrome
Atypical phenotypes associated with pathogenic CHD7 variants and a proposal for broadening CHARGE syndrome clinical diagnostic criteria.
CHARGE Syndrome
Cerebellar vermis hypoplasia in CHARGE syndrome: clinical and molecular characterization of 18 unrelated Korean patients.
CHARGE Syndrome
CHARGE and Kabuki syndromes: A phenotypic and molecular link.
CHARGE Syndrome
CHARGE syndrome associated with
de novo
(I1460Rfs*15) frameshift mutation of CHD7 gene in a patient with arteria lusoria and horseshoe kidney.
CHARGE Syndrome
CHARGE syndrome gastrointestinal involvement: from mouth to anus.
CHARGE Syndrome
CHARGE syndrome.
CHARGE Syndrome
CHARGEd with neural crest defects.
CHARGE Syndrome
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.
CHARGE Syndrome
CHD7 cooperates with PBAF to control multipotent neural crest formation.
CHARGE Syndrome
Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.
CHARGE Syndrome
CHD7 deficiency in "Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment.
CHARGE Syndrome
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
CHARGE Syndrome
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
CHARGE Syndrome
CHD7 mutation spectrum in 28 Swedish patients diagnosed with CHARGE syndrome.
CHARGE Syndrome
CHD7 promotes glioblastoma cell motility and invasiveness through transcriptional modulation of an invasion signature.
CHARGE Syndrome
CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression.
CHARGE Syndrome
CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance.
CHARGE Syndrome
Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning.
CHARGE Syndrome
Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors.
CHARGE Syndrome
Clinical and Genetic Analysis of CHD7 Expands the Genotype and Phenotype of CHARGE Syndrome.
CHARGE Syndrome
Clinical genetics of Kallmann syndrome.
CHARGE Syndrome
Congenital heart defects in CHARGE: The molecular role of CHD7 and effects on cardiac phenotype and clinical outcomes.
CHARGE Syndrome
Congenital T cell deficiency in a patient with CHARGE syndrome.
CHARGE Syndrome
Embryonic expression profile of chicken CHD7, the ortholog of the causative gene for CHARGE syndrome.
CHARGE Syndrome
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
CHARGE Syndrome
Familial CHARGE syndrome because of CHD7 mutation: clinical intra- and interfamilial variability.
CHARGE Syndrome
Feeding difficulty is the dominant feature in 12 Chinese newborns with CHD7 pathogenic variants.
CHARGE Syndrome
Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.
CHARGE Syndrome
Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency.
CHARGE Syndrome
Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.
CHARGE Syndrome
Identification of a novel mutation in the CHD7 gene in a patient with CHARGE syndrome.
CHARGE Syndrome
Identification of one novel CHD7 mutation in a patient from China with atypical CHARGE syndrome.
CHARGE Syndrome
Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome.
CHARGE Syndrome
Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome.
CHARGE Syndrome
Mutations in the CHD7 gene: the experience of a commercial laboratory.
CHARGE Syndrome
Non-homologous end joining repair mechanism-mediated deletion of CHD7 gene in a patient with typical CHARGE syndrome.
CHARGE Syndrome
Novel CHD7 mutations contributing to the mutation spectrum in patients with CHARGE syndrome.
CHARGE Syndrome
Novel Frameshift CHD7 Mutation Related to CHARGE Syndrome.
CHARGE Syndrome
Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome.
CHARGE Syndrome
Screening for CHARGE syndrome mutations in the CHD7 gene using denaturing high-performance liquid chromatography.
CHARGE Syndrome
Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome.
CHARGE Syndrome
Spectrum of CHD7 Mutations in 110 Individuals with CHARGE Syndrome and Genotype-Phenotype Correlation.
CHARGE Syndrome
Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism.
CHARGE Syndrome
Terminal 4q deletion and 8q duplication in a patient with CHARGE-like features.
CHARGE Syndrome
The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
CHARGE Syndrome
Three novel mutations of CHD7 gene in two turkish patients with charge syndrome; A double point mutation and an insertion.
Choanal Atresia
A novel CHD7 mutation in an adolescent presenting with growth and pubertal delay.
Choanal Atresia
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Choanal Atresia
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Choanal Atresia
Complete screening of 50 patients with CHARGE syndrome for anomalies in the CHD7 gene using a denaturing high-performance liquid chromatography-based protocol: new guidelines and a proposal for routine diagnosis.
Choanal Atresia
Discovery of a novel CHD7 CHARGE syndrome variant by integrated omics analyses.
Choanal Atresia
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Cholesteatoma
Expression of pattern recognition receptors in cholesteatoma.
Chorioamnionitis
Hierarchical Maturation of Innate Immune Defences in Very Preterm Neonates.
Chorioamnionitis
Placental and intra-amniotic inflammation are associated with altered fetal immune responses at birth.
Choriocarcinoma
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.
Classical Swine Fever
Autocatalytic Cleavage within Classical Swine Fever Virus NS3 Leads to a Functional Separation of Protease and Helicase.
Classical Swine Fever
Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase.
Classical Swine Fever
Characterization of interaction of classical swine fever virus NS3 helicase with 3' untranslated region.
Classical Swine Fever
Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-kappaB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages.
Classical Swine Fever
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
Classical Swine Fever
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.
Classical Swine Fever
RNA helicase is involved in the expression and replication of classical swine fever virus and interacts with untranslated region.
Classical Swine Fever
TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication.
Classical Swine Fever
What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?
Coccidioidomycosis
RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation.
Cockayne Syndrome
A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription.
Cockayne Syndrome
Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum.
Cockayne Syndrome
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.
Cockayne Syndrome
Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients.
Cockayne Syndrome
Novel missense mutations in a conserved loop between ERCC6 (CSB) helicase motifs V and VI: Insights into Cockayne syndrome.
Cockayne Syndrome
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene.
Cockayne Syndrome
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
Cockayne Syndrome
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Cockayne Syndrome
Werner syndrome: entering the helicase era.
Coinfection
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Coinfection
In vitro and ex vivo analyses of co-infections with swine influenza and porcine reproductive and respiratory syndrome viruses.
Coinfection
Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus.
Coinfection
RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness.
Colitis
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
Colitis
RIG-I has guts: identification of a role for RIG-I in colitis development.
Colitis
Role of DDX3 in the pathogenesis of inflammatory bowel disease.
Colitis-Associated Neoplasms
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Coloboma
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Coloboma
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Coloboma
Complete screening of 50 patients with CHARGE syndrome for anomalies in the CHD7 gene using a denaturing high-performance liquid chromatography-based protocol: new guidelines and a proposal for routine diagnosis.
Coloboma
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Coloboma
The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
Colonic Neoplasms
BRIP-1 germline mutation and its role in colon cancer: presentation of two case reports and review of literature.
Colonic Neoplasms
DEAD-box RNA helicase p68 is not required for nuclear transloction of beta-catenin in colon cancer cells.
Colonic Neoplasms
Delivery of 5'-triphosphate RNA with endosomolytic nanoparticles potently activates RIG-I to improve cancer immunotherapy.
Colonic Neoplasms
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Colonic Neoplasms
Fascin1 Suppresses RIG-I-like Receptor Signaling and Interferon-? Production by Associating with I?B Kinase ? (IKK ?) in Colon Cancer.
Colonic Neoplasms
Helicase Lymphoid-Specific Enzyme Contributes to the Maintenance of Methylation of SST1 Pericentromeric Repeats That Are Frequently Demethylated in Colon Cancer and Associate with Genomic Damage.
Colonic Neoplasms
Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells.
Colonic Neoplasms
Phosphorylation of p68 RNA helicase by p38 MAP kinase contributes to colon cancer cells apoptosis induced by oxaliplatin.
Colonic Neoplasms
PUM1 Is Overexpressed in Colon Cancer Cells With Acquired Resistance to Cetuximab.
Colonic Neoplasms
RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway.
Colonic Neoplasms
RNA helicase and colon cancer.
Colonic Neoplasms
RNA helicase p68 deploys ?-catenin in regulating RelA/p65 gene expression: implications in colon cancer.
Colonic Neoplasms
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1? mRNA is translated.
Colonic Neoplasms
The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration.
Colorectal Neoplasms
Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines.
Colorectal Neoplasms
DDX54 Plays a Cancerous Role Through Activating P65 and AKT Signaling Pathway in Colorectal Cancer.
Colorectal Neoplasms
DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer.
Colorectal Neoplasms
DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells.
Colorectal Neoplasms
DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.
Colorectal Neoplasms
DEAD-box RNA helicase protein DDX21 as a prognosis marker for early stage colorectal cancer with microsatellite instability.
Colorectal Neoplasms
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Colorectal Neoplasms
Downregulation of the Helicase Lymphoid-Specific (HELLS) Gene Impairs Cell Proliferation and Induces Cell Cycle Arrest in Colorectal Cancer Cells.
Colorectal Neoplasms
Genetic and expressional alterations of CHD genes in gastric and colorectal cancers.
Colorectal Neoplasms
Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer.
Colorectal Neoplasms
In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9.
Colorectal Neoplasms
In vivo selection of tumor-targeting RNA motifs.
Colorectal Neoplasms
Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.
Colorectal Neoplasms
Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells.
Colorectal Neoplasms
O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5.
Colorectal Neoplasms
Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer.
Colorectal Neoplasms
Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours.
Colorectal Neoplasms
Potential role of ZEB1 as a DNA repair regulator in colorectal cancer cells revealed by cancer-associated promoter profiling.
Colorectal Neoplasms
Prognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients.
Colorectal Neoplasms
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Colorectal Neoplasms
Targeting MYC Translation in Colorectal Cancer.
Colorectal Neoplasms
Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.
Colorectal Neoplasms
The Significance of Circular RNA DDX17 in Prostate Cancer.
Colorectal Neoplasms
Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer.
Colorectal Neoplasms
Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Communicable Diseases
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Communicable Diseases
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X.
Communicable Diseases, Emerging
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Confusion
RNA binding activates RIG-I by releasing an autorepressed signaling domain.
Confusion
The molecular cloning of the gene encoding the Escherichia coli 75-kDa helicase and the determination of its nucleotide sequence and gentic map position.
Congenital Abnormalities
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
Congenital Abnormalities
SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome.
Connective Tissue Diseases
Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.
Coronary Artery Disease
Coronary artery disease: AQUARIUS findings do not support the use of aliskiren in patients with CAD and prehypertension.
Coronary Artery Disease
Effects of aliskiren in diabetic and non-diabetic patients with coronary artery disease: Insights from AQUARIUS.
Coronary Disease
Effect of aliskiren on progression of coronary disease in patients with prehypertension: the AQUARIUS randomized clinical trial.
Coronavirus Infections
Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase.
Coronavirus Infections
Crystal structure of Middle East respiratory syndrome coronavirus helicase.
Coronavirus Infections
Deducing the Crystal Structure of MERS-CoV Helicase.
Coronavirus Infections
Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Is an Efficient ADP-ribose Binding Module: CRYSTAL STRUCTURE AND BIOCHEMICAL STUDIES.
Coronavirus Infections
Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response.
Coronavirus Infections
Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I Signaling.
Coronavirus Infections
NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV).
Coronavirus Infections
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.
COVID-19
A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice.
COVID-19
Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-? with in-vitro effective drug ivermectin.
COVID-19
Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents.
COVID-19
Differential roles of RIG-I like receptors in SARS-CoV-2 infection.
COVID-19
Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase.
COVID-19
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase.
COVID-19
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase.
COVID-19
Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3.
COVID-19
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
COVID-19
Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters.
COVID-19
Molecular targets for COVID-19 drug development: Enlightening Nigerians about the pandemic and future treatment.
COVID-19
Potential of Flavonoid-Inspired Phytomedicines against COVID-19.
COVID-19
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children.
COVID-19
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection.
COVID-19
Proteomic signature of host response to SARS-CoV-2 infection in the nasopharynx.
COVID-19
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells.
COVID-19
Should We Try SARS-CoV-2 Helicase Inhibitors for COVID-19 Therapy?
COVID-19
The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19.
Craniosynostoses
A novel de novo DDX3X missense variant in a female with brachycephaly and intellectual disability: a case report.
Cryptococcosis
Unlocking the DEAD-box: a key to cryptococcal virulence?
Cytomegalovirus Infections
Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis.
De Lange Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Deafness
Complete screening of 50 patients with CHARGE syndrome for anomalies in the CHD7 gene using a denaturing high-performance liquid chromatography-based protocol: new guidelines and a proposal for routine diagnosis.
Dehydration
A new DEAD-box helicase ATP-binding protein (OsABP) from rice is responsive to abiotic stress.
Dementia
RIG-I detects HIV-1 infection and mediates type I interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders.
Dengue
A comparative retrospective study of RT-PCR-based liquid hybridization assay for early, definitive diagnosis of dengue.
Dengue
A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
Dengue
A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.
Dengue
Activation of dengue virus-specific T cells modulates vascular endothelial growth factor receptor 2 expression.
Dengue
Allostery in the dengue virus NS3 helicase: Insights into the NTPase cycle from molecular simulations.
Dengue
An In-Silico Investigation of Phytochemicals as Antiviral Agents against Dengue Fever.
Dengue
Analysis of the domain interactions between the protease and helicase of NS3 in dengue and hepatitis C virus.
Dengue
Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein.
Dengue
Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery.
Dengue
Automated type specific ELISA probe detection of amplified NS3 gene products of dengue viruses.
Dengue
C5a receptor targeting of partial non-structural protein 3 of dengue virus promotes antigen-specific IFN-?-producing T-cell responses in a mucosal dengue vaccine model.
Dengue
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Dengue
Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain.
Dengue
Dengue neurovirulence in mice: identification of molecular signatures in the E and NS3 helicase domains.
Dengue
Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner.
Dengue
Dengue Virus Capsid Interacts with DDX3X-A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection.
Dengue
Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant.
Dengue
Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.
Dengue
Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3.
Dengue
Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
Dengue
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Dengue
Downregulation of Aedes aegypti chromodomain helicase DNA binding protein 7/Kismet by Wolbachia and its effect on dengue virus replication.
Dengue
Essential role of RIG-I in the activation of endothelial cells by dengue virus.
Dengue
Flaviviral helicase: insights into the mechanism of action of a motor protein.
Dengue
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications.
Dengue
Generation and characterization of a rat monoclonal antibody against the RNA polymerase protein from Dengue Virus-2.
Dengue
Global Consensus Sequence Development and Analysis of Dengue NS3 Conserved Domains.
Dengue
Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors.
Dengue
Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.
Dengue
Identification of Potential Inhibitors for Targets Involved in Dengue Fever.
Dengue
Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.
Dengue
Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response.
Dengue
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein.
Dengue
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Dengue
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Dengue
Modulation of enzymatic activity of dengue virus nonstructural protein NS3 nucleoside triphosphatase/helicase by poly(U).
Dengue
Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.
Dengue
Monomeric nature of dengue virus NS3 helicase and thermodynamic analysis of the interaction with single-stranded RNA.
Dengue
Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.
Dengue
Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase.
Dengue
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Dengue
Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3.
Dengue
Novel Insights into the Molecular Interaction of a Panduratin A Derivative with the Non Structural Protein (NS3) of Dengue Serotypes: A Molecular Dynamics Study.
Dengue
NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.
Dengue
Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection.
Dengue
Nucleotide-dependent dynamics of the Dengue NS3 helicase.
Dengue
Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection.
Dengue
Production and characterization of a monoclonal antibody specific for NS3 protease and the ATPase region of Dengue-2 virus.
Dengue
Recombinant Dengue 2 Virus NS3 Helicase Protein Enhances Antibody and T-Cell Response of Purified Inactivated Vaccine.
Dengue
Rhodiola inhibits dengue virus multiplication by inducing innate immune response genes RIG-I, MDA5 and ISG in human monocytes.
Dengue
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity.
Dengue
RIG-I Recognizes the 5' Region of Dengue and Zika Virus Genomes.
Dengue
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
Dengue
RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.
Dengue
RNA binding property and RNA chaperone activity of dengue virus core protein and other viral RNA-interacting proteins.
Dengue
RNA Helicase A Is an Important Host Factor Involved in Dengue Virus Replication.
Dengue
RNA sensors enable human mast cell anti-viral chemokine production and IFN-mediated protection in response to antibody-enhanced dengue virus infection.
Dengue
Single point mutations in the helicase domain of the NS3 protein enhance dengue virus replicative capacity in human monocyte-derived dendritic cells and circumvent the type I IFN response.
Dengue
Specific Interaction of DDX6 with an RNA Hairpin in the 3'?UTR of the Dengue Virus Genome Mediates G1 Phase Arrest.
Dengue
Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin.
Dengue
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A.
Dengue
Structure of the NS3 helicase from Zika virus.
Dengue
Structure-based mutational analysis of the NS3 helicase from dengue virus.
Dengue
Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format.
Dengue
Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening.
Dengue
The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals.
Dengue
The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure.
Dengue
The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.
Dengue
The role of surface basic amino acids of dengue virus NS3 helicase in viral RNA replication and enzyme activities.
Dengue
The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids.
Dengue
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
Dengue
Thermodynamic study of the effect of ions on the interaction between dengue virus NS3 helicase and single stranded RNA.
Dengue
Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.
Dengue
Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses.
Dengue
Use of NS3 consensus primers for the polymerase chain reaction amplification and sequencing of dengue viruses and other flaviviruses.
Dengue
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Dengue
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.
Dermatomyositis
Anisoosmotic regulation of the Mi-2 autoantigen mRNA in H4IIE rat hepatoma cells and primary hepatocytes.
Dermatomyositis
Influence of UV radiation on immunological system and occurrence of autoimmune diseases.
Dermatomyositis
Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.
Dermatomyositis
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Dermatomyositis
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Dermatomyositis
Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method.
Dermatomyositis
The immunopathologic and inflammatory differences between dermatomyositis, polymyositis and sporadic inclusion body myositis.
Dermatomyositis
The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis.
Dermatomyositis
Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform.
Dermatomyositis
UV radiation regulates Mi-2 through protein translation and stability.
Diabetes Mellitus
Association between interferon-induced helicase (IFIH1) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus IFIH1 polymorphism and type 1 diabetes onset.
Diabetes Mellitus
Does diabetes mellitus as a comorbid condition affect the health-related quality of life in prostate cancer survivors? Results of a population-based observational study Mols F, Aquarius AE, Essink-Bot ML, Aaronson NK, Kil PJ, van de Poll-Franse LV, CoRPS-Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands.
Diabetes Mellitus
The A allele of the rs1990760 polymorphism in the IFIH1 gene is associated with protection for arterial hypertension in type 1 diabetic patients and with expression of this gene in human mononuclear cells.
Diabetes Mellitus
The genetic basis of graves' disease.
Diabetes Mellitus
The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
Diabetes Mellitus, Type 1
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
Diabetes Mellitus, Type 1
An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.
Diabetes Mellitus, Type 1
Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families.
Diabetes Mellitus, Type 1
Association between interferon-induced helicase (IFIH1) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus IFIH1 polymorphism and type 1 diabetes onset.
Diabetes Mellitus, Type 1
Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk.
Diabetes Mellitus, Type 1
Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses.
Diabetes Mellitus, Type 1
Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.
Diabetes Mellitus, Type 1
Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.
Diabetes Mellitus, Type 1
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.
Diabetes Mellitus, Type 1
Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.
Diabetes Mellitus, Type 1
IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population.
Diabetes Mellitus, Type 1
Interferon induced with helicase C domain 1 (IFIH1): trends on helicase domain and type 1 diabetes onset.
Diabetes Mellitus, Type 1
The A allele of the rs1990760 polymorphism in the IFIH1 gene is associated with protection for arterial hypertension in type 1 diabetic patients and with expression of this gene in human mononuclear cells.
Diabetes Mellitus, Type 1
The genetic basis of graves' disease.
Diabetes Mellitus, Type 1
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.
Diabetes Mellitus, Type 1
The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.
Diabetes Mellitus, Type 1
The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.
Diabetes Mellitus, Type 1
Unique pathological changes in the pancreas of fulminant type 1 diabetes.
Diabetes Mellitus, Type 2
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Diffuse Cerebral Sclerosis of Schilder
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
DiGeorge Syndrome
'Black sheep' that don't leave the double-stranded RNA-binding domain fold.
DiGeorge Syndrome
Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism.
Disorders of Sex Development
Variant analysis of the chromodomain helicase DNA-binding protein 7 in pediatric disorders of sex development.
DNA Virus Infections
A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-?B-mediated innate immunity against DNA virus infection.
DNA Virus Infections
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
Drug Hypersensitivity
DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects.
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Dyskeratosis Congenita
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita.
Dyskeratosis Congenita
Telomere shortening by mutations in the RTEL1 helicase cause severe form of dyskeratosis congenita, Hoyerall-Hreidarsson syndrome.
Dystonia
Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients.
Dystonia
Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB.
Encephalitis
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.
Encephalitis
Theoretical study of the Usutu virus helicase 3D structure, by means of computer-aided homology modelling.
Encephalitis
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Encephalitis, Japanese
Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein.
Encephalitis, Japanese
Conserved amino acids 193-324 of non-structural protein 3 are a dominant source of peptide determinants for CD4+ and CD8+ T cells in a healthy Japanese encephalitis virus-endemic cohort.
Encephalitis, Japanese
Crystal structure of the catalytic domain of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase at a resolution of 1.8 A.
Encephalitis, Japanese
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Encephalitis, Japanese
Human DDX3X Unwinds Japanese Encephalitis and Zika Viral 5' Terminal Regions.
Encephalitis, Japanese
Identification and characterization of the RNA helicase activity of Japanese encephalitis virus NS3 protein.
Encephalitis, Japanese
Ilheus virus (Flaviviridae, Flavivirus) is closely related to Japanese encephalitis virus complex.
Encephalitis, Japanese
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Encephalitis, Japanese
Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42.
Encephalitis, Japanese
Japanese encephalitis virus nonstructural protein NS3 has RNA binding and ATPase activities.
Encephalitis, Japanese
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Encephalitis, Japanese
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Encephalitis, Japanese
Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalitis, Japanese
RIG-I knockdown impedes neurogenesis in a murine model of Japanese encephalitis.
Encephalitis, Japanese
RIG-I mediates innate immune response in mouse neurons following Japanese encephalitis virus infection.
Encephalitis, Japanese
Role of the DExH motif of the Japanese encephalitis virus and hepatitis C virus NS3 proteins in the ATPase and RNA helicase activities.
Encephalitis, Japanese
Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection.
Encephalitis, Japanese
STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection.
Encephalitis, Japanese
Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus.
Encephalitis, Japanese
Structure-based virtual screening for novel inhibitors of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase.
Encephalitis, Japanese
The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3' UTR.
Encephalitis, Japanese
The NS3 protease and helicase domains of Japanese encephalitis virus trigger cell death via caspase?dependent and ?independent pathways.
Encephalitis, Tick-Borne
Corrigendum to "Crystal structure of the NS3 helicase of tick-borne encephalitis virus" [Biochem. Biophys. Res. Commun. 528(3) (2020) 601-606].
Encephalitis, Tick-Borne
Crystal structure of the NS3 helicase of tick-borne encephalitis virus.
Encephalitis, Tick-Borne
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Encephalitis, Tick-Borne
Structural modeling of the NS 3 helicase of Tick-borne encephalitis virus and their virtual screening of potent drugs using molecular docking.
Encephalitis, Tick-Borne
[Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus]
Encephalomyelitis
Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.
Encephalomyelitis, Venezuelan Equine
Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3.
Encephalomyelitis, Venezuelan Equine
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.
Enteritis
Duck RIG-I restricts duck enteritis virus infection.
Enterovirus Infections
Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.
Enterovirus Infections
Unique pathological changes in the pancreas of fulminant type 1 diabetes.
Epilepsy
Absence epilepsy and the CHD2 gene: an adolescent male with moderate intellectual disability, short-lasting psychoses, and an interstitial deletion in 15q26.1-q26.2.
Epilepsy
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
Epilepsy
CHD2-related epilepsy: novel mutations and new phenotypes.
Epilepsy
In-Frame Deletion and Missense Mutations of the C-Terminal Helicase Domain of SMARCA2 in Three Patients with Nicolaides-Baraitser Syndrome.
Epilepsy
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Epilepsy
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Epilepsy
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Epilepsy
Smartphones in Epilepsy: The New Age of Aquarius.
Epilepsy
The first reported case of an inherited pathogenic CHD2 variant in a clinically affected mother and daughter.
Epilepsy, Generalized
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
Epilepsy, Reflex
Photosensitivity and CHD2 Variants.
Epileptic Syndromes
Juvenile myoclonic epilepsy mimic associated with CHD2 gene mutation.
Epstein-Barr Virus Infections
Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.
Exanthema
Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.
Fanconi Anemia
A requirement of FancL and FancD2 monoubiquitination in DNA repair.
Fanconi Anemia
Biochemical characterization of Warsaw breakage syndrome helicase.
Fanconi Anemia
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Fanconi Anemia
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Fanconi Anemia
Disease-causing missense mutations in human DNA helicase disorders.
Fanconi Anemia
DNA Helicase Mph1FANCM Ensures Meiotic Recombination between Parental Chromosomes by Dissociating Precocious Displacement Loops.
Fanconi Anemia
Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.
Fanconi Anemia
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
Fanconi Anemia
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress.
Fanconi Anemia
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
Fanconi Anemia
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
Fanconi Anemia
FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.
Fanconi Anemia
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.
Fanconi Anemia
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact to Facilitate the DNA Damage Response.
Fanconi Anemia
Fanconi anemia Group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
Fanconi Anemia
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.
Fanconi Anemia
Helicase-inactivating mutations as a basis for dominant negative phenotypes.
Fanconi Anemia
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Fanconi Anemia
Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair.
Fanconi Anemia
Multiple mechanisms limit meiotic crossovers: TOP3? and two BLM homologs antagonize crossovers in parallel to FANCM.
Fanconi Anemia
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
Fanconi Anemia
Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.
Fanconi Anemia
Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple negative breast and serous ovarian cancers.
Fanconi Anemia
Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.
Fanconi Anemia
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression.
Fanconi Anemia
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Fanconi Anemia
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.
Fanconi Anemia
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair.
Fanconi Anemia
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.
Fanconi Anemia
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461.
Fanconi Anemia
Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
Fasciitis
Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions.
Fatty Liver
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Fetal Growth Retardation
Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth.
Flavivirus Infections
How flaviviruses activate and suppress the interferon response.
Foot-and-Mouth Disease
Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site.
Foot-and-Mouth Disease
Foot-and-Mouth Disease Virus 3B Protein Interacts with Pattern Recognition Receptor RIG-I to Block RIG-I-Mediated Immune Signaling and Inhibit Host Antiviral Response.
Foot-and-Mouth Disease
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells.
Foot-and-Mouth Disease
Identification of RNA helicase A as a new host factor in the replication cycle of foot-and-mouth disease virus.
Foot-and-Mouth Disease
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
Foot-and-Mouth Disease
Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: Role of Jumonji C-domain containing protein 6 in RHA demethylation.
Foot-and-Mouth Disease
Ribosomal Protein L13 Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus in a Helicase DDX3-Dependent Manner.
Foot-and-Mouth Disease
STING1 is essential for an RNA-virus triggered autophagy.
Foot-and-Mouth Disease
Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation.
Foot-and-Mouth Disease
The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication.
Foot-and-Mouth Disease
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate.
Fowlpox
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Gallbladder Neoplasms
Targeting eIF4A using rocaglate CR?1?31B sensitizes gallbladder cancer cells to TRAIL?mediated apoptosis through the translational downregulation of c?FLIP.
Gastric Antral Vascular Ectasia
A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease.
Gastric Antral Vascular Ectasia
Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.
Gastric Antral Vascular Ectasia
Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression.
Gastric Antral Vascular Ectasia
Unique epitopes in RNA helicase II/Gu protein recognized by serum from a watermelon stomach patient.
Gastroenteritis
Cellular RNA Helicase DDX1 Is Involved in Transmissible Gastroenteritis Virus nsp14-Induced Interferon-Beta Production.
Gastroenteritis
Identification of protease and ADP-ribose 1''-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3.
Gastrointestinal Neoplasms
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Gastrointestinal Stromal Tumors
Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.
Gastrointestinal Stromal Tumors
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Gastrointestinal Stromal Tumors
Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour.
Genetic Diseases, Inborn
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Genetic Diseases, Inborn
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Genetic Diseases, Inborn
Bloom syndrome.
Genetic Diseases, Inborn
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.
Genetic Diseases, Inborn
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
Genetic Diseases, Inborn
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
Genetic Diseases, Inborn
DNA helicases associated with genetic instability, cancer, and aging.
Genetic Diseases, Inborn
DNA helicases involved in DNA repair and their roles in cancer.
Genetic Diseases, Inborn
DNA repair helicases as targets for anti-cancer therapy.
Genetic Diseases, Inborn
Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model.
Genetic Diseases, Inborn
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
Genetic Diseases, Inborn
Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges.
Genetic Diseases, Inborn
Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.
Genetic Diseases, Inborn
Overview: what are helicases?
Genetic Diseases, Inborn
Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.
Genetic Diseases, Inborn
Prospective and detailed behavioral phenotyping in DDX3X syndrome.
Genetic Diseases, Inborn
Unique and important consequences of RECQ1 deficiency in mammalian cells.
Genetic Diseases, Inborn
WRN mutations in Werner syndrome.
Glaucoma
Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome.
Glioblastoma
Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.
Glioblastoma
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis.
Glioblastoma
Harnessing the Activation of RIG-I Like Receptors to Inhibit Glioblastoma Tumorigenesis.
Glioblastoma
MiR?500a?5p promotes glioblastoma cell proliferation, migration and invasion by targeting chromodomain helicase DNA binding protein 5.
Glioblastoma
Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12.
Glioblastoma
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
Glioblastoma
Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma.
Glioblastoma
The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.
Glioblastoma
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Glioblastoma
The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition.
Glioblastoma
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I.
Glioma
Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells.
Glioma
Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population.
Glioma
Association between regulator of telomere elongation helicase 1 polymorphism and susceptibility to glioma.
Glioma
Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3?-E2F1 Axis Linking Reversely with Survival in Gliomas.
Glioma
CK2 induced RIG-I drives metabolic adaptations in IFN?-treated glioma cells.
Glioma
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1?-RIG-I axis in IFN? treated glioma cells.
Glioma
Cysteine-rich 61-associated gene expression profile alterations in human glioma cells.
Glioma
DDX3X Biomarker Correlates with Poor Survival in Human Gliomas.
Glioma
DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis.
Glioma
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
Glioma
Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors.
Glioma
p68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF-?B transcription factor p50.
Glioma
P68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5.
Glioma
Regulator of telomere elongation helicase 1 (RTEL1) rs6010620 polymorphism contribute to increased risk of glioma.
Glioma
RNA helicase DHX15 acts as a tumour suppressor in glioma.
Glioma
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
Glioma
Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.
Gonadal Dysgenesis
Expanding DSD Phenotypes Associated with Variants in the DEAH-Box RNA Helicase DHX37.
Gonadal Dysgenesis
Genetic evidence of the association of DEAH-box helicase 37 defects with 46,XY gonadal dysgenesis spectrum.
Gonadal Dysgenesis
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Gonadal Dysgenesis
Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome.
Gonadal Dysgenesis, Mixed
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Gonadoblastoma
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Graves Disease
Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.
Graves Disease
The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves' disease in Chinese population.
Graves Disease
The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.
Hantavirus Infections
New World hantaviruses activate IFNlambda production in type I IFN-deficient vero E6 cells.
Head and Neck Neoplasms
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Hearing Loss
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Hearing Loss
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Hearing Loss
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Heart Defects, Congenital
Discovery of a novel CHD7 CHARGE syndrome variant by integrated omics analyses.
Heart Defects, Congenital
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Failure
The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.
Heart Rupture
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Heart Septal Defects, Atrial
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Ventricular
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Hemangioma
Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report.
Hematologic Neoplasms
Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish.
Hematologic Neoplasms
Nasopharyngeal carcinoma progression is mediated by EBER-triggered inflammation via the RIG-I pathway.
Hemorrhagic Fever, Crimean
Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.
Hemorrhagic Fever, Crimean
RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus.
Hemorrhagic Septicemia, Viral
A20 (tnfaip3) is a negative feedback regulator of RIG-I-Mediated IFN induction in teleost.
Henipavirus Infections
Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters.
Henipavirus Infections
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Hepatitis
Association between fulminant hepatic failure and a strain of GBV virus C.
Hepatitis
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.
Hepatitis
Detection of hepatitis G virus RNA in patients with acute non-A-E hepatitis.
Hepatitis
Expression and characterization of the hepatitis G virus helicase.
Hepatitis
GB virus C/hepatitis G virus infection in Saudi Arabian blood donors and patients with cryptogenic hepatitis.
Hepatitis
Host mechanisms in viral hepatitis.
Hepatitis
Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro.
Hepatitis
New Techniques to Study Intracellular Receptors in Living Cells: Insights Into RIG-I-Like Receptor Signaling.
Hepatitis
New variant groups identified from HGV isolates.
Hepatitis
Persistent hepatitis G virus infection after neonatal transfusion.
Hepatitis
Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase.
Hepatitis
Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus.
Hepatitis
RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3.
Hepatitis
The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis.
Hepatitis
Treatment options in patients with chronic hepatitis C.
Hepatitis
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.
Hepatitis B
Antiviral immunity. Dual attack by RIG-I.
Hepatitis B
DDX3 DEAD-Box RNA helicase inhibits hepatitis B virus reverse transcription by incorporation into nucleocapsids.
Hepatitis B
DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional level.
Hepatitis B
Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a.
Hepatitis B
Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways.
Hepatitis B
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Hepatitis B
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Hepatitis B
Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication.
Hepatitis B
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling.
Hepatitis B
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
Hepatitis B
Nuclear-resident RIG-I senses viral replication inducing antiviral immunity.
Hepatitis B
Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma.
Hepatitis B
RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation.
Hepatitis B
RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes.
Hepatitis B
RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.
Hepatitis B
Single lysophosphatidylcholine components exhibit adjuvant activities in vitro and in vivo.
Hepatitis B
Stimulation of DDX3 expression by ginsenoside Rg3 through the Akt/p53 pathway activates the innate immune response via TBK1/IKK?/IRF3 signalling.
Hepatitis B
Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes.
Hepatitis B
The catcher in the RIG-I.
Hepatitis B
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
Hepatitis B
The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.
Hepatitis B
The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.
Hepatitis B
Use of alpha-N,N-bis[carboxymethyl]lysine-modified peroxidase in immunoassays.
Hepatitis B, Chronic
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Hepatitis B, Chronic
Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.
Hepatitis B, Chronic
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Hepatitis B, Chronic
RIG-I enhances interferon-? response by promoting antiviral protein expression in patients with chronic hepatitis B.
Hepatitis B, Chronic
Toll-like receptors, long non-coding RNA NEAT1, and RIG-I expression are associated with HBeAg-positive chronic hepatitis B patients in the active phase.
Hepatitis C
A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase.
Hepatitis C
A fluorescence-based screening assay for identification of hepatitis C virus NS3 helicase inhibitors and characterization of their inhibitory mechanism.
Hepatitis C
A kinetic analysis of the oligonucleotide-modulated ATPase activity of the helicase domain of the NS3 protein from hepatitis C virus. The first cycle of interaction of ATP with the enzyme is unique.
Hepatitis C
A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities.
Hepatitis C
A novel high throughput screening assay for HCV NS3 helicase activity.
Hepatitis C
A novel recombinant single-chain hepatitis C virus NS3-NS4A protein with improved helicase activity.
Hepatitis C
A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein.
Hepatitis C
A single amino acid is critical for the expression of B-cell epitopes on the helicase domain of the pestivirus NS3 protein.
Hepatitis C
A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain.
Hepatitis C
A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC.
Hepatitis C
Abrogation of hepatitis C virus NS3 helicase enzymatic activity by recombinant human antibodies.
Hepatitis C
Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth.
Hepatitis C
Amantadine and rimantadine have no direct inhibitory effects against hepatitis C viral protease, helicase, ATPase, polymerase, and internal ribosomal entry site-mediated translation.
Hepatitis C
An ELISA for RNA helicase activity: application as an assay of the NS3 helicase of hepatitis C virus.
Hepatitis C
An RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities.
Hepatitis C
Analysis of aptamer binding site for HCV-NS3 protease by alanine scanning mutagenesis.
Hepatitis C
Analysis of interaction between RNA aptamer and protein using nucleotide analogs.
Hepatitis C
Analysis of protein conformational transitions using elastic network model.
Hepatitis C
Analysis of the domain interactions between the protease and helicase of NS3 in dengue and hepatitis C virus.
Hepatitis C
Antigenicity of a recombinant NS3 protein representative of ATPase/helicase domain from hepatitis C virus.
Hepatitis C
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.
Hepatitis C
Apoptosis induced by synthetic retinoic acid CD437 on human melanoma A375 cells involves RIG-I pathway.
Hepatitis C
Artificial neural network for prediction of antigenic activity for a major conformational epitope in the hepatitis C virus NS3 protein.
Hepatitis C
Association of rs2111485 and rs1990760 Polymorphisms of Interferon Induced with Helicase C Domain 1 Gene with Hepatitis C Virus Clearance in Chinese Han Population.
Hepatitis C
ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase.
Hepatitis C
ATP dependent NS3 helicase interaction with RNA: insights from molecular simulations.
Hepatitis C
Aurintricarboxylic Acid Modulates the Affinity of Hepatitis C Virus NS3 Helicase for Both Nucleic Acid and ATP.
Hepatitis C
Backbone 1H, 15N and 13C resonance assignments of the NTPase subdomain of the hepatitis C virus NS3 RNA helicase.
Hepatitis C
Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.
Hepatitis C
Binding by the Hepatitis C Virus NS3 Helicase Partially Melts Duplex DNA.
Hepatitis C
Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus.
Hepatitis C
Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.
Hepatitis C
Biological evaluation of hepatitis C virus helicase inhibitors.
Hepatitis C
Bis-aptazyme sensors for hepatitis C virus replicase and helicase without blank signal.
Hepatitis C
C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity.
Hepatitis C
Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.
Hepatitis C
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Hepatitis C
Cell Transformation and Proteome Alteration in QSG7701 Cells Transfected with Hepatitis C Virus Non-structural Protein 3.
Hepatitis C
Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA.
Hepatitis C
Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication.
Hepatitis C
Characterisation of non-structural protein 3 of hepatitis C virus as modulator of protein phosphorylation mediated by PKA and PKC: evidences for action on the level of substrate and enzyme.
Hepatitis C
Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein.
Hepatitis C
Characterization of a monoclonal antibody and its single-chain antibody fragment recognizing the nucleoside Triphosphatase/Helicase domain of the hepatitis C virus nonstructural 3 protein.
Hepatitis C
Characterization of ATPase activity of a hepatitis C virus NS3 helicase domain, and analysis involving mercuric reagents.
Hepatitis C
Characterization of mimotopes mimicking an immunodominant conformational epitope on the hepatitis C virus NS3 helicase.
Hepatitis C
Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein.
Hepatitis C
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.
Hepatitis C
Chronic hepatitis C and no response to antiviral therapy: potential current and future therapeutic options.
Hepatitis C
Circular dichroism analysis for multidomain proteins: studies of the irreversible unfolding of Hepatitis C virus helicase.
Hepatitis C
Classification Models of HCV NS3 Protease Inhibitors Based on Support Vector Machine (SVM).
Hepatitis C
Cloning and expression of NS3 helicase fragment of hepatitis C virus and the study of its immunoreactivity in HCV infected patients.
Hepatitis C
Cloning and expression of retinoic acid-induced gene-I and its effect on hepatitis C virus replication.
Hepatitis C
Cloning and molecular characterization of human high affinity antibody fragments against Hepatitis C virus NS3 helicase.
Hepatitis C
Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.
Hepatitis C
Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases.
Hepatitis C
Comparisons of RNAi approaches for validation of human RNA helicase A as an essential factor in hepatitis C virus replication.
Hepatitis C
Computational biology approach to uncover hepatitis C virus helicase operation.
Hepatitis C
Computer modeling of helicases using elastic network model.
Hepatitis C
Construction and Immunogenicity Analysis of Hepatitis C Virus (HCV) Truncated Non-Structural Protein 3 (NS3) Plasmid Vaccine.
Hepatitis C
Construction of the dual-functional RNA ligand against HCV NS3 protease and helicase.
Hepatitis C
Control of Innate Immune Signaling and Membrane Targeting by the Hepatitis C Virus NS3/4A Protease Are Governed by the NS3 Helix ?0.
Hepatitis C
Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein.
Hepatitis C
Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA.
Hepatitis C
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Hepatitis C
Crystal structure of the NS3 protease-helicase from dengue virus.
Hepatitis C
Crystallization and preliminary X-ray crystallographic analysis of the helicase domain of hepatitis C virus NS3 protein.
Hepatitis C
Current and evolving therapies for hepatitis C.
Hepatitis C
DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication.
Hepatitis C
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.
Hepatitis C
DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins.
Hepatitis C
Design, high-level expression, purification and characterization of soluble fragments of the hepatitis C virus NS3 RNA helicase suitable for NMR-based drug discovery methods and mechanistic studies.
Hepatitis C
Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.
Hepatitis C
Detection of hepatitis C virus helicase activity using the scintillation proximity assay system.
Hepatitis C
Development of a hepatitis C virus RNA helicase high throughput assay.
Hepatitis C
Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection.
Hepatitis C
Dimerization-driven interaction of hepatitis c virus core protein with NS3 helicase.
Hepatitis C
Direct fluorometric measurement of hepatitis C virus helicase activity.
Hepatitis C
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.
Hepatitis C
Discovery of hepatitis C virus NS3 helicase inhibitors by a multiplexed, high-throughput helicase activity assay based on graphene oxide.
Hepatitis C
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
Hepatitis C
DNA helicase activity of the hepatitis C virus nonstructural protein 3.
Hepatitis C
DNA immunization efficiently targets conserved functional domains of protease and ATPase/helicase of nonstructural 3 protein (NS3) of human hepatitis C virus.
Hepatitis C
Docking studies of Pakistani HCV NS3 helicase: a possible antiviral drug target.
Hepatitis C
Double-stranded DNA-induced localized unfolding of HCV NS3 helicase subdomain 2.
Hepatitis C
Dynamic Interaction of Stress Granule, DDX3X and IKK-? Mediates Multiple Functions in Hepatitis C Virus Infection.
Hepatitis C
Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate.
Hepatitis C
Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.
Hepatitis C
Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects.
Hepatitis C
Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.
Hepatitis C
Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations.
Hepatitis C
Engineering of the hepatitis C virus helicase for enhanced seroreactivity.
Hepatitis C
Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding.
Hepatitis C
Enhanced RIG-I expression is mediated by interferon regulatory factor-2 in peripheral blood B cells from hepatitis C virus-infected patients.
Hepatitis C
Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system.
Hepatitis C
Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli.
Hepatitis C
Enzymatic properties of hepatitis C virus NS3-associated helicase.
Hepatitis C
Establishing a mechanistic basis for the large kinetic steps of the NS3 helicase.
Hepatitis C
Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents.
Hepatitis C
Experimental and emerging therapies for chronic hepatitis C virus infection.
Hepatitis C
Expression and purification of a hepatitis C virus NS3/4A complex, and characterization of its helicase activity with the Scintillation Proximity Assay system.
Hepatitis C
Expression and purification of an active, full-length hepatitis C viral NS4A.
Hepatitis C
Expression of human single-chain variable fragment antibody against non-structural protein 3 of hepatitis C virus antigen in e.coli.
Hepatitis C
Expression of pattern recognition receptors in liver biopsy specimens of children chronically infected with HBV and HCV.
Hepatitis C
Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase.
Hepatitis C
Five new or recently discovered (GBV-A) virus species are indigenous to New World monkeys and may constitute a separate genus of the Flaviviridae.
Hepatitis C
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.
Hepatitis C
Fluorometric assay of hepatitis C virus NS3 helicase activity.
Hepatitis C
Fuel specificity of the hepatitis C virus NS3 helicase.
Hepatitis C
Functional interactions between conserved motifs of the hepatitis C virus RNA helicase protein NS3.
Hepatitis C
Future trends in managing hepatitis C.
Hepatitis C
GB hepatitis agent in cadaver organ donors and their recipients.
Hepatitis C
Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3.
Hepatitis C
Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.
Hepatitis C
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
Hepatitis C
Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.
Hepatitis C
HCV NS3Ag: a reliable and clinically useful predictor of antiviral outcomes in genotype 1b hepatitis C virus-infected patients.
Hepatitis C
Helicase from hepatitis C virus, energetics of DNA binding.
Hepatitis C
Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C.
Hepatitis C
Helicase structure and mechanism.
Hepatitis C
Helicase, a target for novel inhibitors of hepatitis C virus.
Hepatitis C
Hepatitis C NS3 helicase unwinds RNA in leaps and bounds.
Hepatitis C
Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase.
Hepatitis C
Hepatitis C virus controls interferon production through PKR activation.
Hepatitis C
Hepatitis C virus core protein binds to a DEAD box RNA helicase.
Hepatitis C
Hepatitis C virus core protein interacts with cellular putative RNA helicase.
Hepatitis C
Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X.
Hepatitis C
Hepatitis C Virus Helicase Binding Activity Monitored through Site-Specific Labeling Using an Expanded Genetic Code.
Hepatitis C
Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.
Hepatitis C
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Hepatitis C
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target.
Hepatitis C
Hepatitis C virus non-structural protein 3 interacts with cytosolic 5'(3')-deoxyribonucleotidase and partially inhibits its activity.
Hepatitis C
Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles.
Hepatitis C
Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites.
Hepatitis C
Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties.
Hepatitis C
Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro.
Hepatitis C
Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.
Hepatitis C
Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge (Amphimedon) ?Species in Green Synthesized Silver Nanoparticles Assisted by in Silico Modeling and Metabolic Profiling.
Hepatitis C
Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.
Hepatitis C
Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Non-Homologous End Joining.
Hepatitis C
Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.
Hepatitis C
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.
Hepatitis C
Hepatitis C virus reveals a novel early control in acute immune response.
Hepatitis C
Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase.
Hepatitis C
Hepatitis C virus-NS3P in relation to p53, p21waf, mdm2, p21-ras and c-erbB2 in hepatocarcinogenesis.
Hepatitis C
High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon.
Hepatitis C
Human and murine antibody recognition is focused on the ATPase/helicase, but not the protease domain of the hepatitis C virus nonstructural 3 protein.
Hepatitis C
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.
Hepatitis C
Humanized-VH/VHH that inhibit HCV replication by interfering with the virus helicase activity.
Hepatitis C
Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein.
Hepatitis C
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.
Hepatitis C
Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase.
Hepatitis C
Identification and Analysis of Novel Inhibitors against NS3 Helicase and NS5B RNA-Dependent RNA Polymerase from Hepatitis C Virus 1b (Con1).
Hepatitis C
Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.
Hepatitis C
Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.
Hepatitis C
Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase.
Hepatitis C
Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase.
Hepatitis C
Identification of conserved nucleotide sequences within the GB virus C 5'-untranslated region: design of PCR primers for detection of viral RNA.
Hepatitis C
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.
Hepatitis C
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.
Hepatitis C
Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus non-structural 3 protein.
Hepatitis C
In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.
Hepatitis C
In trans interaction of hepatitis C virus helicase domains mediates protease activity critical for internal NS3 cleavage and cell transformation.
Hepatitis C
In Vitro Assessment of Re-treatment Options for Patients with Hepatitis C Virus Genotype 1b Infection Resistant to Daclatasvir Plus Asunaprevir.
Hepatitis C
In vitro selection of RNA aptamers against the HCV NS3 helicase domain.
Hepatitis C
Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities.
Hepatitis C
Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation.
Hepatitis C
Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior.
Hepatitis C
Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp.
Hepatitis C
Inhibition of HCV NS3 protease by RNA aptamers in cells.
Hepatitis C
Inhibition of hepatitis C virus nonstructural protein, helicase activity, and viral replication by a recombinant human antibody clone.
Hepatitis C
Inhibition of Hepatitis C Virus NS3 Helicase by Manoalide.
Hepatitis C
Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain.
Hepatitis C
Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.
Hepatitis C
Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor.
Hepatitis C
Inhibition of the hepatitis C virus helicase-associated ATPase activity by the combination of ADP, NaF, MgCl2, and poly(rU). Two ADP binding sites on the enzyme-nucleic acid complex.
Hepatitis C
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Hepatitis C
Inhibitory mechanism of 5-bromo-3-indoleacetic acid for non-structural-3 helicase hepatitis C virus with dynamics correlation network analysis.
Hepatitis C
Innate Immune Responses against Viral Infection and Its Suppression by Viral Proteins.
Hepatitis C
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA.
Hepatitis C
Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
Hepatitis C
Internal cleavage of hepatitis C virus NS3 protein is dependent on the activity of NS34A protease.
Hepatitis C
Internal processing of hepatitis C virus NS3 protein.
Hepatitis C
Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone.
Hepatitis C
Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase.
Hepatitis C
Isolation of novel virus-like sequences associated with human hepatitis.
Hepatitis C
Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus.
Hepatitis C
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Hepatitis C
Kinetic analysis of the effects of mutagenesis of W501 and V432 of the hepatitis C virus NS3 helicase domain on ATPase and strand-separating activity.
Hepatitis C
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Hepatitis C
Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe.
Hepatitis C
Letter to the editor: Sequence-specific 1H, 15N and 13C resonance assignments for an engineered arginine-rich domain of the hepatitis C virus NS3 RNA helicase.
Hepatitis C
Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo.
Hepatitis C
Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.
Hepatitis C
Mechanism of flexibility control for ATP access of hepatitis C virus NS3 helicase.
Hepatitis C
Mechanisms of HCV NS3 helicase monitored by optical tweezers.
Hepatitis C
Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins.
Hepatitis C
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
Hepatitis C
Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A.
Hepatitis C
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules.
Hepatitis C
Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.
Hepatitis C
Molecular docking investigation of the binding interactions of macrocyclic inhibitors with HCV NS3 protease and its mutants (R155K, D168A and A156V).
Hepatitis C
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.
Hepatitis C
Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase.
Hepatitis C
Monitoring helicase activity with molecular beacons.
Hepatitis C
Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.
Hepatitis C
Multilayer fluorescence optically encoded beads for protein detection.
Hepatitis C
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus.
Hepatitis C
Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro.
Hepatitis C
Mutational analysis of hepatitis C virus NS3-associated helicase.
Hepatitis C
Mutational analysis of the hepatitis C virus RNA helicase.
Hepatitis C
Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase.
Hepatitis C
N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
Hepatitis C
Nanomechanical microcantilever operated in vibration modes with use of RNA aptamer as receptor molecules for label-free detection of HCV helicase.
Hepatitis C
Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array.
Hepatitis C
New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection.
Hepatitis C
New drug targets for HIV and hepatitis C virus coinfection.
Hepatitis C
New therapies on the horizon for hepatitis C: are we close?
Hepatitis C
Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients.
Hepatitis C
Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.
Hepatitis C
Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents.
Hepatitis C
NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.
Hepatitis C
NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork.
Hepatitis C
NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly.
Hepatitis C
NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations.
Hepatitis C
NS3 Peptide, a novel potent hepatitis C virus NS3 helicase inhibitor: its mechanism of action and antiviral activity in the replicon system.
Hepatitis C
Nucleic acid unwinding by hepatitis C virus and bacteriophage t7 helicases is sensitive to base pair stability.
Hepatitis C
Optimization for the detection of hepatitis C virus antigens in the liver.
Hepatitis C
Optimization of Potent Hepatitis C Virus NS3 Helicase Inhibitors Isolated from the Yellow Dyes Thioflavine S and Primuline.
Hepatitis C
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Hepatitis C
Overview of interferon therapy for chronic hepatitis C.
Hepatitis C
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
Hepatitis C
PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase.
Hepatitis C
Peptidic inhibitors of the hepatitis C virus serine protease within non-structural protein 3.
Hepatitis C
Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase.
Hepatitis C
Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase.
Hepatitis C
Physical methods to determine the binding mode of putative ligands for hepatitis C virus NS3 helicase.
Hepatitis C
Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase.
Hepatitis C
Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells.
Hepatitis C
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.
Hepatitis C
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.
Hepatitis C
Product release is the major contributor to kcat for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA.
Hepatitis C
Production and characterization of monoclonal antibody specific for NS3 helicase of hepatitis C virus.
Hepatitis C
Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins.
Hepatitis C
Protease inhibitors block multiple functions of the NS3/4A protease-helicase during the hepatitis C virus life cycle.
Hepatitis C
Psammaplin A inhibits hepatitis C virus NS3 helicase.
Hepatitis C
Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells.
Hepatitis C
Rational design of dual-functional aptamers that inhibit the protease and helicase activities of HCV NS3.
Hepatitis C
Rational design of modular allosteric aptamer sensor for label-free protein detection.
Hepatitis C
Real-time monitoring of RNA helicase activity using fluorescence resonance energy transfer in vitro.
Hepatitis C
Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice.
Hepatitis C
Redesigning the substrate specificity of the hepatitis C virus NS3 protease.
Hepatitis C
Refolding of a recombinant full-length non-structural (NS3) protein from hepatitis C virus by chromatographic procedures.
Hepatitis C
Refolding of the full-length non-structural protein 3 of hepatitis C virus.
Hepatitis C
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.
Hepatitis C
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
Hepatitis C
Regulation of RIG-I Activation by K63-Linked Polyubiquitination.
Hepatitis C
Relationship between sex hormones and RIG-I signaling in peripheral blood mononuclear cells of patients infected with hepatitis C virus.
Hepatitis C
Restoration of the Activated Rig-I Pathway in Hepatitis C Virus (HCV) Replicon Cells by HCV Protease, Polymerase, and NS5A Inhibitors In Vitro at Clinically Relevant Concentrations.
Hepatitis C
RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells.
Hepatitis C
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP.
Hepatitis C
RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase.
Hepatitis C
RNA unwinding by NS3 helicase: a statistical approach.
Hepatitis C
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.
Hepatitis C
Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track.
Hepatitis C
Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: magnesium provides a bridge for ATP to fuel unwinding.
Hepatitis C
Role of the Conserved DECH-Box Cysteine in Coupling Hepatitis C Virus Helicase-Catalyzed ATP Hydrolysis to RNA Unwinding.
Hepatitis C
Role of the DExH motif of the Japanese encephalitis virus and hepatitis C virus NS3 proteins in the ATPase and RNA helicase activities.
Hepatitis C
Roles of the AX(4)GKS and arginine-rich motifs of hepatitis C virus RNA helicase in ATP- and viral RNA-binding activity.
Hepatitis C
Screening and identification of bioactive compounds from citrus against non-structural protein 3 protease of hepatitis C virus genotype 3a by fluorescence resonance energy transfer assay and mass spectrometry.
Hepatitis C
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Hepatitis C
Sequence analysis of hepatitis GB virus C (GBV-C) isolates from 14 patients.
Hepatitis C
Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic Acid unwinding of the viral helicase.
Hepatitis C
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
Hepatitis C
Significance of monoclonal antibodies against the conserved epitopes within non-structural protein 3 helicase of hepatitis C virus.
Hepatitis C
Significance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibody.
Hepatitis C
Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.
Hepatitis C
Single lysophosphatidylcholine components exhibit adjuvant activities in vitro and in vivo.
Hepatitis C
Single strand binding proteins increase the processivity of DNA unwinding by the hepatitis C virus helicase.
Hepatitis C
Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicase.
Hepatitis C
Single-molecule imaging reveals the translocation and DNA looping dynamics of hepatitis C virus NS3 helicase.
Hepatitis C
Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase.
Hepatitis C
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
Hepatitis C
Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase.
Hepatitis C
Step-by-step progress toward understanding the hepatitis C virus RNA helicase.
Hepatitis C
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase.
Hepatitis C
Strand-separating activity of hepatitis C virus helicase in the absence of ATP.
Hepatitis C
Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus.
Hepatitis C
Structural basis for DNA duplex separation by a superfamily-2 helicase.
Hepatitis C
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.
Hepatitis C
Structural studies of Helicase NS3 variants from Hepatitis C virus genotype 3 in virological sustained responder and non-responder patients.
Hepatitis C
Structurally conserved amino Acid w501 is required for RNA helicase activity but is not essential for DNA helicase activity of hepatitis C virus NS3 protein.
Hepatitis C
Structure and function of hepatitis C virus NS3 helicase.
Hepatitis C
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A.
Hepatitis C
Structure of the hepatitis C virus RNA helicase domain.
Hepatitis C
Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors.
Hepatitis C
Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase.
Hepatitis C
Structure-based mutagenesis study of hepatitis C virus NS3 helicase.
Hepatitis C
Structure-based mutational analysis of the hepatitis C virus NS3 helicase.
Hepatitis C
Structure-based simulations of the translocation mechanism of the hepatitis C virus NS3 helicase along single-stranded nucleic acid.
Hepatitis C
Subcellular localisation of NS3 in HCV-infected hepatocytes.
Hepatitis C
Suppression of Hepatitis C Virus Genome Replication in Cells with RNA-Cleaving DNA Enzymes and Short-Hairpin RNA.
Hepatitis C
Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication.
Hepatitis C
The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly.
Hepatitis C
The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.
Hepatitis C
The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.
Hepatitis C
The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.
Hepatitis C
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
Hepatitis C
The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro.
Hepatitis C
The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity.
Hepatitis C
The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3).
Hepatitis C
The helicase from hepatitis C virus is active as an oligomer.
Hepatitis C
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target.
Hepatitis C
The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells.
Hepatitis C
The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.
Hepatitis C
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.
Hepatitis C
The mitochondrial targeting chaperone 14-3-3? regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
Hepatitis C
The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently.
Hepatitis C
The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells.
Hepatitis C
The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.
Hepatitis C
The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase.
Hepatitis C
The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity.
Hepatitis C
The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase.
Hepatitis C
The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.
Hepatitis C
The RNA-unwinding activity of hepatitis C virus non-structural protein 3 (NS3) is positively modulated by its protease domain.
Hepatitis C
The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells.
Hepatitis C
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate.
Hepatitis C
The Spring ?-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action.
Hepatitis C
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Hepatitis C
Toward the mechanism of dynamical couplings and translocation in hepatitis C virus NS3 helicase using elastic network model.
Hepatitis C
Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein.
Hepatitis C
Tracing entire operation cycles of molecular motor hepatitis C virus helicase in structurally resolved dynamical simulations.
Hepatitis C
Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase.
Hepatitis C
Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action.
Hepatitis C
Two-state model for helicase translocation and unwinding of nucleic acids.
Hepatitis C
Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network analysis.
Hepatitis C
Unmasking the active helicase conformation of NS3 from Hepatitis C Virus.
Hepatitis C
Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex.
Hepatitis C
Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1.
Hepatitis C
Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I.
Hepatitis C
Use of alpha-N,N-bis[carboxymethyl]lysine-modified peroxidase in immunoassays.
Hepatitis C
Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.
Hepatitis C
Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity.
Hepatitis C
Viral and cellular RNA helicases as antiviral targets.
Hepatitis C
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.
Hepatitis C
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Hepatitis C
[A HLA-A2-restricted-CTL epitope variation at the N-terminal of HCV helicase and the immune response of CTLs]
Hepatitis C
[Characterization of a panel of monoclonal antibodies to hepatitis C NS3 recombinant protein ]
Hepatitis C
[Inducible expression of non-structural protein 3 of hepatitis C virus in E. coli]
Hepatitis C
[Molecular evolutionary analysis of GB viruses and hepatitis G virus]
Hepatitis C
[The combined application of nucleotide and amino acid sequences of NS3 hepatitis C virus protein, DNA encoding granulocyte macrophage colony-stimulating factor and inhibitor of regulatory T cells induces effective immune response against hepatitis C virus].
Hepatitis C, Chronic
Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.
Hepatitis C, Chronic
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
Hepatitis C, Chronic
New therapies for the treatment of chronic hepatitis C.
Hepatitis C, Chronic
Overview of interferon therapy for chronic hepatitis C.
Hepatitis C, Chronic
Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus.
Hepatitis E
A novel mycovirus that is related to the human pathogen hepatitis E virus and rubi-like viruses.
Hepatitis E
Analysis of complete genome sequences and a V239A substitution in the helicase domain of swine hepatitis E virus strains isolated in Canada.
Hepatitis E
Analysis of helicase domain mutations in the hepatitis E virus derived from patients with fulminant hepatic failure: Effects on enzymatic activities and virus replication.
Hepatitis E
Analysis of the helicase gene of Korean swine hepatitis E virus isolates and trends in viral infection.
Hepatitis E
Avian hepatitis E virus in an outbreak of hepatitis-splenomegaly syndrome and fatty liver haemorrhage syndrome in two flaxseed-fed layer flocks in Ontario.
Hepatitis E
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Hepatitis E
Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease.
Hepatitis E
Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein.
Hepatitis E
Genotyping of hepatitis E virus in clinical specimens by restriction endonuclease analysis.
Hepatitis E
Hepatic rupture hemorrhage syndrome in chickens caused by a novel genotype avian hepatitis E virus.
Hepatitis E
Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I.
Hepatitis E
Hepatitis E virus ORF1 encoded non structural protein-host protein interaction network.
Hepatitis E
Hepatitis E Virus ORF2 Inhibits RIG-I Mediated Interferon Response.
Hepatitis E
Identification and genetic characterization of a porcine hepe-astrovirus (bastrovirus) in the United States.
Hepatitis E
Molecular Analysis and Modeling of Hepatitis E Virus Helicase and Identification of Novel Inhibitors by Virtual Screening.
Hepatitis E
Mutagenesis of hepatitis E virus helicase motifs: effects on enzyme activity.
Hepatitis E
NTPase and 5' to 3' RNA duplex-unwinding activities of the hepatitis E virus helicase domain.
Hepatitis E
Phylogenetic analysis of avian hepatitis E virus samples from European and Australian chicken flocks supports the existence of a different genus within the Hepeviridae comprising at least three different genotypes.
Hepatitis E
RIG-I Is A Key Antiviral Interferon-Stimulated Gene Against Hepatitis E Virus Dispensable Of Interferon Production.
Hepatitis E
RNA 5'-triphosphatase activity of the hepatitis E virus helicase domain.
Hepatitis E
RNA Strand Displacement Assay for Hepatitis E Virus Helicase.
Hepatitis E
Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus.
Hepatitis E
Substitution of amino acid residue V1213 in the helicase domain of the genotype 3 hepatitis E virus reduces virus replication.
Hepatitis E
Viral Macro Domains Reverse Protein ADP-Ribosylation.
Hepatitis, Chronic
Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways.
Hepatitis, Chronic
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Herpes Simplex
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.
Herpes Simplex
Combined transcriptomic/proteomic analysis of crucian carp Carassius auratus gibelio in cyprinid herpesvirus 2 infection.
Herpes Simplex
Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer.
Herpes Simplex
Effect of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum (II) on the activity of a helicase essential for DNA replication, the herpes simplex virus type-1 origin-binding protein.
Herpes Simplex
Functional interaction between the herpes simplex virus type 1 polymerase processivity factor and origin-binding proteins: enhancement of UL9 helicase activity.
Herpes Simplex
Helicase motif Ia is involved in single-strand DNA-binding and helicase activities of the herpes simplex virus type 1 origin-binding protein, UL9.
Herpes Simplex
Helicase primase: targeting the Achilles heel of herpes simplex viruses.
Herpes Simplex
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5.
Herpes Simplex
Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation.
Herpes Simplex
High-throughput screening assay for helicase enzymes.
Herpes Simplex
Induction of interferon-? contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells.
Herpes Simplex
Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex.
Herpes Simplex
Inhibition of herpes simplex virus type 1 replication by adeno-associated virus rep proteins depends on their combined DNA-binding and ATPase/helicase activities.
Herpes Simplex
mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.
Herpes Simplex
New antiviral drugs that target herpesvirus helicase primase enzymes.
Herpes Simplex
Physical interaction between the herpes simplex virus 1 origin-binding protein and single-stranded DNA-binding protein ICP8.
Herpes Simplex
Replacement of gly815 in helicase motif V alters the single-stranded DNA-dependent ATPase activity of the herpes simplex virus type 1 helicase-primase.
Herpes Simplex
Residues within the conserved helicase motifs of UL9, the origin-binding protein of herpes simplex virus-1, are essential for helicase activity but not for dimerization or origin binding activity.
Herpes Simplex
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
Herpes Simplex
RIG-I Mediated STING Up-Regulation Restricts HSV-1 Infection.
Herpes Simplex
Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication.
Herpes Simplex
Suppression of PACT-induced type I interferon production by herpes simplex virus type 1 Us11 protein.
Herpes Simplex
The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression.
Herpes Simplex
The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function.
Herpes Simplex
The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1.
Herpes Simplex
The herpes simplex virus type 1 helicase-primase. Analysis of helicase activity.
Herpes Simplex
The herpes simplex virus type-1 origin binding protein. DNA helicase activity.
Herpes Simplex
The herpes simplex virus type-1 single-strand DNA-binding protein (ICP8) promotes strand invasion.
Herpes Simplex
The herpesvirus accessory protein ?134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I.
Herpes Simplex
The human cytomegalovirus genes and proteins required for DNA synthesis.
Herpes Simplex
The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function.
Herpes Simplex
trans-acting requirements for replication of Epstein-Barr virus ori-Lyt.
Herpes Simplex
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
Herpes Simplex
[Inhibition of herpes simplex virus helicase UL9 by netropsin derivatives and antiviral activities of bis-netropsins].
Herpesviridae Infections
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Herpesviridae Infections
The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling.
Hirschsprung Disease
Male-biased aganglionic megacolon in the TashT mouse model of Hirschsprung disease involves upregulation of p53 protein activity and Ddx3y gene expression.
HIV Infections
Differential expression of Werner and Bloom syndrome genes in the peripheral blood of HIV-1 infected patients.
HIV Infections
State-of-the-art tools unveil potent drug targets amongst clinically approved drugs to inhibit helicase in SARS-CoV-2.
Hodgkin Disease
Association of DDX58 177 C?>?T polymorphism with decreased risk of Epstein-Barr virus-related nodular sclerosis classical Hodgkin lymphoma.
Hodgkin Disease
Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
Hyperpigmentation
Genomic analysis of GBS data reveals genes associated with facial pigmentation in Xinyang blue-shelled layers.
Hypersensitivity
DNA helicases Sgs1 and BLM promote DNA double-strand break resection.
Hypertension
Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report.
Hypogonadism
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Hypoparathyroidism
Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism.
hypoxanthine phosphoribosyltransferase deficiency
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
Ichthyosis
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Ichthyosis
Suppression of UV-induced apoptosis by the human DNA repair protein XPG.
Ichthyosis
The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes.
Idiopathic Interstitial Pneumonias
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Idiopathic Pulmonary Fibrosis
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Infarction, Middle Cerebral Artery
The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke.
Infections
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
Infections
A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.
Infections
A mutation in helicase motif IV of HSV-1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to predicted helicase structure.
Infections
A necrosis-inducing elicitor domain encoded by both symptomatic and asymptomatic Plantago asiatica mosaic virus isolates, whose expression is modulated by virus replication.
Infections
A novel chicken lung epithelial cell line: characterization and response to low pathogenicity avian influenza virus.
Infections
A rapid and transient innate immune response to avian influenza infection in mallards.
Infections
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Infections
A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant.
Infections
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.
Infections
Activation and regulation of pathogen sensor RIG-I.
Infections
Activation of the Beta Interferon Promoter by Unnatural Sendai Virus Infection Requires RIG-I and Is Inhibited by Viral C Proteins.
Infections
Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death.
Infections
Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response.
Infections
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Infections
An important role for MAVS in the KSHV lifecycle.
Infections
An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.
Infections
Analysis of Global Transcriptome Change in Mouse Embryonic Fibroblasts After dsDNA and dsRNA Viral Mimic Stimulation.
Infections
Analysis of oral infection and helicase gene of the nucleopolyhedroviruses isolated from Philosamia cynthia ricini and Antheraea pernyi.
Infections
Annexin-A1 promotes RIG-I-dependent signaling and apoptosis via regulation of the IRF3-IFNAR-STAT1-IFIT1 pathway in A549 lung epithelial cells.
Infections
Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.
Infections
Association of RIG-I with innate immunity of ducks to influenza.
Infections
Association of rs2111485 and rs1990760 Polymorphisms of Interferon Induced with Helicase C Domain 1 Gene with Hepatitis C Virus Clearance in Chinese Han Population.
Infections
Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.
Infections
Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro.
Infections
Bacteriophage T4 gene 41 protein, required for the synthesis of RNA primers, is also a DNA helicase.
Infections
Bacteriophage T4 gene 59 helicase assembly protein binds replication fork DNA. The 1.45 A resolution crystal structure reveals a novel alpha-helical two-domain fold.
Infections
Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo.
Infections
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Infections
Beet necrotic yellow vein virus 42 kDa triple gene block protein binds nucleic acid in vitro.
Infections
Cell type-specific involvement of RIG-I in antiviral response.
Infections
Cell-type-specific innate immune response to oncolytic newcastle disease virus.
Infections
Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein.
Infections
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
Infections
Characterization of mimotopes mimicking an immunodominant conformational epitope on the hepatitis C virus NS3 helicase.
Infections
Characterization of the immune response following in vitro mayaro and chikungunya viruses (Alphavirus, Togaviridae) infection of mononuclear cells.
Infections
Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.
Infections
Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models.
Infections
Cloning and expression of NS3 helicase fragment of hepatitis C virus and the study of its immunoreactivity in HCV infected patients.
Infections
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.
Infections
Combined transcriptomic/proteomic analysis of crucian carp Carassius auratus gibelio in cyprinid herpesvirus 2 infection.
Infections
Comparative Analysis of the Liver and Spleen Transcriptomes between Holstein and Yunnan Humped Cattle.
Infections
Comparative analysis of viral RNA signatures on different RIG-I-like receptors.
Infections
Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.
Infections
Control of Innate Immune Signaling and Membrane Targeting by the Hepatitis C Virus NS3/4A Protease Are Governed by the NS3 Helix ?0.
Infections
Control of the induction of type I interferon by Peste des petits ruminants virus.
Infections
Conventional protein kinase C-? (PKC-?) and PKC-? negatively regulate RIG-I antiviral signal transduction.
Infections
COVID-19: An Update on Pathogenesis and Treatment.
Infections
Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation.
Infections
Critical role of MDA5 in the interferon response induced by human metapneumovirus infection in dendritic cells and in vivo.
Infections
Current Findings Regarding Natural Components With Potential Anti-2019-nCoV Activity.
Infections
Cytokine-independent upregulation of MDA5 in viral infection.
Infections
Cytoplasm and Beyond: The Dynamic Innate Immune Sensing of Influenza A Virus by RIG-I.
Infections
DANCING WITH CHEMICAL FORMULAE OF ANTIVIRALS: A PANORAMIC VIEW (part 2).
Infections
ddPCR increases detection of SARS-CoV-2 RNA in patients with low viral loads.
Infections
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Infections
DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.
Infections
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
Infections
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Infections
De Novo Transcriptome Analysis Shows That SAV-3 Infection Upregulates Pattern Recognition Receptors of the Endosomal Toll-Like and RIG-I-Like Receptor Signaling Pathways in Macrophage/Dendritic Like TO-Cells.
Infections
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
Infections
DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection.
Infections
DEAD-box RNA helicase DDX3X inhibits DENV replication via regulating type one interferon pathway.
Infections
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
Infections
Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.
Infections
Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection.
Infections
Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis.
Infections
Dengue Virus Capsid Interacts with DDX3X-A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection.
Infections
Dengue virus induces interferon-? by activating RNA sensing pathways in megakaryocytes.
Infections
Dengue virus-induced regulation of the host cell translational machinery.
Infections
Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.
Infections
Dicodon monitoring of protein synthesis (DiCoMPS) reveals levels of synthesis of a viral protein in single cells.
Infections
Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection.
Infections
Differential recognition of viral RNA by RIG-I.
Infections
Direct, interferon-independent activation of the CXCL10 promoter by NF-?B and interferon regulatory factor 3 during hepatitis C virus infection.
Infections
Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
Infections
Dissecting the Role of DDX21 in Regulating Human Cytomegalovirus Replication.
Infections
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Infections
Downregulation of Aedes aegypti chromodomain helicase DNA binding protein 7/Kismet by Wolbachia and its effect on dengue virus replication.
Infections
Duck RIG-I restricts duck enteritis virus infection.
Infections
Duckling short beak and dwarfism syndrome virus infection activates host innate immune response involving both DNA and RNA sensors.
Infections
Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism.
Infections
Duox2-derived Reactive Oxygen Species Induce Pattern Recognition Receptors' Expression Against Influenza A Virus in Nasal Mucosa.
Infections
Dynamic Interaction of Stress Granule, DDX3X and IKK-? Mediates Multiple Functions in Hepatitis C Virus Infection.
Infections
Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Infections
Effective treatment of respiratory alphaherpesvirus infection using RNA interference.
Infections
Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.
Infections
EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway.
Infections
Elevation of Alanine Aminotransferase Activity Occurs after Activation of the Cell-Death Signaling Initiated by Pattern-Recognition Receptors ?but before Activation of Cytolytic Effectors in NK or CD8+ T Cells in the Liver During Acute HCV Infection.
Infections
Emerging therapies for herpes viral infections (types 1 - 8).
Infections
Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection.
Infections
Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant.
Infections
Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.
Infections
Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
Infections
Enterovirus 71 inhibits cellular type I interferon signaling by inhibiting host RIG-I ubiquitination.
Infections
Essential role for the Legionella pneumophila rep helicase homologue in intracellular infection of mammalian cells.
Infections
Essential role of RIG-I in the activation of endothelial cells by dengue virus.
Infections
Existence of transdominant and potentiating mutants of UL9, the herpes simplex virus type 1 origin-binding protein, suggests that levels of UL9 protein may be regulated during infection.
Infections
Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor.
Infections
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity.
Infections
Expression and Functional Characterization of Retinoic Acid-Inducible Gene-I-Like Receptors of Mast Cells in Response to Viral Infection.
Infections
Expression of immune genes RIG-I and Mx in mallard ducks infected with low pathogenic avian influenza (LPAI): A dataset.
Infections
Expression of RIG-I, IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus.
Infections
Expression profiles of carp IRF-3/-7 correlate with the up-regulation of RIG-I/MAVS/TRAF3/TBK1, four pivotal molecules in RIG-I signaling pathway.
Infections
Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection.
Infections
First Report of Little cherry virus 2 in Flowering and Sweet Cherry Trees in China.
Infections
FKBP5 Regulates RIG-I-Mediated NF-?B Activation and Influenza A Virus Infection.
Infections
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells.
Infections
Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.
Infections
Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense.
Infections
Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity.
Infections
Fusobacterium nucleatum activates the immune response through retinoic acid-inducible gene I.
Infections
GB hepatitis agent in cadaver organ donors and their recipients.
Infections
Gene Expression Analysis During Dengue Virus Infection In Hepg2 Cells Reveals Virus Control of Innate Immune Response.
Infections
Gene expression profile after activation of RIG-I in 5'ppp-dsRNA challenged DF1.
Infections
Genetic Control of Human Infection with SARS-CoV-2.
Infections
Genetic determinants of host immunity against human rhinovirus infections.
Infections
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
Infections
Goose RIG-I functions in innate immunity against Newcastle disease virus infections.
Infections
Grass Carp Laboratory of Genetics and Physiology 2 Serves As a Negative Regulator in Retinoic Acid-Inducible Gene I- and Melanoma Differentiation-Associated Gene 5-Mediated Antiviral Signaling in Resting State and Early Stage of Grass Carp Reovirus Infection.
Infections
H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades.
Infections
Hantaan virus triggers TLR3-dependent innate immune responses.
Infections
HCV NS3Ag: a reliable and clinically useful predictor of antiviral outcomes in genotype 1b hepatitis C virus-infected patients.
Infections
Helicase Domain Encoded by Cucumber mosaic virus RNA1 Determines Systemic Infection of Cmr1 in Pepper.
Infections
Helicases as antiviral drug targets.
Infections
Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X.
Infections
Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity.
Infections
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Infections
Hepatitis C virus reveals a novel early control in acute immune response.
Infections
Hepatitis E virus from India exhibits significant amino acid mutations in fulminant hepatic failure patients.
Infections
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5.
Infections
Herpes simplex virus type 2 virion host shutoff protein suppresses innate dsRNA antiviral pathways in human vaginal epithelial cells.
Infections
High-mobility group box 1 protein (HMGB1) from Cherry Valley duck mediates signaling pathways and antiviral activity.
Infections
Highly pathogenic New World arenavirus infection activates the pattern recognition receptor PKR without attenuating virus replication in human cells.
Infections
HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3.
Infections
Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.
Infections
Host Innate Immune Responses of Ducks Infected with Newcastle Disease Viruses of Different Pathogenicities.
Infections
Host innate immune responses of geese infected with goose origin nephrotic astrovirus.
Infections
Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.
Infections
How RIG-I like receptors activate MAVS.
Infections
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.
Infections
Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling.
Infections
Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein.
Infections
Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA.
Infections
Identification and rapid diagnosis of the pathogen responsible for haemorrhagic disease of the gill of Allogynogenetic crucian carp.
Infections
Identification of a retinoic acid-inducible gene I from grass carp (Ctenopharyngodon idella) and expression analysis in vivo and in vitro.
Infections
Identification of avian RIG-I responsive genes during influenza infection.
Infections
Identification of DDX58 and CXCL10 as Potential Biomarkers in Acute Respiratory Distress Syndrome.
Infections
Identification of multiple RIG-I-specific pathogen associated molecular patterns within the West Nile virus genome and antigenome.
Infections
Identification of Potential Inhibitors for Targets Involved in Dengue Fever.
Infections
Identification of several key genes by microarray data analysis of bovine mammary gland epithelial cells challenged with Escherichia coli and Staphylococcus aureus.
Infections
Identification of the RNA Pseudoknot within the 3' End of the Porcine Reproductive and Respiratory Syndrome Virus Genome as a Pathogen-Associated Molecular Pattern To Activate Antiviral Signaling via RIG-I and Toll-Like Receptor 3.
Infections
IFN-?-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner.
Infections
IFN? Influences Epithelial Anti-viral Responses via Histone Methylation of the Rig-I Promoter.
Infections
IFN? Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I.
Infections
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus.
Infections
Immune Consequences of in vitro Infection of Human Peripheral Blood Leukocytes with Vesicular Stomatitis Virus.
Infections
Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.
Infections
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Infections
Importance of retinoic acid-inducible gene I and of receptor for type I interferon for cellular resistance to infection by Newcastle disease virus.
Infections
In vivo cellular and molecular study on duck spleen infected by duck Tembusu virus.
Infections
Incoming RNA Virus Nucleocapsids Containing a 5'-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling.
Infections
Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes.
Infections
Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.
Infections
Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities.
Infections
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-?-dependent induction of pro-apoptotic Noxa.
Infections
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling.
Infections
Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling.
Infections
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Infections
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Infections
Influenza PB1-F2 Inhibits Avian MAVS Signaling.
Infections
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I.
Infections
Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation.
Infections
Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response.
Infections
Inhibition of H9N2 Virus Invasion into Dendritic Cells by the S-Layer Protein from L. acidophilus ATCC 4356.
Infections
Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation.
Infections
Inhibition of RIG-I mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64.
Infections
Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones.
Infections
Innate Immune Responses to Avian Influenza Viruses in Ducks and Chickens.
Infections
Innate immune responses to rotavirus infection in macrophages depend on MAVS but involve neither the NLRP3 inflammasome nor JNK and p38 signaling pathways.
Infections
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA.
Infections
Innate sensing of viruses by pattern recognition receptors in birds.
Infections
Insight into the expression of RIG-I-like receptors in human third trimester placentas following ex vivo cytomegalovirus or vesicular stomatitis virus infection.
Infections
Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems.
Infections
Interaction of the bacteriophage T4 gene 59 helicase loading protein and gene 41 helicase with each other and with fork, flap, and cruciform DNA.
Infections
Interactions of the TGB1 protein during cell-to-cell movement of Barley stripe mosaic virus.
Infections
Interferon stimulated genes, CXCR4 and immune cell responses in peripheral blood mononuclear cells infected with bovine viral diarrhea virus.
Infections
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Infections
Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone.
Infections
IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia.
Infections
Isolation and Characterization of Pepper Genes Interacting with the CMV-P1 Helicase Domain.
Infections
Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus.
Infections
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Infections
Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner.
Infections
Lack of evidence of mimivirus replication in human PBMCs.
Infections
Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection.
Infections
LGP2 of black carp plays an important role in the innate immune response against SVCV and GCRV.
Infections
Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication.
Infections
Long-term HIV-1 infection induces an antiviral state in primary macrophages.
Infections
Loss of Sendai virus C protein leads to accumulation of RIG-I immunostimulatory defective interfering RNA.
Infections
MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice.
Infections
MDA-5 is cleaved in poliovirus-infected cells.
Infections
MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells.
Infections
MDA5 plays a critical role in interferon response during hepatitis C virus infection.
Infections
Measles virus C protein interferes with Beta interferon transcription in the nucleus.
Infections
Mechanism of interaction between virus and host is inferred from the changes of gene expression in macrophages infected with African swine fever virus CN/GS/2018 strain.
Infections
Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication.
Infections
Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura.
Infections
Micropterus salmoides rhabdovirus (MSRV) infection induced apoptosis and activated interferon signaling pathway in largemouth bass skin cells.
Infections
MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.
Infections
MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination.
Infections
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules.
Infections
Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro.
Infections
Molecular cloning, characterization and expression analysis of woodchuck retinoic acid-inducible gene I.
Infections
Molecular cloning, functional characterization and antiviral activity of porcine DDX3X.
Infections
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Infections
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.
Infections
Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.
Infections
Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection.
Infections
mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.
Infections
Murine Coronavirus Induces Type I Interferon in Oligodendrocytes Through Recognition by RIG-I and MDA5.
Infections
Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons.
Infections
Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections.
Infections
Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity.
Infections
Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome.
Infections
Mycobacterium tuberculosis DinG is a structure-specific helicase that unwinds G4 DNA: implications for targeting G4 DNA as a novel therapeutic approach.
Infections
N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
Infections
N1L Is an Ectromelia Virus Virulence Factor and Essential for In Vivo Spread upon Respiratory Infection.
Infections
N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Infections
Natural chemical entities from Arisaema genus might be a promising break-through against Japanese encephalitis virus infection: a molecular docking and dynamics approach.
Infections
Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1.
Infections
Nicotiana benthamiana plants transformed with the plum pox virus helicase gene are resistant to virus infection.
Infections
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.
Infections
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-?B signaling pathways.
Infections
Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells.
Infections
O'nyong nyong virus molecular determinants of unique vector specificity reside in non-structural protein 3.
Infections
Origin activation requires both replicative and accessory helicases during T4 infection.
Infections
Oropouche virus infection and pathogenesis is restricted by MAVS, IRF-3, IRF-7, and type I IFN signaling pathways in non-myeloid cells.
Infections
OsBIRH1, a DEAD-box RNA helicase with functions in modulating defence responses against pathogen infection and oxidative stress.
Infections
Osteoblasts from osteoarthritis patients show enhanced to Ross River virus infection associated with delayed type I interferon responses.
Infections
OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
Infections
p53 mediated IFN-? signaling to affect viral replication upon TGEV infection.
Infections
Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection.
Infections
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
Infections
Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production.
Infections
Pigeon RIG-I Function in Innate Immunity against H9N2 IAV and IBDV.
Infections
Piscine orthoreovirus (PRV) replicates in Atlantic salmon (Salmo salar L.) erythrocytes ex vivo.
Infections
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Infections
Polarization of human monocyte-derived dendritic cells to DC1 by in vitro stimulation with Newcastle Disease Virus.
Infections
Poly(dA:dT) Suppresses HSV-2 Infection of Human Cervical Epithelial Cells Through RIG-I Activation.
Infections
Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection.
Infections
Porcine circovirus 2 infection induces IFN? expression through increased expression of genes involved in RIG-I and IRF7 signaling pathways.
Infections
Porcine deltacoronavirus (PDCoV) infection antagonizes interferon-?1 production.
Infections
Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-? production.
Infections
Porcine deltacoronavirus nucleocapsid protein antagonizes IFN-? production by impairing dsRNA and PACT binding to RIG-I.
Infections
Porcine epidemic diarrhea virus infection induces NF-?B activation through the TLR2, TLR3 and TLR9 pathways in porcine intestinal epithelial cells.
Infections
Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway.
Infections
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing.
Infections
Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis.
Infections
Promoter analysis of the Chilo iridescent virus DNA polymerase and major capsid protein genes.
Infections
Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice.
Infections
Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence.
Infections
Rabies virus nucleoprotein functions to evade activation of the RIG-I-mediated antiviral response.
Infections
Recent patents relating to HCV molecules like putative targets for therapeutic intervention.
Infections
Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease.
Infections
Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus.
Infections
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.
Infections
Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6.
Infections
Relationship between sex hormones and RIG-I signaling in peripheral blood mononuclear cells of patients infected with hepatitis C virus.
Infections
Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis.
Infections
Requirements for eIF4A and eIF2 during translation of Sindbis virus subgenomic mRNA in vertebrate and invertebrate host cells.
Infections
Residues Asn118 and Glu119 of hepatitis B virus X protein are critical for HBx-mediated inhibition of RIG-I-MAVS signaling.
Infections
Respiratory syncytial virus infection of microglia exacerbates SH-SY5Y neuronal cell injury by inducing the secretion of inflammatory cytokines: A Transwell in vitro study.
Infections
Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells.
Infections
Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection.
Infections
Retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 are induced but not essential for dengue virus induced type I interferon response.
Infections
Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells.
Infections
Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Down-regulation of the Very Low Density Lipoprotein Receptor.
Infections
Rhabdovirus evasion of the interferon system.
Infections
Rhodiola inhibits dengue virus multiplication by inducing innate immune response genes RIG-I, MDA5 and ISG in human monocytes.
Infections
Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
Infections
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity.
Infections
RIG-I and dsRNA-induced IFNbeta activation.
Infections
RIG-I and MDA5 RNA Helicases Both Contribute to the Induction of Interferon-{alpha}/{beta} in Measles Virus-Infected Human Cells.
Infections
RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus.
Infections
RIG-I detects HIV-1 infection and mediates type I interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders.
Infections
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.
Infections
RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.
Infections
RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells.
Infections
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Infections
RIG-I in RNA virus recognition.
Infections
RIG-I Is A Key Antiviral Interferon-Stimulated Gene Against Hepatitis E Virus Dispensable Of Interferon Production.
Infections
RIG-I is cleaved during picornavirus infection.
Infections
RIG-I Is Required for the Inhibition of Measles Virus by Retinoids.
Infections
RIG-I is responsible for activation of type I interferon pathway in Seneca Valley virus-infected porcine cells to suppress viral replication.
Infections
RIG-I knockdown impedes neurogenesis in a murine model of Japanese encephalitis.
Infections
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
Infections
RIG-I Mediated STING Up-Regulation Restricts HSV-1 Infection.
Infections
RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus.
Infections
RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes.
Infections
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
Infections
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.
Infections
RIG-I Recognizes the 5' Region of Dengue and Zika Virus Genomes.
Infections
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
Infections
RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.
Infections
RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo.
Infections
RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells.
Infections
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
Infections
RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi.
Infections
RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.
Infections
RIG-I-like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation.
Infections
RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells: DEPENDENCE ON TRAF2 AND TAK1.
Infections
RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I.
Infections
RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.
Infections
RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.
Infections
RNA helicase signaling is critical for type I interferon production and protection against Rift Valley fever virus during mucosal challenge.
Infections
RNA helicases in infection and disease.
Infections
RNA Sequencing of Murine Norovirus-Infected Cells Reveals Transcriptional Alteration of Genes Important to Viral Recognition and Antigen Presentation.
Infections
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Infections
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling.
Infections
Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection.
Infections
SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts.
Infections
SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation.
Infections
Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression.
Infections
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Infections
Sensing Adenovirus infection: activation of IRF3 in RAW264.7 cells.
Infections
Sensing and control of Bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases.
Infections
Significance of monoclonal antibodies against the conserved epitopes within non-structural protein 3 helicase of hepatitis C virus.
Infections
Silvestrol Inhibits Chikungunya Virus Replication.
Infections
Small-Molecule Antagonists of the RIG-I Innate Immune Receptor.
Infections
SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy.
Infections
SOCS1 and pattern recognition receptors: TLR9 and RIG-I; novel haplotype associations in Egyptian fibrotic/cirrhotic patients with HCV genotype 4.
Infections
Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.
Infections
Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness.
Infections
Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.
Infections
STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection.
Infections
STING1 is essential for an RNA-virus triggered autophagy.
Infections
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate.
Infections
Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA.
Infections
Suppression of human metapneumovirus (HMPV) infection by the innate sensing gene CEACAM1.
Infections
Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.
Infections
SVCV infection triggers fish IFN response through RLR signaling pathway.
Infections
Targeted mutational analysis to unravel the complexity of African horse sickness virus NS3 function in mammalian cells.
Infections
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.
Infections
The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.
Infections
The Antiviral Molecule 5-Pyridoxolactone Identified Post BmNPV Infection of the Silkworm, Bombyx mori.
Infections
The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans.
Infections
The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression.
Infections
The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing.
Infections
The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2? Phosphorylation and Stress Granule Formation.
Infections
The C-terminal domain of Salmonid Alphavirus nonstructural protein 2 (nsP2) is essential and sufficient to block RIG-I pathway induction and interferon-mediated antiviral response.
Infections
The Caenorhabditis elegans RIG-I Homolog DRH-1 Mediates the Intracellular Pathogen Response upon Viral Infection.
Infections
The cellular immune responses induced in the follow-up of interferon-alpha treated patients with chronic hepatitis C may determine the therapy outcome.
Infections
The core promoter controls basal and inducible expression of duck retinoic acid inducible gene-I (RIG-I).
Infections
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
Infections
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
Infections
The DEAH-box RNA helicase DHX15 activates NF-?B and MAPK signaling downstream of MAVS during antiviral responses.
Infections
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.
Infections
The Effect of the Hepatitis B Virus Surface Protein Truncated sC69? Mutation on Viral Infectivity and the Host Innate Immune Response.
Infections
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
Infections
The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection.
Infections
The insertion of a mitochondrial selfish element into the nuclear genome and its consequences.
Infections
The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines.
Infections
The Long Noncoding RNA NEAT1 Exerts Anti-Hantaviral Effects by Acting as a Positive Feedback for RIG-I Signaling.
Infections
The Microtubule-Associated Innate Immune Sensor GEF-H1 Does Not Influence Mouse Norovirus Replication in Murine Macrophages.
Infections
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
Infections
The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.
Infections
The regulation of type I interferon production by paramyxoviruses.
Infections
The rinderpest virus non-structural C protein blocks the induction of type 1 interferon.
Infections
The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.
Infections
The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling.
Infections
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Infections
The tyrosine 73 and serine 83 dephosphorylation of H1N1 swine influenza virus NS1 protein attenuates virus replication and induces high levels of beta interferon.
Infections
The tyrosine kinase c-Src enhances retinoic acid inducible gene-I (RIG-I)-elicited antiviral signaling.
Infections
The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner.
Infections
The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.
Infections
TLR3-dependent upregulation of RIG-I leads to enhanced cytokine production from cells infected with the parainfluenza virus SV5.
Infections
Toll-like receptors, long non-coding RNA NEAT1, and RIG-I expression are associated with HBeAg-positive chronic hepatitis B patients in the active phase.
Infections
Transcriptome profiling of influenza A virus-infected lung epithelial (A549) cells with lariciresinol-4-?-D-glucopyranoside treatment.
Infections
Transmissible gastroenteritis virus infection induces NF-?B activation through RLR-mediated signaling.
Infections
TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.
Infections
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Infections
UntRIG(er)ing lncRNAs.
Infections
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma.
Infections
Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I.
Infections
Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp.
Infections
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
Infections
West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling.
Infections
Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
Infections
ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.
Infections
Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination.
Infections
[A HLA-A2-restricted-CTL epitope variation at the N-terminal of HCV helicase and the immune response of CTLs]
Infections
[Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus]
Infections
[Cell type specific involvement of RIG-I in antiviral responses]
Infections
[Establishment of RIG-I knockout 293T cell line and its effect on the replication of influenza B virus].
Infections
[RIG-I mediated hepatic innate immune signaling that controls HCV infection]
Infertility
Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe.
Infertility
Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1.
Infertility
RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.
Infertility
Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes.
Infertility, Female
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
Infertility, Male
Association of the gonadotrophin-regulated testicular RNA helicase gene polymorphism with human male infertility.
Infertility, Male
DDX3X and DDX3Y are redundant in protein synthesis.
Infertility, Male
Downregulation of miR-322 promotes apoptosis of GC-2 cell by targeting Ddx3x.
Infertility, Male
Gonadotropin-Regulated Testicular RNA helicase (GRTH/DDX25) a Multifunctional Protein Essential for Spermatogenesis.
Infertility, Male
Human Y chromosome microdeletion analysis by PCR multiplex protocols identifying only clinically relevant AZF microdeletions.
Infertility, Male
Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia.
Infertility, Male
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
Infertility, Male
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
Influenza in Birds
A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance.
Influenza in Birds
Association of RIG-I with innate immunity of ducks to influenza.
Influenza in Birds
Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export.
Influenza in Birds
Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro.
Influenza in Birds
Expression of immune genes RIG-I and Mx in mallard ducks infected with low pathogenic avian influenza (LPAI): A dataset.
Influenza in Birds
Function of duck RIG-I in induction of antiviral response against IBDV and avian influenza virus on chicken cells.
Influenza in Birds
Gene expression profile after activation of RIG-I in 5'ppp-dsRNA challenged DF1.
Influenza in Birds
Identification of avian RIG-I responsive genes during influenza infection.
Influenza in Birds
Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections.
Influenza, Human
5'-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity.
Influenza, Human
5'-Triphosphate-Short Interfering RNA: Potent Inhibition of Influenza A Virus Infection by Gene Silencing and RIG-I Activation.
Influenza, Human
5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication.
Influenza, Human
?-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling.
Influenza, Human
A Dual-Functioning 5'-PPP-NS1shRNA that Activates a RIG-I Antiviral Pathway and Suppresses Influenza NS1.
Influenza, Human
A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection.
Influenza, Human
Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin.
Influenza, Human
Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity.
Influenza, Human
Apigenin suppresses influenza A virus-induced RIG-I activation and viral replication.
Influenza, Human
Association of RIG-I with innate immunity of ducks to influenza.
Influenza, Human
Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro.
Influenza, Human
CEACAM1-Mediated Inhibition of Virus Production.
Influenza, Human
Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein.
Influenza, Human
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
Influenza, Human
Chicken MDA5 Senses Short Double-Stranded RNA with Implications for Antiviral Response against Avian Influenza Viruses in Chicken.
Influenza, Human
Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models.
Influenza, Human
Cigarette Smoke Extract Suppresses the RIG-I Initiated Innate Immune Response To Influenza Virus In Human Lung.
Influenza, Human
Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine.
Influenza, Human
Combined Intranasal Nanoemulsion and RIG-I Activating RNA Adjuvants Enhance Mucosal, Humoral, and Cellular Immunity to Influenza Virus.
Influenza, Human
Cytoplasm and Beyond: The Dynamic Innate Immune Sensing of Influenza A Virus by RIG-I.
Influenza, Human
DANCING WITH CHEMICAL FORMULAE OF ANTIVIRALS: A PANORAMIC VIEW (part 2).
Influenza, Human
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
Influenza, Human
De novo replication of the influenza virus RNA genome is regulated by DNA replicative helicase, MCM.
Influenza, Human
Deciphering interactions used by the influenza virus NS1 protein to silence the host antiviral sensor protein RIG-I using a bacterial reverse two-hybrid system.
Influenza, Human
Defective RNA sensing by RIG-I in severe influenza virus infection.
Influenza, Human
Differential recognition of viral RNA by RIG-I.
Influenza, Human
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Influenza, Human
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Influenza, Human
Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes.
Influenza, Human
Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.
Influenza, Human
Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant.
Influenza, Human
Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.
Influenza, Human
Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling.
Influenza, Human
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Influenza, Human
Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I.
Influenza, Human
Function of duck RIG-I in induction of antiviral response against IBDV and avian influenza virus on chicken cells.
Influenza, Human
Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation.
Influenza, Human
H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades.
Influenza, Human
Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era.
Influenza, Human
Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.
Influenza, Human
Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09.
Influenza, Human
Human interactome of the influenza B virus NS1 protein.
Influenza, Human
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
Influenza, Human
Identification of avian RIG-I responsive genes during influenza infection.
Influenza, Human
Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle.
Influenza, Human
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
Influenza, Human
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
Influenza, Human
IFN-? suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis.
Influenza, Human
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.
Influenza, Human
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus.
Influenza, Human
In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus.
Influenza, Human
Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling.
Influenza, Human
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Influenza, Human
Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction.
Influenza, Human
Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs.
Influenza, Human
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Influenza, Human
Influenza A virus TRIMs the type I interferon response.
Influenza, Human
Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung.
Influenza, Human
Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30.
Influenza, Human
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Influenza, Human
Influenza PB1-F2 Inhibits Avian MAVS Signaling.
Influenza, Human
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I.
Influenza, Human
Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting.
Influenza, Human
Influenza virus NS1- C/EBP? gene regulatory complex inhibits RIG-I transcription.
Influenza, Human
Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation.
Influenza, Human
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus.
Influenza, Human
Innate sensing of viruses by pattern recognition receptors in birds.
Influenza, Human
Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.
Influenza, Human
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Influenza, Human
Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication.
Influenza, Human
MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG-I expression in lung epithelial cells.
Influenza, Human
Mini viral RNAs act as innate immune agonists during influenza virus infection.
Influenza, Human
NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.
Influenza, Human
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-?B signaling pathways.
Influenza, Human
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
Influenza, Human
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.
Influenza, Human
Nuclear-resident RIG-I senses viral replication inducing antiviral immunity.
Influenza, Human
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens.
Influenza, Human
Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production.
Influenza, Human
Phosphorylation of TRIM28 Enhances the Expression of IFN-? and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.
Influenza, Human
Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics.
Influenza, Human
Regulation of RIG-I Activation by K63-Linked Polyubiquitination.
Influenza, Human
Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design.
Influenza, Human
Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.
Influenza, Human
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
Influenza, Human
RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells.
Influenza, Human
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Influenza, Human
RIG-I from waterfowl and mammals differ in their abilities to induce antiviral responses against influenza A viruses.
Influenza, Human
RIG-I is cleaved during picornavirus infection.
Influenza, Human
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.
Influenza, Human
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
Influenza, Human
RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.
Influenza, Human
RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo.
Influenza, Human
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
Influenza, Human
RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.
Influenza, Human
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Influenza, Human
Role of the chaperone protein 14-3-3? in the regulation of influenza A virus-activated beta interferon.
Influenza, Human
Seasonal and pandemic influenza H1N1 viruses induce differential expression of SOCS-1 and RIG-I genes and cytokine/chemokine production in macrophages.
Influenza, Human
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Influenza, Human
Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists.
Influenza, Human
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.
Influenza, Human
Small RNA Plays Important Roles in Virus-Host Interactions.
Influenza, Human
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
Influenza, Human
Standing on three legs: antiviral activities of RIG-I against influenza viruses.
Influenza, Human
Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication.
Influenza, Human
Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs.
Influenza, Human
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
Influenza, Human
Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Influenza, Human
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate.
Influenza, Human
Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes.
Influenza, Human
Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection.
Influenza, Human
Systematic editing of synthetic RIG-I ligands to produce effective antiviral and anti-tumor RNA immunotherapies.
Influenza, Human
The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I.
Influenza, Human
The catcher in the RIG-I.
Influenza, Human
The Cellular DExD/H-Box RNA Helicase UAP56 Co-localizes With the Influenza A Virus NS1 Protein.
Influenza, Human
The Cellular RNA Helicase UAP56 Is Required for Prevention of Double-Stranded RNA Formation during Influenza A Virus Infection.
Influenza, Human
The core promoter controls basal and inducible expression of duck retinoic acid inducible gene-I (RIG-I).
Influenza, Human
The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells.
Influenza, Human
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
Influenza, Human
The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling.
Influenza, Human
The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.
Influenza, Human
Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.
Influenza, Human
TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination.
Influenza, Human
Transcriptome profiling of influenza A virus-infected lung epithelial (A549) cells with lariciresinol-4-?-D-glucopyranoside treatment.
Influenza, Human
TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.
Influenza, Human
Tumor Necrosis Factor Alpha Enhances Influenza A Virus-Induced Expression of Antiviral Cytokines by Activating RIG-I Gene Expression.
Influenza, Human
Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.
Influenza, Human
Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity.
Influenza, Human
[Establishment of RIG-I knockout 293T cell line and its effect on the replication of influenza B virus].
Influenza, Human
[Mechanisms underlying interferon-mediated host innate immunity during influenza A virus infection].
Intellectual Disability
A de novo DDX3X Variant Is Associated With Syndromic Intellectual Disability: Case Report and Literature Review.
Intellectual Disability
A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features.
Intellectual Disability
A novel de novo DDX3X missense variant in a female with brachycephaly and intellectual disability: a case report.
Intellectual Disability
Absence epilepsy and the CHD2 gene: an adolescent male with moderate intellectual disability, short-lasting psychoses, and an interstitial deletion in 15q26.1-q26.2.
Intellectual Disability
Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p.
Intellectual Disability
CHD2 is Required for Embryonic Neurogenesis in the Developing Cerebral Cortex.
Intellectual Disability
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
Intellectual Disability
DDX3 Modulates Neurite Development via Translationally Activating an RNA Regulon Involved in Rac1 Activation.
Intellectual Disability
DDX3X mutations in two girls with a phenotype overlapping Toriello-Carey syndrome.
Intellectual Disability
DDX3X: structure, physiologic functions and cancer.
Intellectual Disability
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
Intellectual Disability
De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome.
Intellectual Disability
Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome.
Intellectual Disability
Expansion of phenotype of DDX3X syndrome: six new cases.
Intellectual Disability
Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders.
Intellectual Disability
In-Frame Deletion and Missense Mutations of the C-Terminal Helicase Domain of SMARCA2 in Three Patients with Nicolaides-Baraitser Syndrome.
Intellectual Disability
JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.
Intellectual Disability
Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.
Intellectual Disability
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Intellectual Disability
Paralog Studies Augment Gene Discovery: DDX and DHX Genes.
Intellectual Disability
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Intellectual Disability
Phenotypic expansion in DDX3X - a common cause of intellectual disability in females.
Intellectual Disability
Prospective and detailed behavioral phenotyping in DDX3X syndrome.
Intellectual Disability
Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation.
Intellectual Disability
Severe gastrointestinal symptoms caused by a novel DDX3X variant.
Intellectual Disability
The clinical presentation caused by truncating CHD8 variants.
Intellectual Disability
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Intellectual Disability
The first reported case of an inherited pathogenic CHD2 variant in a clinically affected mother and daughter.
Intellectual Disability
The RNA helicase DDX3 induces neural crest by promoting AKT activity.
Intellectual Disability
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
Intestinal Pseudo-Obstruction
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Iron Deficiencies
Loss of mitochondrial localization of human FANCG causes defective FANCJ helicase.
Iron Deficiencies
The Cth2 ARE-binding Protein Recruits the Dhh1 Helicase to Promote the Decay of Succinate Dehydrogenase SDH4 mRNA in Response to Iron Deficiency.
Keratitis
TLR3/TRIF signalling pathway regulates IL-32 and IFN-? secretion through activation of RIP-1 and TRAF in the human cornea.
Kidney Diseases
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
Klatskin Tumor
Narrowing of the remnant portal vein diameter and decreased portal vein angle are risk factors for portal vein thrombosis after perihilar cholangiocarcinoma surgery.
Kyphosis
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Lactose Intolerance
The molecular basis of lactose intolerance.
Language Development Disorders
A de novo variant of CHD8 in a patient with autism spectrum disorder.
Language Development Disorders
Prospective and detailed behavioral phenotyping in DDX3X syndrome.
Leishmaniasis
Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast.
Leishmaniasis, Visceral
DDX3 DEAD-box RNA helicase (Hel67) gene disruption impairs infectivity of Leishmania donovani and induces protective immunity against visceral leishmaniasis.
Leukemia
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.
Leukemia
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
Leukemia
EBV in T-/NK-Cell Tumorigenesis.
Leukemia
Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication.
Leukemia
Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.
Leukemia
Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells.
Leukemia
Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition.
Leukemia
Mixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data.
Leukemia
Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.
Leukemia
Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.
Leukemia
MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.
Leukemia
Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.
Leukemia
New dead/H-box helicase gene (ddx41) mutation in an Italian family with recurrent leukemia.
Leukemia
Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies.
Leukemia
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
Leukemia
RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.
Leukemia
Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8.
Leukemia
RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness.
Leukemia
RNA helicase DDX5 participates in oxLDL-induced macrophage scavenger receptor 1 expression by suppressing mRNA degradation.
Leukemia
RNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA Pathway.
Leukemia
Small-molecule inhibitors targeting eIF4A in leukemia.
Leukemia
Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study.
Leukemia
The FMRP-MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes.
Leukemia
The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.
Leukemia
The role of Moloney leukemia virus 10 in hepatitis B virus expression in hepatoma cells.
Leukemia
TLR ligands upregulate RIG-I expression in human plasmacytoid dendritic cells in a type I IFN-independent manner.
Leukemia
Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.
Leukemia, Erythroblastic, Acute
Prevention of anthracycline-induced cytotoxicity in hemopoietic cells by hemin.
Leukemia, Lymphocytic, Chronic, B-Cell
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Gene expression of helicase antigen in patients with acute and chronic myeloid leukemia.
Leukemia, Myeloid, Acute
Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.
Leukemia, Myeloid, Acute
Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies.
Leukemia, Myeloid, Acute
Gene expression of helicase antigen in patients with acute and chronic myeloid leukemia.
Leukemia, Myeloid, Acute
Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia.
Leukemia, Myeloid, Acute
Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Leukemia, Myeloid, Acute
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Leukemia, Myeloid, Acute
Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans.
Leukemia, Myeloid, Acute
RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.
Leukemia, Myeloid, Acute
RIG-I plays a critical role in negatively regulating granulocytic proliferation.
Leukemia, Myeloid, Acute
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.
Leukemia, Myeloid, Acute
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
Leukemia, T-Cell
RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1.
Leukemia-Lymphoma, Adult T-Cell
Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia.
Listeriosis
Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I.
Liver Diseases
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Liver Diseases
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Liver Failure, Acute
Analysis of helicase domain mutations in the hepatitis E virus derived from patients with fulminant hepatic failure: Effects on enzymatic activities and virus replication.
Liver Neoplasms
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Liver Neoplasms
Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a.
Liver Neoplasms
RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.
Loeys-Dietz Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Lung Diseases, Interstitial
Clinically amyopathic dermatomyositis.
Lung Diseases, Interstitial
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Lung Diseases, Interstitial
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Lung Diseases, Interstitial
Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.
Lung Neoplasms
Analysis of the RNA helicase A gene in human lung cancer.
Lung Neoplasms
Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression.
Lung Neoplasms
DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4.
Lung Neoplasms
DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of ?-catenin.
Lung Neoplasms
DDX3X induces primary EGFR-TKI resistance based on intratumor heterogeneity in lung cancer cells harboring EGFR-activating mutations.
Lung Neoplasms
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
Lung Neoplasms
EGFR and Ras regulate DDX59 during lung cancer development.
Lung Neoplasms
Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.
Lung Neoplasms
Identification and validation of HELLS (Helicase, Lymphoid-Specific) and ICAM1 (Intercellular adhesion molecule 1) as potential diagnostic biomarkers of lung cancer.
Lung Neoplasms
Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc.
Lung Neoplasms
Lead DEAD/H box helicase biomarkers with the therapeutic potential identified by integrated bioinformatic approaches in lung cancer.
Lung Neoplasms
Long Noncoding RNA Urothelial Carcinoma Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144.
Lung Neoplasms
Radon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers.
Lung Neoplasms
RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.
Lung Neoplasms
RNA helicase DHX9 may be a therapeutic target in lung cancer and inhibited by enoxacin.
Lung Neoplasms
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
Lung Neoplasms
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.
Lung Neoplasms
The DEAD-box RNA helicase 51 controls non-small cell lung cancer proliferation by regulating cell cycle progression via multiple pathways.
Lung Neoplasms
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Lung Neoplasms
The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer.
Lupus Erythematosus, Systemic
A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients.
Lupus Erythematosus, Systemic
Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis.
Lupus Erythematosus, Systemic
Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis.
Lupus Erythematosus, Systemic
Dysregulation of antiviral helicase pathways in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Evaluation of Impact of Interferon-Induced Helicase C Domain-Containing Protein 1 Gene in Egyptian Systemic Lupus Erythematosus Patients and its Relationship With Vascular Manifestations of the Disease.
Lupus Erythematosus, Systemic
Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.
Lupus Erythematosus, Systemic
High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.
Lupus Erythematosus, Systemic
Novel interferonopathies associated with mutations in RIG-I like receptors.
Lupus Nephritis
Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.
Lupus Nephritis
Retinoic acid-inducible gene-I (RIG-I) is induced by IFN- in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis.
Lyme Disease
Homologues of helicase genes priA and ruvAB of Borrelia burgdorferi, the Lyme borreliosis agent.
Lyme Disease
HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete.
Lyme Disease
HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.
Lyme Disease
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
Lymphatic Metastasis
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
Lymphatic Metastasis
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Lymphocytic Choriomeningitis
Host mechanisms in viral hepatitis.
Lymphocytic Choriomeningitis
Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction.
Lymphoma
Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.
Lymphoma
Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas.
Lymphoma
DDX3X Is the Most Frequently Mutated Gene in Natural Killer/T-cell Lymphoma.
Lymphoma
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Lymphoma
EBV in T-/NK-Cell Tumorigenesis.
Lymphoma
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Lymphoma
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
Lymphoma
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.
Lymphoma
Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A.
Lymphoma
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
Lymphoma
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Lymphoma
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Lymphoma
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Lymphoma
The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy.
Lymphoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma, B-Cell
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
Lymphoma, B-Cell
DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.
Lymphoma, B-Cell
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.
Lymphoma, B-Cell
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
Lymphoma, B-Cell
Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells.
Lymphoma, B-Cell
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Lymphoma, B-Cell
Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells.
Lymphoma, B-Cell
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Lymphoma, B-Cell
Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes.
Lymphoma, B-Cell
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Lymphoma, B-Cell
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma, B-Cell
Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes.
Lymphoma, Large B-Cell, Diffuse
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
Lymphoma, Large B-Cell, Diffuse
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Lymphoma, Large B-Cell, Diffuse
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Lymphoma, Non-Hodgkin
HCV non-structural protein 3 and HCV RNA genome in non-Hodgkin lymphoma and transition of the serum HCV RNA level: a retrospective analysis in one institution.
Lymphoma, Primary Effusion
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Lymphopenia
The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis.
Lymphoproliferative Disorders
Chronic Active Epstein-Barr Virus Infection of T/NK-Cell Type Mimicking Classic Hodgkin Lymphoma: Clinicopathologic and Genetic Features of 8 Cases Supporting a Variant With "Hodgkin/Reed-Sternberg-like" Cells of NK Phenotype.
Macroglossia
A novel de novo DDX3X missense variant in a female with brachycephaly and intellectual disability: a case report.
Malaria
'DEAD-box' helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific.
Malaria
Bipolar, Dual Plasmodium falciparum Helicase 45 Expressed in the Intraerythrocytic Developmental Cycle Is Required for Parasite Growth.
Malaria
Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase.
Mandibular Fractures
A novel computer algorithm for modeling and treating mandibular fractures: A pilot study.
Mandibulofacial Dysostosis
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Marfan Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Massive Hepatic Necrosis
Infection with GB virus C (GBV-C) in patients with fulminant hepatitis.
Measles
A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2.
Measles
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.
Measles
Measles virus C protein interferes with Beta interferon transcription in the nucleus.
Measles
Measles virus interaction with host cells and impact on innate immunity.
Measles
Non-encapsidated 5' copy-back defective-interfering genomes produced by recombinant measles viruses are recognized by RIG-I and LGP2 but not MDA5.
Measles
PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine.
Measles
Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique.
Measles
RIG-I and MDA5 RNA Helicases Both Contribute to the Induction of Interferon-{alpha}/{beta} in Measles Virus-Infected Human Cells.
Measles
RIG-I Is Required for the Inhibition of Measles Virus by Retinoids.
Measles
RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Measles
Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines.
Measles
The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines.
Measles
TLR3 and RIG-I gene variants: associations with functional effects on receptor expression and responses to measles virus and vaccine in vaccinated infants.
Medulloblastoma
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
Medulloblastoma
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.
Medulloblastoma
Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
Medulloblastoma
CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma.
Medulloblastoma
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Medulloblastoma
Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42.
Medulloblastoma
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Medulloblastoma
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.
Medulloblastoma
Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation.
Medulloblastoma
Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33.
Medulloblastoma
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
Megalencephaly
A de novo variant of CHD8 in a patient with autism spectrum disorder.
Megalencephaly
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.
Megalencephaly
Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.
Megalencephaly
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.
Megalencephaly
Chromatin Remodeler CHD8 in Autism and Brain Development.
Melanoma
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
Melanoma
A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome.
Melanoma
Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-?.
Melanoma
Activation of IFN-β expression by a viral mRNA through RNase L and MDA5.
Melanoma
Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Melanoma
Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response.
Melanoma
Anti-cancer function of polyinosinic-polycytidylic acid.
Melanoma
Anti-pyroptotic function of TGF-? is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells.
Melanoma
Anticancer immunochemotherapy using adjuvants with direct cytotoxic effects.
Melanoma
Apoptosis induced by synthetic retinoic acid CD437 on human melanoma A375 cells involves RIG-I pathway.
Melanoma
Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury.
Melanoma
Cardiac-specific overexpression of melanoma differentiation-associated gene-5 protects mice from lethal viral myocarditis.
Melanoma
Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus.
Melanoma
Clinically amyopathic dermatomyositis.
Melanoma
Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi-Goutières Syndrome and Singleton-Merten Syndrome.
Melanoma
Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection.
Melanoma
Critical role of MDA5 in the interferon response induced by human metapneumovirus infection in dendritic cells and in vivo.
Melanoma
Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection.
Melanoma
Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease.
Melanoma
Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.
Melanoma
Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells.
Melanoma
Cytoplasmic nucleic acid sensors in antiviral immunity.
Melanoma
Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.
Melanoma
DDX3X induces primary EGFR-TKI resistance based on intratumor heterogeneity in lung cancer cells harboring EGFR-activating mutations.
Melanoma
Defining the functional determinants for RNA surveillance by RIG-I.
Melanoma
Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.
Melanoma
Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity towards autologous melanoma cells.
Melanoma
Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-?-induced apoptosis in tumor-repopulating cells of melanoma.
Melanoma
Effects of ionizing radiation on retinoic acid-inducible gene-I-like receptors.
Melanoma
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
Melanoma
Enteroviral pathogenesis of type 1 diabetes: queries and answers.
Melanoma
Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.
Melanoma
Evaluation of Innate Immune Mediators Related to Respiratory Viruses in the Lung of Stable COPD Patients.
Melanoma
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Melanoma
Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss).
Melanoma
Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7.
Melanoma
Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense.
Melanoma
Functional RIG-I-like receptors control the survival of mesenchymal stem cells.
Melanoma
Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2.
Melanoma
Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III IFN gene expression.
Melanoma
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS.
Melanoma
Inflammatory chemokine expression via Toll-like receptor 3 signaling in normal human mesangial cells.
Melanoma
Influenza A Virus PA Antagonizes Interferon-? by Interacting with Interferon Regulatory Factor 3.
Melanoma
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Melanoma
Innate RIG-I signaling restores antigen presentation in tumors and overcomes T cell resistance.
Melanoma
Innate sensing of viruses by pattern recognition receptors in birds.
Melanoma
Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes.
Melanoma
Interaction between Interferon-Stimulated Gene 56 and Melanoma Differentiation-Associated Gene 5 in Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells.
Melanoma
KAP1-Mediated Epigenetic Suppression in Anti-RNA Viral Responses by Direct Targeting RIG-I and MDA5.
Melanoma
Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc.
Melanoma
Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.
Melanoma
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
Melanoma
Limited suppression of the interferon-beta production by hepatitis C virus serine protease in cultured human hepatocytes.
Melanoma
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
Melanoma
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
Melanoma
MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction.
Melanoma
MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation.
Melanoma
Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-?-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.
Melanoma
Melanoma Differentiation-Associated Gene 5 Regulates the Expression of a Chemokine CXCL10 in Human Mesangial Cells: Implications for Chronic Inflammatory Renal Diseases.
Melanoma
Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling.
Melanoma
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Melanoma
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.
Melanoma
Negative regulation of cytoplasmic RNA-mediated antiviral signaling.
Melanoma
Oligomerization of RIG-I and MDA5 2CARD domains.
Melanoma
Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts.
Melanoma
Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.
Melanoma
Pigeon RIG-I Function in Innate Immunity against H9N2 IAV and IBDV.
Melanoma
Poly I:C-induced tumor cell apoptosis mediated by pattern-recognition receptors.
Melanoma
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Melanoma
Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome.
Melanoma
Quantitative measurement of circulating lymphoid-specific helicase (HELLS) gene transcript: a potential serum biomarker for melanoma metastasis.
Melanoma
Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation.
Melanoma
Reduced expression of the MDA5 gene IFIH1 prevents autoimmune diabetes.
Melanoma
Regulation of antiviral innate immune signaling by stress-induced RNA granules.
Melanoma
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors.
Melanoma
RIG-I activation induces the release of extracellular vesicles with antitumor activity.
Melanoma
RIG-I activation is critical for responsiveness to checkpoint blockade.
Melanoma
RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1.
Melanoma
RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.
Melanoma
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
Melanoma
RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium.
Melanoma
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Melanoma
RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.
Melanoma
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Melanoma
RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis.
Melanoma
Role of MDA5 in regulating CXCL10 expression induced by TLR3 signaling in human rheumatoid fibroblast-like synoviocytes.
Melanoma
Sensing Adenovirus infection: activation of IRF3 in RAW264.7 cells.
Melanoma
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
Melanoma
Small self-RNA generated by RNase L amplifies antiviral innate immunity.
Melanoma
Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.
Melanoma
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
Melanoma
Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts.
Melanoma
Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.
Melanoma
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells.
Melanoma
Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma.
Melanoma
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Melanoma
Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines.
Melanoma
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy.
Melanoma
The antiviral signaling mediated by black carp MDA5 is positively regulated by LGP2.
Melanoma
The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas.
Melanoma
The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.
Melanoma
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation In Vivo.
Melanoma
The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1.
Melanoma
The laboratory of genetics and physiology 2: emerging insights into the controversial functions of this RIG-I-like receptor.
Melanoma
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.
Melanoma
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Melanoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Melanoma
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.
Melanoma
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
Melanoma
TRIM25 in the Regulation of the Antiviral Innate Immunity.
Melanoma
Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.
Melanoma
Utility of the RIG-I agonist triphosphate RNA for melanoma therapy.
Melanoma
Viral RNA detection by RIG-I-like receptors.
Melanoma
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Melanoma
ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
Melanoma
Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling.
Melanoma
Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.
Melanoma
[DDX10 promotes AIM2-inflammasome activation by maintaining AIM2 protein stability].
Meningeal Neoplasms
Applying DDX3X Biomarker to Discriminate Atypical from Benign Meningiomas in Tissue Microarray.
Meningioma
Applying DDX3X Biomarker to Discriminate Atypical from Benign Meningiomas in Tissue Microarray.
Meningioma
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.
Meningitis
Comparison of real-time florescence quantitative PCR measurements of VAD1 mRNA with three conventional methods in diagnosis and follow-up treatment of Cryptococcus neoformans infection.
Meningitis
The effect of the expression of virulence-associated DEAD-box RNA helicase mRNA on the imbalance of Th1-Th2 cytokines in the CSF of patients with Cryptococcus neoformans meningitis.
Meningitis
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation.
Mental Retardation, X-Linked
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Mental Retardation, X-Linked
dXNP/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neurons.
Mesothelioma
Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.
Mesothelioma
Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.
Mesothelioma
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Mesothelioma, Malignant
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Mesothelioma, Malignant
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Microcephaly
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
Mitochondrial Diseases
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Mitochondrial Diseases
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Mitochondrial Diseases
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
Mitochondrial Myopathies
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Mitochondrial Myopathies
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Motor Neuron Disease
Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration.
Mouth Neoplasms
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma.
Movement Disorders
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
Movement Disorders
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Multiple Myeloma
Cell-type-specific innate immune response to oncolytic newcastle disease virus.
Multiple Myeloma
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Multiple Myeloma
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Multiple Sclerosis
Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients.
Multiple Sclerosis
Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies.
Multiple Sclerosis
Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1.
Mumps
A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2.
Muscle Cramp
Mast cell phenotypic plasticity and their activity under the influence of cathelicidin-related antimicrobial peptide (CRAMP) and IL-33 alarmins.
Muscle Hypotonia
A de novo DDX3X Variant Is Associated With Syndromic Intellectual Disability: Case Report and Literature Review.
Muscle Hypotonia
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
Muscle Hypotonia
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Muscular Atrophy
Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.
Muscular Atrophy, Spinal
Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.
Muscular Atrophy, Spinal
Clinical diversity caused by novel IGHMBP2 variants.
Muscular Atrophy, Spinal
Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ.
Muscular Diseases
Mild ocular myopathy associated with a novel mutation in mitochondrial twinkle helicase.
Muscular Dystrophies
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Musculoskeletal Pain
Development of a U-bent plastic optical fiber biosensor with plasmonic labels for the detection of chikungunya non-structural protein 3.
Myasthenic Syndromes, Congenital
A spontaneous missense mutation in the chromodomain helicase DNA-binding protein 8 (CHD8) gene: a novel association with congenital myasthenic syndrome.
Mycoses
Evaluation of Reference Genes for Reverse Transcription Quantitative PCR Studies of Physiological Responses in the Ghost Moth, Thitarodes armoricanus (Lepidoptera, Hepialidae).
Myelodysplastic Syndromes
Erratum for Fusion of the Nucleoporin Gene, NUP98, and the Putative RNA Helicase Gene, DZXX10, by Inversion 11 (p15q22) Chromosome Translocation in a Patient with Etoposide-related Myelodysplastic Syndrome.
Myelodysplastic Syndromes
Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome.
Myelodysplastic Syndromes
Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans.
Myeloproliferative Disorders
RIG-I plays a critical role in negatively regulating granulocytic proliferation.
Myocardial Infarction
Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.
Myocarditis
Inhibition of RNA Helicase Activity Prevents Coxsackievirus B3-Induced Myocarditis in Human iPS Cardiomyocytes.
Myoclonic Epilepsy, Juvenile
Juvenile myoclonic epilepsy mimic associated with CHD2 gene mutation.
Myositis
Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease.
Myositis
Myositis specific autoantibodies.
Myositis
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Myositis
[Expression of retinoic acid-I nducible gene I in the muscle tissues of idiopathic inflammatory myopathies].
Myositis, Inclusion Body
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Myotonic Dystrophy
Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5.
Myxoma
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
Myxoma
RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells.
Nasopharyngeal Carcinoma
Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver.
Nasopharyngeal Carcinoma
Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.
Nasopharyngeal Carcinoma
Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway.
Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma progression is mediated by EBER-triggered inflammation via the RIG-I pathway.
Nasopharyngeal Carcinoma
RIG-I promotes IFN/JAK2 expression and the endoplasmic reticulum stress response to inhibit chemoradiation resistance in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Tumour inflammasome-derived IL-1? recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma.
Neoplasm Metastasis
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.
Neoplasm Metastasis
A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Neoplasm Metastasis
circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression.
Neoplasm Metastasis
Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.
Neoplasm Metastasis
DDX19A Promotes Metastasis of Cervical Squamous Cell Carcinoma by Inducing NOX1-Mediated ROS Production.
Neoplasm Metastasis
DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG.
Neoplasm Metastasis
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
Neoplasm Metastasis
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
Neoplasm Metastasis
DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.
Neoplasm Metastasis
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Neoplasm Metastasis
Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability.
Neoplasm Metastasis
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Neoplasm Metastasis
eIF4F suppression in breast cancer affects maintenance and progression.
Neoplasm Metastasis
Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer.
Neoplasm Metastasis
Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer.
Neoplasm Metastasis
Helicase antigen (HAGE)-derived vaccines induce immunity to HAGE and ImmunoBody®-HAGE DNA vaccine delays the growth and metastasis of HAGE-expressing tumors in vivo.
Neoplasm Metastasis
Identification of Prognostic and Metastatic Alternative Splicing Signatures in Kidney Renal Clear Cell Carcinoma.
Neoplasm Metastasis
Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis.
Neoplasm Metastasis
Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia.
Neoplasm Metastasis
Mitochondria Autoimmunity and MNRR1 in Breast Carcinogenesis: A Review.
Neoplasm Metastasis
Molecular testing in metastatic basal cell carcinoma.
Neoplasm Metastasis
Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth.
Neoplasm Metastasis
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Neoplasm Metastasis
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Neoplasm Metastasis
Quantitative measurement of circulating lymphoid-specific helicase (HELLS) gene transcript: a potential serum biomarker for melanoma metastasis.
Neoplasm Metastasis
RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 prostate cancer.
Neoplasm Metastasis
RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis.
Neoplasm Metastasis
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1? mRNA is translated.
Neoplasm Metastasis
SMARCAD1 in Breast Cancer Progression.
Neoplasm Metastasis
SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.
Neoplasm Metastasis
The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
Neoplasm Metastasis
The prognostic effect of DDX3 upregulation in distant breast cancer metastases.
Neoplasm Metastasis
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
Neoplasm Metastasis
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
Neoplasms
(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68.
Neoplasms
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
Neoplasms
A computational analysis of ATP binding of SV40 large tumor antigen helicase motor.
Neoplasms
A Computational Approach with Biological Evaluation: Combinatorial Treatment of Curcumin and Exemestane Synergistically Regulates DDX3 Expression in Cancer Cell Lines.
Neoplasms
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
Neoplasms
A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation.
Neoplasms
A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Neoplasms
A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types.
Neoplasms
A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1.
Neoplasms
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).
Neoplasms
A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
Neoplasms
A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance.
Neoplasms
A role for WRN in telomere-based DNA damage responses.
Neoplasms
A specific docking site for DNA polymerase {alpha}-primase on the SV40 helicase is required for viral primosome activity, but helicase activity is dispensable.
Neoplasms
Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases.
Neoplasms
Activation of RIG-I signaling to increase the pro-inflammatory phenotype of a tumor.
Neoplasms
AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses.
Neoplasms
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
Neoplasms
An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis.
Neoplasms
An evolutionarily conserved, alternatively spliced, intron in the p68/DDX5 DEAD-box RNA helicase gene encodes a novel miRNA.
Neoplasms
An Integrative Approach Identified Genes Associated with Drug Response in Gastric Cancer.
Neoplasms
An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation.
Neoplasms
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Neoplasms
Analysis of the RNA helicase p68 (Ddx5) as a transcriptional regulator.
Neoplasms
Aneuploidy and improved growth are coincident but not causal in a yeast cancer model.
Neoplasms
Anti-angiogenic efficacy of 5'-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs.
Neoplasms
Anti-pyroptotic function of TGF-? is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells.
Neoplasms
Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models.
Neoplasms
Application of dsRNA in cancer immunotherapy: current status and future trends.
Neoplasms
Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.
Neoplasms
Association of the chromodomain helicase DNA-binding protein 4 (CHD4) missense variation p.D140E with cancer: potential interaction with smoking.
Neoplasms
Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma.
Neoplasms
Atm is a negative regulator of intestinal neoplasia.
Neoplasms
ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.
Neoplasms
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Neoplasms
BACH1 is a DNA repair protein supporting BRCA1 damage response.
Neoplasms
Bargain with the tooth fairy - The savings accounts for dental stem cells.
Neoplasms
Being Small and Intronic: miRNAs That Count!
Neoplasms
Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.
Neoplasms
BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells.
Neoplasms
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Neoplasms
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Neoplasms
Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.
Neoplasms
BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex.
Neoplasms
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Neoplasms
BRIP-1 germline mutation and its role in colon cancer: presentation of two case reports and review of literature.
Neoplasms
c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy.
Neoplasms
Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.
Neoplasms
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.
Neoplasms
Candidate gene polymorphisms and risk of psoriasis: A pilot study.
Neoplasms
Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.
Neoplasms
Canine keratinocytes upregulate type I interferons and proinflammatory cytokines in response to poly(dA:dT) but not to canine papillomavirus.
Neoplasms
Cell-type-specific innate immune response to oncolytic newcastle disease virus.
Neoplasms
Cellular studies of MrDb (DDX18).
Neoplasms
Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression.
Neoplasms
Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1.
Neoplasms
Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes.
Neoplasms
CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
Neoplasms
CHD4 mediates proliferation and migration of non-small cell lung cancer via the RhoA/ROCK pathway by regulating PHF5A.
Neoplasms
CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma.
Neoplasms
CHD5 is a tumor suppressor at human 1p36.
Neoplasms
CHD5 is down-regulated through promoter hypermethylation in gastric cancer.
Neoplasms
Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
Neoplasms
CHD5, a tumor suppressor that is epigenetically silenced in lung cancer.
Neoplasms
Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver.
Neoplasms
Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.
Neoplasms
Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesis.
Neoplasms
Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer.
Neoplasms
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Neoplasms
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis.
Neoplasms
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.
Neoplasms
Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction.
Neoplasms
circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression.
Neoplasms
CircDDX42 Accelerates the Development of Pancreatic Cancer via miR-613/ID4/PI3K/AKT Axis.
Neoplasms
circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.
Neoplasms
Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.
Neoplasms
Clinical significance of chromatin remodeling factor CHD5 expression in gastric cancer.
Neoplasms
Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers.
Neoplasms
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.
Neoplasms
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
Neoplasms
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Neoplasms
Conformational rearrangements of SV40 large T antigen during early replication events.
Neoplasms
Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotypes to Colorectal Cancer Risk in Taiwan.
Neoplasms
CRISPR Screens Single Out WRN.
Neoplasms
Crystal structure of the eIF4A-PDCD4 complex.
Neoplasms
Cysteine-rich 61-associated gene expression profile alterations in human glioma cells.
Neoplasms
Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes.
Neoplasms
Cytokine-independent upregulation of MDA5 in viral infection.
Neoplasms
Cytoplasmic DDX3 as prognosticator in male breast cancer.
Neoplasms
DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity.
Neoplasms
DDX19A Promotes Metastasis of Cervical Squamous Cell Carcinoma by Inducing NOX1-Mediated ROS Production.
Neoplasms
DDX21 promotes gastric cancer proliferation by regulating cell cycle.
Neoplasms
DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG.
Neoplasms
DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.
Neoplasms
DDX39, Upregulated in Lung Squamous Cell Cancer, Displays RNA Helicase Activities and Promotes Cancer Cell Growth.
Neoplasms
DDX3X induces primary EGFR-TKI resistance based on intratumor heterogeneity in lung cancer cells harboring EGFR-activating mutations.
Neoplasms
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
Neoplasms
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes.
Neoplasms
DDX3X promotes the biogenesis of a subset of miRNAs and the potential roles they played in cancer development.
Neoplasms
DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.
Neoplasms
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Neoplasms
DDX3X: structure, physiologic functions and cancer.
Neoplasms
DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response.
Neoplasms
DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway.
Neoplasms
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
Neoplasms
DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating ?-catenin signaling pathway.
Neoplasms
DDX54 Plays a Cancerous Role Through Activating P65 and AKT Signaling Pathway in Colorectal Cancer.
Neoplasms
De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms.
Neoplasms
Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response.
Neoplasms
DEAD box RNA helicase functions in cancer.
Neoplasms
DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer.
Neoplasms
DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells.
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DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.
Neoplasms
DEAD-Box Helicase 4 (Ddx4)+ Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.
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DEAD-box helicase DP103 defines metastatic potential of human breast cancers.
Neoplasms
DEAD-box proteins, like Leishmania eIF4A, modulate interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production by human monocytes.
Neoplasms
DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis.
Neoplasms
DEAD-box RNA helicase protein DDX21 as a prognosis marker for early stage colorectal cancer with microsatellite instability.
Neoplasms
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells.
Neoplasms
Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma.
Neoplasms
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Neoplasms
Decreased expression of the CHD5 gene and its clinicopathological significance in breast cancer: Correlation with aberrant DNA methylation.
Neoplasms
Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer.
Neoplasms
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
Neoplasms
Delivery of 5'-triphosphate RNA with endosomolytic nanoparticles potently activates RIG-I to improve cancer immunotherapy.
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Design, synthesis, in vitro and in vivo anti-respiratory syncytial virus (RSV) activity of novel oxizine fused benzimidazole derivatives.
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DHX33 Interacts with AP-2? To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival.
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DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription.
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DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration.
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Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity towards autologous melanoma cells.
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Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors.
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DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
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DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
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DNA helicases and their roles in cancer.
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DNA helicases as targets for anti-cancer drugs.
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DNA helicases associated with genetic instability, cancer, and aging.
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DNA helicases involved in DNA repair and their roles in cancer.
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DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism.
Neoplasms
DNA repair gene expression level in peripheral blood and tumour tissue from non-small cell lung cancer and head and neck squamous cell cancer patients.
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DNA repair helicases as targets for anti-cancer therapy.
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DNA sensors, crucial receptors to resist pathogens, are deregulated in colorectal cancer and associated with initiation and progression of the disease.
Neoplasms
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Neoplasms
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Neoplasms
Downregulation of p68 RNA Helicase (DDX5) Activates a Survival Pathway Involving mTOR and MDM2 Signals.
Neoplasms
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
Neoplasms
Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
Neoplasms
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A.
Neoplasms
Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle.
Neoplasms
eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.
Neoplasms
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.
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eIF4A inhibitors suppress cell cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer.
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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
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eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
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Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
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Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death.
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Enhanced tumor formation in mice heterozygous for Blm mutation.
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Environmentally Triggerable Retinoic Acid-Inducible Gene I Agonists Using Synthetic Polymer Overhangs.
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Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs.
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Epigenome-wide data collection in a case of gliofibroma.
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Epstein-Barr virus-encoded circular RNA circBART2.2 promotes immune escape of nasopharyngeal carcinoma by regulating PD-L1.
Neoplasms
Escherichia coli replication terminator protein impedes simian virus 40 (SV40) DNA replication fork movement and SV40 large tumor antigen helicase activity in vitro at a prokaryotic terminus sequence.
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Eukaryotic initiation factor 4F: a vulnerability of tumor cells.
Neoplasms
Eukaryotic Translation Initiation Factor 4A Down-Regulation Mediates Interleukin-24-Induced Apoptosis through Inhibition of Translation.
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Evidence for a structural relationship between BRCT domains and the helicase domains of the replication initiators encoded by the Polyomaviridae and Papillomaviridae families of DNA tumor viruses.
Neoplasms
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
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Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer.
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Expression of CHD5 may serve as an independent biomarker of prognosis in colorectal cancer via immunohistochemical staining.
Neoplasms
Expression of minichromosome maintenance 8 in chronic myelogenous leukemia.
Neoplasms
Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma.
Neoplasms
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Neoplasms
FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation.
Neoplasms
Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of Apc(Min) Mice.
Neoplasms
Frequent Mutations in Natural Killer/T Cell Lymphoma.
Neoplasms
From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis.
Neoplasms
Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes.
Neoplasms
Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies.
Neoplasms
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility.
Neoplasms
Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk.
Neoplasms
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.
Neoplasms
Global analysis of metastasis-associated gene expression in primary cultures from clinical specimens of clear-cell renal-cell carcinoma.
Neoplasms
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Neoplasms
H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades.
Neoplasms
Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment.
Neoplasms
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Neoplasms
Helicase antigen (HAGE)-derived vaccines induce immunity to HAGE and ImmunoBody®-HAGE DNA vaccine delays the growth and metastasis of HAGE-expressing tumors in vivo.
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Helicases as antiviral and anticancer drug targets.
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Helicases as prospective targets for anti-cancer therapy.
Neoplasms
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
Neoplasms
High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancer.
Neoplasms
High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome.
Neoplasms
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Neoplasms
Host-Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis.
Neoplasms
Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.
Neoplasms
Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I-MAVS Pathway and cGAS-STING Pathway.
Neoplasms
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.
Neoplasms
Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.
Neoplasms
Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes.
Neoplasms
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
Neoplasms
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
Neoplasms
Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila melanogaster.
Neoplasms
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Neoplasms
Identification of candidate targets for the diagnosis and treatment of atherosclerosis by bioinformatics analysis.
Neoplasms
Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer.
Neoplasms
Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis.
Neoplasms
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen.
Neoplasms
Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies.
Neoplasms
Implementing combinatorial immunotherapeutic regimens against cancer: The concept of immunological conditioning.
Neoplasms
Importance of retinoic acid-inducible gene I and of receptor for type I interferon for cellular resistance to infection by Newcastle disease virus.
Neoplasms
Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome.
Neoplasms
Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation.
Neoplasms
Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase.
Neoplasms
Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Neoplasms
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
Neoplasms
Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
Neoplasms
Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones.
Neoplasms
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Neoplasms
Inhibitors of translation initiation as cancer therapeutics.
Neoplasms
Innate RIG-I signaling restores antigen presentation in tumors and overcomes T cell resistance.
Neoplasms
Insights into the oligomeric states, conformational changes, and helicase activities of SV40 large tumor antigen.
Neoplasms
Integrated Analysis of DEAD-Box Helicase 56: A Potential Oncogene in Osteosarcoma.
Neoplasms
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.
Neoplasms
Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.
Neoplasms
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses.
Neoplasms
Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.
Neoplasms
Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer.
Neoplasms
Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells.
Neoplasms
Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia.
Neoplasms
Knockdown of DDX46 suppresses the proliferation and invasion of gastric cancer through inactivating Akt/GSK-3?/?-catenin pathway.
Neoplasms
Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells.
Neoplasms
Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo.
Neoplasms
Known Inhibitors of RNA Helicases and Their Therapeutic Potential.
Neoplasms
Label-Free Semiquantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics Analysis of Laryngeal/Hypopharyngeal Squamous Cell Carcinoma on Formalin-Fixed, Paraffin-Embedded Tissue Samples - a Pilot Study.
Neoplasms
Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies.
Neoplasms
Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway.
Neoplasms
Level of Murine DDX3 RNA Helicase Determines Phenotype Changes of Hepatocytes In Vitro and In Vivo.
Neoplasms
LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.
Neoplasms
Lymphoid-specific helicase in epigenetics, DNA repair and cancer.
Neoplasms
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.
Neoplasms
Malignant and nonmalignant brain tissues differ in their messenger RNA expression patterns for ERCC1 and ERCC2.
Neoplasms
Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen.
Neoplasms
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Neoplasms
Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen.
Neoplasms
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
Neoplasms
Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.
Neoplasms
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.
Neoplasms
Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation.
Neoplasms
MicroRNA-34a-Upregulated Retinoic Acid-Inducible Gene-I Promotes Apoptosis and Delays Cell Cycle Transition in Cervical Cancer Cells.
Neoplasms
Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion.
Neoplasms
Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan.
Neoplasms
Modulation of the expression of bloom helicase by estrogenic agents.
Neoplasms
Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).
Neoplasms
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Neoplasms
Molecular pathogenesis of Fanconi anemia: recent progress.
Neoplasms
Molecular testing in metastatic basal cell carcinoma.
Neoplasms
Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells.
Neoplasms
Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth.
Neoplasms
Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17).
Neoplasms
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Neoplasms
Multivalent Recognition of Histone Tails by the PHD Fingers of CHD5.
Neoplasms
Mutation and methylation analysis of the chromodomain-helicase-DNA binding 5 gene in ovarian cancer.
Neoplasms
Mutation screening of CHD5 in melanoma-prone families linked to 1p36 revealed no deleterious coding or splice site changes.
Neoplasms
Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma.
Neoplasms
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
Neoplasms
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Neoplasms
NanoLC-MS coupling of liquid microjunction microextraction for on-tissue proteomic analysis.
Neoplasms
Nasopharyngeal carcinoma progression is mediated by EBER-triggered inflammation via the RIG-I pathway.
Neoplasms
New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy.
Neoplasms
Next-Generation Sequencing of DDX41 in Myeloid Neoplasms Leads to Increased Detection of Germline Alterations.
Neoplasms
Novel blood biomarkers of human urinary bladder cancer.
Neoplasms
Novel Insights into the Biochemical Mechanism of CK1? and its Functional Interplay with DDX3X.
Neoplasms
NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy.
Neoplasms
Nucleic Acid Sensing Machinery: Targeting Innate Immune System for Cancer Therapy.
Neoplasms
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
Neoplasms
Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer.
Neoplasms
Optimization of Potent Hepatitis C Virus NS3 Helicase Inhibitors Isolated from the Yellow Dyes Thioflavine S and Primuline.
Neoplasms
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).
Neoplasms
Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines.
Neoplasms
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Neoplasms
p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.
Neoplasms
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
Neoplasms
P68 RNA helicase as a molecular target for cancer therapy.
Neoplasms
p97 Promotes a Conserved Mechanism of Helicase Unloading During DNA Crosslink Repair.
Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neoplasms
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Neoplasms
Patient gender is associated with distinct patterns of chromosomal abnormalities and sex chromosome linked gene-expression profiles in meningiomas.
Neoplasms
PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Neoplasms
Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats.
Neoplasms
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Neoplasms
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination.
Neoplasms
Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation.
Neoplasms
Pif1 helicase and Pol? promote recombination-coupled DNA synthesis via bubble migration.
Neoplasms
Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.
Neoplasms
Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.
Neoplasms
Prevalence of RECQL germline variants in Pakistani early-onset and familial breast cancer patients.
Neoplasms
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Neoplasms
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Neoplasms
Prognostic role of chromodomain helicase DNA binding protein 1-like protein in human solid cancers: A meta-analysis.
Neoplasms
Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin.
Neoplasms
Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells.
Neoplasms
Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.
Neoplasms
Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects.
Neoplasms
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Neoplasms
RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.
Neoplasms
RecQ DNA Helicase Rqh1 Promotes Rad3ATR Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast.
Neoplasms
RECQ1 Helicase in Genomic Stability and Cancer.
Neoplasms
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
Neoplasms
RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA).
Neoplasms
RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma.
Neoplasms
RECQL4 helicase has oncogenic potential in sporadic breast cancers.
Neoplasms
RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.
Neoplasms
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Neoplasms
Regulation of MCM2-7 function.
Neoplasms
Regulation of miRNA Biogenesis and Histone Modification by K63-Polyubiquitinated DDX17 Controls Cancer Stem-like Features.
Neoplasms
Regulator of telomere elongation helicase 1 (RTEL1) rs6010620 polymorphism contribute to increased risk of glioma.
Neoplasms
Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.
Neoplasms
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
Neoplasms
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR.
Neoplasms
RIG-I activation is critical for responsiveness to checkpoint blockade.
Neoplasms
RIG-I Is a Tumor Suppressor and Biomarker of IFN-? Efficacy in HCC.
Neoplasms
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
Neoplasms
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-?B Pathway.
Neoplasms
RIG-I promotes IFN/JAK2 expression and the endoplasmic reticulum stress response to inhibit chemoradiation resistance in nasopharyngeal carcinoma.
Neoplasms
RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.
Neoplasms
RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
Neoplasms
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.
Neoplasms
RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.
Neoplasms
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
Neoplasms
RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis.
Neoplasms
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
Neoplasms
RNA helicase A in the MEF1 transcription factor complex up-regulates the MDR1 gene in multidrug-resistant cancer cells.
Neoplasms
RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells.
Neoplasms
RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling.
Neoplasms
RNA helicase DDX5 participates in oxLDL-induced macrophage scavenger receptor 1 expression by suppressing mRNA degradation.
Neoplasms
RNA helicase DHX15 acts as a tumour suppressor in glioma.
Neoplasms
RNA helicase DP103 and TAK1: a new connection in cancer.
Neoplasms
RNA helicase p68 deploys ?-catenin in regulating RelA/p65 gene expression: implications in colon cancer.
Neoplasms
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1? mRNA is translated.
Neoplasms
RNA helicases in infection and disease.
Neoplasms
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Neoplasms
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
Neoplasms
Role of SIRT1 in homologous recombination.
Neoplasms
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Neoplasms
Roles of DNA helicases in the maintenance of genome integrity.
Neoplasms
Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
Neoplasms
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
Neoplasms
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Neoplasms
Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase.
Neoplasms
Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment.
Neoplasms
Sequence independent duplex DNA opening reaction catalysed by SV40 large tumor antigen.
Neoplasms
Serpin-derived peptides are antiangiogenic and suppress breast tumor xenograft growth.
Neoplasms
Silencing of CHD5 gene by promoter methylation in leukemia.
Neoplasms
Silencing of p68 and STAT3 synergistically diminishes cancer progression.
Neoplasms
Simulating the electrostatic guidance of the vectorial translocations in hexameric helicases and translocases.
Neoplasms
SLFN11 expression in advanced prostate cancer and response to platinum-based chemotherapy.
Neoplasms
SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.
Neoplasms
Small-molecule inhibitors targeting eIF4A in leukemia.
Neoplasms
SNF2 histone linker PHD RING helicase related Has_circ_0001649 as a diagnostic and prognostic biomarker in solid cancer: A PRISMA-compliant meta-analysis based on the Chinese population.
Neoplasms
Spleen cells from young but not old immunized mice eradicate large established cancers.
Neoplasms
STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A.
Neoplasms
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma.
Neoplasms
Stopping trouble before it starts.
Neoplasms
Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
Neoplasms
Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Neoplasms
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Neoplasms
Structural characterization of ?-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation.
Neoplasms
Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists.
Neoplasms
Structure and expression of the human p68 RNA helicase gene.
Neoplasms
Structure and function of DEAH-box helicase 32 and its role in cancer.
Neoplasms
Structure of Rad5 provides insights into its role in tolerance to replication stress.
Neoplasms
Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A.
Neoplasms
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Neoplasms
Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen.
Neoplasms
Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein.
Neoplasms
Structure of the tandem MA-3 region of Pdcd4 and characterisation of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumour suppressor.
Neoplasms
Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts.
Neoplasms
Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway.
Neoplasms
Susceptibility of polar cod (Boreogadus saida) to a model carcinogen.
Neoplasms
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.
Neoplasms
Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.
Neoplasms
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X.
Neoplasms
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
Neoplasms
Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent FTX Locus to Promote Colon Cancer Development.
Neoplasms
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity.
Neoplasms
Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells.
Neoplasms
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.
Neoplasms
Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA.
Neoplasms
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.
Neoplasms
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Neoplasms
Targeting MYC Translation in Colorectal Cancer.
Neoplasms
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness.
Neoplasms
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Neoplasms
Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas.
Neoplasms
Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma.
Neoplasms
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.
Neoplasms
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy.
Neoplasms
Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.
Neoplasms
Targeting Translation of mRNA as a Therapeutic Strategy in Cancer.
Neoplasms
Termination complex in Escherichia coli inhibits SV40 DNA replication in vitro by impeding the action of T antigen helicase.
Neoplasms
The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy.
Neoplasms
The Bloom's syndrome helicase: keeping cancer at bay.
Neoplasms
The chase for the RIG-I ligand--recent advances.
Neoplasms
The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells.
Neoplasms
The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer.
Neoplasms
The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties.
Neoplasms
The dark side of RNA:DNA hybrids.
Neoplasms
The DDX5/Dbp2 subfamily of DEAD-box RNA helicases.
Neoplasms
The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis.
Neoplasms
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.
Neoplasms
The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.
Neoplasms
The DNA fibre technique - tracking helicases at work.
Neoplasms
The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers.
Neoplasms
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
Neoplasms
The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy.
Neoplasms
The enigmatic helicase DHX9 and its association with the hallmarks of cancer.
Neoplasms
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.
Neoplasms
The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas.
Neoplasms
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
Neoplasms
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Neoplasms
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation In Vivo.
Neoplasms
The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1.
Neoplasms
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Neoplasms
The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.
Neoplasms
The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68.
Neoplasms
The Innate Immune Signalling Pathways: Turning RIG-I Sensor Activation Against Cancer.
Neoplasms
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Neoplasms
The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma.
Neoplasms
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.
Neoplasms
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
Neoplasms
The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest.
Neoplasms
The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics.
Neoplasms
The Multiple Facets of ATRX Protein.
Neoplasms
The natural compound silvestrol is a potent inhibitor of Ebola virus replication.
Neoplasms
The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.
Neoplasms
The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.
Neoplasms
The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3? and decreasing the expression of cyclinD1.
Neoplasms
The prognostic effect of DDX3 upregulation in distant breast cancer metastases.
Neoplasms
The Promoter-Associated Noncoding RNA pncCCND1_B Assembles a Protein-RNA Complex to Regulate Cyclin D1 Transcription in Ewing Sarcoma.
Neoplasms
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
Neoplasms
The quest for the 1p36 tumor suppressor.
Neoplasms
The Regulation of Homologous Recombination by Helicases.
Neoplasms
The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition.
Neoplasms
The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage.
Neoplasms
The RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancers.
Neoplasms
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I.
Neoplasms
The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
Neoplasms
The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype.
Neoplasms
The Role of LncRNAs in Translation.
Neoplasms
The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness.
Neoplasms
The Role of Upregulated DDX11 as A Potential Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma.
Neoplasms
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress.
Neoplasms
The Significance of Circular RNA DDX17 in Prostate Cancer.
Neoplasms
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
Neoplasms
The Tumor Suppressor Chromodomain Helicase DNA-binding Protein 5 (CHD5) Remodels Nucleosomes by Unwrapping.
Neoplasms
The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.
Neoplasms
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
Neoplasms
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
Neoplasms
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-?1 Silencing with RIG-I Activation in Pancreatic Cancer.
Neoplasms
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
Neoplasms
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
Neoplasms
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
Neoplasms
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Neoplasms
Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.
Neoplasms
Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.
Neoplasms
Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.
Neoplasms
Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.
Neoplasms
Tumor cell survival dependence on the DHX9 DExH-box helicase.
Neoplasms
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
Neoplasms
Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
Neoplasms
Tumor Necrosis Factor Alpha Enhances Influenza A Virus-Induced Expression of Antiviral Cytokines by Activating RIG-I Gene Expression.
Neoplasms
Tumor Necrosis Factor-?-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.
Neoplasms
Tumor suppressor activity of RIG-I.
Neoplasms
Tumor suppressor p53 represses transcription of RECQ4 helicase.
Neoplasms
Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.
Neoplasms
Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity.
Neoplasms
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss.
Neoplasms
Tumour inflammasome-derived IL-1? recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma.
Neoplasms
Unwinding the mechanisms of a DEAD-box RNA helicase in cancer.
Neoplasms
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Neoplasms
Up-regulation of TLK1B by eIF4E overexpression predicts cancer recurrence in irradiated patients with breast cancer.
Neoplasms
Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.
Neoplasms
Utility of the RIG-I agonist triphosphate RNA for melanoma therapy.
Neoplasms
Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour.
Neoplasms
VEGFR-2 kinase domain inhibition as a scaffold for anti-angiogenesis: Validation of the anti-angiogenic effects of carotenoids from Spondias mombin in DMBA model of breast carcinoma in Wistar rats.
Neoplasms
Virtual liver resection and volumetric analysis of the future liver remnant using open source image processing software.
Neoplasms
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Neoplasms
Wnt/?-catenin signaling pathway inhibits porcine reproductive and respiratory syndrome virus replication by enhancing the nuclear factor-?B-dependent innate immune response.
Neoplasms
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Neoplasms
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
Neoplasms
[Damage-associated molecular patterns and chronic diseases]
Neoplasms
[DNA helicases and human diseases]
Neoplasms
[Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases]
Neoplasms, Germ Cell and Embryonal
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Neoplasms, Squamous Cell
DDX39, Upregulated in Lung Squamous Cell Cancer, Displays RNA Helicase Activities and Promotes Cancer Cell Growth.
Neoplasms, Squamous Cell
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Nervous System Diseases
RNA helicases in infection and disease.
Nervous System Diseases
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Nervous System Diseases
SETX sumoylation: A link between DNA damage and RNA surveillance disrupted in AOA2.
Neurilemmoma
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor.
Neuroblastoma
Amplification of a DEAD box gene (DDX1) with the MYCN gene in neuroblastomas as a result of cosegregation of sequences flanking the MYCN locus.
Neuroblastoma
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency.
Neuroblastoma
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.
Neuroblastoma
EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma.
Neuroblastoma
Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma.
Neuroblastoma
MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma.
Neuroblastoma
Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines.
Neuroblastoma
RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
Neuroblastoma
Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.
Neuroblastoma
The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
Neuroblastoma
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
Neuroblastoma
The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.
Neuroblastoma
Two microRNAs encoded within the bovine herpesvirus 1 latency-related gene promote cell survival by interacting with RIG-I and stimulating NF-?B-dependent transcription and beta interferon signaling pathways.
Neurodegenerative Diseases
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
Neurodegenerative Diseases
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Neurodegenerative Diseases
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Neurodegenerative Diseases
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Neurodegenerative Diseases
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Neurodegenerative Diseases
Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.
Neurofibromatoses
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatosis 1
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibrosarcoma
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor.
Neurofibrosarcoma
Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas.
Neurofibrosarcoma
Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas.
Neuronal Ceroid-Lipofuscinoses
The visual assignment of genes by fiber-fish: BTF3 protein homologue gene (BTF3) and a novel pseudogene of human RNA helicase A (DDX9P) on 13q22.
Newcastle Disease
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
Newcastle Disease
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Newcastle Disease
Antiviral response dictated by choreographed cascade of transcription factors.
Newcastle Disease
Expression of RIG-I, IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus.
Newcastle Disease
Goose RIG-I functions in innate immunity against Newcastle disease virus infections.
Newcastle Disease
Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1.
Newcastle Disease
Signaling through RIG-I and type I interferon receptor: Immune activation by Newcastle disease virus in man versus immune evasion by Ebola virus (Review).
Newcastle Disease
The rinderpest virus non-structural C protein blocks the induction of type 1 interferon.
Newcastle Disease
Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.
Newcastle Disease
Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation.
Non-alcoholic Fatty Liver Disease
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Obesity
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Obesity
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Oligospermia
Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation.
Oligospermia
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.
Ophthalmoplegia, Chronic Progressive External
A novel variation in the Twinkle linker region causing late-onset dementia.
Ophthalmoplegia, Chronic Progressive External
Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells.
Ophthalmoplegia, Chronic Progressive External
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Ophthalmoplegia, Chronic Progressive External
Extraocular Muscle Reveals Selective Vulnerability of Type IIB Fibers to Respiratory Chain Defects Induced by Mitochondrial DNA Alterations.
Ophthalmoplegia, Chronic Progressive External
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Ophthalmoplegia, Chronic Progressive External
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Orchitis
CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways.
Orofaciodigital Syndromes
Confirmation that mutations in DDX59 cause an autosomal recessive form of oral-facial-digital syndrome: Further delineation of the DDX59 phenotype in two new families.
Orofaciodigital Syndromes
Copy Number Variations of Four Y-Linked Genes in Swamp Buffaloes.
Orofaciodigital Syndromes
Mutations in DDX59 Implicate RNA Helicase in the Pathogenesis of Orofaciodigital Syndrome.
Orthomyxoviridae Infections
The effects of H3N2 swine influenza virus infection on TLRs and RLRs signaling pathways in porcine alveolar macrophages.
Osteoarthritis
Identification of
Osteoarthritis
Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes.
Osteosarcoma
Anti-oncogene product p53 binds DNA helicase.
Osteosarcoma
DEAD-Box Helicase 5 Interacts With Transcription Factor 12 and Promotes the Progression of Osteosarcoma by Stimulating Cell Cycle Progression.
Osteosarcoma
Green fluorescent protein tag for studies of drug-induced translocation of nucleolar protein RH-II/Gu.
Osteosarcoma
Identification of Prognostic RBPs in Osteosarcoma.
Osteosarcoma
Integrated Analysis of DEAD-Box Helicase 56: A Potential Oncogene in Osteosarcoma.
Osteosarcoma
Minichromosome maintenance protein 2 and 3 promote osteosarcoma progression via DHX9 and predict poor patient prognosis.
Osteosarcoma
Retraction: DEAD-Box Helicase 5 Interacts With Transcription Factor 12 and Promotes the Progression of Osteosarcoma by Stimulating Cell Cycle Progression.
Osteosarcoma
Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
Otitis Media
TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion.
Otitis Media with Effusion
TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion.
Ovarian Neoplasms
A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification.
Ovarian Neoplasms
circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade.
Ovarian Neoplasms
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Ovarian Neoplasms
DEAD-Box Helicase 4 (Ddx4)+ Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.
Ovarian Neoplasms
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
Ovarian Neoplasms
High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome.
Ovarian Neoplasms
Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells.
Ovarian Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Ovarian Neoplasms
PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells.
Ovarian Neoplasms
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer.
Ovarian Neoplasms
RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer.
Ovarian Neoplasms
Screening of HELQ in breast and ovarian cancer families.
Ovarian Neoplasms
Structure-function analysis of DNA helicase HELQ: A new diagnostic marker in ovarian cancer.
Ovarian Neoplasms
Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells.
Ovarian Neoplasms
Vitamin D and DDX4 regulate the proliferation and invasion of ovarian cancer cells.
Pancreatic Neoplasms
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.
Pancreatic Neoplasms
Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
Pancreatic Neoplasms
Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer.
Pancreatic Neoplasms
Targeted Nanoparticle Delivery of Bifunctional RIG-I Agonists to Pancreatic Cancer.
Pancreatic Neoplasms
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-?1 Silencing with RIG-I Activation in Pancreatic Cancer.
Pancreatic Neoplasms
TRIM29 alters bioenergetics of pancreatic cancer cells via cooperation of miR-2355-3p and DDX3X recruitment to AK4 transcript.
Pancreatitis
Identification of key transcription factors in caerulein-induced pancreatitis through expression profiling data.
Papilloma
The bovine papilloma virus E1 protein has ATPase activity essential to viral DNA replication and efficient transformation in cells.
Papillomavirus Infections
HPV18 E1 Protein Plus ?-Galactosylceramide Elicit in Mice CD8+ T Cell Cross-Reactivity Against Cells Expressing E1 from Diverse Human Papillomavirus Types.
Papillomavirus Infections
The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling.
Papillomavirus Infections
Vaccination with human papillomavirus-18 E1 protein plus ?-galactosyl-ceramide induces CD8+ cytotoxic response and impairs the growth of E1-expressing tumors.
Paralysis
Coupling of Translation Initiation and Termination Does Not Depend on the Mode of Initiation.
Paralysis
Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.
Paralysis
What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?
Paramyxoviridae Infections
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity.
Paramyxoviridae Infections
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
Paramyxoviridae Infections
TLR3-dependent upregulation of RIG-I leads to enhanced cytokine production from cells infected with the parainfluenza virus SV5.
Paraplegia
A novel pathogenic variant p.Asp797Val in IFIH1 in a Japanese boy with overlapping Singleton-Merten syndrome and Aicardi-Goutières syndrome.
Parkinsonian Disorders
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Persistent Infection
Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level.
Persistent Infection
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Persistent Infection
Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.
Persistent Infection
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
Persistent Infection
IRF-3 activation by sendai virus infection is required for cellular apoptosis and avoidance of persistence.
Persistent Infection
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
Persistent Infection
Modulation of the cellular distribution of human cytomegalovirus helicase by cellular factor snapin.
Persistent Infection
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
Peste-des-Petits-Ruminants
Caprine MAVS Is a RIG-I Interacting Type I Interferon Inducer Downregulated by Peste des Petits Ruminants Virus Infection.
Peste-des-Petits-Ruminants
Peste des petits ruminants virus non-structural C protein inhibits the induction of interferon-? by potentially interacting with MAVS and RIG-I.
Phlebotomus Fever
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation.
Picornaviridae Infections
RIG-I is cleaved during picornavirus infection.
Picornaviridae Infections
The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.
Plague
Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague.
Plant Diseases
Elicitor-mediated oligomerization of the tobacco N disease resistance protein.
Pneumonia
DeaD contributes to Pseudomonas aeruginosa virulence in a mouse acute pneumonia model.
Pneumonia
RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo.
Poliomyelitis
Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamides.
Polycystic Kidney, Autosomal Dominant
RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD.
Polymicrogyria
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Polymyositis
Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.
Polymyositis
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Porcine Reproductive and Respiratory Syndrome
Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.
Porcine Reproductive and Respiratory Syndrome
An RNA helicase, RHIV -1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13.
Porcine Reproductive and Respiratory Syndrome
Application of dsRNA in cancer immunotherapy: current status and future trends.
Porcine Reproductive and Respiratory Syndrome
ATP-dependent effector-like functions of RIG-I-like receptors.
Porcine Reproductive and Respiratory Syndrome
Cross-Talk between Human Dendritic Cell Subsets Influences Expression of RNA Sensors and Inhibits Picornavirus Infection.
Porcine Reproductive and Respiratory Syndrome
Differential interferon system gene expression profiles in susceptible and resistant gynogenetic clones of gibel carp challenged with herpesvirus CaHV.
Porcine Reproductive and Respiratory Syndrome
Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection.
Porcine Reproductive and Respiratory Syndrome
Expression of pattern recognition receptors in liver biopsy specimens of children chronically infected with HBV and HCV.
Porcine Reproductive and Respiratory Syndrome
Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus.
Porcine Reproductive and Respiratory Syndrome
Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure.
Porcine Reproductive and Respiratory Syndrome
Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.
Porcine Reproductive and Respiratory Syndrome
Identification of an Intramolecular Switch That Controls the Interaction of Helicase nsp10 with Membrane-Associated nsp12 of Porcine Reproductive and Respiratory Syndrome Virus.
Porcine Reproductive and Respiratory Syndrome
Identification of the RNA Pseudoknot within the 3' End of the Porcine Reproductive and Respiratory Syndrome Virus Genome as a Pathogen-Associated Molecular Pattern To Activate Antiviral Signaling via RIG-I and Toll-Like Receptor 3.
Porcine Reproductive and Respiratory Syndrome
Identification of the strain-specifically truncated nonstructural protein 10 of porcine reproductive and respiratory syndrome virus in infected cells.
Porcine Reproductive and Respiratory Syndrome
IFN? Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I.
Porcine Reproductive and Respiratory Syndrome
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus.
Porcine Reproductive and Respiratory Syndrome
Induction of IFN-? through TLR-3- and RIG-I-Mediated Signaling Pathways in Canine Respiratory Epithelial Cells Infected with H3N2 Canine Influenza Virus.
Porcine Reproductive and Respiratory Syndrome
Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.
Porcine Reproductive and Respiratory Syndrome
Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes.
Porcine Reproductive and Respiratory Syndrome
Molecular cloning, functional characterization and antiviral activity of porcine DDX3X.
Porcine Reproductive and Respiratory Syndrome
Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.
Porcine Reproductive and Respiratory Syndrome
NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-?B, and also MDA5, RIG-I and MAVS.
Porcine Reproductive and Respiratory Syndrome
Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Suppresses Both MAVS and RIG-I Expression as One of the Mechanisms to Antagonize Type I Interferon Production.
Porcine Reproductive and Respiratory Syndrome
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
Porcine Reproductive and Respiratory Syndrome
Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination.
Porcine Reproductive and Respiratory Syndrome
Parts, assembly and operation of the RIG-I family of motors.
Porcine Reproductive and Respiratory Syndrome
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens.
Porcine Reproductive and Respiratory Syndrome
Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway.
Porcine Reproductive and Respiratory Syndrome
Reading the viral signature by Toll-like receptors and other pattern recognition receptors.
Porcine Reproductive and Respiratory Syndrome
Recognition of viruses by cytoplasmic sensors.
Porcine Reproductive and Respiratory Syndrome
RNA sensors of the innate immune system and their detection of pathogens.
Porcine Reproductive and Respiratory Syndrome
Role of Innate Immunity in Preeclampsia: A Systematic Review.
Porcine Reproductive and Respiratory Syndrome
Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus.
Porcine Reproductive and Respiratory Syndrome
T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R.
Porcine Reproductive and Respiratory Syndrome
The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp9 in vitro.
Porcine Reproductive and Respiratory Syndrome
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
Porcine Reproductive and Respiratory Syndrome
The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites.
Porcine Reproductive and Respiratory Syndrome
TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro.
Porcine Reproductive and Respiratory Syndrome
Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons.
Porcine Reproductive and Respiratory Syndrome
Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses.
Porcine Reproductive and Respiratory Syndrome
Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells.
Porcine Reproductive and Respiratory Syndrome
West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of DHX32 in lymphoid tissues.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia.
Prehypertension
Coronary artery disease: AQUARIUS findings do not support the use of aliskiren in patients with CAD and prehypertension.
Prehypertension
Effect of aliskiren on progression of coronary disease in patients with prehypertension: the AQUARIUS randomized clinical trial.
Primary Ovarian Insufficiency
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Progeria
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Progeria
No detectable mutations at Werner helicase locus in progeria.
Progeria
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
Progeria
[Atypical Werner syndrome: Atypical progeroid syndrome: A case report]
Prostatic Neoplasms
Bloom helicase explicitly unwinds 3'-tailed G4DNA structure in prostate cancer cells.
Prostatic Neoplasms
CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.
Prostatic Neoplasms
CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair.
Prostatic Neoplasms
Construction of a lncRNA-PCG bipartite network and identification of cancer-related lncRNAs: a case study in prostate cancer.
Prostatic Neoplasms
Coupling transcription to RNA processing via the p68 DEAD box RNA helicase androgen receptor co-activator in prostate cancer.
Prostatic Neoplasms
DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling.
Prostatic Neoplasms
Does diabetes mellitus as a comorbid condition affect the health-related quality of life in prostate cancer survivors? Results of a population-based observational study Mols F, Aquarius AE, Essink-Bot ML, Aaronson NK, Kil PJ, van de Poll-Franse LV, CoRPS-Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands.
Prostatic Neoplasms
Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer.
Prostatic Neoplasms
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
Prostatic Neoplasms
Impact of abiraterone acetate plus prednisone or enzalutamide on fatigue and cognition in patients with metastatic castration-resistant prostate cancer: initial results from the observational AQUARiUS study.
Prostatic Neoplasms
Impact of Abiraterone Acetate plus Prednisone or Enzalutamide on Patient-reported Outcomes in Patients with Metastatic Castration-resistant Prostate Cancer: Final 12-mo Analysis from the Observational AQUARiUS Study.
Prostatic Neoplasms
Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.
Prostatic Neoplasms
Organ-specific regulation of CHD1 by acute PTEN and p53 loss in mice.
Prostatic Neoplasms
p68/DdX5 supports ?-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.
Prostatic Neoplasms
RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 prostate cancer.
Prostatic Neoplasms
RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
Prostatic Neoplasms
The human RNA helicase A (DDX9) gene maps to the prostate cancer susceptibility locus at chromosome band 1q25 and its pseudogene (DDX9P) to 13q22, respectively.
Prostatic Neoplasms
The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer.
Prostatic Neoplasms
The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype.
Prostatic Neoplasms
The Significance of Circular RNA DDX17 in Prostate Cancer.
Psoriasis
Candidate gene polymorphisms and risk of psoriasis: A pilot study.
Psoriasis
Carriers of Rare Missense Variants in IFIH1 Are Protected from Psoriasis.
Psoriasis
Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes.
Psoriasis
HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58, and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis.
Psoriasis
IFN-alpha enhances poly-IC responses in human keratinocytes by inducing expression of cytosolic innate RNA receptors: relevance for psoriasis.
Psoriasis
Narrowband ultraviolet B inhibits innate cytosolic double-stranded RNA receptors in psoriatic skin and keratinocytes.
Psoriasis
Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant.
Psoriasis
RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.
Psoriasis
SRSF1 Facilitates Cytosolic DNA-Induced Production of Type I Interferons Recognized by RIG-I.
Pulmonary Disease, Chronic Obstructive
Analysis of protein-protein interaction network in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.
Pulmonary Disease, Chronic Obstructive
Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients.
Pulmonary Disease, Chronic Obstructive
BRIP1 rs10744996C>A variant increases the risk of chronic obstructive pulmonary disease in the Mongolian population of northern China.
Pulmonary Disease, Chronic Obstructive
Deficient pulmonary IFN-? expression in COPD patients.
Pulmonary Disease, Chronic Obstructive
Evaluation of Innate Immune Mediators Related to Respiratory Viruses in the Lung of Stable COPD Patients.
Pulmonary Disease, Chronic Obstructive
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.
Pulmonary Disease, Chronic Obstructive
RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway.
Pulmonary Disease, Chronic Obstructive
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells.
Pulmonary Disease, Chronic Obstructive
Small-Molecule Antagonists of the RIG-I Innate Immune Receptor.
Pulmonary Fibrosis
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Pythiosis
Differential diagnosis for pythiosis using thermophilic helicase DNA amplification and restriction fragment length polymorphism (tHDA-RFLP).
Rabies
Establishment of Myotis myotis cell lines--model for investigation of host-pathogen interaction in a natural host for emerging viruses.
Rabies
Rabies virus nucleoprotein functions to evade activation of the RIG-I-mediated antiviral response.
Rabies
RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Respiratory Distress Syndrome
Identification of DDX58 and CXCL10 as Potential Biomarkers in Acute Respiratory Distress Syndrome.
Respiratory Insufficiency
RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness.
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells.
Respiratory Tract Infections
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.
Retinal Diseases
Generation of two induced pluripotent stem cell lines from a patient with recessive inherited retinal disease caused by compound heterozygous mutations in SNRNP200.
Retinal Diseases
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.
Retinitis
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Retinitis
[Targeted sequencing identifies a hotspot mutation SNRNP200 p.S1087L correlates with novel phenotypes in retinitis pigmentosa].
Retinitis Pigmentosa
A Combined in silico, in vitro and Clinical Approach to Characterize Novel Pathogenic Missense Variants in PRPF31 in Retinitis Pigmentosa.
Retinitis Pigmentosa
A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese family.
Retinitis Pigmentosa
Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs.
Retinitis Pigmentosa
Clinical Characterization of Retinitis Pigmentosa Associated With Variants in SNRNP200.
Retinitis Pigmentosa
Contribution of SNRNP200 sequence variations to retinitis pigmentosa.
Retinitis Pigmentosa
Copy-number variation is an important contributor to the genetic causality of inherited retinal degenerations.
Retinitis Pigmentosa
Genotype-Phenotype Analysis of a Novel Recessive and a Recurrent Dominant SNRNP200 Variant Causing Retinitis Pigmentosa.
Retinitis Pigmentosa
Identification of a PRPF4 loss-of-function variant that abrogates U4/U6.U5 tri-snRNP integration and is associated with retinitis pigmentosa.
Retinitis Pigmentosa
Mutation Analysis of Pre-mRNA Splicing Genes PRPF31, PRPF8, and SNRNP200 in Chinese Families with Autosomal Dominant Retinitis Pigmentosa.
Retinitis Pigmentosa
Next generation sequencing of pooled samples reveals new SNRNP200 mutations associated with retinitis pigmentosa.
Retinitis Pigmentosa
Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity.
Retinitis Pigmentosa
Retinitis pigmentosa mutations of SNRNP200 enhance cryptic splice-site recognition.
Retinitis Pigmentosa
SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa.
Retinitis Pigmentosa
Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.
Retinitis Pigmentosa
Three Gene Targeted Mouse Models of RNA Splicing Factor RP Show Late Onset RPE and Retinal Degeneration.
Retinoblastoma
Amplification of a DEAD box gene (DDX1) with the MYCN gene in neuroblastomas as a result of cosegregation of sequences flanking the MYCN locus.
Retinoblastoma
Differential expression of DNA polymerase alpha in normal and transformed human fibroblasts.
Retinoblastoma
Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines.
Rhabdomyosarcoma, Alveolar
Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.
Rheumatic Diseases
Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Rhinitis, Allergic
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Rhinitis, Allergic
Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice.
Rhinitis, Allergic
Retracted: Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice.
Rift Valley Fever
Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs.
Rift Valley Fever
Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.
Rift Valley Fever
RNA helicase signaling is critical for type I interferon production and protection against Rift Valley fever virus during mucosal challenge.
Rift Valley Fever
Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.
rna helicase deficiency
A complex zinc finger controls the enzymatic activities of nidovirus helicases.
rna helicase deficiency
A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.
rna helicase deficiency
Augmented cell death with Bloom syndrome helicase deficiency.
rna helicase deficiency
Cellular Assays to Study the Functional Importance of Human DNA Repair Helicases.
rna helicase deficiency
DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKK?-IRF3 Interactions and Promoting TBK1 and IKK? Degradation.
rna helicase deficiency
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
rna helicase deficiency
Functional deficit associated with a missense Werner syndrome mutation.
rna helicase deficiency
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
rna helicase deficiency
Induction of tolerogenic dendritic cells by activated TGF-?/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells.
rna helicase deficiency
Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.
rna helicase deficiency
Retinoic acid inducible gene-I slows down cellular senescence through negatively regulating the integrin ?3/p38 MAPK pathway.
rna helicase deficiency
Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.
RNA Virus Infections
Association of rs2111485 and rs1990760 Polymorphisms of Interferon Induced with Helicase C Domain 1 Gene with Hepatitis C Virus Clearance in Chinese Han Population.
RNA Virus Infections
Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs.
RNA Virus Infections
CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.
RNA Virus Infections
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
RNA Virus Infections
Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection.
RNA Virus Infections
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.
RNA Virus Infections
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
RNA Virus Infections
Defective RNA sensing by RIG-I in severe influenza virus infection.
RNA Virus Infections
DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation.
RNA Virus Infections
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.
RNA Virus Infections
Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response.
RNA Virus Infections
FIP200 restricts RNA virus infection by facilitating RIG-I activation.
RNA Virus Infections
Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection.
RNA Virus Infections
Highly pathogenic New World arenavirus infection activates the pattern recognition receptor PKR without attenuating virus replication in human cells.
RNA Virus Infections
Immune signaling by RIG-I-like receptors.
RNA Virus Infections
Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling.
RNA Virus Infections
Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response.
RNA Virus Infections
IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.
RNA Virus Infections
Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway.
RNA Virus Infections
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
RNA Virus Infections
LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation.
RNA Virus Infections
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.
RNA Virus Infections
MAVS self-association mediates antiviral innate immune signaling.
RNA Virus Infections
MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation.
RNA Virus Infections
Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-?B signaling by targeting MAVS complex.
RNA Virus Infections
Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses.
RNA Virus Infections
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
RNA Virus Infections
NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor.
RNA Virus Infections
Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response.
RNA Virus Infections
Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking.
RNA Virus Infections
Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6.
RNA Virus Infections
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
RNA Virus Infections
RIG-I is cleaved during picornavirus infection.
RNA Virus Infections
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
RNA Virus Infections
Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists.
RNA Virus Infections
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity.
RNA Virus Infections
Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.
RNA Virus Infections
The mitochondrial targeting chaperone 14-3-3? regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
RNA Virus Infections
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
RNA Virus Infections
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
RNA Virus Infections
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
RNA Virus Infections
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.
Rotavirus Infections
Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F.
Rotavirus Infections
The Early Interferon Response to Rotavirus Is Regulated by PKR and Depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.
Rothmund-Thomson Syndrome
A patient with Rothmund-Thomson syndrome and all features of RAPADILINO.
Rothmund-Thomson Syndrome
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
Chronic tibial nonunion in a Rothmund-Thomson syndrome patient.
Rothmund-Thomson Syndrome
Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4.
Rothmund-Thomson Syndrome
Disease-causing missense mutations in human DNA helicase disorders.
Rothmund-Thomson Syndrome
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4.
Rothmund-Thomson Syndrome
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
Rothmund-Thomson Syndrome
Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion.
Rothmund-Thomson Syndrome
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
Rothmund-Thomson Syndrome
RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA).
Rothmund-Thomson Syndrome
RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress.
Rothmund-Thomson Syndrome
RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity.
Rothmund-Thomson Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Rothmund-Thomson Syndrome
Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair.
Rothmund-Thomson Syndrome
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress.
Rothmund-Thomson Syndrome
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
Rothmund-Thomson Syndrome
Variable presentation of Rothmund-Thomson syndrome.
Rothmund-Thomson Syndrome
[Rothmund-Thomson syndrome, trisomy 8 mosaicism and RECQ4 gene mutation]
Rubella
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Rubella
Identification of an RNA-stimulated NTPase in the predicted helicase sequence of the Rubella virus nonstructural polyprotein.
Rubella
Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination.
Rubella
Protease and helicase domains are related to the temperature sensitivity of wild-type rubella viruses.
Rubella
Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines.
Salmonella Infections
RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.
Sarcoma
A predictive coarse-grained model for position-specific effects of post-translational modifications.
Sarcoma
RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.
Sarcoma
Werner syndrome gene variants in human sarcomas.
Sarcoma, Ewing
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.
Sarcoma, Ewing
Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9.
Sarcoma, Ewing
RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.
Sarcoma, Kaposi
Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line.
Sarcoma, Kaposi
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Sarcopenia
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Scleroderma, Systemic
Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.
Scleroderma, Systemic
Werner's syndrome: from clinics to genetics.
Scoliosis
CHD7 gene polymorphisms in female patients with idiopathic scoliosis.
Scoliosis
Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis.
Sepsis
Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.
Sertoli Cell-Only Syndrome
Progress in understanding the molecular functions of DDX3Y (DBY) in male germ cell development and maintenance.
Sertoli Cell-Only Syndrome
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.
Severe Acute Respiratory Syndrome
A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA.
Severe Acute Respiratory Syndrome
Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors.
Severe Acute Respiratory Syndrome
Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase.
Severe Acute Respiratory Syndrome
Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents.
Severe Acute Respiratory Syndrome
Correction for Hu et al., "The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination".
Severe Acute Respiratory Syndrome
Differential inhibitory activities and stabilisation of DNA aptamers against the SARS coronavirus helicase.
Severe Acute Respiratory Syndrome
Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Severe Acute Respiratory Syndrome
Identification of a Novel Small Molecule Inhibitor Against SARS Coronavirus Helicase.
Severe Acute Respiratory Syndrome
Mechanism of nucleic acid unwinding by SARS-CoV helicase.
Severe Acute Respiratory Syndrome
Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase.
Severe Acute Respiratory Syndrome
Potential of Flavonoid-Inspired Phytomedicines against COVID-19.
Severe Acute Respiratory Syndrome
Selective Inhibition of Enzymatic Activities of Severe Acute Respiratory Syndrome Coronavirus Helicase with a Thioxopyrimidine Derivative.
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic Acid unwinding of the viral helicase.
Severe Acute Respiratory Syndrome
Structural and biochemical basis for the difference in the helicase activity of two different constructs of SARS-CoV helicase.
Severe Acute Respiratory Syndrome
The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated.
Severe Acute Respiratory Syndrome
The SARS-CoV-2 conserved macrodomain is a highly efficient ADP-ribosylhydrolase enzyme.
Severe Acute Respiratory Syndrome
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.
Severe Acute Respiratory Syndrome
Three dimensional model of severe acute respiratory syndrome coronavirus helicase ATPase catalytic domain and molecular design of severe acute respiratory syndrome coronavirus helicase inhibitors.
Severe Dengue
Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection.
Severe Fever with Thrombocytopenia Syndrome
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Sick Sinus Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Skin Abnormalities
Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse.
Skin Diseases
Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes.
Skin Diseases
IFN-alpha enhances poly-IC responses in human keratinocytes by inducing expression of cytosolic innate RNA receptors: relevance for psoriasis.
Skin Diseases
Microscopic and Molecular Evidence of the First Elasmobranch Adomavirus, the Cause of Skin Disease in a Giant Guitarfish, Rhynchobatus djiddensis.
Skin Diseases
RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.
Skin Neoplasms
Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence.
Small Cell Lung Carcinoma
The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer.
Spastic Paraplegia, Hereditary
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.
Spinocerebellar Ataxias
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Spinocerebellar Ataxias
Identification of Potential Driver Genes Based on Multi-Genomic Data in Cervical Cancer.
Spinocerebellar Ataxias
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Spinocerebellar Ataxias
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Spinocerebellar Ataxias
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Spinocerebellar Ataxias
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Spondylosis
A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women.
Squamous Cell Carcinoma of Head and Neck
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis.
Squamous Cell Carcinoma of Head and Neck
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus-positive oropharyngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma.
Starvation
Differential expression of the murine eukaryotic translation initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon cellular growth status.
Starvation
Essential role for the Legionella pneumophila rep helicase homologue in intracellular infection of mammalian cells.
Starvation
Mitochondrial and nuclear localization of human Pif1 helicase.
Starvation
The initiation factor eIF4A is involved in the response to lithium stress in Saccharomyces cerevisiae.
Stomach Diseases
A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease.
Stomach Diseases
Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression.
Stomach Neoplasms
(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68.
Stomach Neoplasms
An Integrative Approach Identified Genes Associated with Drug Response in Gastric Cancer.
Stomach Neoplasms
DDX21 promotes gastric cancer proliferation by regulating cell cycle.
Stomach Neoplasms
DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.
Stomach Neoplasms
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Stomach Neoplasms
Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer.
Stomach Neoplasms
Downregulation of lncRNA HCP5 has inhibitory effects on gastric cancer cells by regulating DDX21 expression.
Stomach Neoplasms
Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer.
Stomach Neoplasms
Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.
Stomach Neoplasms
lncRNA HOXC-AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/?-catenin signaling.
Stomach Neoplasms
Low expression of RecQ-like helicase 5 is associated with poor prognosis in patients with gastric cancer.
Stomach Neoplasms
Molecular Mechanism of 73HOXC-AS1-Activated Wnt?-Catenin Signaling and eIF4AIII in Promoting Progression of Gastric Cancer.
Stomach Neoplasms
Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells.
Stomach Neoplasms
Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase.
Stroke
Relative Telomere Length and Stroke Risk in a Chinese Han Population.
Stroke
The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke.
Superinfection
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
Telangiectasis
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
Telangiectasis
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Teratoma
Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation.
Testicular Neoplasms
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Testicular Neoplasms
DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.
Testicular Neoplasms
Re: AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Tetralogy of Fallot
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Thrombocytopenia
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Thrombosis
A morphologic study of chronic type B aortic dissections and aneurysms after thoracic endovascular stent grafting.
Thyroid Diseases
Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.
Thyroid Diseases
Genomic Polymorphism in the Interferon-induced Helicase (IFIH1) Gene does not Confer Susceptibility to Autoimmune Thyroid Disease in the Japanese Population.
Thyroid Neoplasms
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
Tongue Neoplasms
Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.
Toxoplasmosis
Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice.
Toxoplasmosis
Sequence variation in the Toxoplasma gondii eIF4A gene among strains from different hosts and geographical locations.
Trauma, Nervous System
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation.
Trichothiodystrophy Syndromes
ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities.
Trichothiodystrophy Syndromes
Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum.
Trichothiodystrophy Syndromes
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
Trichothiodystrophy Syndromes
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.
Trichothiodystrophy Syndromes
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Trichothiodystrophy Syndromes
Werner syndrome: entering the helicase era.
Triple Negative Breast Neoplasms
Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer.
Triple Negative Breast Neoplasms
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness.
Tuberculosis
A novel B cell epitope in cold-shock DEAD-box protein A from Mycobacterium tuberculosis.
Tuberculosis
Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv.
Tuberculosis
Characterization of the helicase activity and substrate specificity of Mycobacterium tuberculosis UvrD.
Tuberculosis
DHX36, BAX, and ARPC1B May Be Critical for the Diagnosis and Treatment of Tuberculosis.
Tuberculosis
Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity.
Tuberculosis
Evidence for the role of Mycobacterium tuberculosis RecG helicase in DNA repair and recombination.
Tuberculosis
Expression, purification and characterization of UvrD2 helicase from Mycobacterium tuberculosis.
Tuberculosis
GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes.
Tuberculosis
Monitoring RNA unwinding by the transcription termination factor Rho from Mycobacterium tuberculosis.
Tuberculosis
Mycobacterium tuberculosis DinG is a structure-specific helicase that unwinds G4 DNA: implications for targeting G4 DNA as a novel therapeutic approach.
Tuberculosis
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions.
Tuberculosis
Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins.
Tuberculosis
Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis.
Tuberculosis
Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis.
Tuberculosis
Structural insights into the interaction of helicase and primase in Mycobacterium tuberculosis.
Tuberculosis
The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains.
Tuberculosis
Thermal lysis and isothermal amplification of Mycobacterium tuberculosis H37Rv in one tube.
Tuberculosis
UvrD2 Is Essential in Mycobacterium tuberculosis, but Its Helicase Activity Is Not Required.
Tuberculosis
Whole exome sequencing of patients who resolved Crohn's disease and complex regional pain syndrome following treatment for paratuberculosis.
Ureteral Obstruction
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Urinary Bladder Neoplasms
Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.
Urinary Bladder Neoplasms
ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer.
Urinary Bladder Neoplasms
Genomic Profiling Identified ERCC2 E606Q Mutation in Helicase Domain Respond to Platinum-Based Neoadjuvant Therapy in Urothelial Bladder Cancer.
Urinary Bladder Neoplasms
Novel blood biomarkers of human urinary bladder cancer.
Urinary Bladder Neoplasms
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Urinary Bladder Neoplasms
Viral Targeting of Non-Muscle-Invasive Bladder Cancer and Priming of Antitumor Immunity Following Intravesical Coxsackievirus A21.
Urinary Tract Infections
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma.
Urogenital Abnormalities
Mutations in PHD-like domain of the ATRX gene correlate with severe psychomotor impairment and severe urogenital abnormalities in patients with ATRX syndrome.
Uterine Cervical Neoplasms
Interactome analysis of gene expression profiles of cervical cancer reveals dysregulated mitotic gene clusters.
Uterine Cervical Neoplasms
MicroRNA-34a-Upregulated Retinoic Acid-Inducible Gene-I Promotes Apoptosis and Delays Cell Cycle Transition in Cervical Cancer Cells.
Vaccinia
A carboxy terminal domain of the L protein of rinderpest virus possesses RNA triphosphatase activity - The first enzyme in the viral mRNA capping pathway.
Vaccinia
Active disruption of an RNA-protein interaction by a DExH/D RNA helicase.
Vaccinia
Are DEAD-box proteins becoming respectable helicases?
Vaccinia
Domain organization of vaccinia virus helicase-primase D5.
Vaccinia
Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase.
Vaccinia
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Vaccinia
Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline.
Vaccinia
Preformed hexamers of SV40 T antigen are active in RNA and origin-DNA unwinding.
Vaccinia
RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication.
Vaccinia
RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis.
Vaccinia
Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track.
Vaccinia
The NPH-II helicase displays efficient DNA x RNA helicase activity and a pronounced purine sequence bias.
Vaccinia
The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication.
Vaccinia
The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding.
Vaccinia
The vaccinia virus A18R gene product is a DNA-dependent ATPase.
Vaccinia
Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes.
Vaccinia
Three African swine fever virus genes encoding proteins with homology to putative helicases of vaccinia virus.
Vaccinia
Unwinding by Local Strand Separation Is Critical for the Function of DEAD-Box Proteins as RNA Chaperones.
Vaccinia
Unwinding initiation by the viral RNA helicase NPH-II.
Vaccinia
Vaccinia virion protein I8R has both DNA and RNA helicase activities: implications for vaccinia virus transcription.
Vaccinia
Vaccinia virions lacking the RNA helicase nucleoside triphosphate phosphohydrolase II are defective in early transcription.
Vaccinia
Vaccinia virus encodes four putative DNA and/or RNA helicases distantly related to each other.
Vaccinia
Vaccinia virus RNA helicase. Directionality and substrate specificity.
Vaccinia
Vaccinia virus RNA helicase: an essential enzyme related to the DE-H family of RNA-dependent NTPases.
Vaccinia
Vaccinia virus RNA helicase: nucleic acid specificity in duplex unwinding.
Vascular Diseases
Protective Role of RNA Helicase DEAD-Box Protein 5 in Smooth Muscle Cell Proliferation and Vascular Remodeling.
Vector Borne Diseases
Development of a U-bent plastic optical fiber biosensor with plasmonic labels for the detection of chikungunya non-structural protein 3.
Vesicular Stomatitis
Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection.
Vesicular Stomatitis
Conventional protein kinase C-? (PKC-?) and PKC-? negatively regulate RIG-I antiviral signal transduction.
Vesicular Stomatitis
Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.
Vesicular Stomatitis
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
Vesicular Stomatitis
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Vesicular Stomatitis
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Vesicular Stomatitis
Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.
Vesicular Stomatitis
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
Vesicular Stomatitis
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.
Vesicular Stomatitis
N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Vesicular Stomatitis
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.
Vesicular Stomatitis
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.
Vesicular Stomatitis
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
Vesicular Stomatitis
RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes.
Vesicular Stomatitis
The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus.
Vesicular Stomatitis
The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance IFN-? response.
Vesicular Stomatitis
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
Vesicular Stomatitis
USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I.
Vesicular Stomatitis
ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
Viremia
A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3.
Viremia
Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response.
Viremia
Genetic immunization and comprehensive screening approaches in HLA-A2 transgenic mice lead to the identification of three novel epitopes in hepatitis C virus NS3 antigen.
Viremia
Hepatic rupture hemorrhage syndrome in chickens caused by a novel genotype avian hepatitis E virus.
Viremia
Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.
Viremia
Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp.
Virus Diseases
5'-Triphosphate RNA is the ligand for RIG-I.
Virus Diseases
5'-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity.
Virus Diseases
5'-Triphosphate-Short Interfering RNA: Potent Inhibition of Influenza A Virus Infection by Gene Silencing and RIG-I Activation.
Virus Diseases
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
Virus Diseases
A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses.
Virus Diseases
A Hierarchical Mechanism of RIG-I Ubiquitination Provides Sensitivity, Robustness and Synergy in Antiviral Immune Responses.
Virus Diseases
A non-canonical role of the p97 complex in RIG-I antiviral signaling.
Virus Diseases
A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand.
Virus Diseases
A tobacco CBL-interacting protein kinase homolog is involved in phosphorylation of the N-terminal domain of the cucumber mosaic virus polymerase 2a protein.
Virus Diseases
Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response.
Virus Diseases
Activation of IFN-β expression by a viral mRNA through RNase L and MDA5.
Virus Diseases
Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis.
Virus Diseases
Activation of the Beta Interferon Promoter by Unnatural Sendai Virus Infection Requires RIG-I and Is Inhibited by Viral C Proteins.
Virus Diseases
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
Virus Diseases
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response.
Virus Diseases
An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation.
Virus Diseases
Analysis of the helicase gene of Korean swine hepatitis E virus isolates and trends in viral infection.
Virus Diseases
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
Virus Diseases
Antiviral RNA recognition and assembly by RLR family innate immune sensors.
Virus Diseases
Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production.
Virus Diseases
ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner.
Virus Diseases
Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Virus Diseases
Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5.
Virus Diseases
ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon.
Virus Diseases
Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I.
Virus Diseases
Brome mosaic virus capsid protein regulates accumulation of viral replication proteins by binding to the replicase assembly RNA element.
Virus Diseases
c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3.
Virus Diseases
Caprine MAVS Is a RIG-I Interacting Type I Interferon Inducer Downregulated by Peste des Petits Ruminants Virus Infection.
Virus Diseases
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Virus Diseases
Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity.
Virus Diseases
Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA.
Virus Diseases
Cellular RNA Helicase DHX9 Interacts with the Essential Epstein-Barr Virus (EBV) Protein SM and Restricts EBV Lytic Replication.
Virus Diseases
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
Virus Diseases
Chicken MDA5 Senses Short Double-Stranded RNA with Implications for Antiviral Response against Avian Influenza Viruses in Chicken.
Virus Diseases
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.
Virus Diseases
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5.
Virus Diseases
Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity.
Virus Diseases
Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection.
Virus Diseases
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.
Virus Diseases
Cytokine-independent upregulation of MDA5 in viral infection.
Virus Diseases
Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response.
Virus Diseases
DDX1 from Cherry valley duck mediates signaling pathways and anti-NDRV activity.
Virus Diseases
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Virus Diseases
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Virus Diseases
DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins.
Virus Diseases
DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation.
Virus Diseases
DDX3X: structure, physiologic functions and cancer.
Virus Diseases
DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling.
Virus Diseases
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
Virus Diseases
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense.
Virus Diseases
DEAD-box RNA helicases: The driving forces behind RNA metabolism at the crossroad of viral replication and antiviral innate immunity.
Virus Diseases
Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response.
Virus Diseases
Defective RNA sensing by RIG-I in severe influenza virus infection.
Virus Diseases
DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection.
Virus Diseases
DHX15 senses double-stranded RNA in myeloid dendritic cells.
Virus Diseases
Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
Virus Diseases
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Virus Diseases
Drosophila DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway.
Virus Diseases
Duck RIG-I restricts duck enteritis virus infection.
Virus Diseases
Duck Tembusu Virus Infection Promotes the Expression of Duck Interferon-Induced Protein 35 to Counteract RIG-I Antiviral Signaling in Duck Embryo Fibroblasts.
Virus Diseases
DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I sensitivity.
Virus Diseases
Dynamic Changes in Host Gene Expression following
Virus Diseases
Dynamic Interaction of Stress Granule, DDX3X and IKK-? Mediates Multiple Functions in Hepatitis C Virus Infection.
Virus Diseases
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Virus Diseases
Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle.
Virus Diseases
Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity.
Virus Diseases
Establishment of Myotis myotis cell lines--model for investigation of host-pathogen interaction in a natural host for emerging viruses.
Virus Diseases
Evolution of MDA-5/RIG-I-dependent innate immunity: independent evolution by domain grafting.
Virus Diseases
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Virus Diseases
Expression and function of RIG-I in oral keratinocytes and fibroblasts.
Virus Diseases
Fascin1 Suppresses RIG-I-like Receptor Signaling and Interferon-? Production by Associating with I?B Kinase ? (IKK ?) in Colon Cancer.
Virus Diseases
Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection.
Virus Diseases
Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7.
Virus Diseases
Flaviviral helicase: insights into the mechanism of action of a motor protein.
Virus Diseases
Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.
Virus Diseases
From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis.
Virus Diseases
Functional characterization of porcine LSm14A in IFN-? induction.
Virus Diseases
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.
Virus Diseases
Genomic analysis and functional characterization of immune genes from the RIG-I- and MAVS-mediated antiviral signaling pathway in lamprey.
Virus Diseases
Goose RIG-I functions in innate immunity against Newcastle disease virus infections.
Virus Diseases
Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity.
Virus Diseases
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Virus Diseases
High-throughput virtual screening lead to discovery of non-peptidic inhibitors of West Nile virus NS3 protease.
Virus Diseases
Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses.
Virus Diseases
HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.
Virus Diseases
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Virus Diseases
Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.
Virus Diseases
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
Virus Diseases
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.
Virus Diseases
Immune response to cytosolic DNA via intercellular receptor modulation in oral keratinocytes and fibroblasts.
Virus Diseases
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.
Virus Diseases
Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.
Virus Diseases
Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling.
Virus Diseases
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I.
Virus Diseases
Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting.
Virus Diseases
Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
Virus Diseases
Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families.
Virus Diseases
Inhibition of Viral Pathogenesis and Promotion of the Septic Shock Response to Bacterial Infection by IRF-3 Are Regulated by the Acetylation and Phosphorylation of Its Coactivators.
Virus Diseases
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Virus Diseases
Interferon-? Stimulation Elicited by the Influenza Virus Is Regulated by the Histone Methylase Dot1L through the RIG-I-TRIM25 Signaling Axis.
Virus Diseases
Intracellular pathogen detection by RIG-I-like receptors.
Virus Diseases
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Virus Diseases
IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia.
Virus Diseases
iTRAQ-based quantitative subcellular proteomic analysis of Avibirnavirus-infected cells.
Virus Diseases
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Virus Diseases
Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.
Virus Diseases
LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs.
Virus Diseases
Limited suppression of the interferon-beta production by hepatitis C virus serine protease in cultured human hepatocytes.
Virus Diseases
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
Virus Diseases
Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer.
Virus Diseases
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.
Virus Diseases
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
Virus Diseases
MasterCARD: a priceless link to innate immunity.
Virus Diseases
MDA5 localizes to stress granules but this localization is not required for the induction of type I interferon.
Virus Diseases
Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors.
Virus Diseases
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Virus Diseases
Mini viral RNAs act as innate immune agonists during influenza virus infection.
Virus Diseases
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Virus Diseases
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules.
Virus Diseases
Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alecto.
Virus Diseases
Molecular characterization, expression patterns, and subcellular localization of RIG-I in the Jinding Duck (Anas platyrhynchos domesticus).
Virus Diseases
Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I).
Virus Diseases
Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.
Virus Diseases
Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused gene (TFG) protein.
Virus Diseases
Negative regulation of the antiviral response by grouper LGP2 against fish viruses.
Virus Diseases
Negative role of RIG-I serine 8 phosphorylation in the regulation of IFN-{beta} production.
Virus Diseases
Nicotiana benthamiana plants transformed with the plum pox virus helicase gene are resistant to virus infection.
Virus Diseases
NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.
Virus Diseases
NLRX1 is a regulator of mitochondrial antiviral immunity.
Virus Diseases
Nonstructural NS1 proteins of several mosquito-borne Flavivirus do not inhibit TLR3 signaling.
Virus Diseases
Novel Insights into the Biochemical Mechanism of CK1? and its Functional Interplay with DDX3X.
Virus Diseases
Novel role of toll-like receptor 3, RIG-I and MDA5 in poly (I:C) RNA-induced mesothelial inflammation.
Virus Diseases
Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection.
Virus Diseases
Opposing forces fight over the same ground to regulate interferon signaling.
Virus Diseases
PAMPer and tRIGer: ligand-induced activation of RIG-I.
Virus Diseases
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
Virus Diseases
Pattern Recognition Receptor MDA5 Modulates CD8+ T Cell-Dependent Clearance of West Nile Virus from the Central Nervous System.
Virus Diseases
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Virus Diseases
Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1.
Virus Diseases
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Virus Diseases
Phosphorylation-mediated negative regulation of RIG-I antiviral activity.
Virus Diseases
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.
Virus Diseases
Poly I:C-induced tumor cell apoptosis mediated by pattern-recognition receptors.
Virus Diseases
Porcine RIG-I and MDA5 Signaling CARD Domains Exert Similar Antiviral Function Against Different Viruses.
Virus Diseases
Positive regulatory role of c-Src-mediated TRIM25 tyrosine phosphorylation on RIG-I ubiquitination and RIG-I-mediated antiviral signaling pathway.
Virus Diseases
Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection.
Virus Diseases
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.
Virus Diseases
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing.
Virus Diseases
Pregnancy and Interferon Tau Regulate DDX58 and PLSCR1 in the Ovine Uterus During the Peri-Implantation Period.
Virus Diseases
Protein interactome of the deamidase phosphoribosylformylglycinamidine synthetase (PFAS) by LC-MS/MS.
Virus Diseases
Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking.
Virus Diseases
Rabies virus nucleoprotein functions to evade activation of the RIG-I-mediated antiviral response.
Virus Diseases
RACK1 attenuates RLR antiviral signaling by targeting VISA-TRAF complexes.
Virus Diseases
Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus.
Virus Diseases
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Virus Diseases
Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: Role of Jumonji C-domain containing protein 6 in RHA demethylation.
Virus Diseases
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Virus Diseases
Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection.
Virus Diseases
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
Virus Diseases
Regulation of interferon production by RIG-I and LGP2: a lesson in self-control.
Virus Diseases
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
Virus Diseases
Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design.
Virus Diseases
Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells.
Virus Diseases
Retinoic acid inducible gene-I slows down cellular senescence through negatively regulating the integrin ?3/p38 MAPK pathway.
Virus Diseases
Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA.
Virus Diseases
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity.
Virus Diseases
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
Virus Diseases
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Virus Diseases
RIG-I enhanced interferon independent apoptosis upon Junin virus infection.
Virus Diseases
RIG-I is cleaved during picornavirus infection.
Virus Diseases
RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity.
Virus Diseases
RIG-I mediates innate immune response in mouse neurons following Japanese encephalitis virus infection.
Virus Diseases
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.
Virus Diseases
RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein.
Virus Diseases
RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Virus Diseases
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
Virus Diseases
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
Virus Diseases
RIG-I-like receptors: sensing and responding to RNA virus infection.
Virus Diseases
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
Virus Diseases
RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.
Virus Diseases
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
Virus Diseases
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Virus Diseases
RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling.
Virus Diseases
RNase L and the NLRP3-inflammasome: An old merchant in a new trade.
Virus Diseases
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Virus Diseases
Role of viral receptors TLR3, RIG-I and MDA5 in mesothelial tissue-type plasminogen activator and plasminogen activator inhibitor-1 synthesis.
Virus Diseases
Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.
Virus Diseases
Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection.
Virus Diseases
Sensing and control of Bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases.
Virus Diseases
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.
Virus Diseases
Spatiotemporal dynamics of innate immune signaling via RIG-I-like receptors.
Virus Diseases
Stimulation of the Internal Ribosome Entry Site (IRES)-Dependent Translation of Enterovirus 71 by DDX3X RNA Helicase and Viral 2A and 3C Proteases.
Virus Diseases
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
Virus Diseases
Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Virus Diseases
Structural insights into RNA recognition and activation of RIG-I-like receptors.
Virus Diseases
Structural, biophysical and biochemical elucidation of the SARS-CoV-2 nonstructural protein 3 macro domain.
Virus Diseases
Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response.
Virus Diseases
Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection.
Virus Diseases
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD.
Virus Diseases
Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity.
Virus Diseases
Synthetic double-stranded RNA induces retinoic acid-inducible gene-I in mouse osteoblastic cells.
Virus Diseases
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Virus Diseases
Targeting Casein kinase 2 with quercetin or enzymatically modified isoquercitrin as a strategy for boosting the type 1 interferon response to viruses and promoting cardiovascular health.
Virus Diseases
Targeting host DEAD-box RNA helicase DDX3X for treating viral infections.
Virus Diseases
The Association of OASL and Type I Interferons in the Pathogenesis and Survival of Intracellular Replicating Bacterial Species.
Virus Diseases
The Caenorhabditis elegans RIG-I Homolog DRH-1 Mediates the Intracellular Pathogen Response upon Viral Infection.
Virus Diseases
The Cellular RNA Helicase UAP56 Is Required for Prevention of Double-Stranded RNA Formation during Influenza A Virus Infection.
Virus Diseases
The chase for the RIG-I ligand--recent advances.
Virus Diseases
The dark side of RNA:DNA hybrids.
Virus Diseases
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
Virus Diseases
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.
Virus Diseases
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.
Virus Diseases
The effects of H3N2 swine influenza virus infection on TLRs and RLRs signaling pathways in porcine alveolar macrophages.
Virus Diseases
The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells.
Virus Diseases
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
Virus Diseases
The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors.
Virus Diseases
The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities.
Virus Diseases
The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response.
Virus Diseases
The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication.
Virus Diseases
The negative regulation of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) signaling pathway in fish.
Virus Diseases
The nucleolar protein GLTSCR2 is required for efficient viral replication.
Virus Diseases
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
Virus Diseases
The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers.
Virus Diseases
The RNA helicase DDX46 inhibits innate immunity by entrapping m(6)A-demethylated antiviral transcripts in the nucleus.
Virus Diseases
The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NF?B transcripts to dampen antiviral innate immunity.
Virus Diseases
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Virus Diseases
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
Virus Diseases
The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling.
Virus Diseases
Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells.
Virus Diseases
TLR3/TRIF signalling pathway regulates IL-32 and IFN-? secretion through activation of RIP-1 and TRAF in the human cornea.
Virus Diseases
Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells.
Virus Diseases
TRIM proteins: another class of viral victims.
Virus Diseases
Tumor suppressor activity of RIG-I.
Virus Diseases
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.
Virus Diseases
Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network analysis.
Virus Diseases
Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.
Virus Diseases
Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight.
Virus Diseases
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression.
Virus Diseases
Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.
Virus Diseases
Visualizing the determinants of viral RNA recognition by innate immune sensor RIG-I.
Virus Diseases
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.
Vitiligo
The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition
Werner Syndrome
A novel splice-site mutation of WRN (c.IVS28+2T>C) identified in a consanguineous family with Werner Syndrome.
Werner Syndrome
A role for WRN in telomere-based DNA damage responses.
Werner Syndrome
Analysis of helicase gene mutations in Japanese Werner's syndrome patients.
Werner Syndrome
Are There Different Kinds of Aging?
Werner Syndrome
C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity.
Werner Syndrome
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Werner Syndrome
Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.
Werner Syndrome
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Werner Syndrome
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Werner Syndrome
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
Werner Syndrome
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
Werner Syndrome
Disease-causing missense mutations in human DNA helicase disorders.
Werner Syndrome
Diverse dealings of the Werner helicase/nuclease.
Werner Syndrome
DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
Werner Syndrome
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease.
Werner Syndrome
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.
Werner Syndrome
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Werner Syndrome
DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA.
Werner Syndrome
Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.
Werner Syndrome
Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model.
Werner Syndrome
Elevation of soluble Fas (APO-1, CD95) ligand in natural aging and Werner syndrome.
Werner Syndrome
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Werner Syndrome
Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide.
Werner Syndrome
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.
Werner Syndrome
Functional deficit associated with a missense Werner syndrome mutation.
Werner Syndrome
Genetic instability syndromes with progeroid features.
Werner Syndrome
Homozygous and compound heterozygous mutations at the Werner syndrome locus.
Werner Syndrome
Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.
Werner Syndrome
Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Werner Syndrome
Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue.
Werner Syndrome
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Werner Syndrome
Inhibition of Werner Syndrome Helicase Activity by Benzo[a]pyrene Diol Epoxide Adducts Can Be Overcome by Replication Protein A.
Werner Syndrome
Instability of the fragile X syndrome repeat in mice: the effect of age, diet and mutations in genes that affect DNA replication, recombination and repair proficiency.
Werner Syndrome
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Werner Syndrome
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains.
Werner Syndrome
Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase.
Werner Syndrome
Loss of Werner syndrome protein function promotes aberrant mitotic recombination.
Werner Syndrome
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Werner Syndrome
Multiple RPAs make WRN syndrome protein a superhelicase.
Werner Syndrome
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.
Werner Syndrome
Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells.
Werner Syndrome
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
Werner Syndrome
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
Werner Syndrome
POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome.
Werner Syndrome
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Werner Syndrome
Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.
Werner Syndrome
Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.
Werner Syndrome
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Werner Syndrome
Recombinational DNA repair and human disease.
Werner Syndrome
Regulation of WRN helicase activity in human base excision repair.
Werner Syndrome
Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA.
Werner Syndrome
Resveratrol Improves Insulin Resistance Hyperglycemia and Hepatosteatosis But Not Hypertriglyceridemia, Inflammation, and Life Span in a Mouse Model for Werner Syndrome.
Werner Syndrome
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Werner Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Werner Syndrome
Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging.
Werner Syndrome
Syndrome-causing mutations in Werner syndrome.
Werner Syndrome
The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer. Mutations in brief no. 136. Online.
Werner Syndrome
The effect of 2-deoxy-D-glucose on Werner syndrome RecQ helicase gene.
Werner Syndrome
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity.
Werner Syndrome
The Werner syndrome protein at the crossroads of DNA repair and apoptosis.
Werner Syndrome
The Werner syndrome protein has separable recombination and survival functions.
Werner Syndrome
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
Werner Syndrome
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity.
Werner Syndrome
Understanding Vascular Diseases: Lessons From Premature Aging Syndromes.
Werner Syndrome
Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks.
Werner Syndrome
Werner helicase expression in human fetal and adult aortas.
Werner Syndrome
Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Werner Syndrome
Werner helicase is localized to transcriptionally active nucleoli of cycling cells.
Werner Syndrome
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
Werner Syndrome
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
Werner Syndrome
Werner syndrome: entering the helicase era.
Werner Syndrome
Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver.
Werner Syndrome
Werner's syndrome: from clinics to genetics.
Werner Syndrome
WRN mutations in Werner syndrome.
Werner Syndrome
[Atypical Werner syndrome: Atypical progeroid syndrome: A case report]
West Nile Fever
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
West Nile Fever
Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.
West Nile Fever
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
West Nile Fever
Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1.
West Nile Fever
Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection.
West Nile Fever
MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis.
West Nile Fever
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.
West Nile Fever
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
West Nile Fever
West Nile Virus Infection Blocks Inflammatory Response and T Cell Costimulatory Capacity of Human Monocyte-Derived Dendritic Cells.
Whooping Cough
Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics.
Xeroderma Pigmentosum
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
Xeroderma Pigmentosum
A temperature-sensitive disorder in basal transcription and DNA repair in humans.
Xeroderma Pigmentosum
A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.
Xeroderma Pigmentosum
Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
Xeroderma Pigmentosum
ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities.
Xeroderma Pigmentosum
Characterization of putative proteins encoded by variable ORFs in white spot syndrome virus genome.
Xeroderma Pigmentosum
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Xeroderma Pigmentosum
Characterization of the properties of a human homologue of Escherichia coli RecQ from xeroderma pigmentosum group C and from HeLa cells.
Xeroderma Pigmentosum
Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair.
Xeroderma Pigmentosum
Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotypes to Colorectal Cancer Risk in Taiwan.
Xeroderma Pigmentosum
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.
Xeroderma Pigmentosum
DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH.
Xeroderma Pigmentosum
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor.
Xeroderma Pigmentosum
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.
Xeroderma Pigmentosum
Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients.
Xeroderma Pigmentosum
KERA: analysis tool for multi-process, multi-state single-molecule data.
Xeroderma Pigmentosum
Mechanism of DNA loading by the DNA repair helicase XPD.
Xeroderma Pigmentosum
Mechanism of promoter melting by the xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking.
Xeroderma Pigmentosum
Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.
Xeroderma Pigmentosum
Restoration of nucleotide excision repair in a helicase-deficient XPD mutant from intragenic suppression by a trichothiodystrophy mutation.
Xeroderma Pigmentosum
Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase.
Xeroderma Pigmentosum
Switch-like control of helicase processivity by single-stranded DNA binding protein.
Xeroderma Pigmentosum
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
Xeroderma Pigmentosum
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Xeroderma Pigmentosum
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
Xeroderma Pigmentosum
The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway.
Xeroderma Pigmentosum
The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair.
Xeroderma Pigmentosum
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Xeroderma Pigmentosum
Ultraviolet-induced DNA damage stimulates topoisomerase I-DNA complex formation in vivo: possible relationship with DNA repair.
Xeroderma Pigmentosum
Werner syndrome: entering the helicase era.
Xeroderma Pigmentosum
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
Xeroderma Pigmentosum
XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage.
Yellow Fever
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Yellow Fever
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Yellow Fever
Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex.
Yellow Fever
RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus.
Yellow Fever
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
Yellow Fever
Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.
Yellow Fever
Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons.
Zika Virus Infection
Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses.
Zika Virus Infection
Comparative Analysis of African and Asian Lineage-Derived Zika Virus Strains Reveals Differences in Activation of and Sensitivity to Antiviral Innate Immunity.
Zika Virus Infection
Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes.
Zika Virus Infection
Molecular mechanism of ATP and RNA binding to Zika virus NS3 helicase and identification of repurposed drugs using molecular dynamics simulations.
Zika Virus Infection
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.
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3.6.4.13 RNA helicase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
