EC Number   |
General Information |
Reference |
|---|
   3.6.4.10 | evolution |
a highly conserved molecular chaperone of the Hsp70 family that is primarily found in the mitochondria |
735005 |
| 3.6.4.10 | evolution |
chloroplast stromal Hsp70s are believed to exist in a variety of plant species, including Arabidopsis, pea, poplar, rice, sorghum and moss |
733398 |
| 3.6.4.10 | evolution |
ClpB is a molecular chaperone from the AAA+ superfamily of ATPases, Hsp100 subfamily of AAA+ ATPases |
733263 |
| 3.6.4.10 | evolution |
enzyme PnHSP70 gene belongs to the HSP70 family |
735150 |
| 3.6.4.10 | evolution |
the enzyme belongs to the class 1 Clp AAA1 proteins of the superfamily of AAA+ proteins harboring signature Walker A and B motifs |
735222 |
| 3.6.4.10 | evolution |
the structural organization and the molecular mechanism of Hsp70 chaperones are well conserved |
734351 |
| 3.6.4.10 | malfunction |
ablation or inactivation of HSP101/ClpB2 in parasites results in the nearly complete block in export with substrates accumulating in the vacuole;33 furthermore this blockade affects all classes of exported proteins, whether they harbor a PEXEL motif or not |
735222 |
| 3.6.4.10 | malfunction |
depletion of mtHsp40 leads tokDNA loss |
734614 |
| 3.6.4.10 | malfunction |
depletion of mtHsp70 leads tokDNA loss |
734614 |
| 3.6.4.10 | malfunction |
in vivo deregulation of mortalin expression and/or function is correlated with agerelated diseases and certain cancers due to its interaction with the p53 protein |
735005 |
