EC Number   |
Protein Variants |
Reference |
|---|
    6.3.2.1 | D63G |
mutation increases the mobility of the gate loop in Escherichia coli pantothenate synthetase |
716880 |
| 6.3.2.1 | E132A |
kcat for beta-alanine is 3.7fold higher than wild-type value, kcat for pantoate is 21fold higher than wild-type value |
674714 |
| 6.3.2.1 | E77G |
87% of wild-type activity |
653802 |
| 6.3.2.1 | G74D |
mutation reduces the mobility of the gate loop in Mycobacterium tuberculosis pantothenate synthetase |
716880 |
| 6.3.2.1 | H44A |
greater than 1000fold reduction in enzyme activity |
661144 |
| 6.3.2.1 | H44A |
site-directed mutagenesis, the mutant shows reduced catalytic activity compared to the wild-type enzyme |
-, 746489 |
| 6.3.2.1 | H47A |
greater than 1000fold reduction in enzyme activity |
661144 |
| 6.3.2.1 | H47A |
site-directed mutagenesis, the mutant shows only weak interactions between ATP and enzyme leading to reduced protein catalytic activity compared to wild-type |
-, 746489 |
| 6.3.2.1 | K160A |
greater than 1000fold reduction in enzyme activity |
661144 |
| 6.3.2.1 | K160A |
site-directed mutagenesis, the mutant shows only weak interactions between ATP and enzyme leading to reduced protein catalytic activity compared to wild-type |
746489 |
