Any feedback?
Literature summary for 3.6.4.13 extracted from
- RNA helicases: regulators of differentiation (2005), Clin. Biochem., 38, 499-503.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | DDX4 can serve as a useful and highly specific biomarker for the diagnosis of germ cell tumors | Rattus norvegicus |
| medicine | DDX4 can serve as a useful and highly specific biomarker for the diagnosis of germ cell tumors | Homo sapiens |
| medicine | DDX4 can serve as a useful and highly specific biomarker for the diagnosis of germ cell tumors | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Homo sapiens | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation | ADP + phosphate | - |
? |  |
| ATP + H2O | Mus musculus | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation | ADP + phosphate | - |
? | |
| ATP + H2O | Rattus norvegicus | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation. DDX17 is involved in mRNA splicing | ADP + phosphate | - |
? | |
| ATP + H2O | Mus musculus | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation. DDX17 is involved in mRNA splicing | ADP + phosphate | - |
? | |
| ATP + H2O | Homo sapiens | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation. DDX17 is involved in mRNA splicing | ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00571 | - |
- |
| Homo sapiens | O15523 | - |
- |
| Homo sapiens | Q9NQI0 | - |
- |
| Homo sapiens | Q9UHL0 | - |
- |
| Mus musculus | Q501J6 | - |
- |
| Mus musculus | Q61656 | - |
- |
| Mus musculus | Q9QY15 | - |
- |
| Rattus norvegicus | Q9QY16 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | helicase activity of DDX5 is regulated by phosphorylation and calmodulin binding | Rattus norvegicus |
| phosphoprotein | helicase activity of DDX5 is regulated by phosphorylation and calmodulin binding | Mus musculus |
| phosphoprotein | helicase activity of DDX5 is regulated by phosphorylation and calmodulin binding | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | DDX17 transcripts are abundant in rat brains in early embryonic stages and becomes downregulated in late post-natal and adults, suggesting involvement during neuronal differentiation during development of the central nervous system | Mus musculus | - |
| germ cell | high level of expression in male germ cells | Mus musculus | - |
| Leydig cell | - |
Rattus norvegicus | - |
| Leydig cell | - |
Mus musculus | - |
| Leydig cell | - |
Homo sapiens | - |
| additional information | the protein is expressed in all tissues | Homo sapiens | - |
| additional information | vasa (DDX4) mRNA and protein are abundantly and specifically expressed in germ cells in both sexes throughout development | Homo sapiens | - |
| spermatid | - |
Rattus norvegicus | - |
| spermatid | - |
Mus musculus | - |
| spermatid | - |
Homo sapiens | - |
| spermatocyte | - |
Rattus norvegicus | - |
| spermatocyte | - |
Mus musculus | - |
| spermatocyte | - |
Homo sapiens | - |
| testis | highly expressed in | Rattus norvegicus | - |
| testis | highly expressed in | Mus musculus | - |
| testis | highly expressed in | Homo sapiens | - |
| testis | expression is restricted to the male germ cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Rattus norvegicus | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Mus musculus | ADP + phosphate | - |
? | |
| ATP + H2O | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation | Homo sapiens | ADP + phosphate | - |
? | |
| ATP + H2O | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation | Mus musculus | ADP + phosphate | - |
? | |
| ATP + H2O | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation. DDX17 is involved in mRNA splicing | Rattus norvegicus | ADP + phosphate | - |
? | |
| ATP + H2O | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation. DDX17 is involved in mRNA splicing | Mus musculus | ADP + phosphate | - |
? | |
| ATP + H2O | the ability of RNA helicases to modulate the structure and thus availability of critical RNA molecules for processing leading to protein expression is the likely mechanism by which RNA helicases contribute to differentiation. DDX17 is involved in mRNA splicing | Homo sapiens | ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDX17 | - |
Mus musculus |
| DDX25 | - |
Rattus norvegicus |
| DDX25 | - |
Mus musculus |
| DDX25 | - |
Homo sapiens |
| DDX3X | - |
Homo sapiens |
| DDX3X | the gene is localized to the X chromosome | Homo sapiens |
| DDX3Y | - |
Homo sapiens |
| DDX3Y | the gene is localized to the Y chromosome | Homo sapiens |
| DDX4 | - |
Homo sapiens |
| DDX5 | - |
Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
