EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.9.1.2 | more |
bacterial SepCysS charges bacterial tRNACys species with cysteine in vitro. Sep-tRNACys is converted by Sep-tRNA:Cys-tRNA synthase (SepCysS) to Cys-tRNACys |
Bacteria |
? |
- |
- |
2.9.1.2 | more |
Sep-tRNACys is converted by Sep-tRNA:Cys-tRNA synthase (SepCysS) to Cys-tRNACys |
Archaea |
? |
- |
- |
2.9.1.2 | more |
SepSecS binds unacylated tRNASec equally well as Sep-tRNASec 1 |
Homo sapiens |
? |
- |
- |
2.9.1.2 | L-phosphoseryl-tRNASec + selenophosphate |
- |
Trypanosoma brucei |
L-selenocysteinyl-tRNASec + phosphate |
- |
? |
2.9.1.2 | L-phosphoseryl-tRNASec + selenophosphate |
selenocysteine is the only genetically encoded amino acid in humans whose biosynthesis occurs on its cognate transfer RNA (tRNA). O-Phosphoseryl-tRNA:selenocysteinyl-tRNA synthase catalyzes the final step of selenocysteine formation by a tRNA-dependent mechanism |
Homo sapiens |
L-selenocysteinyl-tRNASec + phosphate |
- |
? |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate |
- |
Trypanosoma brucei |
L-selenocysteinyl-tRNASec + phosphate |
- |
? |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate |
- |
Homo sapiens |
L-selenocysteinyl-tRNASec + phosphate |
- |
? |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate |
- |
Methanococcus maripaludis |
L-selenocysteinyl-tRNASec + phosphate |
- |
? |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate |
- |
Methanocaldococcus jannaschii |
L-selenocysteinyl-tRNASec + phosphate |
- |
? |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate |
L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) |
Methanococcus maripaludis |
L-selenocysteinyl-tRNASec + phosphate |
- |
? |