Cloned (Comment) | Organism |
---|---|
recombinantly expressed as a His-tagged fusion protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | DDX3 and DDX5 both co-localize in the cytoplasm | Homo sapiens | 5737 | - |
nucleus | DDX5 is shutteld into the nucleus by DDX3 | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | DEAD-Box RNA Helicase DDX3 interacts with DDX5. The protein-protein interaction is increased in the G2/M phase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P17844 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at serine/threonine residues of both DDX3 and DDX5 affect the protein-protein interaction. During the G2/M phase, phosphorylation of DDX3 is decreased, whereas, the phosphorylation of DDX5 is, compared with the G1/S phase | Homo sapiens |
Purification (Comment) | Organism |
---|---|
using Ni-NTA chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | DEAD-Box RNA Helicase DDX3 interacts with DDX5. The protein-protein interaction is increased in the G2/M phase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDX3 | - |
Homo sapiens |
DDX5 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | DDX3 knockdown blocks the shuttling of DDX5 to the nucleus | Homo sapiens |
metabolism | UV cross-linking experiments show that both RNA helicase proteins are involved in mRNP metabolism and that DDX3 affects the shuttling of DDX5 to the nucleus | Homo sapiens |