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Sequence of IKKB_HUMAN

EC Number:2.7.11.10

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
IkappaB kinase
O14920
Homo sapiens
756
86564
Reaction
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
Other sequences found for EC No. 2.7.11.10

General information:

Sequence
show sequence in fasta format
  0 MSWSPSLTTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL SPRNRERWCL
 60 EIQIMRRLTH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRKYLNQ FENCCGLREG
120 AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEQRL IHKIIDLGYA KELDQGSLCT
180 SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE
240 VDIVVSEDLN GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPTYGPNGCF
300 KALDDILNLK LVHILNMVTG TIHTYPVTED ESLQSLKARI QQDTGIPEED QELLQEAGLA
360 LIPDKPATQC ISDGKLNEGH TLDMDLVFLF DNSKITYETQ ISPRPQPESV SCILQEPKRN
420 LAFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN SMASMSQQLK
480 AKLDFFKTSI QIDLEKYSEQ TEFGITSDKL LLAWREMEQA VELCGRENEV KLLVERMMAL
540 QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS
600 FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE KTVVRLQEKR QKELWNLLKI
660 ACSKVRGPVS GSPDSMNASR LSQPGQLMSQ PSTASNSLPE PAKKSEELVA EAHNLCTLLE
720 NAIQDTVREQ DQSFTALDWS WLQTEEEEHS CLEQAS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
47146
Mercurio F.,Zhu H.,Murray B.W.,Shevchenko A.,Bennett B.L.,Li J.W.,Young D.B.,Barbosa M.,Mann M.,Manning A.,Rao A.
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
Science
278
860-866
1997
47147
Woronicz J.D.,Gao X.,Cao Z.,Rothe M.,Goeddel D.V.
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
Science
278
866-869
1997
47148
Hu M.C.-T.,Wang Y.-P.
IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.
Gene
222
31-40
1998
47149
Shindo M.,Nakano H.,Sakon S.,Yagita H.,Mihara M.,Okumura K.
Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization.
Cytogenet. Cell Genet.
82
32-33
1998
47150
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
47152
Nusbaum C.,Mikkelsen T.S.,Zody M.C.,Asakawa S.,Taudien S.,Garber M.,Kodira C.D.,Schueler M.G.,Shimizu A.,Whittaker C.A.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Yang X.,Allen N.R.,Anderson S.,Asakawa T.,Blechschmidt K.,Bloom T.,Borowsky M.L.,Butler J.,Cook A.,Corum B.,DeArellano K.,DeCaprio D.,Dooley K.T.,Dorris L. III,Engels R.,Gloeckner G.,Hafez N.,Hagopian D.S.,Hall J.L.,Ishikawa S.K.,Jaffe D.B.,Kamat A.,Kudoh J.,Lehmann R.,Lokitsang T.,Macdonald P.,Major J.E.,Matthews C.D.,Mauceli E.,Menzel U.,Mihalev A.H.,Minoshima S.,Murayama Y.,Naylor J.W.,Nicol R.,Nguyen C.,O'Leary S.B.,O'Neill K.,Parker S.C.J.,Polley A.,Raymond C.K.,Reichwald K.,Rodriguez J.,Sasaki T.,Schilhabel M.,Siddiqui R.,Smith C.L.,Sneddon T.P.,Talamas J.A.,Tenzin P.,Topham K.,Venkataraman V.,Wen G.,Yamazaki S.,Young S.K.,Zeng Q.,Zimmer A.R.,Rosenthal A.,Birren B.W.,Platzer M.,Shimizu N.,Lander E.S.
DNA sequence and analysis of human chromosome 8.
Nature
439
331-335
2006
47153
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
47154
Mittal R.,Peak-Chew S.Y.,McMahon H.T.
Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.
Proc. Natl. Acad. Sci. U.S.A.
103
18574-18579
2006
47155
Nemoto S.,DiDonato J.A.,Lin A.
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
Mol. Cell. Biol.
18
7336-7343
1998
47156
Cohen L.,Henzel W.J.,Baeuerle P.A.
IKAP is a scaffold protein of the IkappaB kinase complex.
Nature
395
292-296
1998
47157
Sanz L.,Sanchez P.,Lallena M.-J.,Diaz-Meco M.T.,Moscat J.
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
EMBO J.
18
3044-3053
1999
47158
Lallena M.J.,Diaz-Meco M.T.,Bren G.,Paya C.V.,Moscat J.
Activation of IkappaB kinase beta by protein kinase C isoforms.
Mol. Cell. Biol.
19
2180-2188
1999
47159
Delhase M.,Hayakawa M.,Chen Y.,Karin M.
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
Science
284
309-313
1999
47160
Bonnet M.C.,Weil R.,Dam E.,Hovanessian A.G.,Meurs E.F.
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.
Mol. Cell. Biol.
20
4532-4542
2000
47161
Tojima Y.,Fujimoto A.,Delhase M.,Chen Y.,Hatakeyama S.,Nakayama K.,Kaneko Y.,Nimura Y.,Motoyama N.,Ikeda K.,Karin M.,Nakanishi M.
NAK is an IkappaB kinase-activating kinase.
Nature
404
778-782
2000
47162
Salmeron A.,Janzen J.,Soneji Y.,Bump N.,Kamens J.,Allen H.,Ley S.C.
Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis.
J. Biol. Chem.
276
22215-22222
2001
47163
Chariot A.,Leonardi A.,Muller J.,Bonif M.,Brown K.,Siebenlist U.
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
J. Biol. Chem.
277
37029-37036
2002
47164
Wu R.-C.,Qin J.,Hashimoto Y.,Wong J.,Xu J.,Tsai S.Y.,Tsai M.-J.,O'Malley B.W.
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.
Mol. Cell. Biol.
22
3549-3561
2002
47165
Tegethoff S.,Behlke J.,Scheidereit C.
Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.
Mol. Cell. Biol.
23
2029-2041
2003
47166
Hu M.C.,Lee D.F.,Xia W.,Golfman L.S.,Ou-Yang F.,Yang J.Y.,Zou Y.,Bao S.,Hanada N.,Saso H.,Kobayashi R.,Hung M.C.
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
Cell
117
225-237
2004
47167
Han K.J.,Su X.,Xu L.-G.,Bin L.H.,Zhang J.,Shu H.-B.
Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.
J. Biol. Chem.
279
15652-15661
2004
47168
Bruey J.-M.,Bruey-Sedano N.,Newman R.,Chandler S.,Stehlik C.,Reed J.C.
PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.
J. Biol. Chem.
279
51897-51907
2004
47169
Witherow D.S.,Garrison T.R.,Miller W.E.,Lefkowitz R.J.
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
Proc. Natl. Acad. Sci. U.S.A.
101
8603-8607
2004
47170
Reynaert N.L.,Ckless K.,Korn S.H.,Vos N.,Guala A.S.,Wouters E.F.,van der Vliet A.,Janssen-Heininger Y.M.
Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation.
Proc. Natl. Acad. Sci. U.S.A.
101
8945-8950
2004
47171
Hu W.-H.,Pendergast J.S.,Mo X.-M.,Brambilla R.,Bracchi-Ricard V.,Li F.,Walters W.M.,Blits B.,He L.,Schaal S.M.,Bethea J.R.
NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.
J. Biol. Chem.
280
29233-29241
2005
47172
Tanaka H.,Fujita N.,Tsuruo T.
3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.
J. Biol. Chem.
280
40965-40973
2005
47173
Carter R.S.,Pennington K.N.,Arrate P.,Oltz E.M.,Ballard D.W.
Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.
J. Biol. Chem.
280
43272-43279
2005
47174
Meylan E.,Curran J.,Hofmann K.,Moradpour D.,Binder M.,Bartenschlager R.,Tschopp J.
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Nature
437
1167-1172
2005
47175
Cummins E.P.,Berra E.,Comerford K.M.,Ginouves A.,Fitzgerald K.T.,Seeballuck F.,Godson C.,Nielsen J.E.,Moynagh P.,Pouyssegur J.,Taylor C.T.
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
Proc. Natl. Acad. Sci. U.S.A.
103
18154-18159
2006
47176
Mukherjee S.,Keitany G.,Li Y.,Wang Y.,Ball H.L.,Goldsmith E.J.,Orth K.
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.
Science
312
1211-1214
2006
47177
Wu Z.H.,Shi Y.,Tibbetts R.S.,Miyamoto S.
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.
Science
311
1141-1146
2006
47178
Ohnuma K.,Uchiyama M.,Yamochi T.,Nishibashi K.,Hosono O.,Takahashi N.,Kina S.,Tanaka H.,Lin X.,Dang N.H.,Morimoto C.
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
J. Biol. Chem.
282
10117-10131
2007
47179
Park M.Y.,Moon J.H.,Lee K.S.,Choi H.I.,Chung J.,Hong H.J.,Kim E.
FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly.
J. Biol. Chem.
282
27572-27577
2007
47180
Lobry C.,Lopez T.,Israel A.,Weil R.
Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.
Proc. Natl. Acad. Sci. U.S.A.
104
908-913
2007
47181
Jobin C.,Sartor R.B.
The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.
Am. J. Physiol.
278
0-0
2000
47182
Solt L.A.,May M.J.
The IkappaB kinase complex: master regulator of NF-kappaB signaling.
Immunol. Res.
42
3-18
2008
47183
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
47184
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
47185
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
47186
Kuo H.P.,Lee D.F.,Xia W.,Lai C.C.,Li L.Y.,Hung M.C.
Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.
Biochem. Biophys. Res. Commun.
389
156-161
2009
47187
Sun W.,Yu Y.,Dotti G.,Shen T.,Tan X.,Savoldo B.,Pass A.K.,Chu M.,Zhang D.,Lu X.,Fu S.,Lin X.,Yang J.
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
Cell. Signal.
21
95-102
2009
47188
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
47189
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
47190
Cui J.,Zhu L.,Xia X.,Wang H.Y.,Legras X.,Hong J.,Ji J.,Shen P.,Zheng S.,Chen Z.J.,Wang R.F.
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
Cell
141
483-496
2010
47191
Wada K.,Niida M.,Tanaka M.,Kamitani T.
Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling.
J. Biochem.
146
821-832
2009
47192
Yoboua F.,Martel A.,Duval A.,Mukawera E.,Grandvaux N.
Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.
J. Virol.
84
7267-7277
2010
47193
Tsuchiya Y.,Asano T.,Nakayama K.,Kato T. Jr.,Karin M.,Kamata H.
Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.
Mol. Cell
39
570-582
2010
47194
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
47195
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
47196
Clark K.,Peggie M.,Plater L.,Sorcek R.J.,Young E.R.,Madwed J.B.,Hough J.,McIver E.G.,Cohen P.
Novel cross-talk within the IKK family controls innate immunity.
Biochem. J.
434
93-104
2011
47197
Wang W.,Guo M.,Hu L.,Cai J.,Zeng Y.,Luo J.,Shu Z.,Li W.,Huang Z.
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling.
J. Biol. Chem.
287
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2012
47198
Zhou A.Y.,Shen R.R.,Kim E.,Lock Y.J.,Xu M.,Chen Z.J.,Hahn W.C.
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
Cell Rep.
3
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2013
47199
Dauphinee S.M.,Clayton A.,Hussainkhel A.,Yang C.,Park Y.J.,Fuller M.E.,Blonder J.,Veenstra T.D.,Karsan A.
SASH1 is a scaffold molecule in endothelial TLR4 signaling.
J. Immunol.
191
892-901
2013
47200
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
47201
del Vescovo C.D.,Cotecchia S.,Diviani D.
A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy.
Mol. Cell. Biol.
33
14-27
2013
47202
Pannicke U.,Baumann B.,Fuchs S.,Henneke P.,Rensing-Ehl A.,Rizzi M.,Janda A.,Hese K.,Schlesier M.,Holzmann K.,Borte S.,Laux C.,Rump E.M.,Rosenberg A.,Zelinski T.,Schrezenmeier H.,Wirth T.,Ehl S.,Schroeder M.L.,Schwarz K.
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
N. Engl. J. Med.
369
2504-2514
2013
47203
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
47204
Lopez-Pelaez M.,Lamont D.J.,Peggie M.,Shpiro N.,Gray N.S.,Cohen P.
Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
Proc. Natl. Acad. Sci. U.S.A.
111
17432-17437
2014
47205
Zheng C.,Zheng Z.,Zhang Z.,Meng J.,Liu Y.,Ke X.,Hu Q.,Wang H.
IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).
Cell. Signal.
27
2343-2354
2015
47206
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
47207
You D.J.,Park C.R.,Furlong M.,Koo O.,Lee C.,Ahn C.,Seong J.Y.,Hwang J.I.
Dimer of arfaptin 2 regulates NF-kappaB signaling by interacting with IKKbeta/NEMO and inhibiting IKKbeta kinase activity.
Cell. Signal.
27
2173-2181
2015
47208
Romano S.,Xiao Y.,Nakaya M.,D'Angelillo A.,Chang M.,Jin J.,Hausch F.,Masullo M.,Feng X.,Romano M.F.,Sun S.C.
FKBP51 employs both scaffold and isomerase functions to promote NF-kappaB activation in melanoma.
Nucleic Acids Res.
43
6983-6993
2015
47209
Wu C.,Yang Y.,Ou J.,Zhu L.,Zhao W.,Cui J.
LRRC14 attenuates Toll-like receptor-mediated NF-kappa-B signaling through disruption of IKK complex.
Exp. Cell Res.
347
65-73
2016
47210
Tang Q.,Chakraborty S.,Xu G.
Mechanism of vaccinia viral protein B14 mediated inhibition of IkappaB kinase beta activation.
J. Biol. Chem.
293
10344-10352
2018
47211
Cardinez C.,Miraghazadeh B.,Tanita K.,da Silva E.,Hoshino A.,Okada S.,Chand R.,Asano T.,Tsumura M.,Yoshida K.,Ohnishi H.,Kato Z.,Yamazaki M.,Okuno Y.,Miyano S.,Kojima S.,Ogawa S.,Andrews T.D.,Field M.A.,Burgio G.,Morio T.,Vinuesa C.G.,Kanegane H.,Cook M.C.
Gain-of-function IKBKB mutation causes human combined immune deficiency.
J. Exp. Med.
215
2715-2724
2018
47212
DeDiego M.L.,Martinez-Sobrido L.,Topham D.J.
Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses.
J. Virol.
93
0-0
2019
47213
Chathuranga K.,Kim T.H.,Lee H.,Park J.S.,Kim J.H.,Chathuranga W.A.G.,Ekanayaka P.,Choi Y.J.,Lee C.H.,Kim C.J.,Jung J.U.,Lee J.S.
Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
EMBO J.
39
0-0
2020
47214
Rushe M.,Silvian L.,Bixler S.,Chen L.L.,Cheung A.,Bowes S.,Cuervo H.,Berkowitz S.,Zheng T.,Guckian K.,Pellegrini M.,Lugovskoy A.
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.
Structure
16
798-808
2008
47215
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
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