Reference on EC 2.3.2.23 - E2 ubiquitin-conjugating enzyme and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tokgoez, Z.; Bohnsack, R.N.; Haas, A.L.
Pleiotropic effects of ATP*Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme
J. Biol. Chem.
281
14729-14737
2006
Homo sapiens
Pelzer, C.; Kassner, I.; Matentzoglu, K.; Singh, R.K.; Wollscheid, H.P.; Scheffner, M.; Schmidtke, G.; Groettrup, M.
UBE1L2, a novel E1 enzyme specific for ubiquitin
J. Biol. Chem.
282
23010-23014
2007
Homo sapiens (P62837), Homo sapiens
Zheng, M.; Liu, J.; Yang, Z.; Gu, X.; Li, F.; Lou, T.; Ji, C.; Mao, Y.
Expression, purification and characterization of human ubiquitin-activating enzyme, UBE1
Mol. Biol. Rep.
37
1413-1419
2010
Homo sapiens
Plafker, K.S.; Nguyen, L.; Barneche, M.; Mirza, S.; Crawford, D.; Plafker, S.M.
The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2
J. Biol. Chem.
285
23064-23074
2010
Homo sapiens
van Wijk, S.J.; Timmers, H.T.
The family of ubiquitin-conjugating enzymes (E2s):deciding between life and death of proteins
FASEB J.
24
981-93
2010
Homo sapiens
David, Y.; Ziv, T.; Admon, A.; Navon, A.
The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines
J. Biol. Chem.
285
8595-8604
2010
Homo sapiens
Scaglione, K.M.; Basrur, V.; Ashraf, N.S.; Konen, J.R.; Elenitoba-Johnson, K.S.; Todi, S.V.; Paulson, H.L.
The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates
J. Biol. Chem.
288
18784-18788
2013
Homo sapiens
Tokgoez, Z.; Siepmann, T.J.; Streich, F.; Kumar, B.; Klein, J.M.; Haas, A.L.
E1-E2 interactions in ubiquitin and Nedd8 ligation pathways
J. Biol. Chem.
287
311-321
2012
Homo sapiens (P22314), Homo sapiens (Q8TBC4)
Wee, K.E.; Lai, Z.; Auger, K.R.; Ma, J.; Horiuchi, K.Y.; Dowling, R.L.; Dougherty, C.S.; Corman, J.I.; Wynn, R.; Copeland, R.A.
Steady-state kinetic analysis of human ubiquitin-activating enzyme (E1) using a fluorescently labeled ubiquitin substrate
J. Protein Chem.
19
489-498
2000
Homo sapiens (P62837)
Tatham, M.; Kim, S.; Yu, B.; Jaffray, E.; Song, J.; Zheng, J.; Rodriguez, M.; Hay, R.; Chen, Y.
Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation
Biochemistry
42
9959-9969
2003
Homo sapiens (P63279)
Nguyen, L.; Plafker, K.S.; Starnes, A.; Cook, M.; Klevit, R.E.; Plafker, S.M.
The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin
Biochemistry
53
4004-4014
2014
Homo sapiens (Q969T4)
Aichem, A.; Catone, N.; Groettrup, M.
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1
FEBS J.
281
1848-1859
2014
Homo sapiens (Q9H832)
Zulkifle, N.
Systematic yeast two-hybrid analysis of human E2 ubiquitin-conjugating enzyme and deubiquitin (DUB) protein interactions
Int. J. Biol. Chem.
7
1-14
2013
Homo sapiens
-
Yokota, K.; Shibata, H.; Kurihara, I.; Kobayashi, S.; Suda, N.; Murai-Takeda, A.; Saito, I.; Kitagawa, H.; Kato, S.; Saruta, T.; Itoh, H.
Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9
J. Biol. Chem.
282
1998-2010
2007
Homo sapiens
Park, Y.; Yoon, S.K.; Yoon, J.B.
The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway
J. Biol. Chem.
284
1540-1549
2009
Homo sapiens (P51668)
Wang, Y.; Kim, S.M.; Trnka, M.J.; Liu, Y.; Burlingame, A.L.; Correia, M.A.
Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes
J. Biol. Chem.
290
3308-3332
2015
Homo sapiens (P62253)
Fiesel, F.; Moussaud-Lamodiere, E.; Ando, M.; Springer, W.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently
J. Cell Sci.
127
3488-3504
2014
Homo sapiens
Wang, D.; Tian, Y.; Wei, D.; Jing, Y.; Niu, H.; Xie, K.; Song, Y.
DNA Damage-induced foci of E2 ubiquitin-conjugating enzyme are detectable upon co-transfection with an interacting E3 ubiquitin ligase
Biochem. Genet.
54
147-157
2015
Homo sapiens
Goodman, S.; Petrofes Chapa, R.; Zimmer, W.
Spectrin's chimeric E2/E3 enzymatic activity
Exp. Biol. Med.
240
1039-1049
2015
Homo sapiens
Chakrabarti, K.S.; Li, J.; Das, R.; Byrd, R.A.
Conformational dynamics and allostery in E2 E3 interactions drive ubiquitination gp78 and Ube2g2
Structure
25
794-805
2017
Homo sapiens (P60604)
Hewitt, W.M.; Lountos, G.T.; Zlotkowski, K.; Dahlhauser, S.D.; Saunders, L.B.; Needle, D.; Tropea, J.E.; Zhan, C.; Wei, G.; Ma, B.; Nussinov, R.; Waugh, D.S.; Schneekloth, J.S.
Insights into the allosteric inhibition of the SUMO E2 enzyme Ubc9
Angew. Chem. Int. Ed. Engl.
55
5703-5707
2016
Homo sapiens (P63279)
Tan, J.M.E.; Cook, E.C.L.; van den Berg, M.; Scheij, S.; Zelcer, N.; Loregger, A.
Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis
Atherosclerosis
281
137-142
2019
Homo sapiens (P60604), Homo sapiens (Q8N2K1), Homo sapiens (Q9Y385), Homo sapiens
Wang, D.; Tian, Y.; Wei, D.; Jing, Y.; Niu, H.; Xie, K.; Song, Y.
DNA damage-induced foci of E2 ubiquitin-conjugating enzyme are detectable upon co-transfection with an interacting E3 ubiquitin ligase
Biochem. Genet.
54
147-157
2016
Homo sapiens (P49459), Homo sapiens (P63146)
Alpi, A.F.; Chaugule, V.; Walden, H.
Mechanism and disease association of E2-conjugating enzymes lessons from UBE2T and UBE2L3
Biochem. J.
473
3401-3419
2016
Homo sapiens (P68036), Homo sapiens (Q9NPD8)
Hsu, S.H.; Chen, S.H.; Kuo, C.C.; Chang, J.Y.
Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O6-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells
Biochem. Pharmacol.
158
327-338
2018
Homo sapiens (P63146), Homo sapiens
Stewart, M.D.; Ritterhoff, T.; Klevit, R.E.; Brzovic, P.S.
E2 enzymes more than just middle men
Cell Res.
26
423-440
2016
Homo sapiens (A1L167), Homo sapiens (O00762), Homo sapiens (O14933), Homo sapiens (P49427), Homo sapiens (P49459), Homo sapiens (P51668), Homo sapiens (P51965), Homo sapiens (P60604), Homo sapiens (P61077), Homo sapiens (P61086), Homo sapiens (P61088), Homo sapiens (P62253), Homo sapiens (P62256), Homo sapiens (P62837), Homo sapiens (P63146), Homo sapiens (P68036), Homo sapiens (Q13404), Homo sapiens (Q15819), Homo sapiens (Q16763), Homo sapiens (Q5JXB2), Homo sapiens (Q5VVX9), Homo sapiens (Q712K3), Homo sapiens (Q7Z7E8), Homo sapiens (Q8N2K1), Homo sapiens (Q8WVN8), Homo sapiens (Q969T4), Homo sapiens (Q96LR5), Homo sapiens (Q9H832), Homo sapiens (Q9NPD8), Homo sapiens (Q9Y385)
Mizushima, N.
The ubiquitin E2 enzyme UBE2QL1 mediates lysophagy
EMBO Rep.
20
e49104
2019
Homo sapiens (A1L167)
Schelpe, J.; Monte, D.; Dewitte, F.; Sixma, T.; Rucktooa, P.
Structure of UBE2Z enzyme provides functional insight into specificity in the FAT10 protein conjugation machinery
J. Biol. Chem.
291
630-639
2016
Homo sapiens (Q9H832)
Lei, L.; Bandola-Simon, J.; Roche, P.A.
Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I
J. Biol. Chem.
293
3904-3912
2018
Homo sapiens (P51668)
van de Weijer, M.L.; Schuren, A.B.C.; van den Boomen, D.J.H.; Mulder, A.; Claas, F.H.J.; Lehner, P.J.; Lebbink, R.J.; Wiertz, E.J.H.J.
Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation
J. Cell Sci.
130
2883-2892
2017
Homo sapiens (P60604), Homo sapiens (P61077), Homo sapiens (Q8N2K1), Homo sapiens
Morreale, F.E.; Bortoluzzi, A.; Chaugule, V.K.; Arkinson, C.; Walden, H.; Ciulli, A.
Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening
J. Med. Chem.
60
4093-4098
2017
Homo sapiens (Q9NPD8)
Hill, S.; Harrison, J.S.; Lewis, S.M.; Kuhlman, B.; Kleiger, G.
Mechanism of lysine 48 selectivity during polyubiquitin chain formation by the Ube2R1/2 ubiquitin-conjugating enzyme
Mol. Cell. Biol.
36
1720-1732
2016
Homo sapiens (P49427), Homo sapiens (Q712K3)
Williams, K.M.; Qie, S.; Atkison, J.H.; Salazar-Arango, S.; Alan Diehl, J.; Olsen, S.K.
Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
Nat. Commun.
10
3296
2019
Saccharomyces cerevisiae (P14682), Homo sapiens (P49427), Saccharomyces cerevisiae ATCC 204508 (P14682)
Rout, M.K.; Lee, B.L.; Lin, A.; Xiao, W.; Spyracopoulos, L.
Active site gate dynamics modulate the catalytic activity of the ubiquitination enzyme E2-25K
Sci. Rep.
8
7002
2018
Homo sapiens (P61086)
