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Information on EC - receptor protein serine/threonine kinase

for references in articles please use BRENDA:EC2.7.11.30
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IUBMB Comments
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
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The enzyme appears in viruses and cellular organisms
activin receptor-like kinase 1, activin receptor-like kinase 1 gene, activin receptor-like kinase 2, activin receptor-like kinase 5, activin receptor-like kinase 6, activin receptor-like kinase 7, activin receptor-like kinase-5, activin receptor-like kinase-7, activin receptor-like-kinase 1, activin-like kinase receptor 1, more
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
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