Information on EC 3.6.1.59 - 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

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IUBMB Comments
The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body . The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
Dcps, Dcs1, m7GpppN m7GMP phosphohydrolase, m7GpppX pyrophosphatase, scavenger mRNA decapping enzyme, yDcps, YLR270W, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
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