Sequence of IKKA_HUMAN

IkappaB kinase

O15111

745

84640

47074

Regnier C.H.,Song H.Y.,Gao X.,Goeddel D.V.,Cao Z.,Rothe M.

Identification and characterization of an IkappaB kinase.

Cell

90

373-383

1997

47075

DiDonato J.A.,Hayakawa M.,Rothwarf D.M.,Zandi E.,Karin M.

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

Nature

388

548-554

1997

47076

Mercurio F.,Zhu H.,Murray B.W.,Shevchenko A.,Bennett B.L.,Li J.W.,Young D.B.,Barbosa M.,Mann M.,Manning A.,Rao A.

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

Science

278

860-866

1997

47077

Hu M.C.-T.,Wang Y.-P.

IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.

Gene

222

31-40

1998

47079

Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

Nature

429

375-381

2004

47080

Connelly M.A.,Marcu K.B.

CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.

Cell. Mol. Biol. Res.

41

537-549

1995

47081

Mittal R.,Peak-Chew S.Y.,McMahon H.T.

Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.

Proc. Natl. Acad. Sci. U.S.A.

103

18574-18579

2006

47082

Cohen L.,Henzel W.J.,Baeuerle P.A.

IKAP is a scaffold protein of the IkappaB kinase complex.

Nature

395

292-296

1998

47083

Ling L.,Cao Z.,Goeddel D.V.

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.

Proc. Natl. Acad. Sci. U.S.A.

95

3792-3797

1998

47084

Ozes O.N.,Mayo L.D.,Gustin J.A.,Pfeffer S.R.,Pfeffer L.M.,Donner D.B.

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.

Nature

401

82-85

1999

47085

Delhase M.,Hayakawa M.,Chen Y.,Karin M.

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.

Science

284

309-313

1999

47086

Nemoto S.,DiDonato J.A.,Lin A.

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.

Mol. Cell. Biol.

18

7336-7343

1998

47087

Jobin C.,Sartor R.B.

The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.

Am. J. Physiol.

278

0-0

2000

47088

Wu R.-C.,Qin J.,Hashimoto Y.,Wong J.,Xu J.,Tsai S.Y.,Tsai M.-J.,O'Malley B.W.

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.

Mol. Cell. Biol.

22

3549-3561

2002

47089

Tegethoff S.,Behlke J.,Scheidereit C.

Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.

Mol. Cell. Biol.

23

2029-2041

2003

47090

Yamamoto Y.,Verma U.N.,Prajapati S.,Kwak Y.T.,Gaynor R.B.

Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.

Nature

423

655-659

2003

47091

Hu M.C.,Lee D.F.,Xia W.,Golfman L.S.,Ou-Yang F.,Yang J.Y.,Zou Y.,Bao S.,Hanada N.,Saso H.,Kobayashi R.,Hung M.C.

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

Cell

117

225-237

2004

47092

Bruey J.-M.,Bruey-Sedano N.,Newman R.,Chandler S.,Stehlik C.,Reed J.C.

PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

J. Biol. Chem.

279

51897-51907

2004

47093

Witherow D.S.,Garrison T.R.,Miller W.E.,Lefkowitz R.J.

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

Proc. Natl. Acad. Sci. U.S.A.

101

8603-8607

2004

47094

Meylan E.,Curran J.,Hofmann K.,Moradpour D.,Binder M.,Bartenschlager R.,Tschopp J.

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.

Nature

437

1167-1172

2005

47095

Liu B.,Yang Y.,Chernishof V.,Loo R.R.,Jang H.,Tahk S.,Yang R.,Mink S.,Shultz D.,Bellone C.J.,Loo J.A.,Shuai K.

Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.

Cell

129

903-914

2007

47096

Huang W.C.,Ju T.K.,Hung M.C.,Chen C.C.

Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.

Mol. Cell

26

75-87

2007

47097

Solt L.A.,May M.J.

The IkappaB kinase complex: master regulator of NF-kappaB signaling.

Immunol. Res.

42

3-18

2008

47098

Tai D.J.,Su C.C.,Ma Y.L.,Lee E.H.

SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression.

J. Biol. Chem.

284

4073-4089

2009

47099

Li S.,Wang L.,Dorf M.E.

PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.

Mol. Cell

33

30-42

2009

47100

Cui J.,Zhu L.,Xia X.,Wang H.Y.,Legras X.,Hong J.,Ji J.,Shen P.,Zheng S.,Chen Z.J.,Wang R.F.

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.

Cell

141

483-496

2010

47101

Gouin E.,Adib-Conquy M.,Balestrino D.,Nahori M.A.,Villiers V.,Colland F.,Dramsi S.,Dussurget O.,Cossart P.

The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.

Proc. Natl. Acad. Sci. U.S.A.

107

17333-17338

2010

47102

Lahtela J.,Nousiainen H.O.,Stefanovic V.,Tallila J.,Viskari H.,Karikoski R.,Gentile M.,Saloranta C.,Varilo T.,Salonen R.,Kestila M.

Mutant CHUK and severe fetal encasement malformation.

N. Engl. J. Med.

363

1631-1637

2010

47103

Razani B.,Zarnegar B.,Ytterberg A.J.,Shiba T.,Dempsey P.W.,Ware C.F.,Loo J.A.,Cheng G.

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.

Sci. Signal.

3

0-0

2010

47104

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

47105

Shembade N.,Pujari R.,Harhaj N.S.,Abbott D.W.,Harhaj E.W.

The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1.

Nat. Immunol.

12

834-843

2011

47106

Wang W.,Guo M.,Hu L.,Cai J.,Zeng Y.,Luo J.,Shu Z.,Li W.,Huang Z.

The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling.

J. Biol. Chem.

287

42856-42866

2012

47107

Dauphinee S.M.,Clayton A.,Hussainkhel A.,Yang C.,Park Y.J.,Fuller M.E.,Blonder J.,Veenstra T.D.,Karsan A.

SASH1 is a scaffold molecule in endothelial TLR4 signaling.

J. Immunol.

191

892-901

2013

47108

Zheng C.,Zheng Z.,Zhang Z.,Meng J.,Liu Y.,Ke X.,Hu Q.,Wang H.

IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).

Cell. Signal.

27

2343-2354

2015

47109

Wu C.,Yang Y.,Ou J.,Zhu L.,Zhao W.,Cui J.

LRRC14 attenuates Toll-like receptor-mediated NF-kappa-B signaling through disruption of IKK complex.

Exp. Cell Res.

347

65-73

2016

47110

Fullam A.,Gu L.,Hoehn Y.,Schroeder M.

DDX3 directly facilitates IKKalpha activation and regulates downstream signalling pathways.

Biochem. J.

475

3595-3607

2018

47111

Di Rita A.,Peschiaroli A.,D'Acunzo P.,Strobbe D.,Hu Z.,Gruber J.,Nygaard M.,Lambrughi M.,Melino G.,Papaleo E.,Dengjel J.,El Alaoui S.,Campanella M.,Doetsch V.,Rogov V.V.,Strappazzon F.,Cecconi F.

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKalpha.

Nat. Commun.

9

3755-3755

2018

47112

Chathuranga K.,Kim T.H.,Lee H.,Park J.S.,Kim J.H.,Chathuranga W.A.G.,Ekanayaka P.,Choi Y.J.,Lee C.H.,Kim C.J.,Jung J.U.,Lee J.S.

Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.

EMBO J.

39

0-0

2020

47113

Leslie E.J.,O'Sullivan J.,Cunningham M.L.,Singh A.,Goudy S.L.,Ababneh F.,Alsubaie L.,Ch'ng G.S.,van der Laar I.M.,Hoogeboom A.J.,Dunnwald M.,Kapoor S.,Jiramongkolchai P.,Standley J.,Manak J.R.,Murray J.C.,Dixon M.J.

Expanding the genetic and phenotypic spectrum of popliteal pterygium disorders.

Am. J. Med. Genet. A

167A

545-552

2015

47114

Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.

Patterns of somatic mutation in human cancer genomes.

Nature

446

153-158

2007

47115

Rushe M.,Silvian L.,Bixler S.,Chen L.L.,Cheung A.,Bowes S.,Cuervo H.,Berkowitz S.,Zheng T.,Guckian K.,Pellegrini M.,Lugovskoy A.

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.

Structure

16

798-808

2008