EC Number   |
Protein Variants |
Reference  |
|---|
    2.4.2.7 | more |
alignment of amino acid sequences, correlation between human clinical missense mutations and structure, structure taken from Leishmania donovani enzyme |
638166 |
| 2.4.2.7 | F25W |
site-directed mutagenesis, tryptophan at the adenine binding site, kinetic constants similar to the wild-type |
638167 |
| 2.4.2.7 | E106L |
site-directed mutagenesis, decreased turnover, increased Km value for adenine and decreased Km value for 5-phosphoribose 1-phosphate compared to the wild-type |
638171 |
| 2.4.2.7 | E106Q |
site-directed mutagenesis, decreased turnover and Km value for 5-phosphoribose 1-phosphate compared to the wild-type |
638171 |
| 2.4.2.7 | G108A |
site-directed mutagenesis, increased Km value for adenine and 5-phosphoribose 1-phosphate compared to the wild-type |
638171 |
| 2.4.2.7 | G108H |
site-directed mutagenesis, decreased turnover, slightly increased Km value for adenine and 5-phosphoribose 1-phosphate compared to the wild-type |
638171 |
| 2.4.2.7 | K90A |
site-directed mutagenesis, decreased turnover compared to the wild-type |
638171 |
| 2.4.2.7 | K93A |
site-directed mutagenesis, decreased turnover, increased Km value for adenine and 5-phosphoribose 1-phosphate compared to the wild-type |
638171 |
| 2.4.2.7 | R69A |
site-directed mutagenesis, decreased turnover, increased Km value for adenine compared to the wild-type |
638171 |
| 2.4.2.7 | R89A |
site-directed mutagenesis, decreased turnover, increased Km value for adenine and 5-phosphoribose 1-phosphate compared to the wild-type |
638171 |
