EC Number |
Protein Variants |
Reference |
---|
2.7.1.138 | C324A |
same specific acitity as wild-type CerK |
691127 |
2.7.1.138 | C347A |
by site-directed mutagenesis, mutation severely impairs localization at the Golgi complex resulting in cytosolic accumulation instead |
696440 |
2.7.1.138 | C347A |
lower specific acitity than wild-type CerK |
691127 |
2.7.1.138 | C351A |
by site-directed mutagenesis, mutation severely impairs localization at the Golgi complex resulting in cytosolic accumulation instead |
696440 |
2.7.1.138 | C351A |
lower specific acitity than wild-type CerK |
691127 |
2.7.1.138 | C354A |
by site-directed mutagenesis |
696440 |
2.7.1.138 | C354A |
lower specific acitity than wild-type CerK |
691127 |
2.7.1.138 | C398A |
same specific acitity as wild-type CerK |
691127 |
2.7.1.138 | CERKL |
the point mutant enzyme CERKL does not phosphorylate ceramide or diacylglycerol and is localized in the nucleus |
671756 |
2.7.1.138 | DELTA1-123 |
production by site-directed mutagenesis, localization in cytosol |
696440 |