EC Number   |
General Information |
Reference |
|---|
   2.3.1.67 | evolution |
two entities of lyso-PAFAT belonging to the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family: a constitutively expressed lyso-PAFAT, LPCAT1,and an inducible lyso-PAFAT, LPCAT2. LPCAT1 is mainly expressed in the lungs and produces PAF and dipalmitoyl-phosphatidylcholine, which is a main component of a pulmonary surfactant essential for respiration. LPCAT2 is mainly expressed in inflammatory cells and also possesses biosynthetic activities for PAF and cellular membrane phosphatidylcholine |
736604 |
| 2.3.1.67 | metabolism |
following extracellular stimulation, platelet-activating factor is rapidly biosynthesized via a remodeling pathway in inflammatory cells such as macrophages and neutrophils. In the remodeling pathway, one of the membrane phospholipids, 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine is hydrolyzed by phospholipase A2 to produce free fatty acids and lyso-PAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine). Acetyl-CoA:lyso-PAF acetyltransferase (lyso-PAFAT) subsequently converts lyso-PAF to PAF, which is rapidly degraded to lyso-PAF and acetic acid by PAF acetylhydrolases, terminating its effects |
736604 |
| 2.3.1.67 | metabolism |
platelet-activating factor is synthesized rapidly in the remodeling pathway from its precursor membrane phospholipid, 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine, involving the enzyme |
-, 736450 |
| 2.3.1.67 | physiological function |
a key metabolic enzyme of platelet-activating factor (PAF) syntesis, a potent inflammatory lipid mediator. Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid implicated in physiological as well as pathological inflammatory processes such as atherogenesis. It affects several critical points of atherogenesis including thrombosis, inflammation and oxidation. Common risk factors for atherosclerosis, namely diabetes, cigarette smoking, oxidised low-density lipoprotein (LDL) and systemic inflammation, share elevated PAF and PAF-like lipids as a common feature |
736050 |
| 2.3.1.67 | physiological function |
activities of phospholipase A2 and acetyl-CoA:lyso-PAF acetyltransferase (LysoPAFAT) are elevated in the spinal cord of experimental allergic encephalomyelitis (EAE) mice, an animal model for multiple sclerosis, compared with those of naive mice and correlate with disease severity |
688161 |
| 2.3.1.67 | physiological function |
in inflammatory and allergic processes, platelet-activating factor, PAF, is biosynthesized in specific enzymatic reactions, which involve acetyl-CoA:lyso-PAF acetyltransferases |
735644 |
| 2.3.1.67 | physiological function |
platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid mediator. In response to extracellular stimuli, PAF is rapidly biosynthesized by lyso-PAF acetyltransferase. Under inflammatory conditions, LPCAT2, but not LPCAT1, is activated and upregulated to produce the platelet-activating factor |
736604 |
| 2.3.1.67 | physiological function |
platelet-activating factor (PAF), a potent proinflammatory lipid mediator, is synthesized rapidly in response to extracellular stimuli by the activation of acetyl-CoA:lyso-PAF acetyltransferase, lyso-PAFAT. The enzyme is rapidly phosphorylated after methylcarbamylplatelet-activating factor stimulation to enhance its enzymatic activity |
-, 736450 |
