EC Number   |
General Information |
Reference  |
|---|
    2.5.1.16 | physiological function |
in vitro shoots of a transgenic European pear overexpressing apple spermidine synthase (MdSPDS1) and the wild-type are subjected to long-term stress for 0.03 mM AlCl3. SPDS expression level and spermidine titer of the transgenic line are substantially higher than those of wild-type when subjected to long-term Al stress. Transgenic line show showed higher tolerance to Al stress, and its ameliorated performance is closely correlated to polyamine accumulation, especially, to a higher spermidine titer chiefly via alleviating oxidative status as well as by affecting mineral element balance |
703469 |
| 2.5.1.16 | malfunction |
single spe-sdh mutants are isolated after sexual recombination in planta with a compatible wild-type strain. Mutants are auxotrophic for lysine and spermidine, but not for putrescine, and contain putrescine and spermidine, but not spermine. spe-sdh are were sensitive to stress, unable to carry out the yeast-to-mycelium dimorphic transition, and show attenuated virulence to maize. These phenotypic alterations are reverted by complementation with the wild-type gene |
703771 |
| 2.5.1.16 | physiological function |
PgSPD expression is slightly induced by mannitol and CuSO4. Salt, chilling, abscisic acid and jasmonic acid trigger a significant induction of PgSPD expression within 12-24 h post-treatment, especially PgSPD is prominently induced by salt (41.5fold) |
705641 |
| 2.5.1.16 | physiological function |
transgenic plants expressing the cyst nematode (Heterodera glycines) effector protein 10A06 exhibit elevated SPDS2 mRNA abundance, significantly higher spermidine content, and increased polyamine oxidase activity. The SPDS2 promoter is strongly activated in the nematode-induced syncytia, and transgenic plants overexpressing SPDS2 show enhanced plant susceptibility to Heterodera schachtii. These data lend strong support to a model in which the cyst nematode effector 10A06 exerts its function through the interaction with SPDS2, thereby increasing spermidine content and subsequently polyamine oxidase activity |
706337 |
| 2.5.1.16 | physiological function |
to verify whether spermidine synthase can confer long-term multi-heavy metal tolerance, in vitro shoots of a transgenic European pear overexpressing apple SPDS are subjected to stress using either CdCl2, PbCl2, ZnCl2, or a combination thereof. The results suggest that spermidine-levels are implicated in enhanced heavy metal tolerance, possibly by exerting an antioxidant activity as well as by the properties of spermidine per se including metal chelator |
706860 |
| 2.5.1.16 | malfunction |
microarray experiments with a spermidine synthase, spermine oxidase mutant (DELTAspe3DELTAfms1) strain are performed to investigate the responsiveness of yeast genes to supplementation with spermidine or spermine. Expression analysis identified genes responsive to the addition of either excess spermidine or spermine compared to a control culture. Results from global gene expression profiling demonstrate a more major role for spermidine in modulating gene expression in yeast than spermine |
706926 |
| 2.5.1.16 | physiological function |
spermidine synthhase is responsible for spermdine synthesis from putrescine, the polyamines putrescine, spermidine and spermine are cationic molecules that are found in all eukaryotic cells and are clearly essential to growth and development |
721264 |
| 2.5.1.16 | more |
ligand docking modeling using the tertiary structure model, overview |
721733 |
| 2.5.1.16 | physiological function |
spermidine synthase is an important enzyme in the synthetic pathway of polyamines in the parasite, is an essential element for the survival of this protozoan |
721733 |
| 2.5.1.16 | malfunction |
an enzyme-deficient strain is auxotrophic for polyamines, requires spermidine for growth in its insect vector form, and is adversely impacted in its ability to infect mice |
-, 722385 |
