Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine:erythromycin C 3''-O-methyltransferase
The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154, erythromycin 12 hydroxylase.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
the enzyme catalyzes all of the 3''-O-methylation reactions of the erythromycin biosynthetic pathway in Saccharopolyspora erythraea
malfunction
disruption of the transcription unit, herein designated eryG, by insertion of an integrational plasmid vector, causes a block at the terminal step in the biosynthesis of erythromycin, the conversion of erythromycin C to A by 0-methylation
malfunction
eryG mutant strain lacks detectable erythromycin O-methyltransferase activity with erythromycin C, erythromycin D, or the analogs 2-norerythromycin C and 2-norerythromycin D as substrates
malfunction
the eryG mutation affects the conversion of L-mycarose to L-cladinose
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Chen, Y.; Deng, W.; Wu, J.; Qian, J.; Chu, J.; Zhuang, Y.; Zhang, S.; Liu, W.
Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation
Appl. Environ. Microbiol.
74
1820-1828
2008
Saccharopolyspora erythraea (A4F7P5)
brenda
Weber, J.M.; Schoner, B.; Losick, R.
Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus)
Gene
75
235-241
1989
Saccharopolyspora erythraea (A4F7P5)
brenda
Paulus, T.J.; Tuan, J.S.; Luebke, V.E.; Maine, G.T.; DeWitt, J.P.; Katz, L.
Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli
J. Bacteriol.
172
2541-2546
1990
Saccharopolyspora erythraea (A4F7P5)
brenda
Reeves, A.R.; English, R.S.; Lampel, J.S.; Post, D.A.; Vanden Boom, T.J.
Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea
J. Bacteriol.
181
7098-7106
1999
Saccharopolyspora erythraea (A4F7P5)
brenda
Summers, R.G.; Donadio, S.; Staver, M.J.; Wendt-Pienkowski, E.; Hutchinson, C.R., Katz, L.
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production
Microbiology
143
3251-3262
1997
Saccharopolyspora erythraea (A4F7P5)
brenda
Haydock, S.F.; Dowson, J.A.; Dhillon, N.; Roberts, G.A.; Cortes, J.; Leadlay, P.F.
Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases
Mol. Gen. Genet.
230
120-128
1991
Saccharopolyspora erythraea (A4F7P5)
brenda
show
top
