Protein Variants | Comment | Organism |
---|---|---|
additional information | RNAi-mediated downregulation of mtHsp40, Cells depleted for mtHsp70/mtHsp40 machinery lose kDNA but does not disrupt the cell cycle, phenotype | Trypanosoma brucei |
additional information | RNAi-mediated downregulation of mtHsp70, cells depleted for mtHsp70/mtHsp40 machinery lose kDNA but does not disrupt the cell cycle, phenotype | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | the chaperones mtHsp70 and mtHsp40 and their cofactor Mge1 are uniformly distributed throughout the single mitochondrial network | Trypanosoma brucei | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Trypanosoma brucei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Trypanosoma brucei | - |
ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Trypanosoma brucei | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mitochondrial heat shock protein 40 | - |
Trypanosoma brucei |
mitochondrial heat shock protein 70 | - |
Trypanosoma brucei |
mtHsp40 | - |
Trypanosoma brucei |
mtHSP70 | - |
Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of mtHsp40 leads tokDNA loss | Trypanosoma brucei |
malfunction | depletion of mtHsp70 leads tokDNA loss | Trypanosoma brucei |
physiological function | the highly conserved mitochondrial chaperone machinery, essential for proper functioning of mitochondria, is composed of mitochondrial heat shock proteins 70 and 40 (mtHsp70/mtHsp40) and the ATP exchange factor Mge1. The chaperones are indispensable for the maintenance and replication of kDNA, in addition to their already known functions in Fe-S cluster synthesis and protein import | Trypanosoma brucei |