EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
    1.14.11.31 | (R,S)-canadine + 2-oxoglutarate + O2 |
a protoberberine, 32% of activity with oripavine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | (R,S)-tetrahydropalmatine + 2-oxoglutarate + O2 |
a protoberberine, O-demethylation, below 1% of activity with oripavine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | (R,S)-tetrahydropapaverine + 2-oxoglutarate + O2 |
a 1-benzylisoquinoline, O-demethylation, 2.1% of activity with oripavine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | allocryptopine + 2-oxoglutarate + O2 |
a protopine, O-demethylation, 9.5% of activity with oripavine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | cryptopine + 2-oxoglutarate + O2 |
a protopine, O-demethylation, below 1% of activity with oripavine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | more |
no activity with (S)-reticuline, (S)-scoulerine, papaverine, (S)-corytuberine, pavine, salutaridine, noscapine, codeine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | more |
when assayed with a wide range of benzylisoquinoline alkaloids, the enzyme shows efficient dealkylation activities, including regio- and substrate-specific O-demethylation and O,O-demethylenation, substrate specificity, overview. No or poor activity with (S)-reticuline, (S)-isocorydine, (S)-scoulerine, (R,S)-stylopine, berberine, O-demethylcryptopine, protopine, and codeine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | oripavine + 2-oxoglutarate + O2 |
a morphinan, best substrate |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | papaverine + 2-oxoglutarate + O2 |
a 1-benzylisoquinoline,O-demethylation, below 1% of activity with oripavine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.31 | thebaine + 2-oxoglutarate + O2 |
- |
Papaver orientale |
codeinone + formaldehyde + succinate + CO2 |
- |
? |
