Sequence of CP2R1_HUMAN
EC Number:1.14.14.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
calciol + O2 + [reduced NADPH-hemoprotein reductase] = calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.24
General information:
Sequence
0 MWKLWRAEEG AAALGGALFL LLFALGVRQL LKQRRPMGFP PGPPGLPFIG NIYSLAASSE
60 LPHVYMRKQS QVYGEIFSLD LGGISTVVLN GYDVVKECLV HQSEIFADRP CLPLFMKMTK
120 MGGLLNSRYG RGWVDHRRLA VNSFRYFGYG QKSFESKILE ETKFFNDAIE TYKGRPFDFK
180 QLITNAVSNI TNLIIFGERF TYEDTDFQHM IELFSENVEL AASASVFLYN AFPWIGILPF
240 GKHQQLFRNA AVVYDFLSRL IEKASVNRKP QLPQHFVDAY LDEMDQGKND PSSTFSKENL
300 IFSVGELIIA GTETTTNVLR WAILFMALYP NIQGQVQKEI DLIMGPNGKP SWDDKCKMPY
360 TEAVLHEVLR FCNIVPLGIF HATSEDAVVR GYSIPKGTTV ITNLYSVHFD EKYWRDPEVF
420 HPERFLDSSG YFAKKEALVP FSLGRRHCLG EHLARMEMFL FFTALLQRFH LHFPHELVPD
480 LKPRLGMTLQ PQPYLICAER R
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
529698
Cheng J.B.,Motola D.L.,Mangelsdorf D.J.,Russell D.W.
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxylase.
J. Biol. Chem.
278
38084-38093
2003
529699
Shinkyo R.,Sakaki T.,Kamakura M.,Ohta M.,Inouye K.
Metabolism of vitamin D by human microsomal CYP2R1.
Biochem. Biophys. Res. Commun.
324
451-457
2004
529700
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
529702
Strushkevich N.,Usanov S.A.,Plotnikov A.N.,Jones G.,Park H.-W.
Structural analysis of CYP2R1 in complex with vitamin D3.
J. Mol. Biol.
380
95-106
2008
529704
Cheng J.B.,Levine M.A.,Bell N.H.,Mangelsdorf D.J.,Russell D.W.
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Proc. Natl. Acad. Sci. U.S.A.
101
7711-7715
2004
529705
Thacher T.D.,Fischer P.R.,Singh R.J.,Roizen J.,Levine M.A.
CYP2R1 mutations impair generation of 25-hydroxyvitamin D and cause an atypical form of vitamin D deficiency.
J. Clin. Endocrinol. Metab.
100
0-1013
2015
