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Literature summary for 2.3.1.147 extracted from
- Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma (2009), Am. J. Respir. Cell Mol. Biol., 41, 358-366.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SKF 98625 | a reversible antagonist of CoA-IT, in vitro and in vivo inhibition, induces eosinophil apoptosis in vitro | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
individuals with and without asthma | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eosinophil | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CoA-independent transacylase | - |
Homo sapiens |
| CoA-IT | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.005 | 0.01 | pH 7.4, 37°C, in cell-free assays | Homo sapiens | SKF 98625 | |
| 0.015 | 0.025 | pH 7.4, 37°C, in whole cell assays | Homo sapiens | SKF 98625 | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme participates in the high affinity-low capacity pathway. Cells use this pathway to rapidly incorporate and remodel arachinonic acid through various glycerophospholipids. The predominant enzymes in this pathway include long chain fatty-acid ligase, lysophospholipid: acyl-CoA acyltransferase, and acyl-CoA independent transacylase, overview | Homo sapiens |
| physiological function | arachidonic acid-phospholipid remodeling orchestrated by CoA-IT and gIVaPLA2 may function to regulate eosinophil apoptosis, overview. Regulation of arachidonic acid and phospholipid remodeling enzymes provides a mechanism for regulating not only eicosanoid production, but also the increased life-span of eosinophils in allergic asthma, overview | Homo sapiens |
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