Sequence of CP2R1_HUMAN
EC Number:1.14.14.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
calciol + O2 + [reduced NADPH-hemoprotein reductase] = calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.24
General information:
Sequence
show sequence in normal format
>Q6VVX0|vitamin D 25-hydroxylase|EC 1.14.14.24|Homo sapiens|Swiss-Prot
MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE
LPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTK
MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK
QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF
GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL
IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY
TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF
HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD
LKPRLGMTLQPQPYLICAERR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
529698
Cheng J.B.,Motola D.L.,Mangelsdorf D.J.,Russell D.W.
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxylase.
J. Biol. Chem.
278
38084-38093
2003
529699
Shinkyo R.,Sakaki T.,Kamakura M.,Ohta M.,Inouye K.
Metabolism of vitamin D by human microsomal CYP2R1.
Biochem. Biophys. Res. Commun.
324
451-457
2004
529700
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
529702
Strushkevich N.,Usanov S.A.,Plotnikov A.N.,Jones G.,Park H.-W.
Structural analysis of CYP2R1 in complex with vitamin D3.
J. Mol. Biol.
380
95-106
2008
529704
Cheng J.B.,Levine M.A.,Bell N.H.,Mangelsdorf D.J.,Russell D.W.
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Proc. Natl. Acad. Sci. U.S.A.
101
7711-7715
2004
529705
Thacher T.D.,Fischer P.R.,Singh R.J.,Roizen J.,Levine M.A.
CYP2R1 mutations impair generation of 25-hydroxyvitamin D and cause an atypical form of vitamin D deficiency.
J. Clin. Endocrinol. Metab.
100
0-1013
2015