EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    1.1.1.270 | (3)H-dehydroepiandrosterone + NAD(P)+ |
- |
Taeniopygia guttata |
? |
- |
? |
| 1.1.1.270 | (4-methyl)zymosterone + NADPH + H+ |
- |
Homo sapiens |
(4-methyl)zymosterol + NADP+ |
- |
? |
| 1.1.1.270 | (4-methyl)zymosterone + NADPH + H+ |
cholesterol pathway |
Homo sapiens |
(4-methyl)zymosterol + NADP+ |
- |
? |
| 1.1.1.270 | 16alpha-hydroxy-dehydroepiandrosterone + NADH + H+ |
- |
Homo sapiens |
? |
- |
? |
| 1.1.1.270 | 16beta-hydroxy-dehydroepiandrosterone + NADH + H+ |
- |
Homo sapiens |
? |
- |
? |
| 1.1.1.270 | 17alpha-hydroxypregnenolone + NADH + H+ |
- |
Homo sapiens |
17alpha-hydroxyprogesterone + NAD+ |
- |
? |
| 1.1.1.270 | 2 17beta-hydroxy-5alpha-androstan-3-one + 2 NADPH + 2 H+ |
AKR1cs are a source of beta-tetrahydrosteroids. This is of physiological significance because the formation of 3beta-diol in contrast to 3alpha-diol is virtually irreversible, the 3beta-diol is a pro-apoptotic ligand for estrogen receptor beta, and 3beta-tetrahydrosteroids act as gamma-aminobutyric acid type A receptor antagonists |
Homo sapiens |
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3alpha,17beta-diol + 2 NADP+ |
- |
? |
| 1.1.1.270 | 24-ethylidenelophenone + NADPH |
oxidation: poor |
Zea mays |
24-ethylidenelophenol + NADP+ |
- |
r |
| 1.1.1.270 | 24-methylenecycloartanone + NADPH |
7% compared with cholest-7-en-3-one, DELTA7-cholestenone |
Zea mays |
24-methylenecycloartanol + NADP+ |
- |
ir |
| 1.1.1.270 | 24-methylenelophenone + NADPH |
35% compared with cholest-7-en-3-one, DELTA7-cholestenone |
Zea mays |
24-methylenelophenol + NADP+ |
- |
? |
