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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-homophenylalanine + 2-oxoglutarate + O2 mutant enzyme W40M shows 8.3fold increase in turnover number for L-homophenylalanine as compared to wild-type enzyme and mutant enzyme W40M/I103L shows 112fold increase in turnover number. Mutation reprograms the natural hydroxylase to predominantly act as a desaturase, giving almost exclusively 3,4-desaturated L-homophenylalanine, through capability of tyrosine to serve as a catalytic entity in the reaction mechanism Sinorhizobium meliloti ? + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-pipecolate + 2-oxoglutarate + O2 - Mesorhizobium loti cis-5-hydroxypipecolate + cis-3-hydroxypipecolate + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-pipecolate + 2-oxoglutarate + O2 - Sinorhizobium meliloti cis-5-hydroxypipecolate + cis-3-hydroxypipecolate + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-proline + 2-oxoglutarate + O2 - Mesorhizobium loti cis-4-hydroxy-L-proline + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-proline + 2-oxoglutarate + O2 - Sinorhizobium meliloti cis-4-hydroxy-L-proline + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-proline + 2-oxoglutarate + O2 presence of 2-oxoglutarate is strictly required Mesorhizobium loti cis-4-hydroxy-L-proline + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-proline + 2-oxoglutarate + O2 presence of 2-oxoglutarate is strictly required Sinorhizobium meliloti cis-4-hydroxy-L-proline + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-proline + 2-oxoglutarate + O2 acceptance of the native substrate L-proline is almost completely abolished in the mutant enzymes W40M und W40M/I103L Sinorhizobium meliloti cis-4-hydroxy-L-proline + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-proline + 2-oxoglutarate + O2 presence of 2-oxoglutarate is strictly required Mesorhizobium loti MAFF303099 cis-4-hydroxy-L-proline + succinate + CO2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.56L-proline + 2-oxoglutarate + O2 - Mesorhizobium loti MAFF303099 cis-4-hydroxy-L-proline + succinate + CO2 - ?
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