Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | 500 ml/day of low-fat milk fortified with phytosterols, linoleic and alpha linolenic acids, vitamin C, vitamin E, vitamin A, vitamin B6, vitamin B12, folic acid, magnesium and selenium has no effect on the enzyme activity in vivo | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 500 ml/day of low-fat milk fortified with phytosterols, linoleic and alpha linolenic acids, vitamin C, vitamin E, vitamin A, vitamin B6, vitamin B12, folic acid, magnesium and selenium has no effect on the enzyme activity in vivo | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q7L5N7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
lyso-PAF AT | - |
Homo sapiens |
lyso-platelet-activating factor acetyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | a key metabolic enzyme of platelet-activating factor (PAF) syntesis, a potent inflammatory lipid mediator. Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid implicated in physiological as well as pathological inflammatory processes such as atherogenesis. It affects several critical points of atherogenesis including thrombosis, inflammation and oxidation. Common risk factors for atherosclerosis, namely diabetes, cigarette smoking, oxidised low-density lipoprotein (LDL) and systemic inflammation, share elevated PAF and PAF-like lipids as a common feature | Homo sapiens |