EC Number   |
Protein Variants |
Reference |
|---|
   3.4.16.5 | A251E |
the mutant shows increased activity compared to the wild type cathepsin A |
704549 |
| 3.4.16.5 | C341F |
reduced ratio of turnover number to Km-value for the mutant enzyme compared to wild-type enzyme with the substrates benzyloxycarbonyl-Gly-Leu, benzyloxycarbonyl-Phe-Leu, benzyloxycarbonyl-Gly-Phe and benzyloxycarbonyl-Ala-Phe |
647223 |
| 3.4.16.5 | C341G |
reduced ratio of turnover number to Km-value for the mutant enzyme compared to wild-type enzyme with the substrates benzyloxycarbonyl-Gly-Leu, benzyloxycarbonyl-Phe-Leu and benzyloxycarbonyl-Gly-Phe, somewhat increased ratio with benzyloxycarbonyl-Ala-Phe |
647223 |
| 3.4.16.5 | C341S |
reduced ratio of turnover number to Km-value for the mutant enzyme compared to wild-type enzyme with the substrates benzyloxycarbonyl-Gly-Leu, benzyloxycarbonyl-Phe-Leu, benzyloxycarbonyl-Gly-Phe and benzyloxycarbonyl-Ala-Phe |
647223 |
| 3.4.16.5 | C341V |
reduced ratio of turnover number to Km-value for the mutant enzyme compared to wild-type enzyme with the substrates benzyloxycarbonyl-Gly-Leu, benzyloxycarbonyl-Phe-Leu, benzyloxycarbonyl-Gly-Phe and benzyloxycarbonyl-Ala-Phe |
647223 |
| 3.4.16.5 | E355A |
no CPY secretion |
678037 |
| 3.4.16.5 | E355Q |
mutant shows moderate CPY secretion |
678037 |
| 3.4.16.5 | E365A |
mutant shows moderate CPY secretion |
678037 |
| 3.4.16.5 | E369A |
mutant shows moderate CPY secretion |
678037 |
| 3.4.16.5 | E371A |
mutant shows CPY secretion similar to the wild type |
678037 |
