EC Number   |
General Information |
Reference |
|---|
   2.3.1.147 | metabolism |
the enzyme participates in the high affinity-low capacity pathway. Cells use this pathway to rapidly incorporate and remodel arachinonic acid through various glycerophospholipids. The predominant enzymes in this pathway include long chain fatty-acid ligase, lysophospholipid: acyl-CoA acyltransferase, and acyl-CoA independent transacylase, overview |
701639 |
| 2.3.1.147 | physiological function |
arachidonic acid-phospholipid remodeling orchestrated by CoA-IT and gIVaPLA2 may function to regulate eosinophil apoptosis, overview. Regulation of arachidonic acid and phospholipid remodeling enzymes provides a mechanism for regulating not only eicosanoid production, but also the increased life-span of eosinophils in allergic asthma, overview |
701639 |
| 2.3.1.147 | physiological function |
CoA-independent transacylase is a major regulator of arachidonic acid metabolism in human monocytes. Arachidonic acid incorporation into phospholipids is similar in both monocytes and U-937 cells, but a marked difference in the rate of remodeling is appreciated. U-937 cells remodel arachidonic acid at a much faster rate than human monocytes. This difference is not related to the differentiation state of the U-937 cells, but rather to the low levels of esterified arachidonate found in U-937 cells compared to human monocytes. Incubating the U-937 cells in arachidonic acid-rich media increases the cellular content of this fatty acid and leads to a substantial decrease of the rate of phospholipid arachidonic acid remodeling, which is due to reduced CoA-independent transacylase activity |
718983 |
