EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.7.1.154 | Breast Neoplasms |
22586300 |
GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
4
4
0 |
| 2.7.1.154 | Breast Neoplasms |
22744290 |
PI3KCA mutations and/or PTEN loss in Her2-positive breast carcinomas treated with trastuzumab are not related to resistance to anti-Her2 therapy. |
unassigned |
0 |
| 2.7.1.154 | Breast Neoplasms |
25368680 |
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer. |
causal interaction
unassigned |
3
0 |
| 2.7.1.154 | Breast Neoplasms |
26934321 |
Class II phosphoinositide 3-kinase C2? regulates a novel signaling pathway involved in breast cancer progression. |
causal interaction
therapeutic application
unassigned |
4
2
0 |
| 2.7.1.154 | Breast Neoplasms |
33783250 |
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay. |
causal interaction
diagnostic usage
unassigned |
2
2
0 |
| 2.7.1.154 | Burkitt Lymphoma |
26561567 |
Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: effects on Burkitt lymphoma cell growth and migration. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
4
2
0 |
| 2.7.1.154 | Carcinogenesis |
11552264 |
[Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis] |
unassigned |
0 |
| 2.7.1.154 | Carcinogenesis |
18043260 |
Class IA phosphoinositide 3-kinase isoforms and human tumorigenesis: implications for cancer drug discovery and development. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
4
0 |
| 2.7.1.154 | Carcinogenesis |
18270679 |
Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.7.1.154 | Carcinogenesis |
25622909 |
Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2?) isoform contributes to neuroblastoma tumorigenesis. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
2
3 |
