EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.14.20.13 | (6S)-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Anisodus acutangulus |
scopolamine + succinate + CO2 |
- |
? |
| 1.14.20.13 | 3-hydroxy-3-phenylpropionyltropine + 2-oxoglutarate + O2 |
- |
Hyoscyamus niger |
3-hydroxy-3-phenylpropionyl-6-hydroxytropine + succinate + CO2 + H2O |
- |
? |
| 1.14.20.13 | 6,7-dehydrohyoscyamine + 2-oxoglutarate + O2 |
- |
Hyoscyamus niger |
scopolamine + succinate + CO2 |
- |
? |
| 1.14.20.13 | 6,7-dehydrohyoscyamine + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
? |
- |
? |
| 1.14.20.13 | 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-(4-(dimethylamino)phenyl)acetate + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
? |
- |
? |
| 1.14.20.13 | 8-methyl-8-azabicyclo[3.2.1]octan-3-yl benzoate + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
? |
- |
? |
| 1.14.20.13 | apoatropine + 2-oxoglutarate + O2 |
- |
Hyoscyamus niger |
6-hydroxyapoatropine + succinate + CO2 + H2O |
- |
? |
| 1.14.20.13 | l-homatropine + 2-oxoglutarate + O2 |
- |
Hyoscyamus niger |
6-hydroxyhomatropine + succinate + CO2 + H2O |
- |
? |
| 1.14.20.13 | more |
hyoscyamine 6beta-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, converts L-hyoscyamine to its 6,7-epoxy derivative, scopolamine, in two sequential steps, the enzyme also catalyzes the reaaction of EC 1.14.11.11. 6,7-Dehydrohyoscyamine, a potential precursor for the last step of epoxidation, is an obligatory intermediate in the biosynthesis of scopolamine |
Atropa belladonna |
? |
- |
? |
| 1.14.20.13 | more |
hyoscyamine 6beta-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, converts L-hyoscyamine to its 6,7-epoxy derivative, scopolamine, in two sequential steps. The catalytic efficiency of AbH6H, especially for the second oxidation, is low. The epoxidation step is much slower than the hydroxylation step. Substrate analogues 1-methylpiperidin-4-yl 2-phenylacetate, 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-phenylpropanoate, 8-oxabicyclo[3.2.1]octan-3-yl 2-phenylacetate, and 4 are no substrates for the enzyme |
Atropa belladonna |
? |
- |
? |
