EC Number   |
General Information |
Reference |
|---|
   3.4.21.B57 | more |
pernisine is a subtilisin-like serine protease (i.e., a subtilase) with the catalytic triad of Asp149, His184 and Ser355. Catalytic nucleophile Ser355 has an important role in pernisine activity, but not in its activation process |
732679 |
| 3.4.21.B57 | more |
prepro-Tk-subtilisin (Prepro-TKS), which consists of the signal sequence [Met (-24)-Ala(-1)], propeptide (Tkpro, Gly1-Leu69), and mature domain (Tk-subtilisin, Gly70-Gly398). the pro-enzyme form contains the insertion sequence, IS1, at the N-terminus of the mature domain which is required not only for hyperstabilization of Pro-TKS but also for its rapid maturation |
731774 |
| 3.4.21.B57 | physiological function |
enzymatic degradation of protein aggregates by pernisine, such as for infective prions (PrPSc) from different origins (i.e., mouse, bovine, deer, human) |
732679 |
