EC Number   |
General Information |
Reference |
|---|
   3.6.1.59 | malfunction |
depletion of Dcs1, reduces chronological life span, possibly by modulating m7G misincorporation into nucleic acids. This can potentially link control of mRNA metabolism with senescence |
688336 |
| 3.6.1.59 | malfunction |
disruption of the DCS1 gene manifests a threefold increase of the TIF51A mRNA half-life. 5' to 3' exoribonucleolytic activity is impeded in the dcs1DELTAstrain, resulting in the accumulation of uncapped mRNA |
716209 |
| 3.6.1.59 | physiological function |
DcpS is a molecule that modulates cap concentrations for cellular homeostasis of gene expression activities involving at least RNA processing. A nuclear function for DcpS in maintaining proper pre-mRNA splicing |
716897 |
| 3.6.1.59 | physiological function |
eukaryotic cells utilize DcpS, a scavenger decapping enzyme, to degrade the residual cap structure following 30-50 mRNA decay, thereby preventing the premature decapping of the capped long mRNA and misincorporation of methylated nucleotides in nucleic acids |
715901 |
| 3.6.1.59 | physiological function |
eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce 7-methylguanosine 5'-diphosphate and 5'-phosphorylated mRNA |
716801 |
