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TaxTree of Organism Mus musculus C57BL/6
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EC NUMBER 
COMMENTARY 
-
preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
11-oxyandrogens biosynthesis
-
-
PWY-8202
15-epi-lipoxin biosynthesis
-
-
PWY66-393
1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)
-
-
PWY-6361
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
-
-
PWY-6362
2-arachidonoylglycerol biosynthesis
-
-
PWY-8052
2-methylpropene degradation
-
-
PWY-7778
24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)
-
-
PWY-8238
3-hydroxy-4-methyl-anthranilate biosynthesis I
-
-
PWY-7717
3-hydroxy-4-methyl-anthranilate biosynthesis II
-
-
PWY-7765
3-hydroxypropanoate/4-hydroxybutanate cycle
-
-
PWY-5789
3-phosphoinositide biosynthesis
-
-
PWY-6352
4-aminobutanoate degradation I
-
-
PWY-6535
4-aminobutanoate degradation IV
-
-
PWY-6473
4-hydroxy-2-nonenal detoxification
-
-
PWY-7112
6-hydroxymethyl-dihydropterin diphosphate biosynthesis
-
-
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
-
-
PWY-6147
6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)
-
-
PWY-7852
Ac/N-end rule pathway
-
-
PWY-7800
adenine and adenosine salvage III
-
-
PWY-6609
adenine and adenosine salvage V
-
-
PWY-6611
adenosine nucleotides degradation I
-
-
PWY-6596
adenosine nucleotides degradation II
-
-
SALVADEHYPOX-PWY
aerobic respiration I (cytochrome c)
-
-
PWY-3781
aerobic respiration II (cytochrome c) (yeast)
-
-
PWY-7279
alliin metabolism
-
-
PWY-5706
alpha-linolenate metabolites biosynthesis
-
-
PWY-8398
anandamide biosynthesis I
-
-
PWY-8051
anandamide biosynthesis II
-
-
PWY-8053
anandamide lipoxygenation
-
-
PWY-8056
androgen biosynthesis
-
-
PWY66-378
arachidonate metabolites biosynthesis
-
-
PWY-8397
Arg/N-end rule pathway (eukaryotic)
-
-
PWY-7799
arsenite to oxygen electron transfer
-
-
PWY-4521
arsenite to oxygen electron transfer (via azurin)
-
-
PWY-7429
aspirin triggered resolvin D biosynthesis
-
-
PWY66-395
aspirin triggered resolvin E biosynthesis
-
-
PWY66-394
backdoor pathway of androgen biosynthesis
-
-
PWY-8200
bile acid biosynthesis, neutral pathway
C20 prostanoid biosynthesis
-
-
PWY66-374
camalexin biosynthesis
-
-
CAMALEXIN-SYN
carotenoid cleavage
-
-
PWY-6806
catecholamine biosynthesis
ceramide and sphingolipid recycling and degradation (yeast)
-
-
PWY-7119
ceramide de novo biosynthesis
-
-
PWY3DJ-12
ceramide degradation (generic)
-
-
PWY-6483
cholesterol biosynthesis (algae, late side-chain reductase)
-
-
PWY-8191
cholesterol biosynthesis (diatoms)
-
-
PWY-8239
cholesterol biosynthesis (plants, early side-chain reductase)
-
-
PWY18C3-1
cholesterol biosynthesis I
-
-
PWY66-341
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
-
-
PWY66-3
cholesterol biosynthesis III (via desmosterol)
-
-
PWY66-4
cholesterol degradation to androstenedione II (cholesterol dehydrogenase)
-
-
PWY-6946
cholesterol degradation to androstenedione III (anaerobic)
-
-
PWY-8151
choline biosynthesis I
-
-
PWY-3385
chondroitin biosynthesis
-
-
PWY-6566
chondroitin sulfate biosynthesis
-
-
PWY-6567
complex N-linked glycan biosynthesis (vertebrates)
-
-
PWY-7426
crotonate fermentation (to acetate and cyclohexane carboxylate)
-
-
PWY-7401
cytosolic NADPH production (yeast)
-
-
PWY-7268
D-arabinose degradation V
-
-
PWY-8334
D-galactose degradation IV
-
-
PWY-6693
D-myo-inositol (1,3,4)-trisphosphate biosynthesis
-
-
PWY-6364
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
-
-
PWY-6351
D-myo-inositol-5-phosphate metabolism
-
-
PWY-6367
D-xylose degradation to ethylene glycol (engineered)
-
-
PWY-7178
dermatan sulfate biosynthesis
-
-
PWY-6568
detoxification of reactive carbonyls in chloroplasts
-
-
PWY-6786
di-homo-gamma-linolenate metabolites biosynthesis
-
-
PWY-8396
dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)
-
-
PWY-6053
docosahexaenoate metabolites biosynthesis
-
-
PWY-8400
drosopterin and aurodrosopterin biosynthesis
-
-
PWY-7442
erythritol biosynthesis I
-
-
PWY-8372
erythritol biosynthesis II
-
-
PWY-8373
erythro-tetrahydrobiopterin biosynthesis I
-
-
PWY-5663
ethene biosynthesis III (microbes)
-
-
PWY-6854
ethene biosynthesis V (engineered)
-
-
PWY-7124
eumelanin biosynthesis
-
-
PWY-6498
fatty acid biosynthesis initiation (type I)
-
-
PWY-5966-1
Fe(II) oxidation
-
-
PWY-6692
folate transformations I
-
-
PWY-2201
folate transformations II (plants)
-
-
PWY-3841
folate transformations III (E. coli)
-
-
1CMET2-PWY
formaldehyde oxidation VII (THF pathway)
-
-
PWY-7909
formate assimilation into 5,10-methylenetetrahydrofolate
-
-
PWY-1722
GABA shunt I
-
-
GLUDEG-I-PWY
GABA shunt II
-
-
PWY-8346
gala-series glycosphingolipids biosynthesis
-
-
PWY-7840
gallate degradation III (anaerobic)
-
-
P3-PWY
ganglio-series glycosphingolipids biosynthesis
-
-
PWY-7836
gliotoxin biosynthesis
-
-
PWY-7533
glutaryl-CoA degradation
-
-
PWY-5177
glutathione-mediated detoxification I
-
-
PWY-4061
glutathione-mediated detoxification II
-
-
PWY-6842
glycerol degradation I
-
-
PWY-4261
glycerol-3-phosphate shuttle
-
-
PWY-6118
glycerol-3-phosphate to cytochrome bo oxidase electron transfer
-
-
PWY0-1561
glycerol-3-phosphate to fumarate electron transfer
-
-
PWY0-1582
glycerol-3-phosphate to hydrogen peroxide electron transport
-
-
PWY0-1591
glycerophosphodiester degradation
-
-
PWY-6952
guanosine nucleotides degradation I
-
-
PWY-6607
guanosine nucleotides degradation II
-
-
PWY-6606
guanosine nucleotides degradation III
-
-
PWY-6608
heme degradation I
-
-
PWY-5874
heparan sulfate biosynthesis
-
-
PWY-6558
heparan sulfate degradation
-
-
PWY-7651
heparin degradation
-
-
PWY-7644
icosapentaenoate metabolites biosynthesis
-
-
PWY-8399
indole glucosinolate activation (intact plant cell)
-
-
PWYQT-4477
inosine 5'-phosphate degradation
-
-
PWY-5695
inositol diphosphates biosynthesis
-
-
PWY-6369
jadomycin biosynthesis
-
-
PWY-6679
L-arabinose degradation II
-
-
PWY-5515
L-ascorbate biosynthesis VI (plants, myo-inositol pathway)
-
-
PWY-8142
L-glutamate degradation IX (via 4-aminobutanoate)
-
-
PWY0-1305
L-glutamate degradation V (via hydroxyglutarate)
-
-
P162-PWY
L-homomethionine biosynthesis
-
-
PWY-1186
L-isoleucine degradation I
-
-
ILEUDEG-PWY
L-selenocysteine biosynthesis I (bacteria)
-
-
PWY0-901
L-selenocysteine biosynthesis II (archaea and eukaryotes)
-
-
PWY-6281
L-serine biosynthesis I
-
-
SERSYN-PWY
L-tryptophan degradation I (via anthranilate)
-
-
TRPCAT-PWY
L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
-
-
PWY-5651
L-tryptophan degradation X (mammalian, via tryptamine)
-
-
PWY-6307
L-tryptophan degradation XI (mammalian, via kynurenine)
-
-
PWY-6309
L-valine degradation I
-
-
VALDEG-PWY
lacto-series glycosphingolipids biosynthesis
-
-
PWY-7839
leukotriene biosynthesis
-
-
PWY66-375
linoleate metabolites biosynthesis
-
-
PWY-8395
lipoxin biosynthesis
-
-
PWY66-392
maresin biosynthesis
-
-
PWY-8356
methiin metabolism
-
-
PWY-7614
methyl indole-3-acetate interconversion
-
-
PWY-6303
methylaspartate cycle
methylglyoxal degradation III
-
-
PWY-5453
methylsalicylate degradation
-
-
PWY18C3-24
mixed acid fermentation
-
-
FERMENTATION-PWY
monoacylglycerol metabolism (yeast)
-
-
PWY-7420
mucin core 1 and core 2 O-glycosylation
-
-
PWY-7433
mucin core 3 and core 4 O-glycosylation
-
-
PWY-7435
N-methylpyrrolidone degradation
-
-
PWY-7978
NAD salvage (plants)
-
-
PWY-5381
NAD salvage pathway III (to nicotinamide riboside)
-
-
NAD-BIOSYNTHESIS-II
NADPH to cytochrome c oxidase via plastocyanin
-
-
PWY-8271
neolacto-series glycosphingolipids biosynthesis
-
-
PWY-7841
nicotine degradation IV
-
-
PWY66-201
nitrate reduction IX (dissimilatory)
-
-
PWY0-1581
nitrate reduction X (dissimilatory, periplasmic)
-
-
PWY0-1584
nitric oxide biosynthesis II (mammals)
-
-
PWY-4983
nitrogen remobilization from senescing leaves
-
-
PWY-6549
noradrenaline and adrenaline degradation
-
-
PWY-6342
oleate beta-oxidation
-
-
PWY0-1337
palmitoyl ethanolamide biosynthesis
-
-
PWY-8055
partial TCA cycle (obligate autotrophs)
-
-
PWY-5913
pentachlorophenol degradation
-
-
PCPDEG-PWY
peptido-conjugates in tissue regeneration biosynthesis
-
-
PWY-8355
phosphatidate metabolism, as a signaling molecule
-
-
PWY-7039
phosphatidylcholine resynthesis via glycerophosphocholine
-
-
PWY-7367
phosphatidylethanolamine biosynthesis II
-
-
PWY4FS-6
phospholipases
-
-
LIPASYN-PWY
phospholipid remodeling (phosphatidylethanolamine, yeast)
-
-
PWY-7409
photorespiration I
-
-
PWY-181
phytosterol biosynthesis (plants)
-
-
PWY-2541
plasmalogen biosynthesis I (aerobic)
-
-
PWY-7782
plasmalogen degradation
-
-
PWY-7783
poly-hydroxy fatty acids biosynthesis
-
-
PWY-6710
preQ0 biosynthesis
-
-
PWY-6703
procollagen hydroxylation and glycosylation
-
-
PWY-7894
propanethial S-oxide biosynthesis
-
-
PWY-5707
propanoate fermentation to 2-methylbutanoate
-
-
PWY-5109
protectin biosynthesis
-
-
PWY-8357
protein N-glycosylation processing phase (endoplasmic reticulum, yeast)
-
-
PWY-7918
protein N-glycosylation processing phase (plants and animals)
-
-
PWY-7919
purine deoxyribonucleosides degradation I
-
-
PWY-7179
purine deoxyribonucleosides degradation II
-
-
PWY-7179-1
purine nucleobases degradation II (anaerobic)
-
-
PWY-5497
purine ribonucleosides degradation
-
-
PWY0-1296
putrescine biosynthesis III
-
-
PWY-46
pyrimidine deoxyribonucleotides biosynthesis from CTP
-
-
PWY-7210
pyruvate fermentation to butanoate
-
-
CENTFERM-PWY
pyruvate fermentation to butanol I
-
-
PWY-6583
pyruvate fermentation to butanol II (engineered)
-
-
PWY-6883
pyruvate fermentation to hexanol (engineered)
-
-
PWY-6863
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria)
-
-
CODH-PWY
reductive glycine pathway of autotrophic CO2 fixation
-
-
PWY-8303
reductive TCA cycle I
-
-
P23-PWY
resolvin D biosynthesis
-
-
PWY66-397
retinol biosynthesis
-
-
PWY-6857
serine racemization
-
-
PWY-8140
serotonin and melatonin biosynthesis
-
-
PWY-6030
sphingolipid biosynthesis (plants)
-
-
PWY-5129
sphingolipid biosynthesis (yeast)
-
-
SPHINGOLIPID-SYN-PWY
sphingosine and sphingosine-1-phosphate metabolism
-
-
PWY3DJ-11470
sterol:steryl ester interconversion (yeast)
-
-
PWY-7424
succinate to chytochrome c oxidase via cytochrome c6
-
-
PWY1YI0-2
succinate to cytochrome c oxidase via plastocyanin
-
-
PWY1YI0-3
superpathway of methylsalicylate metabolism
-
-
PWY18C3-25
superpathway of ornithine degradation
-
-
ORNDEG-PWY
taurine biosynthesis I
-
-
PWY-5331
taurine biosynthesis II
-
-
PWY-7850
TCA cycle I (prokaryotic)
-
-
TCA
TCA cycle IV (2-oxoglutarate decarboxylase)
-
-
P105-PWY
TCA cycle V (2-oxoglutarate synthase)
-
-
PWY-6969
TCA cycle VI (Helicobacter)
-
-
REDCITCYC
TCA cycle VII (acetate-producers)
-
-
PWY-7254
terminal O-glycans residues modification (via type 2 precursor disaccharide)
-
-
PWY-7434
tetrahydromonapterin biosynthesis
-
-
PWY0-1433
tetrapyrrole biosynthesis I (from glutamate)
-
-
PWY-5188
threo-tetrahydrobiopterin biosynthesis
-
-
PWY-6983
thyroid hormone metabolism I (via deiodination)
-
-
PWY-6260
thyroid hormone metabolism II (via conjugation and/or degradation)
-
-
PWY-6261
traumatin and (Z)-3-hexen-1-yl acetate biosynthesis
-
-
PWY-5410
triacylglycerol degradation
-
-
LIPAS-PWY
tRNA charging
-
-
TRNA-CHARGING-PWY
tunicamycin biosynthesis
-
-
PWY-7821
UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)
-
-
PWY-4841
urea cycle
UTP and CTP dephosphorylation I
-
-
PWY-7185
vancomycin resistance II
-
-
PWY-6455
vitamin D3 biosynthesis
-
-
PWY-6076
bile acid biosynthesis, neutral pathway
-
-
PWY-6061
catecholamine biosynthesis
-
-
PWY66-301
methylaspartate cycle
-
-
PWY-6728
urea cycle
-
-
PWY-4984
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
440239, 686181, 709340, 712118, 712886, 714338, 714339, 715146, 715534, 716352, 717077, 717419, 717826, 717845, 717960, 718020, 718301, 718403, 718541, 721994, 722677, 725065, 726309, 726664, 727366, 728085, 730002, 731237, 731239, 732158, 732268, 732521, 732823, 733065, 734695, 736544, 740545, 740886, 745971, 753117, 759460
-
-
-
731229, 733800, 734544, 736018, 736606, 737419, 739113, 740583, 741420, 742114, 744160, 744739, 746253, 746716, 752443, 752445, 753120, 753929, 754083, 754360, 754779, 755118, 755285, 755766, 756973, 760454, 762448
O35400, O55055, P00860, P11032, P16406, P26361, P28652, P28776, P34914, P45376, P48776, P54071, P59941, Q10738, Q3UHN9, Q61847, Q64505, Q80W65, Q8CI15, Q924Z4, Q9D6K9, Q9JJS6, Q9QXN5, Q9R0E1
SwissProt
-
715704, 732369, 733959, 734361, 735049, 736580, 737160, 741065, 741302, 742346, 742845, 742856, 742978, 744160, 744785, 745102, 745815, 745867, 745868, 746221, 747021, 748047, 748646, 750705, 751970, 752926, 753531, 754245, 754337, 754754, 755165, 756394, 756537, 756563, 756577, 759759, 759848, 760824, 760851, 763340, 763831, 764557
A0A1Y7VM56, D3YZG8, E9QAS3, O09005, O09174, O55123, O70138, O89023, P21958, P29477, P32921, P34960, P39654, P41245, P97872, Q2NL51, Q61263, Q64455, Q64521, Q6VVW9, Q6ZPY7, Q8BHN3, Q8BJQ9, Q8BW72, Q8BWF0, Q8C1A5, Q8C2B3, Q8CGC7, Q8K4Q7, Q8R2H9, Q8VCD7, Q8VDW4, Q91VL8, Q91VY5, Q99NF1, Q9DBE0, Q9JHD2, Q9QUI0, Q9WTK2, Q9WU19, Q9WV60, Q9Z0K8
UniProt
alpha-L-iduronidase (IDUA) knockout mutant variant, gene B4GALNT1
SwissProt
alpha-L-iduronidase (IDUA) knockout mutant variant, gene St3gal5
Uniprot
alpha-L-iduronidase (IDUA) knockout mutant variant, gene ST8SIA1
UniProt
C57/BL6 mice
-
-
C57BL/6 mice
669716, 669717, 671959, 673481, 675204, 680845, 680875, 681543, 681911, 682112, 682136, 683046, 683054, 683480, 683525, 683738, 683741, 683863, 684007, 684350, 684803, 686304, 687032, 688149, 688223, 689353, 690342, 690367, 690860, 691542, 693098, 693776, 695619, 697358, 698165, 698235, 698935, 699321, 699336, 699337, 699349, 700198, 700471, 700916, 701687, 702101, 702855, 703809, 704003, 704426, 704943, 704949, 704951, 705402, 707042, 707048, 707370, 707851, 707992, 708146, 708250, 708448, 708597, 708599, 708641, 709116, 709821, 710118
-
-
C57BL/6 mice
SwissProt
C57BL/6 mice
UniProt
CX3CR1GFP mice carrying aldose reductase mutant alleles
SwissProt
mice injected i.p. with 106 Plasmodium berghei ANKA infected red blood cells
UniProt
two evolutionary conserved splicing isoforms of Pcyt2, Pcyt2alpha and Pcyt2beta, and a third splicing isozyme Pcyt2gamma are encoded by a single Pcyt2 gene
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
a macrophage cell line established by immortalization of bone marrow macrophages from C57BL/6 mice with J2 recombinant retrovirus-expressing v-myc/v-raf oncogenes
-
while all cell layers of the esophagus express NTPDase3, NTPDase3 localization in the forestomach is limited to the basal cell layer
-
SULT2B1b mRNA levels in clinical hepatocarcinoma tumor samples are higher than in the non-tumorous tissue adjacent to the tumors
-
represents as much as 1% of total cytosolic protein in the kidney
-
unstimulated/resident and inflammatory, peritoneal leukocytes, constitutive expression
-
genetically engineered Kras-driven mouse pancreatic tumors
-
an immortalized epididymal cell line, quantitative enzyme expression analysis, overview
-
a dramatic reduction in Sirt6 is detected in the podocytes in diabetic mice relative to those in control mice
-
NTPDase3 in epithelial cells in serous acini of salivary glands and mucous acini and duct cells of sublingual salivary glands
-
mucosa, post-transcriptional regulation of expression, the enzyme expression is also developmentally regulated, quantitative RT-PCR analysis, overview
-
of tunica muscularis and blood vessels of the muscular layer of oviductal serosa, NTPDase1
-
Cyp46A1 mRNA and CYP46A1 protein levels are decreased in the striatum of the R6/2 Huntington's disease mouse model and in SThdhQ111 cell lines
additional information
-
from mice with acute kidney injury, MIOX expression is undetectable in healthy mice plasma
-
quantitative gene expression and in situ hybridization of genes associated with endochondral ossification
-
C4ST-2 expression occurs in the early stage bone marrow cell cultures, the process of mast cell maturation does not alter the expression, low expression at day 0, followed by an increase in expression at later stages of culture
-
GalNAc4S6ST expression occurs in the early stage bone marrow cell cultures, low expression at day 0, followed by an increase in expression at later stages of culture
-
NDST-2 correlates strongly with mast cell maturation, whereas the expression of the NDST-1 isoform is approximately equal at all stages of maturation. NDST-2 correlates strongly with mast cell maturation, whereas the expression of the NDST-1 isoform is approximately equal at all stages of maturation. NDST-1 expression is detected already in the early stage, day 0, bone marrow cells, but the level of expression does not increase throughout the process of mast cell maturation. NDST-2 expression follows an entirely different pattern, with low expression in day 0 and day 7 cultures, followed by a markedly increased level of expression starting from day 14 and has a continuously increased expression throughout the entire culture period. NDST-2 is downregulated after mast cell activation
-
12/15-LOX is selectively enhanced in the periphery, 12/15-LOX-expressing myeloid cells are enriched in the brain during chronic toxoplasmosis
-
expression of sEH is significantly increased on day 7, 14, 21 and 28 after pilocarpine-induced status epilepticus
-
expression pattern in mouse brain of TyrRS and KTP synthesis after Arg administration
-
mEH distribution, immunohistochemical analysis, overview. mEH immunoreactivity is present in specific neuronal populations of the hippocampus, striatum, amygdala, and cerebellum, as well as in a fraction of astrocytes
-
of young and old mice, comparison of enzyme expression and activity in brain regions, e.g. cortex, hippocampus and cerebellum, overview
-
sEH distribution, immunohistochemical analysis, overview. sEH immunoreactivity is almost exclusively located in astrocytes throughout the brain, except in the central amygdala, where neurons are also positive for sEH
-
upregulated in brown adipose tissue in comparison to white adipose tissue
-
knee, quantitative RT-PCR enzyme expression analysis of CSGALNACT1
-
knee, quantitative RT-PCR enzyme expression analysis of CSGALNACT2
-
age-dependent increase in the central nervous system expression of MMP-3 in Twitcher mice suffering globoid cell leukodystrophy
-
adult, weak but significant enzyme signals are detected in GABAergic Purkinje cells
-
highest AC1 expression, present in molecular layer, weak AC8 expression at postnatal day 7 and decreases further by postnatal day 14
-
MMP7 is induced upon mucosal injury in several tissues, e.g. in colon mucosa, overview
-
E17 fetus, both head and body show strong expression of Lc3 synthase in wild-type (Wt/Wt) and heterozygous (Wt/KO) mice
-
enzyme MTHFD2L is expressed in embryonic tissues during neural tube closure. Expression of the MTHFD2L transcript is low in early mouse embryos but begins to increase at embryonic day 10.5 and remains elevated through birth, in situ hybridization of whole mouse embryos
-
cathepsin L (human cathepsin V homologue) is increased in the thoracic aorta endothelial cells of hyperhomocysteinaemic mice
-
synaptosome fractions from the adult brain show robust expression of AC1 in the postsynaptic density and extrasynaptic regions, while expression of AC8 is observed in the presynaptic active zone and extrasynaptic fractions
-
the amount of NOX4 is elevated in hearts of db/db diabetic mice compared to wild-type mice
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negligible expression of cathepsin B in hepatic stellate cells
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cellular distribution and phosphorylation of MARCKS by PKC isozymes in the hippocampus following kainic acid-induced seizures, immunohistochemic detection, overview
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in the hippocampus of wild-type mice, sEH is mainly expressed in astrocytes (GFAP+), neurons (NeuN+) and scattered microglia (Iba-1+) in the regions of CA1, CA3 and dentate gyrus, immunohistochemical analysis
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lowest expression of AC1, protein increases in abundance in the neonatal hippocampus from postnatal days 714. By adulthood, abundant AC1 protein expression in the mossy fiber tract. AC8 protein levels are abundant during development, with diffuse and increasing expression in the hippocampus that intensify in the CA1/CA2 region by adulthood
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distal ileum, wild-type mice subjected to I/R injury have significantly higher MMP8 serum concentrations compared to sham-treated mice
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fetal kidney, 10fold higher enzymatic activity observed compared with other tissues
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kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule
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determination of PDK4 expression level in presence or absence of farnesoid X receptor agonists
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distribution of vitamin D receptor and enzyme proteins in the liver by immunostaining, overview
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liver MGL mRNA, protein and activity all increased 5-10-fold during development
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GZMA is expressed in lungs from wild-type and Mycobacterium tuberculosis-infected mice
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high enzyme expression level, pulmonary LASS5 is developmentally regulated, but its expression is spatially and gender-nonspecific
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immunohistochemical analysis showing the expression of the sEH in lungs from wild-type mice kept under normoxic conditions or after exposure to 21 days hypoxia, overview
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method development and evaluation for immunostaining MMP-9 in mouse lung paraffin-embedded tissue utilizing human ovary as a control, overview. MMP-9 localization in lung tissue of a murine model of allergic asthma induced by chicken ovalbumin. The murine model of allergic asthma consists of a tissue inhibitor of metalloproteinase (TIMP)-1 genetic knockout backcrossed over 10 generations from 129/sv mice on a C57Bl/6 background
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enzyme Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. Mmp10 and Notch4 expression in primary and metastatic lung tumors
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12/15-LOX is a macrophage-selective regulator of interleukin-12 production
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12/15-LOX is expressed by 95% of resident peritoneal CD11bhigh cells, with the remaining 5% being 12/15-LOX-. 12/15-LOX+ cells are phenotypically defined by high F4/80, SR-A, and Siglec1 expression, and enhanced IL-10 and G-CSF generation. In contrast, 12/15-LOX- cells are a dendritic cell population. Resident peritoneal macrophage numbers are significantly increased in 12/15-LOX-/- mice, suggesting alterations in migratory trafficking or cell differentiation in vivo
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bone marrow macrophages prepared from femurs of five to eight-week-old mice
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peritoneal macrophages, activation of Toll-like receptors selectively decreases arrestin-2 and GRK5 protein level in primary macrophages, mechanism, overview
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peritoneal macrophages, activation of Toll-like receptors selectively decreases arrestin-2 and GRK6 protein level in primary macrophages, mechanism, overview
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peritoneal macrophages, activation of Toll-like receptors significantly increases GRK2 expression in primary macrophages, mechanism, overview
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secretion of MMP-9 in the early phase of peritonitis, no MMP-9 production in unstimulated macrophages
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developed from bone marrow cells isolated from femur and tibia from C57BL/6 mice, mast cell maturation strongly correlates with the expression of C4ST-1
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developed from bone marrow cells isolated from femur and tibia from C57BL/6 mice, mast cell maturation strongly correlates with the expression of GalNAc4S6ST
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NDST-2 correlates strongly with mast cell maturation, whereas the expression of the NDST-1 isoform is approximately equal at all stages of maturation. NDST-1 expression is detected already in the early stage, day 0, bone marrow cells, but the level of expression does not increase throughout the process of mast cell maturation. NDST-2 expression follows an entirely different pattern, with low expression in day 0 and day 7 cultures, followed by a markedly increased level of expression starting from day 14 and has a continuously increased expression throughout the entire culture period. NDST-2 is downregulated after mast cell activation
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murine microglia are isolated from newborn mice, DEP-1 is expressed in microglial cells in a cell density-dependent manner
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invariant natural killer T (iNKT) cells. Enzyme GCN5 promotes iNKT development during the maturation stage. iNKT cells undergo several well-defined developmental stages in the thymus. Dramatic accumulation of iNKT cells at the stage 0 in thymus of Gcn5 knockout mice
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GSK3 exists in neurons as 3 isoforms (GSK3alpha, beta, and beta2) that are encoded by 2 separate genes, immunohistochemic study of isozyme localization in neurons, detailed overview
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isozyme inositol-1,4,5-trisphosphate-3-kinase-A is a neuron-specific, actin bundling protein concentrated at dendritic spines
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secretion of MMP-9, high MMP-9 expression in the early phase and especially in the late phase of peritonitis
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elevated ECE-1 expression level when developing lipopolysaccharide-induced premature delivery (Western blot)
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retinal blood vessels of wild-type and mutant mice, diabetic mice show increased expression of leukotriene B4 receptors
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contains two nucleases, DNase1 and DNase1/3. DNase1/3 is not N-glycosylated, whereas DNase1 is di-N-glycosylated
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localization of the enzme protein in the granular and cornified layer of the epidermis
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low gene expression level, gene expression but no enzyme protein content
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the levels of selenocysteine lyase in the stomach of 7 out of 8 mice fed a Se-supplemented diet are markedly lower than those of mice fed a Se-deficient diet
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high enzyme level. Ecto-5'-nucleotidase is immunolocalized in testes, in association with germinal cells along all stages of spermatogenesis, but not in spermatozoa
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elevated ECE-1 expression level when developing lipopolysaccharide-induced premature delivery (Western blot)
additional information
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ACAT1 is the major isozyme in mouse primary hepatic stellate cells, and ACAT2 is the major isozyme in mouse primary hepatocytes and Kupffer cells
additional information
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alveolar type II cells and macrophages but not neutrophils are the main sources of MMP-12 in the lungs of mice with Streptococcus pneumoniae infection
additional information
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analysis of TPH2 expression in brain tissues, overview
additional information
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CerS2 tissue expression analysis, comparisons with the other CerS isozymes (CerS1, 3, 4-6). CerS2 mRNA is widely distributed and found at high levels in various tissues
additional information
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correlation of Senp2 and myostatin expression in cachexia
additional information
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DEP-1 protein levels increase in several cell types at high-cell density. DEP-1 is a widely expressed in cells of the immune system
additional information
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during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes
additional information
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enzyme expression analysis in mice fed normal or Western diets for 3 weeks and then given intraperitoneal injections of vehicle (corn oil) or 1alpha,25-dihydroxyvitamin D3 in 4 doses of 0.0025 mg/kg, every other day. Increased levels of Cyp7a1/CYP7A1 mRNA in mouse hepatocytes treated with 1alpha,25-dihydroxyvitamin D3
additional information
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expression of GCN5 is decreased significantly in the bone tissue sections of ovariectomized mice or aged mice
additional information
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ganglioside profile analyses in brain tissues, overview. Tissue dependent ganglioside alteration in IDUA KO mice with a total ganglioside increase in cortex and cerebellum, and a selective presence of GM3, GM2 and GD3 gangliosides in the hippocampus and hypothalamus. Evaluation of gene expression of ganglioside synthesis (GM3, GD3 and GM2/GD2 synthases) and degradation of (neuraminidase1) enzymes in the cerebellum and hippocampus by RT-sq-PCR. Percentage distribution of gangliosides in wild-type and IDUA knockout mice, overview
additional information
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granzyme A is produced by a variety of cell types involved in the immune response
additional information
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in LDL-receptor null mutant cells, gene expression and protein profiles, overview
additional information
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in primary type II epithelial cells, murine lung fibroblasts, and MLE cells, LASS5 is the predominant ceramide synthase species identified
additional information
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isozymes NDST-1 and NDST-2 appear to be predominant in adult tissue
additional information
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Kdm3b is highly expressed in the female reproductive organs including ovary, oviduct and uterus
additional information
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MMP-9 co-localizes with macrophages and neutrophils in gastritic stomach, overview
additional information
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Mmp13 is expressed in mouse choroidal neovascular lesions induced by laser burn
additional information
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most of the GZMA-positive cells (over 95%) in non-infected mice are positive for the NK1.1 surface marker with a small proportion of CD8+ and CD4+ T cells, indicating that in the absence of infection GZMA expression in lungs is mainly restricted to natural killer (NK) cells. Conversely, four weeks post-infection, percentage of NK1.1-positive GZMA-expressing cells decreases to 80%, due to the substantial increase observed in the percentage of GZMA-positive CD8+ and CD4+ T cells, (15% and 5%, respectively). In concurrence with these observations, both frequency and absolute number of CD4+ and CD8+ GZMA-expressing cells dramatically increase in lungs upon infection. Tuberculosis infection also leads to an increase in the number of GZMA-expressing NK cells
additional information
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pulmonary CD103+ dendritic cells are significantly increased in bleomycin-injured wild-type compared with Mmp7-/- mice, and CD103+ leukocytes
additional information
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quantitative real-time PCR enzyme expression analysis, no or low expression in kidney and ovaries
additional information
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R6/2 mice express exon 1 of the human mutant Huntingtons disease gene containing 160 CAG repeats, under control of the human HTT (IT15) promoter
additional information
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Rap1b is expressed in all tissues, including endothelial cells
additional information
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Sirt6 expression is reduced in the kidney of streptozotocin(STZ)-induced diabetic mice
additional information
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specific localization of NTPDase3 in the digestive system, by semiquantitative RT-PCR, immunohistochemistry, and in situ activity assay, detailed overview
additional information
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strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. Oncosphere cultures exhibit Mmp10-dependent tumor-initiating activity in vivo
additional information
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the enzyme colocalizes with neuron-specific nuclear protein, but not with astrocytic markers, namely, glial fibrillary acidic protein, and 3-phosphoglycerate dehydrogenase
additional information
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the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart
additional information
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the uPA receptor, a GPI-linked cell surface protein, occurs in macrophages infiltrating the central nervous system, and in the cerebrospinal fluid during a number of CNS pathologies
additional information
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THOP1 is ubiquitously expressed in mammalian cells and tissues, and in rodents its specific activity is highest in brain, endocrine tissues, bone marrow and immune system
additional information
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tPA colocalizes with neuronal marker MAP2, astrocytic marker glial fibrillary acidic protein, microglial marker isolectin IB4, or endothelial marker von Willebrand factor, overview
additional information
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transcriptome analysis in pacreatic carcinomas and healthy tissues
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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recruitment of the Jmjd2 H3K9/H3K36 demethylases to H3K4me3-marked nucleosomes
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isozyme AC8 is preferentially localized in the presynaptic active zone and copurifies with Rab3A
additional information
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pantetheinase is an ectoenzyme that is attached to the outer plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. GPI anchors consist of three domains: a phosphoethanolamine linker that attaches to the C terminal end of the target protein, a conserved glycan core and a phospholipid tail for anchoring to the lipid membrane
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iNOS contains several characteristic endoplasmic reticulum (ER)-localization sequences. iNOS is likely to be glycosylated in the endoplasmic reticulum
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the soluble alpha subunit is retained in the endoplasmic reticulum through its interaction with the HDEL-containing beta subunit
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the enzyme is secreted. THOP1 secretion from cultured cells has been shown to occur through an unconventional secretory pathway, and is facilitated by interaction with 14-3-3 epsilon and/or calmodulin, the process is regulated by phosphorylation of THOP1 at Ser644
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the active site of mGPDH faces the mitochondrial intermembrane space, as does its calcium-sensitive EF-hand domain
additional information
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in AtT20 cells AC9 mainly in irregular discrete punctae which are distinct from lysosomes, early endosomes or tubulovesicular endosomes, AC9 present in the cis-Golgi network
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additional information
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Jmjd2a and Jmjd2c both localize to H3K4me3-positive regions. Recruitment of the Jmjd2 H3K9/H3K36 demethylases to H3K4me3-marked nucleosomes
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additional information
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N-glycosylation of proteins starts in the endoplasmic reticulum, continues in the Golgi, and ends at the plasma membrane. As mentioned above, iNOS has characteristic ER localization sequences and locates in the Golgi and cell membrane. iNOS is located both in cytoplasm and on cell membrane, it is not only a cytoplasmic protein but also a membrane protein
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additional information
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no activity in membranes of B16F10-Nex2 cells, overview
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additional information
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subcellular localization of wild-type and mutant enzymes in the retina, overview
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additional information
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THOP1 can be secreted or associated to the external surface of the plasma membrane to function as a neuropeptide-degrading enzyme. The amount of THOP1 found in the nucleus is inversely correlated with that found in the cytosol and associated to the cytosolic face of organelles, suggesting that the enzyme can be mobilized from one intracellular compartment to the other. Predominant intracellular localization of THOP1
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LINKS TO OTHER DATABASES (specific for Mus musculus C57BL/6)
SILVA: 16S/18S rRNA, 23S/28S rRNA
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Release 2023.1 (January 2023)
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