Sequence of IKKB_MOUSE
EC Number:2.7.11.10
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
Other sequences found for EC No. 2.7.11.10
General information:
Sequence
0 MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL SPKNRNRWCL
60 EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG
120 AVLTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT
180 SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE
240 VDIVVSEDLN GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF
300 RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QENTGILETD QELLQKAGLV
360 LLPDKPATQC ISDSKTNEGL TLDMDLVFLL DNSKINYETQ ITPRPPPESV SCILQEPKRN
420 LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMSLLR NNSCLSKMKN AMASTAQQLK
480 AKLDFFKTSI QIDLEKYKEQ TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL
540 QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRKLREKPRD QRTEGDSQEM VRLLLQAIQS
600 FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR QKELWNLLKI
660 ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE SDKKSEELVA EAHALCSRLE
720 SALQDTVKEQ DRSFTTLDWS WLQMEDEERC SLEQACD
Download this sequence
in fasta formatDownload all sequences for 2.7.11.10
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
47217
Nakano H.,Shindo M.,Sakon S.,Nishinaka S.,Mihara M.,Yagita H.,Okumura K.
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.
Proc. Natl. Acad. Sci. U.S.A.
95
3537-3542
1998
47219
Tanaka M.,Fuentes M.E.,Yamaguchi K.,Durnin M.H.,Dalrymple S.A.,Hardy K.L.,Goeddel D.V.
Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice.
Immunity
10
421-429
1999
47220
Hu M.C.-T.,Wang Y.-P.,Qiu W.R.,Mikhail A.,Meyer C.F.,Tan T.-H.
Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkappaB kinases (IKK-alpha/beta) and IKK-beta is a developmentally regulated protein kinase.
Oncogene
18
5514-5524
1999
47221
Nemoto S.,DiDonato J.A.,Lin A.
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
Mol. Cell. Biol.
18
7336-7343
1998
47222
Li Q.,Van Antwerp D.,Mercurio F.,Lee K.F.,Verma I.M.
Severe liver degeneration in mice lacking the IkappaB kinase 2 gene.
Science
284
321-325
1999
47223
Jobin C.,Sartor R.B.
The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.
Am. J. Physiol.
278
0-0
2000
47224
Bonnet M.C.,Weil R.,Dam E.,Hovanessian A.G.,Meurs E.F.
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.
Mol. Cell. Biol.
20
4532-4542
2000
47225
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
47226
Teo H.,Ghosh S.,Luesch H.,Ghosh A.,Wong E.T.,Malik N.,Orth A.,de Jesus P.,Perry A.S.,Oliver J.D.,Tran N.L.,Speiser L.J.,Wong M.,Saez E.,Schultz P.,Chanda S.K.,Verma I.M.,Tergaonkar V.
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.
Nat. Cell Biol.
12
758-767
2010
47227
Iwasaki H.,Takeuchi O.,Teraguchi S.,Matsushita K.,Uehata T.,Kuniyoshi K.,Satoh T.,Saitoh T.,Matsushita M.,Standley D.M.,Akira S.
The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.
Nat. Immunol.
12
1167-1175
2011
47228
del Vescovo C.D.,Cotecchia S.,Diviani D.
A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy.
Mol. Cell. Biol.
33
14-27
2013
47229
Ren J.,Chen X.,Chen Z.J.
IKKbeta is an IRF5 kinase that instigates inflammation.
Proc. Natl. Acad. Sci. U.S.A.
111
17438-17443
2014
47230
Dondelinger Y.,Delanghe T.,Priem D.,Wynosky-Dolfi M.A.,Sorobetea D.,Rojas-Rivera D.,Giansanti P.,Roelandt R.,Gropengiesser J.,Ruckdeschel K.,Savvides S.N.,Heck A.J.R.,Vandenabeele P.,Brodsky I.E.,Bertrand M.J.M.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
Nat. Commun.
10
1729-1729
2019
