EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.3.1.B43 | more |
it is proposed that YfiQ and CobB catalyze the reversible acetylation of a protein that mediates carbon-induced cpxP transcription |
Escherichia coli |
? |
- |
? |
| 2.3.1.B43 | more |
catalytic efficiency (kcat/Km) of Sirt5 with the histone H3K9 acetyl peptide is about 500fold lower than that of Sirt1. Sirtuin 5 has only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr102 and Arg105) that bind to malonylated and succinylated substrates and define the specificity |
Homo sapiens |
? |
- |
? |
| 2.3.1.B43 | more |
global identification of CobB substrates using an Escherichia coli proteome microarray |
Escherichia coli |
? |
- |
? |
| 2.3.1.B43 | more |
no activity with Ac-Leu-Gly-(N6-acetyl)Lys-7-amido-4-methylcoumarin |
Homo sapiens |
? |
- |
? |
| 2.3.1.B43 | more |
Sirt5 does not deacetylate glutamate dehydrogenase or isocitrate dehydrogenase 2 |
Homo sapiens |
? |
- |
? |
| 2.3.1.B43 | more |
Sirt5 shows negligible activity toward lysine deacetylation |
Mus musculus |
? |
- |
? |
| 2.3.1.B43 | more |
the enzyme shows dual enzymatic activities to catalyze the removal of two structurally different lysine acyl groups, acetyl and succinyl, from the modified lysine residues |
Escherichia coli |
? |
- |
? |
| 2.3.1.B43 | more |
Sirt5 catalyzes the desuccinylation of histone peptides, molecular mechanism, overview. Human Sirt5 is a ubiquitous desuccinylase that catalyzes the desuccinylation of diverse histone succinyl sites with sequence selectivity. Among the 13 identified sites, H2BK116su is the most favorable Sirt5 substrate, with H4K12su showing the lowest catalytic efficiency and no activity observed in the presence of H4K31su |
Homo sapiens |
? |
- |
- |
| 2.3.1.B43 | more |
SIRT5 catalyzes the removal of negatively charged lysine acyl modifications: succinyl, malonyl, and glutaryl groups. SIRT5 is selective only for 3-5 carbon chains acidic acyl modifications, and displays no detectable activity against either an acetyl modification, a neutral 2 carbon group, or an adipoyl, a 6-carbon acidic modification |
Homo sapiens |
? |
- |
- |
| 2.3.1.B43 | more |
SIRT5 catalyzes the removal of negatively charged lysine acyl modifications: succinyl, malonyl, and glutaryl groups. SIRT5 is selective only for 3-5 carbon chains acidic acyl modifications, and displays no detectable activity against either an acetyl modification, a neutral 2 carbon group, or an adipoyl, a 6-carbon acidic modification |
Mus musculus |
? |
- |
- |
