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Literature summary for 1.1.1.81 extracted from
- Comparison of D-glycerate dehydrogenases from beef liver, beef spinal cord and hog spinal cord (1975), Arch. Biochem. Biophys., 166, 417-425.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | 1 mM, 62% and 64% inhibition of liver and spinal cord enzyme respectively, 73% and 89% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively | Bos taurus |  |
| CTP | 1 mM, 73% and 71% inhibition of liver and spinal cord enzyme respectively | Bos taurus | |
| GTP | 1 mM, 94% and 93% inhibition of liver and spinal cord enzyme respectively | Bos taurus | |
| phosphohydroxypyruvate | 0.025 mM, 66% and 64% inhibition of liver and spinal cord enzyme respectively | Bos taurus | |
| UTP | 1 mM, 83% and 84% inhibition of liver and spinal cord enzyme respectively | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
NADPH | - |
Bos taurus | |
| 0.1 | - |
Hydroxypyruvate | - |
Bos taurus | |
| 0.112 | - |
NADH | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hydroxypyruvate + NAD(P)H | Sus scrofa | - |
D-glycerate + NAD(P)+ + H+ | - |
? | |
| hydroxypyruvate + NAD(P)H | Bos taurus | - |
D-glycerate + NAD(P)+ + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
| spinal cord | - |
Sus scrofa | - |
| spinal cord | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 104.8 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxypyruvate + NADH + H+ | - |
Bos taurus | D-glycerate + NAD+ | - |
r | |
| hydroxypyruvate + NAD(P)H | - |
Sus scrofa | D-glycerate + NAD(P)+ + H+ | - |
? | |
| hydroxypyruvate + NAD(P)H | - |
Bos taurus | D-glycerate + NAD(P)+ + H+ | - |
? | |
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Release 2023.1 (January 2023)
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