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Literature summary for 3.6.4.10 extracted from

  • Tyc, J.; Klingbeil, M.M.; Lukes, J.
    Mitochondrial heat shock protein machinery hsp70/hsp40 is indispensable for proper mitochondrial DNA maintenance and replication (2015), mBio, 6, e02425-14.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information RNAi-mediated downregulation of mtHsp40, Cells depleted for mtHsp70/mtHsp40 machinery lose kDNA but does not disrupt the cell cycle, phenotype Trypanosoma brucei
additional information RNAi-mediated downregulation of mtHsp70, cells depleted for mtHsp70/mtHsp40 machinery lose kDNA but does not disrupt the cell cycle, phenotype Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion the chaperones mtHsp70 and mtHsp40 and their cofactor Mge1 are uniformly distributed throughout the single mitochondrial network Trypanosoma brucei 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Trypanosoma brucei
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Trypanosoma brucei ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
mitochondrial heat shock protein 40
-
Trypanosoma brucei
mitochondrial heat shock protein 70
-
Trypanosoma brucei
mtHsp40
-
Trypanosoma brucei
mtHSP70
-
Trypanosoma brucei

General Information

General Information Comment Organism
malfunction depletion of mtHsp40 leads tokDNA loss Trypanosoma brucei
malfunction depletion of mtHsp70 leads tokDNA loss Trypanosoma brucei
physiological function the highly conserved mitochondrial chaperone machinery, essential for proper functioning of mitochondria, is composed of mitochondrial heat shock proteins 70 and 40 (mtHsp70/mtHsp40) and the ATP exchange factor Mge1. The chaperones are indispensable for the maintenance and replication of kDNA, in addition to their already known functions in Fe-S cluster synthesis and protein import Trypanosoma brucei