Reference on EC 3.1.21.2 - deoxyribonuclease IV
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Aparicio, J.F.; Freije, J.M.P.; Lopez-Otin, C.; Cal, S.; Sanchez, J.
A Streptomyces glaucens endodeoxyribonuclease which shows a strong preference for CC dinucleotide
Eur. J. Biochem.
205
695-699
1992
Streptomyces glaucescens
Demple, B.; Johnson, A.; Fung, D.
Exonuclease III and endonuclease IV remove 3'-blocks from DNA synthesis primers in H2O2-damaged Escherichia coli
Proc. Natl. Acad. Sci. USA
83
7731-7735
1986
Bacteria, Escherichia coli
Nagae, S.; Nakayama, J.; Nakano, I.; Anai, M.
Purification and properties of a neutral endodeoxyribonuclease from rat small intestinal mucosa
Biochemistry
21
1339-1344
1982
Rattus
Anai, M.; Sasaki, M.; Muta, A.; Miyagawa, T.
Purification and properties of a neutral endodeoxyribonuclease from guinea pig epidermis
Biochim. Biophys. Acta
656
183-188
1981
Cavia porcellus
Sadowski, P.D.; Hurwitz, J.
Enzymatic breakage of deoxyribonucleic acid. II. Purification and properties of endonuclease IV from T4 phage-infected Escherichia coli
J. Biol. Chem.
244
6192-6198
1969
BRENDA: Escherichia coli, Escherichia coli B / ATCC 11303
Textmining: Escherichia
McMillan, S.; Edenberg, H.J.; Radany, E.H.; Friedberg, R.C.; Friedberg, E.C.
denV gene of bacteriophage T4 codes for both pyrimidine dimer-DNA glycosylase and apyrimidinic endonuclease activities
J. Virol.
40
211-223
1981
Escherichia virus T4, Escherichia coli, Macaca mulatta polyomavirus 1
Sibghat-Ullah; Sancar, A.
In vitro characterization of repair synthesis initiated by T4 endonuclease V on a synthetic DNA substrate
Indian J. Biochem. Biophys.
29
227-230
1992
Escherichia coli
Bjelland, S.; Seeberg, E.
Purification and characterization of 3-methyladenine DNA glycosylase I from Escherichia coli
Nucleic Acids Res.
15
2787-2801
1987
Escherichia virus T4
Thibodeau, L.; Bricteux, S.; Verly, W.G.
Purification and properties of the major apurinic/apyrimidinic endodeoxyribonuclease of rat-liver chromatin
Eur. J. Biochem.
110
379-385
1980
Rattus
Thibodeau, L.; Verly, W.G.
Cellular localization of the apurinic/apyrimidinic endodeoxyribonucleases in rat liver
Eur. J. Biochem.
107
555-563
1980
Rattus
Ivanov, V.A.; Tretyak, T.M.; Afonin, Y.N.
Excision of apurinic and/or apyrimidinic sites from DNA by nucleolytical enzymes from rat brain
Eur. J. Biochem.
172
155-159
1988
Rattus
Verly, W.G.; Colson, P.; Zocchi, G.; Goffin, C.; Liuzzi, M.; Buchsenschmidt, G.; Muller, M.
Localization of the phosphoester bond hydrolyzed by the major apurinic/apyrmidinic endodeoxyribonuclease from rat-liver chromatin
Eur. J. Biochem.
118
195-201
1981
Escherichia coli, Rattus
Brictreux-Gregoire, S.; Habraken, Y.; Verly, W.G.
The apurinic/apyrimidinic endodeoxyribonuclease of rat-liver chromatin
Eur. J. Biochem.
129
509-517
1983
Rattus, DNA molecule
Talpaert-Borle, M.; Liuzzi, M.
Base-excision repair in carrot cells. Partial purification and characterization of uracil-DNA glycosylase and apurinic/apyrimidinic endodeoxyribonuclease
Eur. J. Biochem.
124
435-440
1982
Daucus carota
Takeshita, M.; Chang, C.N.; Johnson, F.; Will, S.; Grollman, A.P.
Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases
J. Biol. Chem.
262
10171-10179
1982
Escherichia coli, Avian myeloblastosis virus
Bibor, V.; Verly, W.G.
Purification and properties of endonuclease specific for apurinic sites of Bacillus stearothermophilus
J. Biol. Chem.
253
850-855
1978
Escherichia coli, bacterium
Inoue, T.; Kada, T.
Purification and properties of a Bacillus subtilis endonuclease specific for apurinic sites in DNA
J. Biol. Chem.
253
8559-8563
1978
Escherichia coli, bacterium
Shaper, N.L.; Grafstrom, R.H.; Grossman, L.
Human placental apurinic/apyrimidinic endonuclease. Its isolation and characterization
J. Biol. Chem.
257
13455-13458
1982
Homo sapiens
Spiering, A.L.; Deutsch, W.A.
Drosophila apurinic/apyrimidinic DNA endonucleases. Characterization of mechanism of action and demonstration of a novel type of enzyme activation
J. Biol. Chem.
261
3222-3228
1986
Drosophila, Escherichia coli, Homo sapiens
Robson, C.N.; Hickson, I.D.
Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants
Nucleic Acids Res.
19
5519-5523
1991
Bos taurus, Drosophila, Escherichia coli, Homo sapiens, Streptococcus pneumoniae, Homo sapiens (P27695)
Henner, W.D.; Kiker, N.P.; Jorgensen, T.J.; Munck, J.N.
Purification and amino-terminal amino acid sequence of an apurinic/apyrimidinic endonuclease from calf thymus
Nucleic Acids Res.
15
5529-5544
1987
Homo sapiens
Warner, H.R.; Persson, M.L.; Bensen, R.J.; Mosbaugh, D.W.; Linn, S.
Selective inhibition by harmane of apurinic/apyrimidinic endonuclease activity of phage T4-induced UV endonuclease
Nucleic Acids Res.
9
6083-6092
1981
Escherichia coli, Escherichia virus T4, Homo sapiens
Grafstrom, R.H.; Shaper, N.L.; Grossman, L.
Human placental apurinic/apyrimidinic endonuclease. Mechanism of action
J. Biol. Chem.
257
13459-13464
1982
Homo sapiens
Lucas, J.A.; Masuda, Y.; Bennett, R.A.O.; Strauss, N.S.; Strauss, P.R.
Single-turnover analysis of mutant human apurinic/apyrimidinic endonuclease
Biochemistry
38
4958-4964
1999
Homo sapiens
Pope, M.A.; Porello, S.L.; David, S.S.
Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G:A substrates
J. Biol. Chem.
277
22605-22615
2002
Escherichia coli
Greenberg, M.M.; Weledji, Y.N.; Kim, J.; Bales, B.C.
Repair of oxidized abasic sites by exonuclease III, endonuclease IV, and endonuclease III
Biochemistry
43
8178-8183
2004
Escherichia coli
Shatilla, A.; Ishchenko, A.A.; Saparbaev, M.; Ramotar, D.
Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA
Biochemistry
44
12835-12848
2005
Caenorhabditis elegans
Shatilla, A.; Leduc, A.; Yang, X.; Ramotar, D.
Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation
DNA Repair
4
655-670
2005
Escherichia coli
Faustoferri, R.C.; Hahn, K.; Weiss, K.; Quivey, R.G., Jr.
Smx nuclease is the major, low-pH-inducible apurinic/apyrimidinic endonuclease in Streptococcus mutans
J. Bacteriol.
187
2705-2714
2005
Streptococcus mutans, Streptococcus mutans (Q9AIV4)
Friedberg, E.C.; Hadi, S.M.; Goldthwait, D.A.
Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid
J. Biol. Chem.
244
5879-5889
1969
Escherichia coli
Carlson, K.; Lagerback, P.; Nystrom, A.C.
Bacteriophage T4 endonuclease II: concerted single-strand nicks yield double-strand cleavage
Mol. Microbiol.
52
1403-1411
2004
Tequatrovirus T4
Souza, L.L.; Eduardo, I.R.; Padula, M.; Leitao, A.C.
Endonuclease IV and exonuclease III are involved in the repair and mutagenesis of DNA lesions induced by UVB in Escherichia coli
Mutagenesis
21
125-130
2006
BRENDA: Escherichia coli (P0A6C1), Escherichia coli
Textmining: Chelator
Beloglazova, N.G.; Kirpota, O.O.; Starostin, K.V.; Ishchenko, A.A.; Yamkovoy, V.I.; Zharkov, D.O.; Douglas, K.T.; Nevinsky, G.A.
Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta
Nucleic Acids Res.
32
5134-5146
2004
Homo sapiens
Gros, L.; Ishchenko, A.A.; Ide, H.; Elder, R.H.; Saparbaev, M.K.
The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway
Nucleic Acids Res.
32
73-81
2004
Homo sapiens
Sukhanova, M.V.; Khodyreva, S.N.; Lebedeva, N.A.; Prasad, R.; Wilson, S.H.; Lavrik, O.I.
Human base excision repair enzymes apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymerase b and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity
Nucleic Acids Res.
33
1222-1229
2005
Homo sapiens
Guliaev, A.B.; Singer, B.; Hang, B.
Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts
DNA Repair
3
1311-1321
2004
Escherichia coli
Yang, B.; Chen, K.; Zhang, C.; Huang, S.; Zhang, H.
Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA
J. Biol. Chem.
282
11667-11675
2007
Human immunodeficiency virus 1
Vidal, A.E.; Harkiolaki, M.; Gallego, C.; Castillo-Acosta, V.M.; Ruiz-Perez, L.M.; Wilson, K.; Gonzalez-Pacanowska, D.
Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major
J. Mol. Biol.
373
827-838
2007
Homo sapiens, Leishmania major, Leishmania major (O15922)
Ho, R.; Rachek, L.I.; Xu, Y.; Kelley, M.R.; LeDoux, S.P.; Wilson, G.L.
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
J. Neurochem.
102
13-24
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P22936)
Redrejo-Rodriguez, M.; Garcia-Escudero, R.; Yanez-Munoz, R.J.; Salas, M.L.; Salas, J.
African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages
J. Virol.
80
4847-4857
2006
African swine fever virus, Escherichia coli, Homo sapiens, Sus scrofa
Hirano, N.; Ohshima, H.; Takahashi, H.
Biochemical analysis of the substrate specificity and sequence preference of endonuclease IV from bacteriophage T4, a dC-specific endonuclease implicated in restriction of dC-substituted T4 DNA synthesis
Nucleic Acids Res.
34
4743-4751
2006
BRENDA: Tequatrovirus T4
Textmining: Escherichia virus T4, Escherichia coli, Triticum aestivum
Wong, H.K.; Muftuoglu, M.; Beck, G.; Imam, S.Z.; Bohr, V.A.; Wilson, D.M.
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates
Nucleic Acids Res.
35
4103-4113
2007
Escherichia coli, Homo sapiens
Ohshima, H.; Hirano, N.; Takahashi, H.
A hexanucleotide sequence (dC1-dC6 tract) restricts the dC-specific cleavage of single-stranded DNA by endonuclease IV of bacteriophage T4
Nucleic Acids Res.
35
6681-6689
2007
BRENDA: Tequatrovirus T4
Textmining: Escherichia virus T4
Hirano, N.; Ohshima, H.; Sakashita, H.; Takahashi, H.
The Ser176 of T4 endonuclease IV is crucial for the restricted and polarized dC-specific cleavage of single-stranded DNA implicated in restriction of dC-containing DNA in host Escherichia coli
Nucleic Acids Res.
35
6692-6700
2007
BRENDA: Tequatrovirus T4
Textmining: Escherichia coli, Escherichia virus T4
Ivanov, I.; Tainer, J.A.; McCammon, J.A.
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV
Proc. Natl. Acad. Sci. USA
104
1465-1470
2007
Escherichia coli (P0A6C1)
Back, J.H.; Chung, J.H.; Park, J.H.; Han, Y.S.
A versatile endonuclease IV from Thermus thermophilus has uracil-excising and 3-5 exonuclease activity
Biochem. Biophys. Res. Commun.
346
889-895
2006
BRENDA: Thermus thermophilus (Q72KH8), Thermus thermophilus
Textmining: Escherichia coli, bacterium
Yang, S.; Meyskens, F.L.
Apurinic/apyrimidinic endonuclease /redox effector factor-1 (APE/Ref-1) a unique target for the prevention and treatment of human melanoma
Antioxid. Redox Signal.
11
639-650
2008
Homo sapiens
Sung, J.S.
Mosbaugh, D.W.: Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV
Biochemistry
39
10224-10235
2000
Escherichia coli
Jiang, Y.; Rabbi, M.; Kim, M.; Ke, C.; Lee, W.; Clark, R.L.; Mieczkowski, P.A.; Marszalek, P.E.
UVA generates pyrimidine dimers in DNA directly
Biophys. J.
96
1151-1158
2009
plasmids
Garcin, E.D.; Hosfield, D.J.; Desai, S.A.; Haas, B.J.; Bjoeras, M.; Cunningham, R.P.; Tainer, J.A.
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV
Nat. Struct. Mol. Biol.
15
515-522
2008
Escherichia coli
Longley, M.J.; Prasad, R.; Srivastava, D.K.; Wilson, S.H.; Copeland, W.C.
identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro
Proc. Natl. Acad. Sci. USA
95
12244-12248
1998
Homo sapiens
Barraza-Salas, M.; Ibarra-Rodriguez, J.R.; Mellado, S.J.; Salas-Pacheco, J.M.; Setlow, P.; Pedraza-Reyes, M.
Effects of forespore-specific overexpression of apurinic/apyrimidinic endonuclease Nfo on the DNA-damage resistance properties of Bacillus subtilis spores
FEMS Microbiol. Lett.
302
159-165
2010
Bacillus subtilis
Bapat, A.; Glass, L.S.; Luo, M.; Fishel, M.L.; Long, E.C.; Georgiadis, M.M.; Kelley, M.R.
Novel small molecule inhibitor of Ape1 endonuclease blocks proliferation and reduces viability of glioblastoma cells
J. Pharmacol. Exp. Ther.
334
988-998
2010
Escherichia coli
Kiyonari, S.; Tahara, S.; Shirai, T.; Iwai, S.; Ishino, S.; Ishino, Y.
Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus
Nucleic Acids Res.
37
6439-6453
2009
Pyrococcus furiosus, Pyrococcus furiosus (Q8U437)
Simeonov, A.; Kulkarni, A.; Dorjsuren, D.; Jadhav, A.; Shen, M.; McNeill, D.R.; Austin, C.P.; Wilson, D.M.
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1
PLoS ONE
4
e5740
2009
Escherichia coli, Homo sapiens, collection
Hughes, R.C.; Tomanicek, S.J.; Ng, J.D.; Coates, L.
Purification, crystallization and preliminary crystallographic analysis of a thermostable endonuclease IV from Thermotoga maritima
Acta Crystallogr. Sect. F
65
1317-1319
2009
BRENDA: Thermotoga maritima (Q9WYJ7), Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (Q9WYJ7)
Textmining: Escherichia coli, Thermotoga maritima MSB8, bacterium
Motta, E.S.; Souza-Santos, P.T.; Cassiano, T.R.; Dantas, F.J.; Caldeira-de-Araujo, A.; De Mattos, J.C.
Endonuclease IV is the main base excision repair enzyme involved in DNA damage induced by UVA radiation and stannous chloride
J. Biomed. Biotechnol.
2010
376218
2010
Escherichia coli, Escherichia coli AB1157
Asano, R.; Ishikawa, H.; Nakane, S.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
An additional C-terminal loop in endonuclease IV, an apurinic/apyrimidinic endonuclease, controls binding affinity to DNA
Acta Crystallogr. Sect. D
67
149-155
2011
Thermus thermophilus, Geobacillus kaustophilus, Geobacillus kaustophilus (Q5KX27), Thermus thermophilus HB8
Su, D.; Delaplane, S.; Luo, M.; Rempel, D.; Vu, B.; Kelley, M.; Gross, M.; Georgiadis, M.
Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: Evidence for an alternate conformation of the enzyme
Biochemistry
50
82-92
2011
Mammalia
Onyango, D.O.; Naguleswaran, A.; Delaplane, S.; Reed, A.; Kelley, M.R.; Georgiadis, M.M.; Sullivan, W.J.
Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii
DNA Repair
10
466-475
2011
Toxoplasma, Toxoplasma gondii, Toxoplasma gondii (F6KAZ5), eukaryota, Homo sapiens
Borjigin, M.; Martinez, B.; Purohit, S.; de la Rosa, G.; Arenaz, P.; Stec, B.
Chinese hamster apurinic/apyrimidinic endonuclease (chAPE1) expressed in sf9 cells reveals that its endonuclease activity is regulated by phosphorylation
FEBS J.
277
4732-4740
2010
Cricetulus griseus
Andersson, C.E.; Lagerbaeck, P.; Carlson, K.
Structure of bacteriophage T4 endonuclease II mutant E118A, a tetrameric GIY-YIG enzyme
J. Mol. Biol.
397
1003-1016
2010
BRENDA: Tequatrovirus T4
Textmining: Escherichia virus T4
Golan, G.; Ishchenko, A.; Khassenov, B.; Shoham, G.; Saparbaev, M.
Coupling of the nucleotide incision and 3'-5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences
Mutat. Res.
685
70-79
2010
Escherichia coli, Escherichia coli AB1157
Liu, G.; Ou, H.; Wang, T.; Li, L.; Tan, H.; Zhou, X.; Rajakumar, K.; Deng, Z.; He, X.
Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA
PLoS Genet.
6
1-13
2010
BRENDA: Streptomyces coelicolor, Streptomyces coelicolor A(3)2
Textmining: Streptomyces lividans 1326
Bernardi, A.; Maat, J.; De Waard, A.; Bernardi, G.
Preparation and specificity of endonuclease IV induced by bacteriophage T4
Eur. J. Biochem.
66
175-179
1976
Escherichia virus T4, Bacteriophage sp.
Carlson, K.; Overvatn, A.
Bacteriophage T4 endonucleases II and IV, oppositely affected by dCMP hydroxymethylase activity, have different roles in the degradation and in the RNA polymerase-dependent replication of T4 cytosine-containing DNA
Genetics
114
669-685
1986
Escherichia virus T4, Escherichia coli
Saporito, S.M.; Gedenk, M.; Cunningham, R.P.
Role of exonuclease III and endonuclease IV in repair of pyrimidine dimers initiated by bacteriophage T4 pyrimidine dimer-DNA glycosylase
J. Bacteriol.
171
2542-2546
1989
Bacteriophage sp., Escherichia coli, Escherichia virus T4
Xie, J.J.; Liu, X.P.; Han, Z.; Yuan, H.; Wang, Y.; Hou, J.L.; Liu, J.H.
Chlamydophila pneumoniae endonuclease IV prefers to remove mismatched 3 ribonucleotides: implication in proofreading mismatched 3-terminal nucleotides in short-patch repair synthesis
DNA Repair
12
140-147
2013
Chlamydia pneumoniae
Tsutakawa, S.E.; Shin, D.S.; Mol, C.D.; Izumi, T.; Arvai, A.S.; Mantha, A.K.; Szczesny, B.; Ivanov, I.N.; Hosfield, D.J.; Maiti, B.; Pique, M.E.; Frankel, K.A.; Hitomi, K.; Cunningham, R.P.; Mitra, S.; Tainer, J.A.
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes
J. Biol. Chem.
288
8445-8455
2013
BRENDA: Thermotoga maritima (Q9WYJ7), Thermotoga maritima DSM 3109 (Q9WYJ7)
Textmining: Homo sapiens
Puri, R.V.; Singh, N.; Gupta, R.K.; Tyagi, A.K.
Endonuclease IV Is the major apurinic/apyrimidinic endonuclease in Mycobacterium tuberculosis and is important for protection against oxidative damage
PLoS ONE
8
e71535
2013
BRENDA: Mycobacterium tuberculosis (P9WQ13), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ13)
Textmining: Homo sapiens
Joldybayeva, B.; Prorok, P.; Grin, I.R.; Zharkov, D.O.; Ishenko, A.A.; Tudek, B.; Bissenbaev, A.K.; Saparbaev, M.
Cloning and characterization of a wheat homologue of apurinic/apyrimidinic endonuclease Ape1L
PLoS ONE
9
e92963
2014
Triticum aestivum
Pope, M.A.; Porello, S.L.; David, S.S.
Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G A substrates
J. Biol. Chem.
277
22605-22615
2002
Escherichia coli
Uechi, K.; Takata, G.; Yoneda, K.; Ohshima, T.; Sakuraba, H.
Structure of D-tagatose 3-epimerase-like protein from Methanocaldococcus jannaschii
Acta Crystallogr. Sect. F
70
890-895
2014
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii (Q58707), Agrobacterium tumefaciens, Ruminiclostridium cellulolyticum, Pseudomonas cichorii, archaeon
Yan, Z.; Yuan, Z.; Ni, J.; Gu, L.; Shen, Y.
Crystal structure of the crenarchaeal ExoIII AP endonuclease SisExoIII reveals a conserved disulfide bond endowing the protein with thermostability
Biochem. Biophys. Res. Commun.
490
774-779
2017
Bacteria
Dyakonova, E.S.; Koval, V.V.; Lomzov, A.A.; Ishchenko, A.A.; Fedorova, O.S.
The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA
Biochim. Biophys. Acta
1850
1297-1309
2015
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P22936), Escherichia coli
Dyakonova, E.S.; Koval, V.V.; Lomzov, A.A.; Ishchenko, A.A.; Fedorova, O.S.
Apurinic/apyrimidinic endonuclease Apn1 from Saccharomyces cerevisiae is recruited to the nucleotide incision repair pathway Kinetic and structural features
Biochimie
152
53-62
2018
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P22936)
Haas, B.; Sandigursky, M.; Tainer, J.; Franklin, W.; Cunningham, R.
Purification and characterization of Thermotoga maritima endonuclease IV, a thermostable apurinic/apyrimidinic endonuclease and 3-repair diesterase
J. Bacteriol.
181
2834-2839
1999
BRENDA: Thermotoga maritima (Q9WYJ7), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WYJ7)
Textmining: Escherichia coli, bacterium
Turgimbayeva, A.; Abeldenov, S.; Zharkov, D.O.; Ishchenko, A.A.; Ramankulov, Y.; Saparbaev, M.; Khassenov, B.
Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori
PLoS ONE
13
e0202232
2018
Helicobacter pylori, Helicobacter pylori (Q9ZJ98)
Kong, X.J.; Wu, S.; Cen, Y.; Chen, T.T.; Yu, R.Q.; Chu, X.
Endonuclease IV cleaves apurinic/apyrimidinic sites in single-stranded DNA and its application for biosensing
Analyst
141
4373-4380
2016
Homo sapiens
Zhang, W.; Xu, Y.; Yan, M.; Li, S.; Wang, H.; Yang, H.; Zhou, W.; Rao, Z.
Crystal structure of the apurinic/apyrimidinic endonuclease IV from Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
498
111-118
2018
BRENDA: Mycobacterium tuberculosis (P9WQ13), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ13)
Textmining: Escherichia coli
Abeldenov, S.; Talhaoui, I.; Zharkov, D.O.; Ishchenko, A.A.; Ramanculov, E.; Saparbaev, M.; Khassenov, B.
Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis
DNA Repair
33
1-16
2015
BRENDA: Mycobacterium tuberculosis (P96273), Mycobacterium tuberculosis (P9WQ13), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P96273), Mycobacterium tuberculosis H37Rv (P9WQ13)
Textmining: Bacteria, Escherichia coli
Wang, W.W.; Zhou, H.; Xie, J.J.; Yi, G.S.; He, J.H.; Wang, F.P.; Xiao, X.; Liu, X.P.
Thermococcus eurythermalis endonuclease IV can cleave various apurinic/apyrimidinic site analogues in ssDNA and dsDNA
Int. J. Mol. Sci.
20
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Saccharomyces cerevisiae, Escherichia coli, Macaca mulatta polyomavirus 1
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Escherichia coli, Saccharomyces cerevisiae
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Escherichia coli, Homo sapiens
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Escherichia coli, Dictyostelium discoideum, Dictyostelium
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Chlamydia, Chlamydia pneumoniae, Escherichia coli
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Nucleic Acids Res
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Escherichia coli
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Radiat Res
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Escherichia coli
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Exonuclease I of Escherichia coli removes phosphoglycolate 3'-end groups from DNA.
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Escherichia coli
Sanchez, G; Mamet-Bratley, MD
Development of T7 phage and T7 phage containing apurinic sites in an exonuclease III, endonuclease IV double mutant of Escherichia coli.
Biochem Cell Biol
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Escherichia coli, Escherichia phage T7
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cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III.
Biochim Biophys Acta
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Mus musculus
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The relative importance of Escherichia coli exonuclease III and endonuclease IV for the hydrolysis of 3'-phosphoglycolate ends in polydeoxynucleotides.
Nucleic Acids Res
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Escherichia coli
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Escherichia coli
Agnez, LF; Costa de Oliveira, RL; Di Mascio, P; Menck, CF
Involvement of Escherichia coli exonuclease III and endonuclease IV in the repair of singlet oxygen-induced DNA damage.
Carcinogenesis
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Bacteria, Escherichia coli
Hang, B; Chenna, A; Sági, J; Singer, B
Differential cleavage of oligonucleotides containing the benzene-derived adduct, 1,N6-benzetheno-dA, by the major human AP endonuclease HAP1 and Escherichia coli exonuclease III and endonuclease IV.
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Escherichia coli, Homo sapiens
Agnez-Lima, LF; Di Mascio, P; Napolitano, RL; Fuchs, RP; Menck, CF
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Photochem Photobiol
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Escherichia coli
Hadi, MZ; Wilson, DM
Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III.
Environ Mol Mutagen
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Escherichia coli, Mammalia
Harrison, L; Brame, KL; Geltz, LE; Landry, AM
Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage.
DNA Repair (Amst)
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Escherichia coli, Bacteria
Chou, KM; Cheng, YC
The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G.
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Homo sapiens
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Characterization of the 3' exonuclease of Chlamydophila pneumoniae endonuclease IV on double-stranded DNA and the RNA strand of RNA/DNA hybrid.
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Chlamydia pneumoniae
Alleva, JL; Doetsch, PW
The nature of the 5'-terminus is a major determinant for DNA processing by Schizosaccharomyces pombe Rad2p, a FEN-1 family nuclease.
Nucleic Acids Res
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Schizosaccharomyces pombe, Escherichia coli, Saccharomyces cerevisiae, Escherichia virus T5
Venugopal, J; Rao, KS
A broad-specific alkaline DNase from rat brain with a putative role in DNA excision repair.
Biochem Mol Biol Int
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[Induction of synthesis of extracellular DNAase from Proteus mirabilis under the effect of compounds, blocking DNA replication]
Mol Gen Mikrobiol Virusol
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Raffoul, JJ; Cabelof, DC; Nakamura, J; Meira, LB; Friedberg, EC; Heydari, AR
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Isolation, characterization, and activation of the magnesium dependent endodeoxyribonuclease from Bacillus subtilis.
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Carestia, C; Gauthier, S; Granieri, A; Scarano, E
Purification and properties of a 3'-phosphoryl former endodeoxyribonuclease from eggs of Asterias forbesi.
Biochemistry
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Asterias forbesi
Tsuruo, T; Arens, M; Padmanabhan, R; Green, M
An endodeoxyribonuclease of human KB cells. Purification and properties of the enzyme.
J Biol Chem
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Homo sapiens
Harbers, K; Spencer, JH
Sequence studies on mouse L-cell satellite DNA by base-specific degradation with T4 endonuclease IV.
Biochim Biophys Acta
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Mus musculus
Chater, KF
A site-specific endodeoxyribonuclease from Streptomyces albus CMI 52766 sharing site-specificity with Providencia stuartii endonuclease PstI.
Nucleic Acids Res
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Providencia stuartii, Streptomyces albus
Parson, KA; Snustad, DP
Host DNA degradation after infection of Escherichia coli with bacteriophage T4: dependence of the alternate pathway of degradation which occurs in the absence of both T4 endonuclease II and nuclear disruption on T4 endonuclease IV.
J Virol
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Escherichia coli, Escherichia virus T4
Izumi, T; Ishizaki, K; Ikenaga, M; Yonei, S
A mutant endonuclease IV of Escherichia coli loses the ability to repair lethal DNA damage induced by hydrogen peroxide but not that induced by methyl methanesulfonate.
J Bacteriol
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1992
Escherichia coli
Zhao, B; Grandy, DK; Hagerup, JM; Magenis, RE; Smith, L; Chauhan, BC; Henner, WD
The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12.
Nucleic Acids Res
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Homo sapiens
Tsai-Wu, JJ; Liu, HF; Lu, AL
Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A.C and A.G mispairs.
Proc Natl Acad Sci U S A
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Escherichia coli
Popoff, SC; Spira, AI; Johnson, AW; Demple, B
Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV.
Proc Natl Acad Sci U S A
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Escherichia coli, Saccharomyces cerevisiae
Ramotar, D; Popoff, SC; Demple, B
Complementation of DNA repair-deficient Escherichia coli by the yeast Apn1 apurinic/apyrimidinic endonuclease gene.
Mol Microbiol
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Bacteria, Escherichia coli, Saccharomyces cerevisiae
Levin, JD; Shapiro, R; Demple, B
Metalloenzymes in DNA repair. Escherichia coli endonuclease IV and Saccharomyces cerevisiae Apn1.
J Biol Chem
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Escherichia, Escherichia coli, Saccharomyces, Saccharomyces cerevisiae
Aparicio, JF; Hardisson, C; Sánchez, J
Purification and characterization of a nutritionally controlled endodeoxyribonuclease from Streptomyces glaucescens.
Biochem J
281 ( Pt 1)
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Streptomyces glaucescens
Cunningham, RP; Saporito, SM; Spitzer, SG; Weiss, B
Endonuclease IV (nfo) mutant of Escherichia coli.
J Bacteriol
168
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1986
Escherichia coli, insertion sequences
Chan, E; Weiss, B
Endonuclease IV of Escherichia coli is induced by paraquat.
Proc Natl Acad Sci U S A
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1987
Escherichia coli, Escherichia coli K-12
Liuzzi, M; Weinfeld, M; Paterson, MC
Selective inhibition by methoxyamine of the apurinic/apyrimidinic endonuclease activity associated with pyrimidine dimer-DNA glycosylases from Micrococcus luteus and bacteriophage T4.
Biochemistry
26
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Escherichia virus T4, Micrococcus luteus
Ivanov, VA
[Specific for apurine-apyrimidine DNA endodeoxyribonuclease from the rat brain]
Biokhimiia
52
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1987
Rattus
Levin, JD; Johnson, AW; Demple, B
Homogeneous Escherichia coli endonuclease IV. Characterization of an enzyme that recognizes oxidative damage in DNA.
J Biol Chem
263
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Escherichia coli
Bailly, V; Verly, WG
The multiple activities of Escherichia coli endonuclease IV and the extreme lability of 5'-terminal base-free deoxyribose 5-phosphates.
Biochem J
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761-8
1989
Escherichia coli, Rattus
Haukanes, BI; Wittwer, CU; Helland, DE
Mechanism of incision by an apurinic/apyrimidinic endonuclease present in human placenta.
Nucleic Acids Res
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5529-35
1989
Homo sapiens
Nakagawa, K; Hashikawa, J; Makino, O; Ando, T; Shibata, T
Subunit structure of a yeast site-specific endodeoxyribonuclease, endo SceI. A study using monoclonal antibodies.
Eur J Biochem
171
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1988
Saccharomyces cerevisiae
Kazlauskene, R; Manialene, Z; Butkus, V; Piatrushite, M; Ianulaĭtis, A
[A new specific endodeoxyribonuclease from Escherichia coli RFL 72]
Bioorg Khim
12
836-8
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Escherichia coli
Johnson, AW; Demple, B
Yeast DNA 3'-repair diesterase is the major cellular apurinic/apyrimidinic endonuclease: substrate specificity and kinetics.
J Biol Chem
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Saccharomyces cerevisiae
Grondal-Zocchi, G; Verly, WG
Deoxyribonuclease IV from rat liver chromatin and the excision of apurinic sites from depurinated DNA.
Biochem J
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Rattus
Gromkova, R; Goodgal, SH
Action of haemophilus endodeoxyribonuclease on biologically active deoxyribonucleic acid.
J Bacteriol
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Haemophilus
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[Partial purification of an endodeoxyribonuclease from non-fertilized ova of Asterias forbesii]
Boll Soc Ital Biol Sper
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Asterias forbesi
Gauthier, S; Noviello, L
[Some kinetic characteristics of endodeoxyribonuclease of non-fertilized ova of Asterias forbesii]
Boll Soc Ital Biol Sper
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Asterias forbesi
Sadowski, PD
An endodeoxyribonuclease induced after infection with phage T7 bearing amber mutations in genes 3, 5, and 6.
Can J Biochem
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1972
Escherichia phage T7
Sadowski, PD; Vetter, D
Control of T4 endonuclease IV by the D2a region of bacteriophage T4.
Virology
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1973
Escherichia virus T4
Vetter, D; Sadowski, PD
Point mutants in the D2a region of bacteriophage T4 fail to induce T4 endonuclease IV.
J Virol
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Escherichia virus T4
Becker, A
An endodeoxyribonuclease induced in E. coli by infection with lambda-pbio transducing phages.
Biochem Biophys Res Commun
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63-70
1970
Escherichia coli
Ljungquist, S
Endonuclease IV from Escherichia coli.
Methods Enzymol
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Escherichia coli
Shaper, NL; Grossman, L
Purification and properties of the human placental apurinic/apyrimidinic endonuclease.
Methods Enzymol
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1980
Homo sapiens
Nakayama, J; Fujiyoshi, T; Nakamura, M; Anai, M
Purification and properties of an endodeoxyribonuclease from nuclei of bovine small intestinal mucosa.
J Biol Chem
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Bos taurus
Kopchick, JJ; Harless, J; Geisser, BS; Killam, R; Hewitt, RR; Arlinghaus, RB
Endodeoxyribonuclease activity associated with Rauscher murine leukemia virus.
J Virol
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1981
Rauscher murine leukemia virus
Janulaitis, A; Stakenas, P; Berlin YuA,
A new site-specific endodeoxyribonuclease from Citrobacter freundii.
FEBS Lett
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1983
Citrobacter freundii
Nagae, S; Ikeda, M; Anai, M
Endodeoxyribonuclease from nuclei of bovine small intestinal mucosa: further studies on intranuclear localization and cleavage mechanism of the enzyme.
Biochem Biophys Res Commun
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952-8
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Bos taurus
Huq, I; Wilson, TM; Kelley, MR; Deutsch, WA
Expression in Escherichia coli of a rat cDNA encoding an apurinic/apyrimidinic endonuclease.
Mutat Res
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Escherichia coli, Rattus, Homo sapiens, Bos taurus
Wilson, TM; Carney, JP; Kelley, MR
Cloning of the multifunctional rat apurinic/apyrimidinic endonuclease (rAPEN)/redox factor from an immature T cell line.
Nucleic Acids Res
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Rattus
Ide, H; Tedzuka, K; Shimzu, H; Kimura, Y; Purmal, AA; Wallace, SS; Kow, YW
Alpha-deoxyadenosine, a major anoxic radiolysis product of adenine in DNA, is a substrate for Escherichia coli endonuclease IV.
Biochemistry
33
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1994
Escherichia coli, Micrococcus luteus
Takiguchi, Y; Chen, DJ
Genomic structure of the mouse apurinic/apyrimidinic endonuclease gene.
Mamm Genome
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717-22
1994
Mus musculus, Bacteria, Homo sapiens, Mammalia
Kadyrov, FA; Kriukov, VM; Shliapnikov, MG; Baev, AA
[SegE--a new site-specific endodeoxyribonuclease from bacteriophage T4]
Dokl Akad Nauk
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Escherichia virus T4
Ono, Y; Matsumoto, K; Furuta, T; Ohmoto, T; Akiyama, K; Seki, S
Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines.
J Neurooncol
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Homo sapiens
Ramotar, D; Demple, B
Functional expression of Escherichia coli endonuclease IV in apurinic endonuclease-deficient yeast.
J Biol Chem
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Escherichia coli, Saccharomyces cerevisiae, plasmids
Wakabayashi, H; Tsuji, T; Seki, S
Purification and characterization of a 39kDa apurinic/apyrimidinic endonuclease from mouse ascites sarcoma cells.
Acta Med Okayama
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Mus musculus, Staphylococcus aureus V8
Yacoub, A; Kelley, MR; Deutsch, WA
Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity.
Nucleic Acids Res
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1996
Drosophila, Escherichia coli
Masson, JY; Tremblay, S; Ramotar, D
The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease.
Gene
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1996
Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans
Ramotar, D; Vadnais, J; Masson, JY; Tremblay, S
Schizosaccharomyces pombe apn1 encodes a homologue of the Escherichia coli endonuclease IV family of DNA repair proteins.
Biochim Biophys Acta
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1998
Escherichia coli, Schizosaccharomyces pombe, Saccharomyces cerevisiae, Ursidae
Ramana, CV; Boldogh, I; Izumi, T; Mitra, S
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.
Proc Natl Acad Sci U S A
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Homo sapiens, Alocasia macrorrhizos
Pérez, J; Gallego, C; Bernier-Villamor, V; Camacho, A; González-Pacanowska, D; Ruiz-Pérez, LM
Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli.
Nucleic Acids Res
27
771-7
1999
Escherichia coli, Trypanosomatidae, Leishmania major, Trypanosoma cruzi, Leishmania, Trypanosoma
Kawase, M; Fujimura, M; Morita-Fujimura, Y; Chan, PH
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis.
Stroke
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Rattus
Yang, X; Tellier, P; Masson, JY; Vu, T; Ramotar, D
Characterization of amino acid substitutions that severely alter the DNA repair functions of Escherichia coli endonuclease IV.
Biochemistry
38
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1999
Escherichia coli
Fujimura, M; Morita-Fujimura, Y; Kawase, M; Chan, PH
Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice.
J Cereb Blood Flow Metab
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Mus sp.
Serafini, DM; Schellhorn, HE
Endonuclease III and endonuclease IV protect Escherichia coli from the lethal and mutagenic effects of near-UV irradiation.
Can J Microbiol
45
632-7
1999
Escherichia coli
Morita-Fujimura, Y; Fujimura, M; Kawase, M; Chan, PH
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Neuroscience
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1999
Mus sp.
Fujimura, M; Morita-Fujimura, Y; Narasimhan, P; Copin, JC; Kawase, M; Chan, PH
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Stroke
30
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1999
Mus sp., Mus musculus
Haltiwanger, BM; Karpinich, NO; Taraschi, TF
Characterization of class II apurinic/apyrimidinic endonuclease activities in the human malaria parasite, Plasmodium falciparum.
Biochem J
345 Pt 1
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Homo sapiens, Plasmodium, Plasmodium falciparum
Galhardo, RS; Almeida, CE; Leitão, AC; Cabral-Neto, JB
Repair of DNA lesions induced by hydrogen peroxide in the presence of iron chelators in Escherichia coli: participation of endonuclease IV and Fpg.
J Bacteriol
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2000
Escherichia coli
Blackmore, RV; Linn, S
Partial purification and characterization of four endodeoxyribonuclease activities from Escherichia coli K-12.
Nucleic Acids Res
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Escherichia coli K-12
Bobola, MS; Blank, A; Berger, MS; Stevens, BA; Silber, JR
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
Clin Cancer Res
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3510-8
2001
Homo sapiens
He, YH; Wu, M; Kobune, M; Xu, Y; Kelley, MR; Martin, WJ
Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity.
Am J Respir Cell Mol Biol
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2001
Saccharomyces cerevisiae
Silber, JR; Bobola, MS; Blank, A; Schoeler, KD; Haroldson, PD; Huynh, MB; Kolstoe, DD
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
Clin Cancer Res
8
3008-18
2002
Homo sapiens
Urtiz-Estrada, N; Salas-Pacheco, JM; Yasbin, RE; Pedraza-Reyes, M
Forespore-specific expression of Bacillus subtilis yqfS, which encodes type IV apurinic/apyrimidinic endonuclease, a component of the base excision repair pathway.
J Bacteriol
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2003
Bacillus subtilis
Back, JH; Chung, JH; Park, YI; Kim, KS; Han, YS
Endonuclease IV enhances base excision repair of endonuclease III from Methanobacterium thermoautotrophicum.
DNA Repair (Amst)
2
455-70
2003
Methanothermobacter thermautotrophicus, Escherichia coli
Brnáková, Z; Godány, A; Timko, J
An extracellular endodeoxyribonuclease from Streptomyces aureofaciens.
Biochim Biophys Acta
1721
116-23
2005
Kitasatospora aureofaciens
Narasimhan, P; Sugawara, T; Liu, J; Hayashi, T; Noshita, N; Chan, PH
Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia.
J Neurochem
93
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Homo sapiens, Metazoa
Lamarche, BJ; Tsai, MD
Contributions of an Endonuclease IV Homologue to DNA Repair in the African Swine Fever Virus.
Biochemistry
45
2790-803
2006
African swine fever virus, Alocasia macrorrhizos, Phocidae
Kim, HW; Cho, KJ; Park, SC; Kim, HJ; Kim, GW
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice.
Brain Res
2009
Mus sp.
Kim, HW; Cho, KJ; Lee, BI; Kim, HJ; Kim, GW
Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice.
Neurosci Lett
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Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma LoVo and Escherichia coli cell extracts.
Prog Nucleic Acid Res Mol Biol
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165-88
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Escherichia coli, Homo sapiens
Yu, J; Garfinkel, AB; Wolfner, MF
Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location.
Dev Biol
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Drosophila
Jilani, A; Vongsamphanh, R; Leduc, A; Gros, L; Saparbaev, M; Ramotar, D
Characterization of two independent amino acid substitutions that disrupt the DNA repair functions of the yeast Apn1.
Biochemistry
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Saccharomyces cerevisiae, Escherichia coli
Cao, XJ; Dai, N; Yi, WJ; Li, ZP; Yang, YX; Wang, D; Hu, CM
[Preparation and characterization of rabbit anti-human apurinic/apyrimidinic endonuclease(APE1)polyclonal antibody.]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
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Oryctolagus cuniculus
González-Cerón, G; Miranda-Olivares, OJ; Servín-González, L
Characterization of the methyl-specific restriction system of Streptomyces coelicolor A3(2) and of the role played by laterally acquired nucleases.
FEMS Microbiol Lett
2009
Streptomyces coelicolor
He, MX; Zeng, JS; Hua, HY; Xing, SH; Ba, YP
[Changes in DNA repair enzymes in rat ventroposterior nucleus of the thalamus after cerebral cortex infarction.]
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
22
587-590
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Rattus, Escherichia coli
Flaender, M; Sicoli, G; Aci-Seche, S; Reignier, T; Maurel, V; Saint-Pierre, C; Boulard, Y; Gambarelli, S; Gasparutto, D
A triple spin-labeling strategy coupled with DEER analysis to detect DNA modifications and enzymatic repair.
Chembiochem
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Cervidae
Lindert, S; Bucher, D; Eastman, P; Pande, V; McCammon, JA
Accelerated Molecular Dynamics Simulations with the AMOEBA Polarizable Force Field on Graphics Processing Units.
J Chem Theory Comput
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Amoeba
Keen, EC; Bliskovsky, VV; Malagon, F; Baker, JD; Prince, JS; Klaus, JS; Adhya, SL
Novel "Superspreader" Bacteriophages Promote Horizontal Gene Transfer by Transformation.
MBio
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Transformation, Escherichia virus T4
Rivkees, SA; Kelley, MR
Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei.
Brain Res
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Alocasia macrorrhizos, Rattus
Xu, Y; Moore, DH; Broshears, J; Liu, L; Wilson, TM; Kelley, MR
The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer.
Anticancer Res
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Alocasia macrorrhizos
Chang, YY; Fujimura, M; Morita-Fujimura, Y; Kim, GW; Huang, CY; Wu, HS; Kawase, M; Copin, JC; Chan, PH
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Neurosci Lett
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Mus sp.
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Thermus thermophilus
Bricteux-Grégoire, S; Verly, WG
The use of thioglycollate to demonstrate DNA AP (apurinic/apyrimidinic-site) lyase activities. Biological consequences of thiol addition to the 5' product of a beta-elimination reaction at an AP site in DNA.
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Escherichia coli
Talpaert-Borlé, M
Formation, detection and repair of AP sites.
Mutat Res
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Daucus carota
Sági, J; Hang, B; Singer, B
Sequence-dependent repair of synthetic AP sites in 15-mer and 35-mer oligonucleotides: role of thermodynamic stability imposed by neighbor bases.
Chem Res Toxicol
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917-23
1999
Escherichia coli
Lu, H; Bhat, AA; Peng, D; Chen, Z; Zhu, S; Hong, J; Maacha, S; Yan, J; Robbins, DJ; Washington, MK; Belkhiri, A; El-Rifai, W
APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma.
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Homo sapiens
Kerins, SM; Collins, R; McCarthy, TV
Characterization of an endonuclease IV 3'-5' exonuclease activity.
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Escherichia coli, Thermotoga maritima
Hagensee, ME; Moses, RE
Bleomycin-treated DNA is specifically cleaved only by endonuclease IV in E. coli.
Biochim Biophys Acta
1048
19-23
1990
Escherichia coli
Kuhnlein, U
Comparison of apurinic DNA-binding protein from an ataxia telangiectasia and a HeLa cell line. Evidence for an altered processing of apurinic/apyrimidinic endonuclease.
J Biol Chem
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snake
Kaysen, JH; Amari, NM; Lambert, MW
Enhancement of two apurinic/apyrimidinic endonuclease activities from normal but not xeroderma pigmentosum lymphoblastoid cells by nucleosome structure.
Mutat Res
165
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DNA molecule
Bose, KK; Tatsumi, K; Strauss, BS
Apurinic/apyrimidinic endonuclease sensitive sites as intermediates in the in vitro degradation of deoxyribonucleic acid by neocarzinostatin.
Biochemistry
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1980
Homo sapiens
Kane, CM; Linn, S
Purification and characterization of an apurinic/apyrimidinic endonuclease from HeLa cells.
J Biol Chem
256
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1981
Homo sapiens, Oryctolagus cuniculus
La Belle, M; Linn, S; Thompson, LH
Apurinic/apyrimidinic endonuclease activities appear normal in the CHO-cell ethyl methanesulfonate-sensitive mutant, EM9.
Mutat Res
141
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1984
Homo sapiens, Mus musculus
Seki, S; Takata, A; Nakamura, T; Akiyama, K; Watanabe, S
A possible cause of heterogeneity of mammalian apurinic/apyrimidinic endonuclease.
Int J Biochem
25
53-9
1993
Escherichia coli, Homo sapiens
Robertson, KA; Hill, DP; Xu, Y; Liu, L; Van Epps, S; Hockenbery, DM; Park, JR; Wilson, TM; Kelley, MR
Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells.
Cell Growth Differ
8
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1997
Homo sapiens, Alocasia macrorrhizos
Ramotar, D
The apurinic-apyrimidinic endonuclease IV family of DNA repair enzymes.
Biochem Cell Biol
75
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1997
Escherichia coli
Purohit, S; Arenaz, P
Molecular cloning, sequence and structure analysis of hamster apurinic/apyrimidinic endonuclease (chAPE1) gene.
Mutat Res
435
215-24
1999
Cricetulus griseus, Homo sapiens, Bos taurus, Mus musculus, Rattus
Mol, CD; Hosfield, DJ; Tainer, JA
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means.
Mutat Res
460
211-29
2000
Escherichia coli, Saccharomyces cerevisiae, Homo sapiens
Yang, H; Clendenin, WM; Wong, D; Demple, B; Slupska, MM; Chiang, JH; Miller, JH
Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch.
Nucleic Acids Res
29
743-52
2001
Escherichia coli, Homo sapiens, Mammalia, Mus musculus
Aramini, JM; Cleaver, SH; Pon, RT; Cunningham, RP; Germann, MW
Solution structure of a DNA duplex containing an alpha-anomeric adenosine: insights into substrate recognition by endonuclease IV.
J Mol Biol
338
77-91
2004
Escherichia coli
Bobola, MS; Finn, LS; Ellenbogen, RG; Geyer, JR; Berger, MS; Braga, JM; Meade, EH; Gross, ME; Silber, JR
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Clin Cancer Res
11
7405-14
2005
Homo sapiens
Hou, J; Liu, X; Zheng, Y; Liu, J
An efficient cloning of DNA fragments by a method based on uracil-DNA glycosylase and endonuclease IV.
J Biochem Biophys Methods
70
1196-8
2008
Transformation
Daley, JM; Zakaria, C; Ramotar, D
The endonuclease IV family of apurinic/apyrimidinic endonucleases.
Mutat Res
2010
vertebrata, Mammalia
Bobola, MS; Jankowski, P; Gross, ME; Schwartz, J; Finn, LS; Blank, A; Ellenbogen, RG; Silber, JR
Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma.
Int J Cancer
2011
Homo sapiens
Poletto, M; Vascotto, C; Scognamiglio, PL; Lirussi, L; Marasco, D; Tell, G
Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).
Biochem J
452
545-57
2013
eukaryota
Kanchan, S; Sharma, P; Chowdhury, S
Evolution of endonuclease IV protein family: an in silico analysis.
3 Biotech
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168
2019
eukaryota, Saccharomyces, Coccidioides
Tummanatsakun, D; Proungvitaya, T; Roytrakul, S; Proungvitaya, S
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Molecules
26
2021
Homo sapiens
Levin, JD; Demple, B
In vitro detection of endonuclease IV-specific DNA damage formed by bleomycin in vivo.
Nucleic Acids Res
24
885-9
1996
Escherichia coli, Varanidae
Kanno, S; Iwai, S; Takao, M; Yasui, A
Repair of apurinic/apyrimidinic sites by UV damage endonuclease; a repair protein for UV and oxidative damage.
Nucleic Acids Res
27
3096-103
1999
Escherichia coli, Schizosaccharomyces pombe, Neurospora crassa
Lau, JP; Weatherdon, KL; Skalski, V; Hedley, DW
Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.
Br J Cancer
91
1166-73
2004
Homo sapiens
Zhang, H; Wang, LJ; Wang, L; Chen, H; Chen, X; Zhang, CY
Development of a cascade isothermal amplification approach for the sensitive detection of DNA methyltransferase.
J Mater Chem B
7
157-162
2019
Escherichia coli
Breton, CV; Kile, ML; Catalano, PJ; Hoffman, E; Quamruzzaman, Q; Rahman, M; Mahiuddin, G; Christiani, DC
GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study.
Environ Health
6
39
2007
Homo sapiens
Prasad, R; Lavrik, OI; Kim, SJ; Kedar, P; Yang, XP; Vande Berg, BJ; Wilson, SH
DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis.
J Biol Chem
276
32411-4
2001
Homo sapiens
Hayward, C; Colville, S; Swingler, RJ; Brock, DJ
Molecular genetic analysis of the APEX nuclease gene in amyotrophic lateral sclerosis.
Neurology
52
1899-901
1999
Homo sapiens
Tomkins, J; Dempster, S; Banner, SJ; Cookson, MR; Shaw, PJ
Screening of AP endonuclease as a candidate gene for amyotrophic lateral sclerosis (ALS).
Neuroreport
11
1695-7
2000
Alocasia macrorrhizos, Homo sapiens
Zhang, K; Taylor, JS
Phototriggered formation and repair of DNA containing a site-specific single strand break of the type produced by ionizing radiation or AP lyase activity.
Biochemistry
40
153-9
2001
Escherichia coli
Schindl, M; Oberhuber, G; Pichlbauer, EG; Obermair, A; Birner, P; Kelley, MR
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Int J Oncol
19
799-802
2001
Homo sapiens
Kang, MW; Kang, SK; Choi, S; Lee, CS; Jeon, BH; Lim, SP
Upregulation of APE/ref-1 in recurrence stage I, non small cell lung cancer.
Asian Cardiovasc Thorac Ann
20
36-41
2012
Homo sapiens
Sage, E; Le Doan, T; Boyer, V; Helland, DE; Kittler, L; Helene, C; Moustacchi, E
Oxidative DNA damage photo-induced by 3-carbethoxypsoralen and other furocoumarins. Mechanisms of photo-oxidation and recognition by repair enzymes.
J Mol Biol
209
297-314
1989
Electron, Escherichia coli, Lethrinidae
Häring, M; Rüdiger, H; Demple, B; Boiteux, S; Epe, B
Recognition of oxidized abasic sites by repair endonucleases.
Nucleic Acids Res
22
2010-5
1994
Escherichia coli
Legault, J; Tremblay, A; Ramotar, D; Mirault, ME
Clusters of S1 nuclease-hypersensitive sites induced in vivo by DNA damage.
Mol Cell Biol
17
5437-52
1997
Escherichia coli, Homo sapiens, Mus musculus
Dianov, G; Lindahl, T
Reconstitution of the DNA base excision-repair pathway.
Curr Biol
4
1069-76
1994
Escherichia coli, Homo sapiens
Harrison, L; Hatahet, Z; Wallace, SS
In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites.
J Mol Biol
290
667-84
1999
Escherichia coli, DNA molecule
McNeill, DR; Narayana, A; Wong, HK; Wilson, DM
Inhibition of Ape1 nuclease activity by lead, iron, and cadmium.
Environ Health Perspect
112
799-804
2004
Escherichia coli
Datta, K; Neumann, RD; Winters, TA
Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break.
Proc Natl Acad Sci U S A
102
10569-74
2005
Escherichia coli
Liu, X; Liu, J
The mechanism of base excision repair in Chlamydiophila pneumoniae.
DNA Repair (Amst)
4
1295-305
2005
Bacteria, Escherichia coli, Chlamydia pneumoniae
Heater, SJ; Rains, JD; Wells, MC; Guerrero, PA; Walter, RB
Perturbation of DNA repair gene expression due to interspecies hybridization.
Comp Biochem Physiol C Toxicol Pharmacol
145
156-63
2007
Xiphophorus, Xiphophorus andersi
Asada, K; Sakaue, F; Nagata, T; Zhang, JC; Yoshida-Tanaka, K; Abe, A; Nawa, M; Nishina, K; Yokota, T
Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing.
Nucleic Acids Res
49
4864-4876
2021
Mus musculus
Tiwari, A; Kuldeep, J; Siddiqi, MI; Habib, S
Plasmodiumfalciparum Apn1 homolog is a mitochondrial base excision repair protein with restricted enzymatic functions.
FEBS J
2019
Saccharomyces cerevisiae, Homo sapiens
Levin, JD; Demple, B
Analysis of class II (hydrolytic) and class I (beta-lyase) apurinic/apyrimidinic endonucleases with a synthetic DNA substrate.
Nucleic Acids Res
18
5069-75
1990
Escherichia coli, Homo sapiens, Saccharomyces cerevisiae
Povirk, LF; Houlgrave, CW
Effect of apurinic/apyrimidinic endonucleases and polyamines on DNA treated with bleomycin and neocarzinostatin: specific formation and cleavage of closely opposed lesions in complementary strands.
Biochemistry
27
3850-7
1988
Escherichia coli
Singer, B; Hang, B
What structural features determine repair enzyme specificity and mechanism in chemically modified DNA?
Chem Res Toxicol
10
713-32
1997
Escherichia coli, Homo sapiens, Bacteria, eukaryota
Datta, K; Neumann, RD; Winters, TA
Characterization of a complex 125I-induced DNA double-strand break: implications for repair.
Int J Radiat Biol
81
13-21
2005
Escherichia coli, plasmids
Ishchenko, AA; Deprez, E; Maksimenko, A; Brochon, JC; Tauc, P; Saparbaev, MK
Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles.
Proc Natl Acad Sci U S A
103
2564-9
2006
Escherichia coli, Homo sapiens
Shiina, T; Watanabe, R; Shiraishi, I; Suzuki, M; Sugaya, Y; Fujii, K; Yokoya, A
Induction of DNA damage, including abasic sites, in plasmid DNA by carbon ion and X-ray irradiation.
Radiat Environ Biophys
52
99-112
2013
Escherichia coli
Müller, E; Boiteux, S; Cunningham, RP; Epe, B
Enzymatic recognition of DNA modifications induced by singlet oxygen and photosensitizers.
Nucleic Acids Res
18
5969-73
1990
Escherichia coli
Ide, H; Shimizu, H; Kimura, Y; Sakamoto, S; Makino, K; Glackin, M; Wallace, SS; Nakamuta, H; Sasaki, M; Sugimoto, N
Influence of alpha-deoxyadenosine on the stability and structure of DNA. Thermodynamic and molecular mechanics studies.
Biochemistry
34
6947-55
1995
Escherichia coli
Epe, B; Henzl, H; Adam, W; Saha-Möller, CR
Endonuclease-sensitive DNA modifications induced by acetone and acetophenone as photosensitizers.
Nucleic Acids Res
21
863-9
1993
Pseudoalteromonas virus PM2
Sander, M
In situ activity gel for DNA repair 3'-phosphodiesterase.
Nucleic Acids Res
25
1868-9
1997
Escherichia coli
Pflaum, M; Will, O; Mahler, HC; Epe, B
DNA oxidation products determined with repair endonucleases in mammalian cells: types, basal levels and influence of cell proliferation.
Free Radic Res
29
585-94
1998
Homo sapiens, Sus scrofa, Rattus
Moran, MF; Ebisuzaki, K
In vivo benzo[a]pyrene diol epoxide-induced alkali-labile sites are not apurinic sites.
Mutat Res
262
79-84
1991
Escherichia coli
Hsieh, CL; McCloskey, RP; Radany, E; Lieber, MR
V(D)J recombination: evidence that a replicative mechanism is not required.
Mol Cell Biol
11
3972-7
1991
Escherichia coli, plasmids
Cannon-Carlson, SV; Gokhale, H; Teebor, GW
Purification and characterization of 5-hydroxymethyluracil-DNA glycosylase from calf thymus. Its possible role in the maintenance of methylated cytosine residues.
J Biol Chem
264
13306-12
1989
Bacteria
Povirk, LF; Goldberg, IH
Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at cytosine residues in DNA: evidence for a possible role in mutagenesis.
Proc Natl Acad Sci U S A
82
3182-6
1985
Escherichia coli
Goffin, C; Verly, WG
Excision of apurinic sites from DNA with enzymes isolated from rat-liver chromatin.
Eur J Biochem
127
619-23
1982
Rattus, Escherichia virus phiX174
Mullokandov, EA; Franklin, WA; Brownlee, M
DNA damage by the glycation products of glyceraldehyde 3-phosphate and lysine.
Diabetologia
37
145-9
1994
Escherichia coli
Kisby, GE; Milne, J; Sweatt, C
Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue.
Neuroreport
8
1337-40
1997
Homo sapiens, Alocasia macrorrhizos
Legault, J; Tremblay, A; Mirault, ME
Preferential localization of DNA damage induced by depurination and bleomycin in a plasmid containing a scaffold-associated region.
Biochem Cell Biol
75
369-75
1997
Escherichia coli
Wilson, DM; Bianchi, C
Improved immunodetection of nuclear antigens after sodium dodecyl sulfate treatment of formaldehyde-fixed cells.
J Histochem Cytochem
47
1095-100
1999
Homo sapiens, Bos taurus
Zupunski, V; Gubensek, F; Kordis, D
Evolutionary dynamics and evolutionary history in the RTE clade of non-LTR retrotransposons.
Mol Biol Evol
18
1849-63
2001
Squamata
Romanenko, A; Morimura, K; Wei, M; Zaparin, W; Vozianov, A; Fukushima, S
DNA damage repair in bladder urothelium after the Chernobyl accident in Ukraine.
J Urol
168
973-7
2002
Homo sapiens
Pastwa, E; Neumann, RD; Mezhevaya, K; Winters, TA
Repair of radiation-induced DNA double-strand breaks is dependent upon radiation quality and the structural complexity of double-strand breaks.
Radiat Res
159
251-61
2003
Escherichia coli, Homo sapiens
Bodnarchuk, IA
[Analysis of the role of DNA repair, regulation of cell cycle and apoptosis in the radiation-induced adaptive response of mammalian cells]
Radiats Biol Radioecol
43
19-28
0
Alocasia macrorrhizos
Breton, CV; Zhou, W; Kile, ML; Houseman, EA; Quamruzzaman, Q; Rahman, M; Mahiuddin, G; Christiani, DC
Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes.
Carcinogenesis
28
1520-5
2007
Homo sapiens
Chaudhry, MA
Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases.
Cancer Cell Int
7
15
2007
Homo sapiens
Guikema, JE; Linehan, EK; Tsuchimoto, D; Nakabeppu, Y; Strauss, PR; Stavnezer, J; Schrader, CE
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
J Exp Med
204
3017-26
2007
Alocasia macrorrhizos
Nevinsky, GA
Structural, thermodynamic, and kinetic basis for the activities of some nucleic acid repair enzymes.
J Mol Recognit
24
656-77
0
Escherichia coli, Homo sapiens
Fujihara, J; Soejima, M; Yasuda, T; Koda, Y; Kunito, T; Iwata, H; Tanabe, S; Takeshita, H
Polymorphic trial in oxidative damage of arsenic exposed Vietnamese.
Toxicol Appl Pharmacol
2011
Homo sapiens
Gordon-Thomson, C; Gupta, R; Tongkao-on, W; Ryan, A; Halliday, GM; Mason, RS
1?,25 dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin.
Photochem Photobiol Sci
11
1837-47
2012
Homo sapiens, Calloplesiops altivelis
Wu, XY; Chen, C; Yao, XQ; Cao, QH; Xu, Z; Li, WS; Liu, FK; Li, G
Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair.
Mol Med Rep
10
486-90
2014
Indicator, Calloplesiops altivelis
Christov, PP; Son, KJ; Rizzo, CJ
Synthesis and characterization of oligonucleotides containing a nitrogen mustard formamidopyrimidine monoadduct of deoxyguanosine.
Chem Res Toxicol
27
1610-8
2014
Escherichia coli
Azevedo, AP; Silva, SN; De Lima, JP; Reichert, A; Lima, F; Jnior, E; Rueff, J
DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: The role of base excision repair genes polymorphisms.
Oncol Lett
13
4641-4650
2017
Homo sapiens
Li, CC; Zhang, Y; Tang, B; Zhang, CY
Integration of single-molecule detection with magnetic separation for multiplexed detection of DNA glycosylases.
Chem Commun (Camb)
54
5839-5842
2018
Homo sapiens
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