Sequence of ERYG_SACEN
EC Number:2.1.1.254
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
erythromycin 3''-O-methyltransferase
A4F7P5
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
306
33990
Reaction
S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A
Other sequences found for EC No. 2.1.1.254
General information:
Sequence
0 MSVKQKSALQ DLVDFAKWHV WTRVRPSSRA RLAYELFADD HEATTEGAYI NLGYWKPGCA
60 GLEEANQELA NQLAEAAGIS EGDEVLDVGF GLGAQDFFWL ETRKPARIVG VDLTPSHVRI
120 ASERAERENV QDRLQFKEGS ATDLPFGAET FDRVTSLESA LHYEPRTDFF KGAFEVLKPG
180 GVLAIGDIIP LDLREPGSDG PPKLAPQRSG SLSGGIPVEN WVPRETYAKQ LREAGFVDVE
240 VKSVRDNVME PWLDYWLRKL QDESFKKSVS RLFYSQVKRS LTSDSGMKGE LPALDFVIAS
300 ARKPGA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
158991
Haydock S.F.,Dowson J.A.,Dhillon N.,Roberts G.A.,Cortes J.,Leadlay P.F.
Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases.
Mol. Gen. Genet.
230
120-128
1991
158992
Oliynyk M.,Samborskyy M.,Lester J.B.,Mironenko T.,Scott N.,Dickens S.,Haydock S.F.,Leadlay P.F.
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.
Nat. Biotechnol.
25
447-453
2007
158993
Weber J.M.,Leung J.O.,Swanson S.J.,Idler K.B.,McAlpine J.B.
An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.
Science
252
114-117
1991
158994
Paulus T.J.,Tuan J.S.,Luebke V.E.,Maine G.T.,DeWitt J.P.,Katz L.
Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli.
J. Bacteriol.
172
2541-2546
1990
158995
Summers R.G.,Donadio S.,Staver M.J.,Wendt-Pienkowski E.,Hutchinson C.R.,Katz L.
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
Microbiology
143
3251-3262
1997
