EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.1.4.54 | more |
recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview |
Mus musculus |
? |
- |
? |
| 3.1.4.54 | more |
substrate specificity of the brain enzyme, detailed overview |
Mus musculus |
? |
- |
? |
| 3.1.4.54 | more |
recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview |
Mus musculus C57BL/6 |
? |
- |
? |
| 3.1.4.54 | more |
substrate specificity of the brain enzyme, detailed overview |
Mus musculus C57BL/6 |
? |
- |
? |
| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
- |
Rattus norvegicus |
N-acylethanolamine + phosphatidate |
- |
? |
| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
biosynthetic enzyme of anandamide and its related bioactive congeners, the N-acylethanolamines |
Mus musculus |
N-acylethanolamine + phosphatidate |
- |
? |
| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
N-acylethanolamines constitute a family of endogenous bioactive lipids that includes arachidonoylethanolamide, i.e. anandamide, palmitoylethanolamide, and oleoylethanolamide. These lipids are formed from their respective N-acylated ethanolamine phospholipid precursor by the action of a phospholipase D enzyme, NAPE-PLD. The bioactive lipids may influence, amongst others: neuroinflammation, food intake, and oocyte implantation |
Homo sapiens |
N-acylethanolamine + phosphatidate |
- |
? |
| 3.1.4.54 | N-acylphosphatidylethanolamine + H2O |
the enzyme is involved in formation of N-acylethanolamines, membrane-derived lipids that are utilized as signaling molecules in the nervous system (e.g., the endocannabinoid anandamide) |
Mus musculus |
N-acylethanolamine + phosphatidate |
- |
? |
| 3.1.4.54 | N-arachidonoyl-1,2-dioleoyl-phosphatidylehanolamine + H2O |
hydrolysis rate with 0.1 mM N-arachidonoyl-1,2-dioleoyl-phosphatidylehanolamine is about 50% of that with 0.1 mM N-palmitoyl-1,2-dioleoyl-phosphatidylethanolamine |
Rattus norvegicus |
N-arachidonoylethanolamine + 1,2-dioleoyl-sn-glycerol 3-phosphate |
- |
? |
| 3.1.4.54 | N-arachidonoyl-1,2-dioleoyl-phosphatidylethanolamine + H2O |
- |
Rattus norvegicus |
N-arachidonoylethanolamine + 1,2-dioleoyl-sn-glycerol 3-phosphate |
- |
? |
