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2,3-diphospho-D-glycerate
-
1 mM, 83% and 91% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
2-oxoglutarate
-
5 mM, 80% of initial activity
2-phospho-DL-glycerate
-
1 mM, 93% and 81% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
3-phospho-D-glycerate
-
1 mM, 53% and 65% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
Ag+
-
0.1 mM, complete inhibition
alpha-D-fructose 1,6-diphosphate
-
0.1 mM, 28% and 74% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
Cl-
-
100 mM, 50% inhibition of D-glycerate oxidation
CTP
-
1 mM, 73% and 71% inhibition of liver and spinal cord enzyme respectively
glycolate
-
5 mM, 15% of NADPH linked reduction
glyoxylate
-
10 mM, 55% inhibition of NADH linked hydroxypyruvate reduction, 15% of NADPH linked reduction, 80% of NAD+ linked glycerate oxidation
GTP
-
1 mM, 94% and 93% inhibition of liver and spinal cord enzyme respectively
Hg2+
-
0.1 mM, complete inhibition
NaNO3
-
80 mM, 50% inhibition
NO3-
-
100 mM, 87% inhibition of D-glycerate oxidation
oxaloacetate
-
2.5 mM, 10% inhibition of NADH linked hydroxypyruvate reduction, 20% of NADPH linked reduction
p-chloromercuribenzoate
-
0.1 mM, complete inhibition
SO42-
-
100 mM, 55% inhibition of D-glycerate oxidation
Sodium bisulfite
-
0.01 mM, 16% inhibition, 0.1 mM, 67% inhibition
UTP
-
1 mM, 83% and 84% inhibition of liver and spinal cord enzyme respectively
additional information
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not inhibited by 2 mM acetohydroxamate
-
acetyl-CoA
5 mM, 58% of initial activity
acetyl-CoA
-
5 mM, 58% of initial activity
ADP
5 mM, 94% of initial activity
ADP
-
5 mM, 78% of initial activity
ATP
-
1 mM, 62% and 64% inhibition of liver and spinal cord enzyme respectively, 73% and 89% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
ATP
5 mM, 78% of initial activity
ATP
-
5 mM, 57% of initial activity
bromide
-
100 mM, 70% inhibition of D-glycerate oxidation
bromide
-
33 mM, 38% inhibition
citrate
-
5 mM, 20% inhibition of NADH linked hydroxypyruvate reduction, 25% of NADPH linked reduction
citrate
-
competitive vs. hydroxypyruvate
D-glycerate
-
the enzyme shows product inhibition
D-glycerate
-
5 mM, 20% inhibition of NADH linked hydroxypyruvate reduction, 40% of NADPH linked reduction
glucose 6-phosphate
5 mM, 49% of initial activity
glucose 6-phosphate
-
5 mM, 91% of initial activity
Hydroxypyruvate
-
substrate inhibition at high concentrations
Hydroxypyruvate
-
2 mM, 79% inhibition of enzyme activity in LaPr 88/29 mutant which lacks NADH-prefering hydroxypyruvate reductase
Hydroxypyruvate
-
0.5 mM, 90% of NAD+ linked glycerate oxidation
Iodide
-
100 mM, 90% inhibition of D-glycerate oxidation
Iodide
-
33 mM, 39% inhibition
NAD+
1 mM, substrate NADH, 92% of initial activity; 1 mM, substrate NADPH, 54% of initial activity
NAD+
-
4 mM, 10% inhibition of NADH linked hydroxypyruvate reduction, 60% of NADPH linked reduction
NAD+
-
1 mM, substrate NADH, 86% of initial activity; 1 mM, substrate NADPH, 72% of initial activity
NAD+
-
1 mM, substrate NADPH, 64% of initial activity
NADP+
-
4 mM, 15% inhibition of NADH linked hydroxypyruvate reduction, 40% of NADPH linked reduction, 8% of NAD+ linked glycerate oxidation
NADP+
-
1 mM, substrate NADH, 81% of initial activity; 1 mM, substrate NADPH, 87% of initial activity
oxalate
strong inhibition of HPR2
oxalate
strong inhibition
oxalate
strong inhibition
oxalate
-
2 mM, 90% inhibition
phosphate
5 mM, 67% of initial activity
phosphate
-
5 mM, 67% of initial activity
phosphoenolpyruvate
5 mM, 41% of initial activity
phosphoenolpyruvate
-
5 mM, 41% of initial activity
phosphoenolpyruvate
-
5 mM, 41% of initial activity
phosphohydroxypyruvate
-
0.025 mM, 66% and 64% inhibition of liver and spinal cord enzyme respectively
phosphohydroxypyruvate
-
2 mM, 44-71% inhibition
pyruvate
-
1 mM, 73% and 89% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
pyruvate
5 mM, 78% of initial activity
pyruvate
-
10 mM, 40% inhibition of NADH linked hydroxypyruvate reduction
pyruvate
-
5 mM, 67% of initial activity
pyruvate
-
5 mM, 78% of initial activity
ribulose 5-phosphate
5 mM, 47% of initial activity
ribulose 5-phosphate
-
5 mM, 47% of initial activity
Tartronate
-
2 mM, 83% inhibition of enzyme activity in LaPr 88/29 mutant which lacks NADH-prefering hydroxypyruvate reductase
Tartronate
-
2 mM, 30-55% inhibition