EC Number |
Cofactor |
Reference |
---|
1.1.1.27 | NAD+ |
- |
654758, 654778, 670394, 684548, 684561, 685322, 685502, 685618, 686014, 686223, 686260, 686648, 686655, 686679, 687249, 688101, 688389, 689763, 690058, 700558, 710724, 710929, 711181, 711801, 712102, 712279, 721235, 739793, 740001, 740081, 740253, 740254, 740255, 740337, 740458, 740460, 740541, 740628, 741355, 741368 |
1.1.1.27 | NAD+ |
binding structure, overview |
711801 |
1.1.1.27 | NAD+ |
coenzyme |
286431, 286435, 286436, 286437, 286438, 286439, 286440, 286443, 286445, 286446, 286447, 286448, 286450, 286453, 286454, 286459, 286460, 286461 |
1.1.1.27 | NAD+ |
the coenzyme is in an open conformation and the adenine ribose ring of it is surrounded by Asp 38, Val 39, and Gly 99. Asp 38 and Gly 99 give some specificity to the adenine orientation, overview |
684519 |
1.1.1.27 | NAD+ |
wild-type enzyme is specific for NAD+. Mutant enzyme F16Q/I37K/D38SC81S/N85R utilizes NADP+ better than wild-type enzyme, prefers NADP+ to NAD+. Mutant F16Q/C81S/N85R utilizes NAD+ better than wild-type enzyme, weakly active wth NADP+ |
670748 |
1.1.1.27 | NADH |
- |
654758, 654763, 654778, 654791, 655068, 655268, 656389, 656750, 656752, 656764, 667816, 668243, 670846, 684548, 684561, 685322, 685502, 685618, 686223, 686260, 686648, 686655, 687249, 688101, 688389, 689763, 690058, 696769, 696774, 700558, 710929, 711181, 711801, 712102, 712279, 721235, 736365, 739793, 740001, 740253, 740254, 740255, 740337, 740458, 740460, 740541, 740628, 741355, 741368 |
1.1.1.27 | NADH |
coenzyme |
286430, 286431, 286432, 286433, 286434, 286435, 286436, 286437, 286438, 286439, 286440, 286441, 286442, 286443, 286444, 286445, 286446, 286447, 286448, 286449, 286451, 286452, 286453, 286454, 286456, 286457, 286458, 286459, 286460, 286461, 286462, 286463, 286464, 286465, 286468, 286469, 286470, 286471 |
1.1.1.27 | NADH |
enzyme binding structure, overview |
740460 |
1.1.1.27 | NADH |
kinetic modelling of NADH binding to the enzyme, overview |
740081 |
1.1.1.27 | NADH |
NADH is 10fold preferred over NADPH |
762306 |