Sequence of TGFR2_HUMAN
EC Number:2.7.11.30
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Other sequences found for EC No. 2.7.11.30
General information:
Sequence
0 MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST
60 CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK
120 CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPDL LLVIFQVTGI SLLPPLGVAI
180 SVIIIFYCYR VNRQQKLSST WETGKTRKLM EFSEHCAIIL EDDRSDISST CANNINHNTE
240 LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK
300 HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH
360 LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG
420 TARYMAPEVL ESRMNLENVE SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE
480 HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE
540 LEHLDRLSGR SCSEEKIPED GSLNTTK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
745415
Lin H.Y.,Wang X.-F.,Ng-Eaton E.,Weinberg R.A.,Lodish H.F.
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
Cell
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775-785
1992
745417
Nikawa J.
A cDNA encoding the human transforming growth factor beta receptor suppresses the growth defect of a yeast mutant.
Gene
149
367-372
1994
745418
Takenoshita S.,Hagiwara K.,Nagashima M.,Gemma A.,Bennett W.P.,Harris C.C.
The genomic structure of the gene encoding the human transforming growth factor beta type II receptor (TGF-beta RII).
Genomics
36
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1996
745419
Lu S.-L.,Zhang W.C.,Akiyama Y.,Nomizu T.,Yuasa Y.
Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers.
Cancer Res.
56
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1996
745420
Ogasa H.,Noma T.,Murata H.,Kawai S.,Nakazawa A.
Cloning of a cDNA encoding the human transforming growth factor-beta type II receptor: heterogeneity of the mRNA.
Gene
181
185-190
1996
745421
Bertolio M.S.,La Colla A.,Carrea A.,Romo A.,Canziani G.,Echarte S.M.,Campisano S.,Barletta G.P.,Monzon A.M.,Rodriguez T.M.,Chisari A.N.,Dewey R.A.
A Novel Splice Variant of Human TGF-beta Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo.
Front. Cell Dev. Biol.
9
690397-690397
2021
745423
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
745425
Zhang Z.,Henzel W.J.
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Protein Sci.
13
2819-2824
2004
745426
Wieser R.,Wrana J.L.,Massague J.
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.
EMBO J.
14
2199-2208
1995
745427
Reddy K.B.,Karode M.C.,Harmony A.K.,Howe P.H.
Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin.
Biochemistry
35
309-314
1996
745428
Hirai R.,Fijita T.
A human transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain.
Exp. Cell Res.
223
135-141
1996
745429
Tsukazaki T.,Chiang T.A.,Davison A.F.,Attisano L.,Wrana J.L.
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.
Cell
95
779-791
1998
745430
Gilboa L.,Wells R.G.,Lodish H.F.,Henis Y.I.
Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane.
J. Cell Biol.
140
767-777
1998
745431
Perlman R.,Schiemann W.P.,Brooks M.W.,Lodish H.F.,Weinberg R.A.
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
Nat. Cell Biol.
3
708-714
2001
745432
Felici A.,Wurthner J.U.,Parks W.T.,Giam L.R.,Reiss M.,Karpova T.S.,McNally J.G.,Roberts A.B.
TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.
EMBO J.
22
4465-4477
2003
745433
Meng Q.-J.,Lux A.,Holloschi A.,Li J.,Hughes J.M.X.,Foerg T.,McCarthy J.E.G.,Heagerty A.M.,Kioschis P.,Hafner M.,Garland J.M.
Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors.
J. Biol. Chem.
281
37069-37080
2006
745434
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
745435
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
745436
Wu Y.Y.,Peck K.,Chang Y.L.,Pan S.H.,Cheng Y.F.,Lin J.C.,Yang R.B.,Hong T.M.,Yang P.C.
SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer.
Oncogene
30
3682-3693
2011
745437
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
745438
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
745439
Hwangbo C.,Tae N.,Lee S.,Kim O.,Park O.K.,Kim J.,Kwon S.H.,Lee J.H.
Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.
Oncogene
35
389-401
2016
745440
Hart P.J.,Deep S.,Taylor A.B.,Shu Z.,Hinck C.S.,Hinck A.P.
Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.
Nat. Struct. Biol.
9
203-208
2002
745441
Boesen C.C.,Radaev S.,Motyka S.A.,Patamawenu A.,Sun P.D.
The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain.
Structure
10
913-919
2002
745442
Deep S.,Walker K.P. III,Shu Z.,Hinck A.P.
Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain.
Biochemistry
42
10126-10139
2003
745443
Groppe J.,Hinck C.S.,Samavarchi-Tehrani P.,Zubieta C.,Schuermann J.P.,Taylor A.B.,Schwarz P.M.,Wrana J.L.,Hinck A.P.
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
Mol. Cell
29
157-168
2008
745444
Radaev S.,Zou Z.,Huang T.,Lafer E.M.,Hinck A.P.,Sun P.D.
Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.
J. Biol. Chem.
285
14806-14814
2010
745445
Lu S.-L.,Kawabata M.,Imamura T.,Akiyama Y.,Nomizu T.,Miyazono K.,Yuasa Y.
HNPCC associated with germline mutation in the TGF-beta type II receptor gene.
Nat. Genet.
19
17-18
1998
745446
Tanaka S.,Mori M.,Mafune K.,Ohno S.,Sugimachi K.
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
Br. J. Cancer
82
1557-1560
2000
745447
Luecke C.D.,Philpott A.,Metcalfe J.C.,Thompson A.M.,Hughes-Davies L.,Kemp P.R.,Hesketh R.
Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer.
Cancer Res.
61
482-485
2001
745448
Watanabe Y.,Kinoshita A.,Yamada T.,Ohta T.,Kishino T.,Matsumoto N.,Ishikawa M.,Niikawa N.,Yoshiura K.
A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway.
J. Hum. Genet.
47
478-483
2002
745449
Mizuguchi T.,Collod-Beroud G.,Akiyama T.,Abifadel M.,Harada N.,Morisaki T.,Allard D.,Varret M.,Claustres M.,Morisaki H.,Ihara M.,Kinoshita A.,Yoshiura K.,Junien C.,Kajii T.,Jondeau G.,Ohta T.,Kishino T.,Furukawa Y.,Nakamura Y.,Niikawa N.,Boileau C.,Matsumoto N.
Heterozygous TGFBR2 mutations in Marfan syndrome.
Nat. Genet.
36
855-860
2004
745450
Pannu H.,Fadulu V.T.,Chang J.,Lafont A.,Hasham S.N.,Sparks E.,Giampietro P.F.,Zaleski C.,Estrera A.L.,Safi H.J.,Shete S.,Willing M.C.,Raman C.S.,Milewicz D.M.
Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections.
Circulation
112
513-520
2005
745451
Loeys B.L.,Chen J.,Neptune E.R.,Judge D.P.,Podowski M.,Holm T.,Meyers J.,Leitch C.C.,Katsanis N.,Sharifi N.,Xu F.L.,Myers L.A.,Spevak P.J.,Cameron D.E.,De Backer J.F.,Hellemans J.,Chen Y.,Davis E.C.,Webb C.L.,Kress W.,Coucke P.J.,Rifkin D.B.,De Paepe A.M.,Dietz H.C.
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.
Nat. Genet.
37
275-281
2005
745452
Disabella E.,Grasso M.,Marziliano N.,Ansaldi S.,Lucchelli C.,Porcu E.,Tagliani M.,Pilotto A.,Diegoli M.,Lanzarini L.,Malattia C.,Pelliccia A.,Ficcadenti A.,Gabrielli O.,Arbustini E.
Two novel and one known mutation of the TGFBR2 gene in Marfan syndrome not associated with FBN1 gene defects.
Eur. J. Hum. Genet.
14
34-38
2006
745453
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006
745454
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
745455
Chung B.H.,Lam S.T.,Tong T.M.,Li S.Y.,Lun K.S.,Chan D.H.,Fok S.F.,Or J.S.,Smith D.K.,Yang W.,Lau Y.L.
Identification of novel FBN1 and TGFBR2 mutations in 65 probands with Marfan syndrome or Marfan-like phenotypes.
Am. J. Med. Genet. A
149A
1452-1459
2009
745456
Drera B.,Ritelli M.,Zoppi N.,Wischmeijer A.,Gnoli M.,Fattori R.,Calzavara-Pinton P.G.,Barlati S.,Colombi M.
Loeys-Dietz syndrome type I and type II: clinical findings and novel mutations in two Italian patients.
Orphanet J. Rare Dis.
4
24-24
2009
745457
Muramatsu Y.,Kosho T.,Magota M.,Yokotsuka T.,Ito M.,Yasuda A.,Kito O.,Suzuki C.,Nagata Y.,Kawai S.,Ikoma M.,Hatano T.,Nakayama M.,Kawamura R.,Wakui K.,Morisaki H.,Morisaki T.,Fukushima Y.
Progressive aortic root and pulmonary artery aneurysms in a neonate with Loeys-Dietz syndrome type 1B.
Am. J. Med. Genet. A
152
417-421
2010
745458
Kirmani S.,Tebben P.J.,Lteif A.N.,Gordon D.,Clarke B.L.,Hefferan T.E.,Yaszemski M.J.,McGrann P.S.,Lindor N.M.,Ellison J.W.
Germline TGF-beta receptor mutations and skeletal fragility: a report on two patients with Loeys-Dietz syndrome.
Am. J. Med. Genet. A
152
1016-1019
2010
745459
Yang J.H.,Ki C.S.,Han H.,Song B.G.,Jang S.Y.,Chung T.Y.,Sung K.,Lee H.J.,Kim D.K.
Clinical features and genetic analysis of Korean patients with Loeys-Dietz syndrome.
J. Hum. Genet.
57
52-56
2012
745460
Ha J.S.,Kim Y.H.
A sporadic case of Loeys-Dietz syndrome type I with two novel mutations of the TGFBR2 gene.
Korean J. Pediatr.
54
272-275
2011
